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| 1 | Secondary causes of inflammatory bowel diseases显示文摘Inflammatory bowel diseases(IBD),conventionally consist of Crohn’s disease(CD)and ulcerative colitis.They occur in individuals with high risk genotype for the disease in the setting of appropriate environmental factors.The pathogenesis of IBD involves a dysregulated autoimmune response to gut dysbiosis,which in turn is triggered due to exposure to various inciting environmental factors.But there is no clearly defined etiology of IBD and this type of disease is termed as“idiopathic IBD”,“classic IBD”,or“primary IBD”.We reviewed the current medical literature and found that certain etiological factors may be responsible for the development of IBD or IBD-like conditions,and we consider this form of de novo IBD as“secondary IBD”.Currently known factors that are potentially responsible for giving rise to secondary IBD are medications;bowel altering surgeries and transplantation of organs,stem cells or fecal microbiome.Medications associated with the development of secondary IBD include;immunomodulators,anti-tumor necrosis factor alpha agents,anti-interleukin agents,interferons,immune stimulating agents and checkpoint inhibitors.Colectomy can in some cases give rise to de novo CD,pouchitis of the ileal pouch,or postcolectomy enteritis syndrome.After solid organ transplantation or hematopoietic stem cell transplantation,the recipient may develop de novo IBD or IBD flare.Fecal microbiota transplantation has been widely used to treat patients suffering from recurrent Clostridium difficile infection but can also causes IBD flares. | Yezaz A Ghouri Veysel Tahan Bo Shen | 2020 | World Journal of Gastroenterology2020，26，28： | 13 |
| 2 | N-acetylcysteine attenuates alcohol-induced oxidative stess in rats显示文摘AIM: To investigate free-radical scavenger effect of nacetylcysteine in rats intragastrically fed with ethanol.METHODS: Twenty-four rats divided into three groups were fed with ethanol (6 g/kg/day, Group 1), ethanol and nacetylcysteine (1 g/kg, Group 2), or isocaloric dextrose (control group, Group 3) for 4 weeks. Then animals were sacrificed under ether anesthesia, and intracardiac blood and liver tissues were obtained. Measurements were made in both serum and homogenized liver tissues.Malondialdehyde (MDA) level was measured by TBARS method. Glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) levels were studied by commercial kits.Kruskal-Wallis test was used for statistical analysis.RESULTS: ALT and AST in Group 1 (154 U/L and 302 U/L,respectively) were higher than those in Group 2 (94 U/L and 155 U/L) and Group 3 (99 U/L and 168 U/L) (P=0.001for both). Serum and tissue levels of MDA in Group 1 (1.84nmol/mL and 96 nmol/100 mg-protein) were higher than that in Group 2 (0.91 nmol/mL and 64 nmol/100 mg protein)and Group 3 (0.94 nmol/mL and 49 nmol/100 mg-protein)(P<0.001 for both). On the other hand, serum GSH-Px level in Group 1 (8.21 U/g Hb) was lower than that in Group 2(16 U/g Hb) and Group 3 (16 U/g-Hb) (P<0.001). Serum and liver tissue levels of SOD in Group 1 (11 U/mL and 26U/100 mg-protein) were lower than that in Group 2 (18 U/mL and 60 U/100 mg protein) and Group 3 (20 U/mL and 60 U/100 mg-protein) (P<0.001 for both).CONCLUSION: Ethanol-induced liver damage was associated with oxidative stress, and co-administration of n-acetylcysteine attenuates this damage effectively in rat model. | Resat Ozaras Veysel Tahan Seval Aydin Hafize Uzun Safiye Kaya Hakan Senturk | 2003 | World Journal of Gastroenterology2003，9，4： | 9 |
| 3 | Fatty liver without a large“belly”:Magnified review of nonalcoholic fatty liver disease in non-obese patients显示文摘Nonalcoholic fatty liver disease(NAFLD) is well described as a common cause of chronic liver disease, mostly in the obese population. It refers to a spectrum of chronic liver disease that starts with simple steatosis than progresses to nonalcoholic steatohepatitis and cirrhosis in patients without significant alcohol consumption. NAFLD in the non-obese population has been increasingly reported and studied recently. The pathogenesis of nonobese NAFLD is poorly understood and is related to genetic predisposition, most notably patatin-like phospholipase