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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Field-activated pressure-assisted synthesis of NiTi显示文摘 | Loccia A M Orru R C ao G | 2003 | Intermetallics2003，，11： | 1 |
| 3 | Detection of isoniazid and rifampin resistance in mycobacterium tuberculosis strains by single-strand conformation polymorphism analysis and restriction fragment length polymorphism 显示文摘 | Piana A Orru M Masia MD | 2003 | New Microbiol2003，26，4： | 1 |
| 4 | Treatment with flutamide improves hyperinsulinemic women with idiopathic hirsutism显示文摘 | Paoletti AM Cagnacci A Orru M | 1999 | Fertil Steril1999，72，3： | 1 |
| 5 | A test for creutzfeldt-jakob disease using nasal brushings显示文摘 | Orru CD Bongianni M Tonoli G | 2014 | N Engl J Med2014，371，6： | 1 |
| 6 | Evidence of hepatitis E virus (HEV) infection in human and pigs in Sardinia,Italy显示文摘 | Masia G Orru G Liciardi M | 2009 | Journal of Preventive Medicine and Hygiene2009，50，4： | 1 |
| 7 | Combustion synthesis of TiC-metal composites and related plasma spraying deposition显示文摘 | Licheri R Orru R Locci A M | 2004 | International Journal of Materials & Product Technology2004，20，5： | 1 |
| 8 | Treatment and Recycling of Zinc Hydrometallurgical Wastes by Self-propagatingReactions显示文摘 | Orru R Sannia M Cincotti A | 1999 | Chem Eng Sci1999，54，1516： | 1 |
| 9 | Effect of phase transformation during high energy milling on field activated synthesis of dense MoSi2显示文摘 | SANNIA M ORRU R GARAY J E | 2003 | Mater Sci Eng2003，345，12： | 1 |
| 10 | Comparative evaluation of two hypofraetionated radiotherapy regimens for painful bone metastases显示文摘 | Amichetti M Orru P Madeddu A | 2004 | Tumor2004，90，： | 1 |
| 11 | Substrate specificity and stereospecificity of limonene-1,2-epoxide hydrolase from Rhodococcus erythropolis DCL14:an enzyme showing sequential and enantioconvergent substrate conversion显示文摘 | Vander Werf M J Orru R V A Overkamp K M | 1999 | Applied Microbiology and Biotechnology1999，52，3： | 1 |
| 12 | 显示文摘 | Sannia M Orru R Garay J E | 2003 | Mater Sci & Eng A2003，345，12： | 1 |
| 13 | Effect of Phase Transformation During High Energy Milling on Field Activated Synthesis of Dense MoSi2 显示文摘 | Sannia M Orru R Garay J E | 2003 | Materials Science and Engineering A2003，345，12： | 1 |
| 14 | Functional proteomics 显示文摘 | Monti M Orru S Pagnozzi D | 2005 | Clinica Chimica Acta2005，357，： | 1 |
| 15 | Psychopharmacological treatment of depression, anxiety, irritability and insomnia in patients reeeiving interferon-alpha:a prospective case series and a discussion of biological mechanisms显示文摘 | Maddock C Baita A Orru M G | 2004 | J Psychopharmacol2004，15，1： | 1 |
| 16 | Striatal pre- and postsynaptic profile of adenosine A(gA) receptor antagonlsts 显示文摘 | Orru M Bakesova J Brugarolas M | 2011 | PLoS One2011，6，16： | 1 |
| 17 | 显示文摘 | Loccia A M Orru R Cao G | 2003 | Intermetallics2003，11，： | 1 |
| 18 | Low-gravity combustion synthe- sis theoretical nalysis of experimental evidences显示文摘 | Locci A M Orru R Cao G | 2006 | American In- stitute of Chemical Engineers Journal2006，52，11： | 1 |
| 19 | Alkylphenols in adipose tissues of Italian population显示文摘 | FERRARA F ADEMOLLO N ORRU M A | 2011 | Chemosphere2011，82，7： | 1 |
| 20 | Psoriasis is associated with a SNP haplotype of the comeodesmosin gene (CDSN)显示文摘 | Giuressi E Casula M | 2002 | Tissue Antigens2002，60，： | 1 |
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