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| 1 | 认知行为疗法与佐匹克隆治疗老年慢性原发性失眠患者的比较:一项随机对照试验显示文摘Context: Insomnia is a common condition in older adults and is associated with a number of adverse medical, social, and psychological consequences. Previous research has suggested beneficial outcomes of both psychological and pharmacological treatments, but blinded placebo-controlled trials comparing the effects of these treatments are lacking. Objective: To examine short-and long-term clinical efficacy of cognitive behavioral therapy (CBT) and pharmacological treatment in older adults experiencing chronic primary insomnia. Design, Setting, and Participants: A randomized, double-blinded, placebo-controlled trial of 46 adults (mean age, 60.8 y; 22 women) with chronic primary insomnia conducted between January 2004 and December 2005 in a single Norwegian university-based outpatient clinic for adults and elderly patients. Intervention: CBT (sleep hygiene, sleep restriction, stimulus control, cognitive therapy, and relaxation; n=18), sleep medication (7.5-mg zopiclone each night; n=16), or placebo medication (n=12). All treatment duration was 6 weeks, and the 2 active treatments were followed up at 6 months. Main Outcome Measures: Ambulant clinical polysomnographic data and sleep diaries were used to determine total wake time, total sleep time, sleep efficiency, and slow-wave sleep (only assessed using polysomnography) on all 3 assessment points. Results: CBT resulted in improved short-and long-term outcomes compared with zopiclone on 3 out of 4 outcome measures. For most outcomes, zopiclone did not differ from placebo. Participants receiving CBT improved their sleep efficiency from 81.4%at pretreatment to 90.1%at 6-month follow-up compared with a decrease from 82.3%to 81.9%in the zopiclone group. Participants in the CBT group spent much more time in slow-wave sleep (stages 3 and 4) compared with those in other groups, and spent less time awake during the night. Total sleep time was similar in all 3 groups; at 6 months, patients receiving CBT had better sleep efficiency using polysomnography than those taking zopiclone. Conclusion: These results suggest that interventions based on CBT are superior to zopiclone treatment both in short-and long-term management of insomnia in older adults. | Sivertsen B Omvik S Pallesen S. 谢琰臣 | 2006 | 世界核心医学期刊文摘(神经病学分册)2006，2，11： | 3 |
| 2 | Cognitive behavioral therapy vs zopiclone for treatment of chronic primary insomnia in older adults: a randomized controlled trial 显示文摘 | Sivertsen B Omvik S Pallesen S | 2006 | JAMA2006，295，24： | 1 |
| 3 | Comparison of angiotensin Ⅱ antagonist losartan with the angiotension converting enzyme inhibitor enalapril in patients with essential hypertension显示文摘 | Omvik P Jense HA | 1995 | J Hypertens1995，13，： | 1 |
| 4 | Prevalence and risk factors of subjective sleepiness in general adult population显示文摘 | Pallesen S Nordhus IH Omvik S etal | 2007 | Sleep2007，30，5： | 1 |
| 5 | Double blind, parallel, comparative study on quality of life during treatment with amlodipine or enalapril in mild or moderate hypertensive patients: A multicentre study显示文摘 | Omvik P Thaulow E Herland OB | 1993 | J Hypertension1993，11，： | 1 |
| 6 | Left atrial size and risk of major cardiovascu- lar events during antihypertensive treatment: losartan intervention for endpoint reduction in hypertension trial显示文摘 | Gerdts E Wachtell K Omvik P | 2007 | Hypertension2007，49，2： | 1 |
| 7 | Vasartan with the ACEI enalapril in patients withessential hypertension显示文摘 | Tikkanen I Omvik P Jensen HA | 1995 | J Hypertens1995，13，： | 1 |
| 8 | Comparison of the angiotensin Ⅱantagonist losartan with the angiotensin converting enzyme inhibitor enapril in patients with essential hypertension显示文摘 | Tikkanen I Omvik P Jensen HE | 1995 | J Hypertens1995，13，： | 1 |
| 9 | The Norwegian office-,home-,and ambulatory blood pressure study (NOHA)显示文摘 | Gerhardsen G | 2003 | Blood pressure2003，12，： | 1 |
| 10 | A double-blind,long-term,comparative study on quality of life,safety,and effcacy during treatment with amlodipine or enalapril in mild or moderate hypertensive patients:a multionenter study显示文摘 | Thaulow E Herland OB | 1993 | J Csrdiovasc Pharmacol1993，，： | 1 |
| 11 | Comparison of the angiotensin Ⅱ antagonist losartan with the angiontensin Ⅱ antagonist losartan with the angiotensin converting enzyme inhibitor enalapril in patients with essential hypertension显示文摘 | Tikkanen I Omvik P Jensen HAE | 1995 | Hypertension1995，13，： | 1 |
| 12 | Comparison of the angiotensin Ⅱ antagonist losartan with the angiotrnsin converting enzyme inhibitor enalapril in patients with essential hypertension显示文摘 | Tikkanen Ⅰ Omvik P Jensen HA | 1995 | J Hypertens1995，13，11： | 1 |
| 13 | Comparison of the angiotensin Ⅱ antagonist losartan with the angiotensin converting enzyme inhibitor enalapril in patients with essential hypertension显示文摘 | Tikkanen I Omvik P Jensen HA | 1995 | J Hypertens1995，13，11： | 1 |
| 14 | Comparison of the angiotensin Ⅱ antagonist losartan with the angiotensin converting enzyme inhibitor enalapril in patients with essential hypertension显示文摘 | Omvik O Jensen H | 1995 | J Hypertens1995，13，： | 1 |
| 15 | Prevalence and Risk Factors of Subjective Sleepiness in the General AdultPopulation显示文摘 | STALE PALLESEN IHN SIRI OMVIK | 2007 | Sleep2007，30，5： | 1 |
| 16 | Cognitive behavioral therapy vs zopiclone for treatment of chronic primary insomnia in older adults:a randomized controlled trial显示文摘 | Sivertsen B Omvik S Pallesen S | | 0，，： | 1 |
| 17 | Comparison of the angiotensin Ⅱ antagonist losartan with the angiontensin Ⅱ antagonist losartan with the angiotensin converting enzyme inhibitor enalapril in patients with essential hypertension显示文摘 | Tikkanen I Omvik P Jensen HAE | | Hypertension0，，： | 1 |
| 18 | Daytime functioning in older patients suffering from chronic insomnia: treatment outcome in a randomized controlled trial comparing CBT with Zopiclone 显示文摘 | Omvik S Sivertsen B Pallesen S! | 2008 | Behav Res Ther2008，46，5： | 1 |
| 19 | Left atrial size and risk of major cardiovascular events during antihy pertensive treatment显示文摘 | Gerdts E Wachtell K Omvik P | 2007 | Hypertension2007，49，： | 1 |
| 20 | Comparison of the angiotensin Ⅱ antagonist Losartan with the angiotensin converting enzyme inhibitor enalapril in patients with essential hypertension显示文摘 | Tikkanen I Omvik P Jensen HA | 1995 | J Hypertens1995，13，： | 1 |
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