domain-containing 33 G allele polymorphism that leads to intrahepatic triglyceride accumulation and insulin resistance. Nonobese NAFLD is associated with components of metabolic syndrome and, especially, visceral obesity which seems to be an important etiological factor in this group. Dietary factors and, specifically, a high fructose diet seem to play a role. Cardiovascular events remain the main cause of mortality and morbidity in NAFLD, including in the nonobese population. There is not enough data regarding treatment in non-obese NAFLD patients, but similar to NAFLD in obese subjects, lifestyle changes that include dietary modification, physical activity, and weight loss remain the mainstay of treatment. | Mohamad H Yousef Alhareth Al Juboori Abdulmajeed A Albarrak Jamal A Ibdah Veysel Tahan | 2017 | World Journal of Gastrointestinal Pathophysiology2017，8，3： | 9 |
| 4 | Interventions to improve sarcopenia in cirrhosis: A systematic review显示文摘BACKGROUND Sarcopenia, i.e., muscle loss is now a well-recognized complication of cirrhosis and in cases of non-alcoholic fatty liver disease can contribute to accelerate liver fibrosis leading to cirrhosis. Hence, it is imperative to study interventions which targets to improve sarcopenia in cirrhosis.AIM To examine the relationship between interventions such nutritional supplementation, exercise, combined life style intervention, testosterone replacement and trans jugular intrahepatic portosystemic shunt(TIPS) to improve muscle mass in cirrhosis.METHODS We search PubMed, EMBASE and Cochrane between June-August 2018, without a limiting period and the types of articles(RCTs, clinical trial, comparative study)in adult patients with sarcopenia and cirrhosis. The primary outcome of interest was improvement in muscle mass, strength and physical function interventions mentioned above. In the screening process, 154 full text articles were included in the review and 129 studies were excluded.RESULTS We identified 24 studies that met review inclusion criteria. The studies were diverse in terms of the design, setting, interventions, and outcome measurements.We performed only qualitative synthesis of evidence due to heterogeneity amongst studies. Risk of bias was medium in most of the included studies and low quality of evidence showed improvement in the muscle mass, strength and physical function following aerobic exercise. 60% of the included studies on the nutritional intervention, 100% of the studies on testosterone replacement in hypogonadal men and trans-jugular portosystemic shunt were proved to be effective in improving sarcopenia in cirrhosis.CONCLUSION Although the quality of evidence is low, the findings of our systematic review suggest improvement in the sarcopenia in cirrhosis with exercise, nutritional interventions, hormonal and TIPS interventions. High quality randomized controlled trials needed to further strengthen these findings. | Maliha Naseer Erica P Turse Ali Syed Francis E Dailey Mallak Zatreh Veysel Tahan | 2019 | World Journal of Clinical Cases2019，7，2： | 8 |
| 5 | N-acetylcysteine attenuates alcohol-induced oxidative stress in the rat显示文摘AIM: There is increasing evidence that alcohol-induced liverdamage may be associated with increased oxidative stress.We aimed to investigate free-radical scavenger effect of n-acetylcysteine in rats intragastrically fed with ethanol.METHODS: Twenty-four rats divided into three groups werefed with ethanol (6 g/kg/day, Group 1), ethanol and n-acetylcysteine (1 g/kg, Group 2), or isocaloric dextrose(control group, Group 3) for 4 weeks. Then animals weresacrificed under ether anesthesia, intracardiac blood andliver tissues were obtained. Measurements were performedboth in serum and in homogenized liver tissues.Malondialdehyde (MDA) level was measured by TBARSmethod. Glutathione peroxidase (GSH-Px) and superoxidedismutase (SOD) levels were studied by commercial kits.Kruskal-Wallis test was used for statistical analysis.RESULTS: ALT and AST in Group 1 (154 U/Land 302 U/L,respectively) were higher than those in Group 2 (94 U/L and155 U/L) and Group 3 (99 U/L and 168 U/L) (P=0.001 forboth). Serum and tissue levels of MDA in Group 1 (1.84 nmol/mL and 96 nmol/100 mg-protein) were higher than Group 2(0.91 nmol/mL and 