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| 1 | Perioperative blood transfusion decreases long-term survival in pediatric living donor liver transplantation显示文摘BACKGROUND The impact of perioperative blood transfusion on short-and long-term outcomes in pediatric living donor liver transplantation(PLDLT)must still be ascertained,mainly among young children.Clinical and surgical postoperative complications related to perioperative blood transfusion are well described up to three months after adult liver transplantation.AIM To determine whether transfusion is associated with early and late postoperative complications and mortality in small patients undergoing PLDLT.METHODS We evaluated the effects of perioperative transfusion on postoperative complications in recipients up to 20 kg of body weight,submitted to PLDLT.A total of 240 patients were retrospectively allocated into two groups according to postoperative complications:Minor complications(n=109)and major complications(n=131).Multiple logistic regression analysis identified the volume of perioperative packed red blood cells(RBC)transfusion as the only independent risk factor for major postoperative complications.The receiver operating characteristic curve was drawn to identify the optimal volume of the perioperative RBC transfusion related to the presence of major postoperative complications,defining a cutoff point of 27.5 mL/kg.Subsequently,patients were reallocated to a low-volume transfusion group(LTr;n=103,RBC≤27.5 mL/kg)and a high-volume transfusion group(HTr;n=137,RBC>27.5 mL/kg)so that the outcome could be analyzed.RESULTS High-volume transfusion was associated with an increased number of major complications and mortality during hospitalization up to a 10-year follow-up period.During a short-term period,the HTr showed an increase in major infectious,cardiovascular,respiratory,and bleeding complications,with a decrease in rejection complications compared to the LTr.Over a long-term period,the HTr showed an increase in major infectious,cardiovascular,respiratory,and minor neoplastic complications,with a decrease in rejection complications.Additionally,Cox hazard regression found that high-volume RBC transfusion increased the mortality risk by 3.031-fold compared to low-volume transfusion.The Kaplan-Meier survival curves of the studied groups were compared using log-rank tests and the analysis showed significantly decreased graft survival,but with no impact in patient survival related to major complications.On the other hand,there was a significant decrease in both graft and patient survival,with high-volume RBC transfusion.CONCLUSION Transfusion of RBC volume higher than 27.5 mL/kg during the perioperative period is associated with a significant increase in short-and long-term postoperative morbidity and mortality after PLDLT. | Karina Gordon Estela Regina Ramos Figueira Joel Avancini Rocha-Filho Luiz Antonio Mondadori Eduardo Henrique Giroud Joaquim Joao Seda-Neto Eduardo Antunes da Fonseca Renata Pereira Sustovitch Pugliese Agustin Moscoso Vintimilla Jose Otavio Costa Auler Jr Maria Jose Carvalho Carmona Luiz Augusto Carneiro D'Alburquerque | 2021 | World Journal of Gastroenterology2021，27，12： | 6 |
| 2 | Effect of trimetazidine on quality of life in elderly patients with ischemic dilated cardiomyopathy显示文摘 | Giuseppe Marazzi Otavio Gebara Cristiana Vitale Giuseppe Caminiti Mauricio Wajngarten Maurizio Volterrani José A. F. Ramires Giuseppe Rosano Massimo Fini | 2009 | Advances in Therapy2009，，4： | 1 |
| 3 | Foreign Direct Investment and Decoupling between Energy and Gross Domestic Product in Developing Countries显示文摘 | Otavio Mielnik Jose Goldemberg | 2002 | Energy Policy2002，30，2： | 1 |
