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| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | Intestinal eryptosporidio- sis in pigeons ( Columba livia) 显示文摘 | Rodriguez F J Oros J L Rodriguez | 1997 | Avian Diseases1997，41，3： | 1 |
| 3 | Haematological parameters in Umbrina cirrosa (Teleostei, Sciaenidae): a comparison between diploid and triploid specimens显示文摘 | Ballarin L Dall'Oro M Bertotto D | 2004 | Comp Biochem Physiol2004，138，： | 1 |
| 4 | Organiccarbon and nitrogen in soils of semiarid Argentina显示文摘 | Mendez M J Oro L D Panebianeo J E | 2006 | Joumal of Soil and Water Conservation2006，61，4： | 1 |
| 5 | Degradation of the soil surface roughness by rainfall in two loess soils显示文摘 | De Oro L A and Buschiazzo D E | 2011 | Geoderma2011，164，1： | 1 |
| 6 | Numerical modeling of the piston effect in longitudinal ventilation systems for subway tunnels显示文摘 | GONZLEZ M L VEGA M G ORO J M F | 2014 | Tunnelling and Underground Space Technology2014，40，： | 1 |
| 7 | Biocontrol of postharvest brown rot of sweet cherries by Saccharomyces cerevisiae Disva 599, Metschnikowia pulcherrima Disva 267 and Wickerhamomyces anomalus Disva 2 strains显示文摘 | Oro L Feliziani E Ciani M | 2014 | Postharvest Biology and Technology2014，96，： | 1 |
| 8 | Dihydrogen Complexes as Homogeneous Reduction Catalysts显示文摘 | Esteruelas M A Oro L A | 1998 | Chem Rev1998，98，： | 1 |
| 9 | Oxidation of substrates by an iridium dioxygen complexes:intramolecular oxidation of carbon monoxide and activation of a carbonyl group by attack of a heterocyclic nitrogen显示文摘 | Ciriano M A López J Oro L A Pérez-Torrente J J Canfranchi M Tiripicchio A | 1995 | Organometallics1995，14，： | 1 |
| 10 | Synthesis of New Hydride-Carbyne and Hydride-Vinylcarbyne Complexes of Osmium(Ⅱ) by Reaction of OsH2Cl2(P-i-Pr3)2 with Terminal Alkynes显示文摘 | Espuelas J Esteruelas M A Oro L A | 1993 | J Am Chem Soc1993，115，： | 1 |
| 11 | Mechanism of the hydrogenation of phenylacetylene catalyzed byBF4显示文摘 | Esteruelas M A Lo′pez A M Oro L A | 1993 | Organometallics1993，12，： | 1 |
| 12 | MATILDE regimen followed by radiotherapy is an active strategy against primary CNS lymphomas显示文摘 | A J.M. Ferreri S Dell’Oro M Foppoli M Bernardi A A. Brandes A Tosoni M Montanari M Balzarotti M Spina F Ilariucci F Zaja C Stelitano F Bobbio G Corazzelli L Baldini M Ponzoni P Picozzi F Caligaris Cappio M Reni | 2006 | Neurology2006，，9： | 1 |
| 13 | The effect of nicotinic acid on the plasma freefatty acid;demonstration of a metabolic type of sympathicolysis显示文摘 | Carlson LA Oro L | 1962 | Acta Med Scand1962，172，： | 1 |
| 14 | Threshold wind velocity as an index of soil susceptibility to wind erosion under variable climatic conditions 显示文摘 | De Oro L A Buschiazzo D E | 2009 | Land Degradation & Development2009，20，1： | 1 |
| 15 | Trophic niche width and overlap of two syrnpatrlc gulls in the southwestern Mexliterranean 显示文摘 | Gonzalez-Solfs J Oro D Jover L | 1997 | Oecologia1997，112，1： | 1 |
| 16 | The effect of nicofinie acid on piasma free fally acid显示文摘 | Carlson I A Oro L | | 0，，： | 1 |
| 17 | Antimicrobial activity of Metschnikowia pulcherrima on wine yeasts显示文摘 | ORO L OAl'JI M COlVIITINI F | 2014 | Journal of Applied Microbiology2014，116，5： | 1 |
| 18 | Improving thermal perform- ance of freezers using phase change materials 显示文摘 | Oro E Miro L Farid M M | 2012 | Int J Re- frig2012，35，4： | 1 |
| 19 | Effects of oral calcium upon serum cholesterol and triglycerides in patients with hyperlipidemia显示文摘 | Carlson LA Olsson AG Oro L | 1971 | Atherosclerosis1971，14，3： | 1 |
| 20 | 查看详情显示文摘 | Esteruelas M A García M P López A M Oro L A | | 0，，1： | 1 |
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