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| 1 | Gastric cancer with peritoneal metastases: Efficiency of standard treatment methods显示文摘BACKGROUND Peritoneal metastasis(PM),arising from gastric cancer(GC),is the most common pattern of synchronous and metachronous dissemination and is generally associated with poor prognosis.New therapeutic modalities are being increasingly employed for such patients.AIM To develop more advanced methods,it becomes necessary to study the results of existing standard treatment methods in patients with PM in order to perform a comparative analysis of the strategies.METHODS A retrospective analysis of the efficiency of standard treatment methods(i.e.,palliative chemotherapy,palliative gastrectomy,and the best supportive care)was performed on 200 GC patients with synchronous PM.RESULTS The overall survival(OS)rate in 200 GC patients with PM under standard treatment was 5.4 mo.One-year survival occurred in 18.4%of patients.In multivariate analysis,the survival rate was significantly influenced by the following factors:Presence of extraperitoneal metastases,and stage of PM according to both the Japanese Gastric Cancer Association(JGCA)and the peritoneal cancer index(PCI).The median OS and 1-year survival of patients withР1,P2,and P3(JGCA)carcinomatosis were 9.8 mo,6.7 mo,and 4.0 mo,and 47.2%,18.8%,and 5.1%,respectively.The application of the palliative gastrectomy resulted in an increase in the median OS by up to 17 mo compared to the conservative approach where the value was 8.5 mo(P=0.05)in patients withР1РМ.In patients withР3,palliative chemotherapy increased the OS by up to 5.6 mo compared to the OS of 3.2 mo(P=0.0006)for best supportive care.The median OS and 1-year survival of patients withРCI of 1-6,7-12 and 13+points were 8.5 mo,4.2 mo,and 4.1 mo,and 39.8%,6.7%,and 5.5%,respectively.Palliative gastrectomy increased the median OS to 12.6 mo compared to conservative approach of 8.0 mo(P=0.03)in patients withРCI of 1-6 points.In patients withРCI 13+points,only palliative chemotherapy increased the OS to 6.0 mo compared to the OS of 3.4 mo for best supportive care(P=0.0008).CONCLUSION GC patients with PM are characterized by extremely poor prognoses.Long-term survivors were found in the group with PCI of 1-6 points,and there was no survival difference in groups with PCI 7-12 vs PCI 13+points.Palliative gastrectomy could prove effective in treating patients with early stage PM.The three standard treatment methods are equally effective for moderate stages of PM.In cases with advanced peritoneal carcinomatosis,a significant increase in prognosis was registered only after treatment with palliative chemotherapy. | Roman Yarema МyronОhorchak Petro Hyrya Yuriy Kovalchuk Victor Safiyan Ivan Karelin Severyn Ferneza Markiyan Fetsych Myron Matusyak Yuriy Oliynyk Тaras Fetsych | 2020 | World Journal of Gastrointestinal Oncology2020，12，5： | 3 |
| 2 | Targeting Cancer Cells with Dendrimers显示文摘 | Sampathkumar SG Yarema KJ | 2005 | Chem Biol2005，12，1： | 1 |
| 3 | Key concepts in postmortem drug redistribution 显示文摘 | Yarema M 'C Becker C E | 2005 | Clin Toxicol ( Phila)2005，43，4： | 1 |
| 4 | Low-dose corticosteroids to treat Septic shock: a critical literature review显示文摘 | Yarema TC Yost S | 2011 | Crit Care Nurse2011，31，6： | 1 |
| 5 | Optical and lasing properties of fluorophosphate glass显示文摘 | S E Stokowski W E Martin S M Yarema | 1980 | Journal of Non-Crystal- line Solids1980，40，： | 1 |
| 6 | Ostwald ripening under dislocation diffusion 显示文摘 | Vengrenovich R D Gudyma Y V Yarema S V | 2002 | Scripta Mater2002，46，： | 1 |
| 7 | Nondestructive testing and technical diagnostics 显示文摘 | Yarema S Y | 2003 | Materials Science2003，1，： | 1 |
| 8 | Low-dose corticosteroids to treat septic shock:a critical literature review显示文摘 | Yarema TC Yost S | | 0，，06： | 1 |
