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| 1 | N-acetylcysteine attenuates alcohol-induced oxidative stess in rats显示文摘AIM: To investigate free-radical scavenger effect of nacetylcysteine in rats intragastrically fed with ethanol.METHODS: Twenty-four rats divided into three groups were fed with ethanol (6 g/kg/day, Group 1), ethanol and nacetylcysteine (1 g/kg, Group 2), or isocaloric dextrose (control group, Group 3) for 4 weeks. Then animals were sacrificed under ether anesthesia, and intracardiac blood and liver tissues were obtained. Measurements were made in both serum and homogenized liver tissues.Malondialdehyde (MDA) level was measured by TBARS method. Glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) levels were studied by commercial kits.Kruskal-Wallis test was used for statistical analysis.RESULTS: ALT and AST in Group 1 (154 U/L and 302 U/L,respectively) were higher than those in Group 2 (94 U/L and 155 U/L) and Group 3 (99 U/L and 168 U/L) (P=0.001for both). Serum and tissue levels of MDA in Group 1 (1.84nmol/mL and 96 nmol/100 mg-protein) were higher than that in Group 2 (0.91 nmol/mL and 64 nmol/100 mg protein)and Group 3 (0.94 nmol/mL and 49 nmol/100 mg-protein)(P<0.001 for both). On the other hand, serum GSH-Px level in Group 1 (8.21 U/g Hb) was lower than that in Group 2(16 U/g Hb) and Group 3 (16 U/g-Hb) (P<0.001). Serum and liver tissue levels of SOD in Group 1 (11 U/mL and 26U/100 mg-protein) were lower than that in Group 2 (18 U/mL and 60 U/100 mg protein) and Group 3 (20 U/mL and 60 U/100 mg-protein) (P<0.001 for both).CONCLUSION: Ethanol-induced liver damage was associated with oxidative stress, and co-administration of n-acetylcysteine attenuates this damage effectively in rat model. | Resat Ozaras Veysel Tahan Seval Aydin Hafize Uzun Safiye Kaya Hakan Senturk | 2003 | World Journal of Gastroenterology2003，9，4： | 9 |
| 2 | N-acetylcysteine attenuates alcohol-induced oxidative stress in the rat显示文摘AIM: There is increasing evidence that alcohol-induced liverdamage may be associated with increased oxidative stress.We aimed to investigate free-radical scavenger effect of n-acetylcysteine in rats intragastrically fed with ethanol.METHODS: Twenty-four rats divided into three groups werefed with ethanol (6 g/kg/day, Group 1), ethanol and n-acetylcysteine (1 g/kg, Group 2), or isocaloric dextrose(control group, Group 3) for 4 weeks. Then animals weresacrificed under ether anesthesia, intracardiac blood andliver tissues were obtained. Measurements were performedboth in serum and in homogenized liver tissues.Malondialdehyde (MDA) level was measured by TBARSmethod. Glutathione peroxidase (GSH-Px) and superoxidedismutase (SOD) levels were studied by commercial kits.Kruskal-Wallis test was used for statistical analysis.RESULTS: ALT and AST in Group 1 (154 U/Land 302 U/L,respectively) were higher than those in Group 2 (94 U/L and155 U/L) and Group 3 (99 U/L and 168 U/L) (P=0.001 forboth). Serum and tissue levels of MDA in Group 1 (1.84 nmol/mL and 96 nmol/100 mg-protein) were higher than Group 2(0.91 nmol/mL and 64 nmol/100 mg-protein) and Group 3(0.94 nmol/mL and 49 nmol/100 mg-protein) (P<0.001 forboth). On the other hand, serum GSH-Px level in Group 1(8.21 U/g-Hb) was lower than Group 2 (16 U/g-Hb) andGroup 3 (16 U/g-Hb) (P<0.001). Serum and liver tissue levelsof SOD in Group 1 (11 U/mL and 26 U/100 mg-protein)were lower than Group 2 (18 U/mL and 60 U/100 mg-protein)and Group 3 (20 U/mL and 60 U/100 mg-protein) (P<0.001for both).CONCLUSION: This study demonstrated that ethanol-induced liver damage is associated with oxidative stress,and co-administration of n-acetylcysteine attenuates thisdamage effectively in rat model. | Resat Ozaras Veysel Tahan Seval Aydin Hafize Uzun Safiye Kaya Hakan Senturk | 2003 | World Journal of Gastroenterology2003，9，1： | 7 |
