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| 1 | Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer显示文摘Inflammatory bowel diseases are characterised by inflammation that compromises the integrity of the epithelial barrier. The intestinal epithelium is not only a static barrier but has evolved complex mechanisms to control and regulate bacterial interactions with the mucosal surface. Apical tight junction proteins are critical in the maintenance of epithelial barrier function and control of paracellular permeability. The characterisation of alterations in tight junction proteins as key players in epithelial barrier function in inflammatory bowel diseases is rapidly enhancing our understanding of critical mechanisms in disease pathogenesis as well as novel therapeutic opportunities. Here we give an overview of recent literature focusing on the role of tight junction proteins, in particular claudins, in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer. | Jonathan Landy Emma Ronde Nick English Sue K Clark Ailsa L Hart Stella C Knight Paul J Ciclitira Hafid Omar Al-Hassi | 2016 | World Journal of Gastroenterology2016，22，11： | 39 |
| 2 | Systematic review and meta-analysis of colon cleansing preparations in patients with inflammatory bowel disease显示文摘AIM To performed a systematic review and meta-analysis to determine any possible differences in terms of effectiveness, safety and tolerability between existing colon-cleansing products in patients with inflammatory bowel disease.METHODS Systematic searches were performed( January 1980-September 2016) using MEDLINE, EMBASE, Scopus, CENTRAL and ISI Web of knowledge for randomized trials assessing preparations with or without adjuvants, given in split and non-split dosing, and in high(> 3 L) or low-volume(2 L or less) regimens. Bowel cleansing quality was the primary outcome. Secondary outcomes included patient willingness-torepeat the procedure and side effects/complications.RESULTS Out of 439 citations, 4 trials fulfilled our inclusion criteria(n = 449 patients). One trial assessed the impact of adding simethicone to polyethylene glycol(PEG) 4 L with no effect on bowel cleansing quality, but a better tolerance. Another trial compared senna to castor oil, again without any differences in term of bowel cleansing. Two trials compared the efficacy of PEG high-volume vs PEG low-volume associated to an adjuvant in split-dose regimens: PEG low-dose efficacy was not different to PEG high-dose; OR = 0.84(0.37-1.92). A higher proportion of patients were willing to repeat low-volume preparations vs high-volume; OR = 5.11(1.31-20.0). CONCLUSION In inflammatory bowel disease population, PEG lowvolume regimen seems not inferior to PEG high-volume to clean the colon, and yields improved willingness-torepeat. Further additional research is urgently required to compare contemporary products in this population. | Sophie Restellini Omar Kherad Talat Bessissow Charles Ménard Myriam Martel Maryam Taheri Tanjani Peter L Lakatos Alan N Barkun | 2017 | World Journal of Gastroenterology2017，23，32： | 16 |
| 3 | Clinicopathological predictors of long-term benefit in breast cancer treated with neoadjuvant chemotherapy显示文摘AIM To investigate the survival impact of clinicopathological factors, including pathological complete response(p CR) and tumor-infiltrating lymphocytes(s TIL) levels according to subtypes, in breast cancer(BC) patients who received neo-adjuvant chemotherapy(NAC).METHODS We evaluated 435 BC patients who presented and received NAC at the Instituto Nacional de Enfermedades Neoplasicas from 2003 to 2014. s TIL was analyzed as the proportion of tumor stroma occupied by lymphocytes, and was prospectively evaluated on hematoxylin and eosin-stained sections of the preN AC core biopsy. p CR was considered in the absence of infiltrating cancer cells in primary tumor and axillary lymph nodes. Analysis of statistical association between clinical pathological features, s TIL, p CR and survival were carried out using SPSSvs19.RESULTS Median age was 49 years(range 24-84 years) and the most frequent clinical stage was ⅢB(58.3%). Luminal A, Luminal B, HER2-enriched and(triple-negative) TN phenotype was found in 24.6%, 37.9%, 17.7% and 19.8%, respectively. p CR was observed in 11% and median percentage of s TIL was 40%(2%-95%) in the whole population. p CR was associated to Ct1-2(P = 0.045) and to high s TIL(P = 0.029) in the whole population. There was a slight trend towards significance for s TIL(P = 0.054) in Luminal A. s TIL was associated with grade Ⅲ(P < 0.001), no-Luminal A subtype(P < 0.001), RE-negative(P < 0.001), PgR-negative(P < 0.001), HER2-positive(P = 0.002) and p CR(P = 0.029) in the whole population. Longer disease-free survival was associated with grade Ⅰ-Ⅱ(P = 0.006), cN 0(P < 0.001), clinical stage Ⅱ(P = 0.004), ER-positive(P < 0.001), Pg R-positive(P < 0.001), luminal A(P < 0.001) and p CR(P = 0.002). Longer disease-free survival was associated with grade Ⅰ-Ⅱ in Luminal A(P < 0.001), N0-1 in Luminal A(P = 0.045) and TNBC(P = 0.01), clinical stage Ⅱ in Luminal A(P = 0.003) and TNBC(P = 0.038), and pC R in TNBC(P < 0.001). Longer overall survival was associated with grade Ⅰ-Ⅱ(P < 0.001), ER-positive(P < 0.001), PgR-positive(P < 0.001), Luminal A(P < 0.001), cN 0(P = 0.002) and p CR(P = 0.002) in the whole population. Overall survival was associated with clinical stage Ⅱ(P = 0.017) in Luminal A, older age(P = 0.042) in Luminal B, and pC R in TNBC(P = 0.005).CONCLUSION Predictive and prognostic values of clinicopathological features, like p CR and s TIL, differ depending on the evaluated molecular subtype. | Marco Galvez Carlos A Castaneda Joselyn Sanchez Miluska Castillo Lia Pamela Rebaza Gabriela Calderon Miguel De La Cruz Jose Manuel Cotrina Julio Abugattas Jorge Dunstan Henry Guerra Omar Mejia Henry L Gomez | 2018 | World Journal of Clinical Oncology2018，9，2： | 4 |