| 9 | Key concepts in postmortem drug redistribution显示文摘 | Yarema MC Becker CE | 2005 | Clin Toxicol(Phila)2005，43，4： | 1 |
| 10 | On the road to standardization of D2 lymph node dissection in a European population of patients with gastric cancer显示文摘The amount of lymph node dissection(LD) required during surgical treatment of gastric cancer surgery has been quite controversial.In the 1970 s and 1980 s,Japanese surgeons developed a doctrine of aggressive preventive gastric cancer surgery that was based on extended(D2) LD volumes.The West has relatively lower incidence rates of gastric cancer,and in Europe and the United States the most common LD volume was D0-1.This eventually caused a scientific conflict between the Eastern and Western schools of surgical thought.:Japanese surgeons determinedly used D2 LD in surgical practice,whereas European surgeons insisted on repetitive clinical trials in the European patient population.Today,however,one can observe the results of this complex evolution of views.The D2 LD is regarded as an unambiguous standard of gastric cancer surgical treatment in specialized European centers.Such a consensus of the Eastern and Western surgical schools became possible due to the longstanding scientific and practical search for methods that would help improve the results of gastric cancer surgeries using evidence-based medicine.Today,we can claim that D2 LD could improve the prognosis in European populations of patients with gastric cancer,but only when the surgical quality of LD execution is adequate. | Roman Yarema Giovanni de Manzoni Taras Fetsych Myron Ohorchak Mykhailo Pliatsko Maria Bencivenga | 2016 | World Journal of Gastrointestinal Oncology2016，8，6： | 1 |
| 11 | Comparison of the 20-hour intravenous and 72-hour oral acetylcysteine protocols for the treatment of acute acetaminophen poisoning显示文摘 | Yarema MC Johnson DW Berlin RJ | 2009 | Ann Emerg Med2009，54，4： | 1 |
| 12 | Engineering chemical reactivity on cell surfaces through oligo saccharide biosynthesis显示文摘 | Mahal L K Yarema K J Bertozzi C R | 1997 | Science1997，276，5315： | 1 |
| 13 | Hyperthermic intraperitoneal chemoperfusion in combined treatment of locally advanced and disseminated gastric cancer: Results of a single-centre retrospective study显示文摘 | Roman Romanovych Yarema Myron A. Ohorchak Gennadyi P. Zubarev Yuriy P. Mylyan Yuriy Y. Oliynyk Mykola G. Zubarev Petro I. Gyrya Yuriy J. Kovalchuk Victor I. Safiyan Taras G. Fetsych | 2014 | International Journal of Hyperthermia2014，，3： | 1 |
| 14 | Metabolic expression of thiol-derivatized sialic acids on the cell surface and their quantitative estimation by flow cytometry 显示文摘 | Sampathkumar S G Jones M B Yarema K J | 2006 | Nat Protoc2006，1，4： | 1 |
| 15 | Low-dose corticosteroids to treat septic shock:a critical literature review显示文摘 | Yarema TC Yost S | 2011 | Crit Care Nurse2011，31，6： | 1 |
| 16 | Targeting cancer cells with dendrimers显示文摘 | Sampathkumar SG Yarema KJ | 2005 | Chem Biol2005，12，： | 1 |
| 17 | Engineering chemical reactivity on cell surfaces through oligosaccharide biosynthesis显示文摘 | Mahal L K Yarema K J Bertozzi C R | 1997 | Science1997，276，： | 1 |
| 18 | Development of delivery methods for carbohydrate-based drugs: controlled release of biologically-active short chain fatty acid-hexosamine analogs显示文摘 | Udayanath Aich M. Adam Meledeo Srinivasa-Gopalan Sampathkumar Jie Fu Mark B. Jones Christopher A. Weier Sung Yun Chung Benjamin C. Tang Ming Yang Justin Hanes Kevin J. Yarema | 2010 | Glycoconjugate Journal2010，，4： | 1 |
| 19 | Low-dose corticosteroids to treat septic shock: acritical literature review 显示文摘 | Yarema TC Yost S | 2011 | Crit Care Nurse2011，31，6： | 1 |
| 20 | PbS nanocrys- tal solar cells with high efficiency and fill factor显示文摘 | Szendrei K Gomulya W Yarema M | 2010 | Ap- plied Physics Letters2010，97，20： | 1 |
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