64 nmol/100 mg-protein) and Group 3(0.94 nmol/mL and 49 nmol/100 mg-protein) (P<0.001 forboth). On the other hand, serum GSH-Px level in Group 1(8.21 U/g-Hb) was lower than Group 2 (16 U/g-Hb) andGroup 3 (16 U/g-Hb) (P<0.001). Serum and liver tissue levelsof SOD in Group 1 (11 U/mL and 26 U/100 mg-protein)were lower than Group 2 (18 U/mL and 60 U/100 mg-protein)and Group 3 (20 U/mL and 60 U/100 mg-protein) (P<0.001for both).CONCLUSION: This study demonstrated that ethanol-induced liver damage is associated with oxidative stress,and co-administration of n-acetylcysteine attenuates thisdamage effectively in rat model. | Resat Ozaras Veysel Tahan Seval Aydin Hafize Uzun Safiye Kaya Hakan Senturk | 2003 | World Journal of Gastroenterology2003，9，1： | 7 |
| 6 | Epidemiology,determinants,and management of AIDS cholangiopathy:A review显示文摘Diseases of the liver and biliary tree have been described with significant frequency among patients with human immunodeficiency virus(HIV), and its advanced state, acquired immunodeficiency syndrome(AIDS). Through a variety of mechanisms, HIV/AIDS has been shown to affect the hepatic parenchyma and biliary tree, leading to liver inflammation and biliary strictures. One of the potential hepatobiliary complications of this viral infection is AIDS cholangiopathy, a syndrome of biliary obstruction and liver damage due to infection-related strictures of the biliary tract. AIDS cholangiopathy is highly associated with opportunistic infections and advanced immunosuppression in AIDS patients, and due to the increased availability of highly active antiretroviral therapy, is now primarily seen in instances of poor access to antiretroviral therapy and medication non-compliance. While current published literature describes well the clinical, biochemical, and endoscopic management of AIDS-related cholangiopathy, information on its epidemiology, natural history, and pathology are not as well defined. The objective of this review is to summarize the available literature on AIDS cholangiopathy, emphasizing its epidemiology, course of disease, and determinants, while also revealing an updated approach for its evaluation and management. | Maliha Naseer Francis E Dailey Alhareth Al Juboori Sami Samiullah Veysel Tahan | 2018 | World Journal of Gastroenterology2018，24，7： | 5 |
| 7 | Coffee:The magical bean for liver diseases显示文摘Coffee has long been recognized as having hepatoprotective properties,however,the extent of any beneficial effect is still being elucidated.Coffee appears to reducerisk of hepatocellular carcinoma,reduce advancement of fibrotic disease in a variety of chronic liver diseases,and perhaps reduce ability of hepatitis C virus to replicate.This review aims to catalog the evidence for coffee as universally beneficial across a spectrum of chronic liver diseases,as well as spotlight opportunities for future investigation into coffee and liver disease. | Ryan D Heath Mihir Brahmbhatt Asli C Tahan Jamal A Ibdah Veysel Tahan | 2017 | World Journal of Hepatology2017，9，15： | 1 |
| 8 | Role of Ursodeoxycholic Acid in Prevention of Methotrexate-induced Liver Toxicity显示文摘 | Suleyman Uraz Veysel Tahan Cem Aygun Fatih Eren Goksenin Unluguzel Meral Yuksel Omer Senturk Erol Avsar Goncagul Haklar Cigdem Celikel Sadettin Hulagu Nurdan Tozun | 2008 | Digestive Diseases and Sciences2008，，4： | 1 |
| 9 | Correlation of Quantitative Assay of HBsAg and HBV DNA Levels During Chronic HBV Treatment显示文摘 | Resat Ozaras Fehmi Tabak Veysel Tahan Recep Ozturk Hakan Akin Ali Mert Hakan Senturk | 2008 | Digestive Diseases and Sciences2008，，11： | 1 |
| 10 | Correlation of Quantitative Assay of HBsAg and HBV DNA Levels During Chronic HBV Treatment显示文摘 | Resat Ozaras Fehmi Tabak Veysel Tahan Recep Ozturk Hakan Akin Ali Mert Hakan Senturk | 2008 | Digestive Diseases and Sciences2008，，11： | 1 |
| 11 | Correlation of Quantitative Assay of HBsAg and HBV DNA Levels During Chronic HBV Treatment显示文摘 | Resat Ozaras Fehmi Tabak Veysel Tahan Recep Ozturk Hakan Akin Ali Mert Hakan Senturk | 2008 | Digestive Diseases and Sciences2008，，11： | 1 |