| 4 | Liver dysfunction and SARS-CoV-2 infection显示文摘Severe acute respiratory syndrome coronavirus 2 infection is the cause of coronavirus disease 2019(COVID-19),which predominantly affects the respiratory system;it also causes systemic and multi-organic disease.Liver damage is among the main extrapulmonary manifestations.COVID-19-associated liver injury is defined as any liver damage occurring during the disease course and treatment of COVID-19 in patients with or without pre-existing liver disease,and occurs in approximately one in five patients.Abnormal liver test results have been associated with a more severe course of COVID-19 and other complications,including death.Mechanisms linking COVID-19 to liver injury are diverse.Particular consideration should be made for patients with pre-existing liver disease,such as metabolic dysfunction-associated fatty liver disease,chronic liver disease due to viral or autoimmune disease,liver transplant carriers,or cirrhosis,given the risk for more severe outcomes.This manuscript summarizes the current lines of evidence on COVID-19-associated liver injury regarding pathophysiology,clinical significance,and management in both patients with or without preexisting liver disease,to facilitate clinicians’access to updated information and patient care.Finally,we mention the ideas and recommendations to be considered for future research. | Abraham Edgar Gracia-Ramos Joel Omar Jaquez-Quintana Raúl Contreras-Omaña Moises Auron | 2021 | World Journal of Gastroenterology2021，27，26： | 2 |
| 5 | Bacteriocin-based strategies for food biopreservation显示文摘 | Antonio Gálvez Hikmate Abriouel Rosario Lucas López Nabil Ben Omar | 2007 | International Journal of Food Microbiology2007，，1： | 2 |
| 6 | Single cell oil pro- duction by Goldoni DG using agro-industrial wastes 显示文摘 | Gouda M K Omar S Hi Aouad L M | 2008 | World J Microbial Biotech2008，，24： | 1 |
| 7 | Explicit nonlinear fi- nite element geometric analysis of parabolic leaf spring under various loads 显示文摘 | Kong Y S Omar M Z Chua L B | 2013 | The Scientific World Journal2013，，： | 1 |
| 8 | Antioxidant activity of three edible seaweeds from two areas in South East Asia显示文摘 | CHEW Y L LIM Y Y OMAR M | 2008 | LWT-Food Science and Technology2008，41，6： | 1 |
| 9 | Coplanar waveguide with top and bottom shields in place of air-bridges 显示文摘 | OMAR A A CHOW Y L | 1993 | IEEE Trans Microwave Theory and Techniques1993，41，9： | 1 |
| 10 | Brain Region-Selective Mechanisms Contribute to the Progression of Cerebral Alterations in Acute Liver Failure in Rats显示文摘 | Omar Cauli Pilar López–Larrubia Regina Rodrigo Ana Agusti Jordi Boix Laura Nieto–Charques Sebastián Cerdán Vicente Felipo | 2011 | Gastroenterology2011，，2： | 1 |
| 11 | Equivocal roles of tissue-type plasminogen activator in stroke-induced injury显示文摘 | Karim Benchenane José P. López-Atalaya Mónica Fernández-Monreal Omar Touzani Denis Vivien | 2004 | Trends in Neurosciences2004，，3： | 1 |
| 12 | Application of an eviden- tial belief function model in landslide susceptibility map- ping显示文摘 | Omar F A Biswajeet P Saro L | 2012 | Computers & Geosciences2012，，44： | 1 |
| 13 | Metal - organic frameworks: A new class of porous materials 显示文摘 | Jesse L C Rowsell Omar M Y | 2004 | Microporous and Mesoporous Materials2004，73，12： | 1 |
| 14 | Ectopic intramural pregnancy developing at the site of a cesarean section scar显示文摘 | A1-Nazer A Omar L | 2009 | Cases J2009，，2： | 1 |
| 15 | Cardioprotection by GSK-3 inhibition: role of enhanced glycogen synthesis and attenuation of calcium overload 显示文摘 | Omar MA Wang L Clanachan AS | 2010 | Cardiovase Res2010，86，3： | 1 |
| 16 | Diagnosis and management of hyperprolactinemia显示文摘 | Omar Serri Constance L Chik | 2003 | CMAJ2003，169，： | 1 |
| 17 | Circulating levels of highsensitivity C-Reactive protein and soluble markers of vascular en dothelial cell activation in growth hormone deficient adolescents 显示文摘 | Roberto L Henry M Omar V | 2008 | Horm Res2008，70，： | 1 |
| 18 | Severe vincristine neurotoxicity with concomitant use of itraconazole 显示文摘 | Ariffin H Omar K Z Ang E L | 2003 | J Paediatr Child Health2003，39，8： | 1 |
| 19 | A laboratory scale bioremediation of Tapis crude oil contaminated soil by bioaugmentation of Aeinetobaeter baumannii T30C 显示文摘 | Chang L K Ibrahim D Omar I C | 2011 | African Journal Of Microbiology Research2011，9，5： | 1 |
| 20 | Pathogenicity of Ssp I positive infectious bursal disease virus and molecular characteri- zation of the VP2 hypervariable region 显示文摘 | Hoque M M Omar A R Chong L K | 2001 | Avian Pathol2001，30，： | 1 |
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