| 3 | Correlation of Quantitative Assay of HBsAg and HBV DNA Levels During Chronic HBV Treatment显示文摘 | Ozaras R Tabak F Tahan V | 2008 | Dig DisSci2008，53，11： | 1 |
| 4 | Fever of unknown origin: a review of 20 patients with adult-onset Still's disease 显示文摘 | Mert A Ozaras R Tabak F | 2003 | Clin Rheumatol2003，22，2： | 1 |
| 5 | Ornidazole-induced liver damage:report of three cases and review of the literature显示文摘 | Tabak F Ozaras R Erzin Y | | 0，，05： | 1 |
| 6 | Ornidazole-induced liver damage:report of three cases and review of the literature显示文摘 | Tabak F Ozaras R Erzin Y | 2003 | Liver International2003，23，5： | 1 |
| 7 | Is Family Screening Necessary in Brucellosis?显示文摘 | F. Tabak E. Hakko B. Mete R. Ozaras A. Mert R. Ozturk | 2008 | Infection2008，，： | 1 |
| 8 | Correlation of quantitative assay of HBsAg and HBV DNA levels during chronic HBV treatment 显示文摘 | Ozaras R Tabak F Tahan V | 2008 | Dig Dis Sci2008，53，11： | 1 |
| 9 | Intracranial paradoxical reaction during treatment of kidney tuberculosis显示文摘 | Yemisen M Mete B Ozaras R | 2011 | Intern Med2011，50，18： | 1 |
| 10 | Is lalmrotomy necessary in the diagnosis of fe-er of unknown origin? 显示文摘 | Ozaras R Celik AD Zengin K et at | 2005 | Acta Chir Belg2005，105，1： | 1 |
| 11 | Fever of unknown origin:a review of 20 patients with adult-onset Still's disease显示文摘 | Mert A Ozaras R Tabak F | 2003 | Clin Rheumatol2003，22，1： | 1 |
| 12 | The sensitivity and specificity of Brucella agglutination tests 显示文摘 | All Merta Resat Ozaras Fehmi Tabak etal | 2003 | Diagnostic Microbiology and Infectious Disease2003，46，： | 1 |
| 13 | The sensitivity and specificity of Brucella agglutination tests 显示文摘 | Mert A Resat Ozaras R Tabak F | 2003 | Diag Microbiol Infect Dis2003，46，4： | 1 |
| 14 | Carbamazepine-induced hypogammaglobulinemia显示文摘 | OZARAS N GOKSUGUR N EROGLU S | 2012 | Seizure2012，21，3： | 1 |
| 15 | Acute hepatitis due to brucellosis in a laboratory technician显示文摘 | Ozaras R Celik AD Demirel A | 2004 | Eur J Intern Med2004，15，4： | 1 |
| 16 | The role of antibiotic treatment alone for the management of Brucella endocarditis in adults: a case report and literature review显示文摘 | Mert A Kocak F Ozaras R | 2002 | Ann ThoracCardiovasc Surg2002，8，： | 1 |
| 17 | Acute hepatitis due to brucellosis in a laboratory technician 显示文摘 | Ozaras R Celik AD Demirel A | 2004 | Eur J Intern Med2004，15，4： | 1 |
| 18 | Correlation of Quantitative Assay of HBsAg and HBV DNA Levels During Chronic HBV Treatment 显示文摘 | Ozaras R Tabak F Tahan V | 2008 | Dig Dis Sci2008，53，11： | 1 |
| 19 | Ornidazole inducede liver damage:report of three cases and review of the literature显示文摘 | Tabak F Ozaras R Erzin Y | 2003 | Liver Int2003，23，5： | 1 |
| 20 | Erythema Nodosum:an ex- perience of 10 years显示文摘 | Mert A Ozaras R Tahak N | 2004 | Scand J Infect Dis2004，36，67： | 1 |
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