| 12 | Exosomes:A new frontier under the spotlight for diagnosis and treatment of gastrointestinal diseases显示文摘Exosomes are small plasma membrane-bound multivesicular bodies ranging in size from 20-100 nm.Exosomes are degraded fragments of mRNA,microRNA,and enriched in proteins,lipids,and nucleic acid.They are produced in the endosomes of most eukaryotic cells and once secreted,exosomes are involved in cell to cell communication and remodeling of the matrix in the extracellular compartment.Exosome biogenesis plays a crucial role in cellular development,inflammation,immunity,hemostasis,carcinogenesis,and degeneration.Due to their unique biochemical and biophysical properties,exosomes serve a variety of functions including biomarkers of diagnostic and prognostic significance.Besides,there is an increasing level of evidence to expand our understanding of the exosomes as novel therapeutic agents.Inflammatory bowel disease(IBD)such as Crohn's disease and ulcerative colitis,hepatic fibrosis,and gastrointestinal malignancies such as colorectal cancer are the potential avenues where exosomes can be applied as cell therapy and immunotherapy and have shown promising results in several in-vitro and animal models.The purpose of this review article is to highlight the emerging role of exosomes as the diagnostic and therapeutic tool in various diseases involving the gastrointestinal tract like IBD,hepatocellular carcinoma,and colon cancer.A thorough literature search was performed on databases such as PubMed,Ovid Medline,and EMBASE to achieve the objectives of this review article. | Maliha Naseer Syeda Hadi Ali Syed Amer Safdari Veysel Tahan | 2021 | World Journal of Meta-Analysis2021，9，1： | 0 |
| 13 | One more chance of fistula healing in inflammatory bowel disease:Stem cell therapy显示文摘Patients with fistulizing inflammatory bowel disease are traditionally difficult to treat. This patient population often experiences delayed or insufficient healing of fistulas using current standard regimens including anti-biotics, immunomodulators, anti-tumor necrosis factor--α drug, placement of setons, and surgical repair. Several studies over the last ten to fifteen years have been conducted using stem cell therapies with promising results in this patient population. These studies show stem cell therapy in fistulizing disease to be successful in healing between 60%--88% compared to currently 50% with infliximab. Moreover, remission was seen 24 wk to 52 wk in these studies. Further research with a multi--approach treatment using medications, stem cell therapy, and surgical interventions will likely be the future of this innovative treatment approach. | Erica P Turse Francis E Dailey Maliha Naseer Edward K Partyka Veysel Tahan | 2018 | World Journal of Clinical Cases2018，6，12： | 0 |
| 14 | Hepatocyte transplantation:Consider infusion before incision显示文摘Human hepatocyte transplantation is undergoing study as a bridge,or even alternative,to orthotopic liver transplantation(OLT).This technique has undergone multiple developments over the past thirty years in terms of mode of delivery,source and preparation of cell cultures,monitoring of graft function,and use of immunosuppression.Further refinements and improvements in these techniques will likely allow improved graft survival and function,granting patients higher yield from this technique and potentially significantly delaying need for OLT. | Ryan D Heath Furkan Ertem Bhupinder S Romana Jamal A Ibdah Veysel Tahan | 2017 | World Journal of Transplantation2017，7，6： | 0 |
| 15 | Extension for Community Health Outcomes-hepatitis C:Small steps carve big footprints in the allocation of scarce resources for hepatitis C virus treatment to remote developing areas显示文摘Hepatitis C virus(HCV)infection is still a major health problem throughout the world.HCV patients living in rural areas are less fortunate than their counterparts residing in populous urbanized regions.The lack of medical resources and properly trained medical personnel in rural regions make it especially burdensome for HCV patients seeking treatment.Dr.Sanjeev Arora at the University of New Mexico Health Sciences Center took initiative to resolve the issue at hand by developing a model named Project Extension for Community Health Outcomes(ECHO).ECHO connects primary care providers(PCPs),usually family medicine physicians,in local communities with specialists.ECHO providers test the efficacy of