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| 1 | Treatment with NADPH oxidase inhibitor apocynin alleviates diabetic neuropathic pain in rats显示文摘Increased reactive oxygen species by the activation of NADPH oxidase(NOX) contributes to the development of diabetic complications.Apocynin,a NOX inhibitor,increases sciatic nerve conductance and blood flow in diabetic rats.We investigated potential protective effect of apocynin in rat diabetic neuropathy and its precise mechanism of action at molecular level.Rat models of streptozotocin-induced diabetes were treated with apocynin(30 and 100 mg/kg per day,intragastrically) for 4 weeks.Mechanical hyperalgesia and allodynia were determined weekly using analgesimeter and dynamic plantar aesthesiometer.Western blot analysis and histochemistry/immunohistochemistry were performed in the lumbar spinal cord and sciatic nerve respectively.Streptozotocin injection reduced pain threshold in analgesimeter,but not in aesthesiometer.Apocynin treatment increased pain threshold dose-dependently.Western blot analysis showed an increase in catalase and NOX-p47 phox protein expression in the spinal cord.However,protein expressions of neuronal and inducible nitric oxide synthase(n NOS,i NOS),superoxide dismutase,glutathion peroxidase,nitrotyrosine,tumor necrosis factor-α,interleukin-6,interleukin-1β,aldose reductase,cyclooxygenase-2 or MAC-1(marker for increased microgliosis) in the spinal cord remained unchanged.Western blot analysis results also demonstrated that apocynin decreased NOX-p47 phox expression at both doses and catalase expression at 100 mg/kg per day.Histochemistry of diabetic sciatic nerve revealed marked degeneration.n NOS and i NOS immunoreactivities were increased,while S-100 immunoreactivity(Schwann cell marker) was decreased in sciatic nerve.Apocynin treatment reversed these changes dose-dependently.In conclusion,decreased pain threshold of diabetic rats was accompanied by increased NOX and catalase expression in the spinal cord and increased degeneration in the sciatic nerve characterized by increased NOS expression and Schwann cell loss.Apocynin treatment attenuates neuropathic pain by decelerating the increased oxidative stress-mediated pathogenesis in diabetic rats. | Murat Olukman Aytül onal Fatma Gül celenk Yigit Uyankgil Türker cavusoglu Neslihan Düzenli Sibel ülker | 2018 | Neural Regeneration Research2018，13，9： | 4 |
| 2 | Endobronchial schwannoma with massive hemoptysis显示文摘 | Onal M Ernam D Atikcan S | 2009 | Tuberk Toraks2009，57，1： | 1 |
| 3 | Ketamine or alfentanil administration prior to propofol anaesthesia: the effects on ProSeal laryngeal mask airway insertion conditions and haemodynamic changes in children 显示文摘 | Begec Z Demirbilek S Onal D | 2009 | Anaesthesia2009，64，3： | 1 |
| 4 | Ketamine or alfentanil administration prior to propofol anaesthesia : the effects on ProSeal laryngeal mask airway insertion conditions and haemodynamic changes in children 显示文摘 | Begec Z Demirbilek S Onal D | 2009 | Anaes- thesia2009，64，3： | 1 |
| 5 | Ketamine or alfentanil administration prior to propofol anaesthesia:the effects on ProSeal laryngeal mask airway insertion conditions and haemodynamic changes in children显示文摘 | Begec Z Demirbilek S Onal D | 2009 | Anaesthesia2009，64，3： | 1 |
| 6 | Effect of enzymatic pretreatment on the mechanical properties of jute fiber-reinforced polyester com- posites 显示文摘 | Karaduman Y Gokcan D Onal L | 2013 | Journal of Composite Materials2013，47，10： | 1 |
| 7 | Teleoperated 3-D force feedback from the nanoscale with an atomic force microscope显示文摘 | Onal C D Sitti M | | 0，，01： | 1 |
| 8 | Modeling of seismic wave attenuation in soil structures using fractional derivative scheme 显示文摘 | Onal D | 2005 | Journal of Balkan Geophysical Society2005，8，4： | 1 |
| 9 | Anti-Mr) Uerian hormone as a marker of premature ovarian aging in autoimmune thyroid disease显示文摘 | Saglam F Onal E D Ersoy R | 2015 | Gynecological Endocrinology2015，31，2： | 1 |
| 10 | Do micrometastases detected with cytokeratin immunoperoxidase reactivity affect the treatment approach to neck in supraglottic cancers 显示文摘 | Kocaturk S Yihnazer D Onal B | 2003 | Otolaryngol Head Neck Surg2003，128，3： | 1 |
| 11 | Design of automation for telerobots and the effect on performance, operator situation awareness, and subjective workload显示文摘 | Kaber D B Onal E Endsley M R | 2000 | Human Factors and Ergonomics in Manufacturing2000，10，4： | 1 |
| 12 | A comparative study of tissue glue and vicryl suture for closing limbal-conjunctival autografts and histologic evaluation after pterygium excision显示文摘 | Ozdamar Y Mutevelli S Han U Ⅱeri D Onal B Ilhan O | 2008 | Cornea2008，27，5： | 1 |
| 13 | Autonomous soft robotic fish capable of escape maneuvers using fluidic elastomer actuators 显示文摘 | MARCHESE A D ONAL C D PLUS D | 2014 | Soft Robotics2014，1，1： | 1 |
| 14 | Determination of trace metals in different fish species and sediments from the River Yesihrmakin Tokat, Turkey显示文摘 | Mendil D Onal 0 F T:izen M | 2010 | Food and Chemical Toxicology2010，48，5： | 1 |
| 15 | Computed tomography findings in 66 patients with malignant pleural mesothelioma due to environmental exposure to asbestos显示文摘 | Okten F Koksal D Onal M | 2006 | Clin Imaging2006，30，3： | 1 |
| 16 | 显示文摘 | Onal Y Akmil-Basar C Eren D | 2006 | J Hazard Mater2006，128，： | 1 |
| 17 | Do micro metastases detected with eytokeratin immunoperoxidase reactivity affect the treatment approch to neck in supraglottic cancers 显示文摘 | Kocature S Yilmazer D Onal B | 2003 | Otolaryngol2Head Neck Surg2003，128，3： | 1 |
| 18 | Endobronchial schwannoma with massive hemoptysis显示文摘 | Onal M Ernam D Atikcan S Memis L | 2009 | Tuberk Toraks2009，57，1： | 1 |
| 19 | Do micro metastases detected with cytokeratin immunoperoxidase reactivity affect the treatment approch to neck in supraglottic cancers显示文摘 | Kocature S Yilmazer D Onal B | 2003 | Otolaryngol-Head Neck Surg2003，128，3： | 1 |
| 20 | Automated 2-D nanoparticle manipulation using atomic force microscopy 显示文摘 | ONAL C D OZCAN O SITTI M | 2011 | IEEE Transactions on Nanotechnology2011，10，3： | 1 |
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