| 4 | Volume Replacement Therapy during Hip Arthroplasty using Hydroxyethyl Starch (130/0.4) Compared to Lactated Ringer Decreases Allogeneic Blood Transfusion and Postoperative Infection显示文摘 | Adilson Hamaji Ludhmila Hajjar Marcelo Caiero Juliano Almeida Rosana Ely Nakamura Eduardo A Osawa Julia Fukushima Filomena R Galas Jose Otavio Costa Auler Junior | 2013 | Brazilian Journal of Anesthesiology2013，，1： | 1 |
| 5 | J Electrochem Soc显示文摘 | Maria A B Gomes Luis Otavio de S Bulboes | 1990 | 137( 10):30671990，137，10： | 1 |
| 6 | The Evolution of the 'Caborniza- tion Index' in Developing Countries显示文摘 | Otavio Mielnik Jose Goldemberg | 1999 | Energy Policy1999，27，5： | 1 |
| 7 | A role for cGMP-dependent protein kinase Ⅱ in AMPA receptor trafficking and synaptic plasticity显示文摘 | Yafell S Otavio A Edward BZ | 2008 | Landes Bioscience2008，2，4： | 1 |
| 8 | Evaluation of physiologic complexity in time series using generalized sample entropy and surrogate data analysis显示文摘 | Eduardo Virgilio Silva L Otavio Murta L | | 0，，： | 1 |
| 9 | Myocardial Extracellular Volume Expansion and the Risk of Recurrent Atrial Fibrillation After Pulmonary Vein Isolation显示文摘 | Tomas G. Neilan Francois-Pierre Mongeon Ravi V. Shah Otavio Coelho-Filho Siddique A. Abbasi John A. Dodson Ciaran J. McMullan Bobak Heydari Gregory F. Michaud Roy M. John Ron Blankstein Michael Jerosch-Herold Raymond Y. Kwong | 2014 | JACC: Cardiovascular Imaging2014，，1： | 1 |
| 10 | Foreign direct investment and decoupling between energy and gross domestic product in developing countries显示文摘 | Otavio Mielnik Jose Goldemberg | 2002 | Energy Policy2002，30，2： | 1 |
| 11 | Effect of trimetazidine on quality of life in elderly patients with ischemic dilated cardiomyopathy显示文摘 | Giuseppe Marazzi Otavio Gebara Cristiana Vitale Giuseppe Caminiti Mauricio Wajngarten Maurizio Volterrani José A. F. Ramires Giuseppe Rosano Massimo Fini | 2009 | Advances in Therapy2009，，： | 1 |
| 12 | Effect of Bayluscide WP 70 on the survival and waterleaving behaviour of Biomphalaria straminea,snail host of schistosomiasis in northeast Brazil显示文摘 | Otalia S Otavio SP Jose AS | 1997 | Mem Inst Oswaldo Cruz1997，92，2： | 1 |
| 13 | Stratifying risk: asymptomatic carotid disease显示文摘 | Rafael Malgor D Emily Wood A Otavio Lavarone A | 2012 | Vasc Bras2012，11，1： | 1 |
| 14 | Common goals to face crisis at coronary care units 显示文摘 | Antnio Pazin - Filho Otavio Rizzi Coelho Andre | 2013 | Arquivos brasileiros de cardiologia2013，100，2： | 1 |
| 15 | Association between increased estrogen status and increased fibrinolytic parential in the Framingham off spring study显示文摘 | Otavio CE Mitle MA Sutherland P | 1995 | Circulation1995，41，： | 1 |
| 16 | Structural and magnetic properties of Fe and Co nanopaticles embedded in powdered Al2O3 显示文摘 | Otavio Santini | 2005 | Journal of Colloid and Interface Science2005，289，： | 1 |
| 17 | Foreign direct investment and decoupling between energy and gross domestic product in developing countries显示文摘 | Otavio Mielnika Josle Goldembergh | 2002 | Energy Policy2002，30，： | 1 |
| 18 | Simulating the panama canal : Present and future显示文摘 | FRANZESE Luiz Augusto G ABDENUR Luiz Otavio BOTTER Rui Carlos | 2004 | Computer Simulation2004，2，： | 1 |
| 19 | Tissue Doppler imaging in the evaluation of the regional diastolic function in chagas' disease 显示文摘 | Vinicius LB Otavio DC Luiz PR | 2001 | Eur J Echocardioar2001，2，2： | 1 |
| 20 | Foreign direct investment and decoupling between energy and gross domestic product in developing countries 显示文摘 | Otavio Mielnik Jos6 Goldemberg | 2002 | Energy Policy2002，30，2： | 1 |
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