treatment given using the ECHO model vs that at academic medical centers.The ECHO model has produced promising results such that the sustained virologic response rates for both types of sites were near-equivalent.Show Me ECHO was adapted from Project ECHO to train PCPs in Missouri and equip them with the tools and skills to properly treat and diagnose HCV in a timely manner.This healthcare model can be implemented for treating other common infections and chronic diseases.Telemedicine is the direction healthcare is headed for the next several decades.It has potential to be applied in developing countries to alleviate agony and despair resulting from limited resources and lack of access to expert medical care. | Veysel Tahan Ashraf Almashhrawi Ali M Kahveci Rachel Mutrux Jamal A Ibdah | 2016 | World Journal of Hepatology2016，8，11： | 0 |
| 16 | Elderly donor graft for liver transplantation:Never too late显示文摘The definitive treatment for end stage liver disease remains a liver transplant and hence livers are needed for these patients along with cases of acute fulminant liver failure.Hence livers are a scarce and highly valuable commodity in the current time.By extending the pool of donors to include the elderly livers,it allows for increased availability of donors and reduces the mortality that is associated with the waiting list itself.There is an increasing prevalence of end stage liver disease due to conditions like chronic hepatitis B and C,non-alcoholic steatohepatitis,alcoholic liver disease.Many studies show non-inferior outcomes when elderly livers are used as a vigorous selection process is implemented.The process takes into account the characteristics of the donor,graft and recipient allowing for appropriate donor-recipient coupling.To meet the increasing demands of livers,elderly donors should be utilized for liver transplantation.The aim of this review article is to describe the aging process of the liver and the outcomes associated with use of elderly livers for transplantation. | Harleen Chela Mohamad H Yousef Abdelmajeed A Albarrak Bhupinder S Romana Dania N Hudhud Veysel Tahan | 2017 | World Journal of Transplantation2017，7，6： | 0 |
| 17 | Implications of COVID-19 for inflammatory bowel disease:Opportunities and challenges amidst the pandemic显示文摘Since the beginning of the coronavirus disease 2019(COVID-19)pandemic various measures have been taken to mitigate the effects of the global health crisis in this unprecedented time.According to the World Health Organization,more than 5 million people have been infected with severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)and with more than 300000 deaths attributed to COVID-19 worldwide.There is emerging evidence that SARS-CoV-2 utilizes angiotensin-converting enzyme 2 receptors to enter human cells which are found in abundance in the alveoli and intestines.In addition,the infection is noted to be more severe in patients with co-morbid conditions,those who are malnourished,immunosuppressed and immunocompromised.Inflammatory bowel disease(IBD)which includes ulcerative colitis and Crohn’s disease is chronic remitting and relapsing disorders with intestinal and extraintestinal manifestation.IBD patients are often malnourished and on immunosuppressive medications and there is a hypothetical concern that IBD patients are at substantial risk of COVID-19 infection.The management of IBD patients is often complex and poses unique challenges for gastroenterologists during the pandemic.The purpose of this review article is to summarize the growing level of evidence and understanding of the management of IBD during the COVID-19 pandemic,in the light of international and national gastroenterology society guidelines.We performed a thorough literature search on IBD,SARS-CoV-2 and COVID-19 on PubMed,EMBASE,OVID Medline and Google Scholar and pertaining literature was critically examined and summarized.Per national and international society guidelines and recommendations,IBD is not a risk factor for SARS-CoV-2 infection.IBD patients should continue with their medications and they should follow universal precautions i.e.masks,hand and respiratory hygiene and avoidance of health care facilities and public toilets as general population.Among IBD patients older age,having active disease,and co-morbid conditions are risk factors for a severe SARS-CoV-2 infection.Furthermore,elective endoscopic and surgical procedures can be delayed or deferred until discussing the risks and benefits with patients. | Maliha Naseer Shiva Poola Francis E Dailey Hakan Akin Veysel Tahan | 2020 | World Journal of Meta-Analysis2020，8，5： | 0 |
| 18 | Liver in the limelight in the corona(COVID-19)time显示文摘The novel coronavirus,severe acute respiratory syndrome-corona virus-2(SARSCoV-2),is a topic of great interest currently in the medical field due to the significant morbidity and mortality associated with it.There is immense curiosity about this virus as knowledge about it is limited from pathogenesis,host related factors and the variable effect it has on different patient populations.Though it has claimed fame due to its ability to compromise the respiratory system,it possess the capability to infect other organs as well including the liver.It is important for clinicians to recognize that the virus can result in multi-organ dysfunction as well.Presentation with gastrointestinal symptoms and involvement of the liver can be subtle and can be misdiagnosed.Those with preexisting liver disease may be more susceptible as well as those who are immunosuppressed or have other co-morbidities.This review article provides a brief overview of some of the information that is available so far with regards to how the liver is impacted by the coronavirus. | Harleen Kaur Chela Syed Bilal Pasha Omer Basar Ebubekir Daglilar Veysel Tahan | 2020 | World Journal of Clinical Cases2020，8，16： | 0 |
| 19 | Role of echo Doppler ultrasonography in the evaluation of postprandial hyperemia in cirrhotic patients显示文摘AIM: To assess the role of echo-Doppler ultrasonography in postprandial hyperemia in cirrhotic patients by comparing the results with the hepatic vein catheterization technique.METHODS: Patients with cirrhosis, admitted to the portal hemodynamic laboratory were included into the study. After an overnight fast, echo-Doppler ultrasonography (basal and 30 min after a standard meal) and hemodynamic studies by hepatic vein catheterization (basal, 15 min and 30 min after a standard meal) were performed. Ensure Plus (Abbot Laboratories, North Chicago, IL) was used as the standard liquid meal. Correlation analysis of the echo-Doppler and hepatic vein catheterization measurements were done for the basal and postprandial periods.RESULTS: Eleven patients with cirrhosis (5 Child A, 4 Child B, 2 Child C) were enrolled into the study. After the standard meal, 8 of the 11 patients showed postprandial hyperemia with increase in portal blood flow, portal blood velocity and hepatic venous pressure gradient. Hepatic venous pressure gradient in the postprandial period correlated positively with postprandial portal blood velocity (r = 0.8, P < 0.05) and correlated inversely with postprandial superior mesenteric artery pulsatility index (r = -1, P < 0.01).CONCLUSION: Postprandial hyperemia can be efficiently measured by echo-Doppler ultrasonography and the results are comparable to those obtained with the hemodynamic studies. | Ozdogan Osman Atalay Huseyin Cimsit Cagatay Tahan Veysel Tokay Sena Giral Adnan Imeryuz Nese Baltac|oglu Feyyaz Tuney Davut Erzen Canan Tozun Nurdan | 2008 | World Journal of Gastroenterology2008，14，2： | 0 |
| 20 | Review of stem cells as promising therapy for perianal disease in inflammatory bowel disease显示文摘Those patients with perianal Crohn's disease or ul-cerative colitis experience a difficult to treat disease process with a delayed state and often inability to heal despite current therapies. The approaches currently used to treat these patients with corticosteroids,antibiotics,immunomodulators, anti-tumor necrosis factor-α drug, and surgical repair are limited in their healing ability. This review presents all current literature since emergence in the early 2000s of stem cell therapy for patients with perianal inflammatory bowel disease and analyzes the efficacy, outcomes and safety within these studies. | Francis E Dailey Erica P Turse Maliha Naseer Jack D Bragg Veysel Tahan | 2018 | World Journal of Transplantation2018，8，4： | 0 |
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