|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Increased syndecan-1 and glypican-3 predict poor perinatal outcome and treatment resistance in intrahepatic cholestasis显示文摘Background:Intrahepatic cholestasis of pregnancy(ICP)increases the risk of adverse pregnancy outcomes.This study aimed to explore the association between serum syndecan-1 and glypican-3 levels and the adverse perinatal outcome as well as the responses to the treatment of ursodeoxycholic acid(UDCA).Methods:This prospective,case control study included 88 pregnant women(44 women with ICP and 44 healthy controls).The primary end points were the perinatal outcome and the response to UDCA therapy.A logistic regression model was used to identify the independent risk factors of adverse pregnancy outcomes and reduced response to UDCA therapy.Results:Women with ICP had significantly higher serum syndecan-1(1.27±0.36 ng/m L vs.0.98±0.50 ng/m L;P=0.003),glypican-3(1.78±0.13 ng/m L vs.1.69±0.16 ng/m L;P=0.004),AST(128.59±1.44 vs.13.29±1.32 U/L;P<0.001),and ALT(129.84±1.53 vs.8.00±3.67 U/L;P<0.001)levels compared with the controls.The increased levels of syndecan-1(OR=4.715,95%CI:1.554–14.310;P=0.006),glypican-3(OR=8.465,95%CI:3.372–21.248;P=0.007),ALT(OR=1.382,95%CI:1.131–1.690;P=0.002),and postprandial bile acid(PBA)(OR=3.392,95%CI:1.003–12.869;P=0.026)were correlated to ICP.The adverse neonatal outcome was related to increased glypican-3(OR=4.275,95%CI:2.726–5.635;P=0.039),and PBA(OR=3.026,95%CI:1.069–13.569;P=0.037).Increases of syndecan-1(OR=7.464,95%CI:2.130–26.153,P=0.017)and glypican-3(OR=6.194,95%CI:2.951–13.002;P=0.025)were the risk factors of decreased response to UDCA treatment.Conclusion:Syndecan-1 and glypican-3 might be powerful determinants in predicting adverse perinatal outcome in patients with ICP,and they can be used to predict the response to the UDCA treatment. | Basak Gümüs Güler Sibel Ozler | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，3： | 3 |
| 2 | Political Instab- ility and Economic Growth 显示文摘 | ALESINA A Ozler S Roubini S Swagel P | 1996 | Journal of Economic Growth1996，1，2： | 1 |
| 3 | Treatment of Chronic Deep Vein Thrombosis Using Ultrasound Accelerated Catheter-directed Thrombolysis显示文摘 | Dumantepe M Tarhan IA Ozler A | 2013 | Eur J Vasc Endovasc Surg2013，46，3： | 1 |
| 4 | Increased neutrophil-lymphocyte ratio in patients with idiopathic suddensensorineural hearing loss显示文摘 | Ozler GS | 2014 | J Craniofac Surg2014，25，3： | 1 |
| 5 | Multi-product newsvendor problem with value-at-risk considerations 显示文摘 | Ozler A Tan B Karaesmen F | 2009 | International Journal of Production Economics2009，117，2： | 1 |
| 6 | Export Led Industrialization and Gender Differences in Job Creation and Destruction: Microevidence from Turkish Manufacturing Sector 显示文摘 | Ozler S | 2001 | University of California at Los Angeles2001，，： | 1 |
| 7 | Tilt and decentration of bag-fixated intraocular lenses: a comparative study between capsulorhexis and envelope techniques 显示文摘 | Akkin C Ozler SA Mentes J | 1994 | Doc Ophthalmol1994，87，3： | 1 |
| 8 | Optimisation for hot turning operations with multiple performance characteristics显示文摘 | N. Tosun L. Ozler | 2004 | The International Journal of Advanced Manufacturing Technology (-)2004，，11： | 1 |
| 9 | A novel model of retinopathy of prematurity in normobaric hyperoxic conditions显示文摘AIM:To examine changes in retinal vasculature after treatment with different oxygen concentrations from common retinopathy of prematurity(ROP) models and to determine a novel and practical ROP model.METHODS:A sample of 14 newborn Sprague-Dawley rats was used.The study group(n=7) was exposed to95%oxygen for 4h per day followed by normoxic laboratory conditions for 20 h.This cycle was repeated for 14 d.The control group(n=7) was subjected to normobaric normoxic conditions.On postnatal day 14(P14),the two groups were placed in room air for 7d.On P21,the two groups were examined using indirect ophthalmoscopy.All eyes were enucleated for immunofluorescence(IF) staining of the vasculature of retinas and analysis of vascular endothelial growth factor(VEGF),hypoxia inducible factor-1 alpha(HIF-1α),placental growth factor(PLGF) in vitreous humor,and then the rats were sacrificed by decapitation.All procedures were repeated using another litter of 14 pups.RESULTS:In the study group and under normobaric hyperoxic conditions,retinal neovascularization and peripheral avascular retina were determined in 85%of the rats through indirect ophthalmoscopic examination.Also IF staining of retina of the study group showed retarded peripheral vascular growth.The difference between the two groups for VEGF,HIF-1α and PLGF concentrations of vitreous humor was statistically significant(P=0.003,0.007,0.027 respectively).CONCLUSION:Fluctuating oxygen concentrations are primarily responsible for retinal neovascularization.Our new ROP model is practical and applicable for all retinal neovascularization studies,considering the laboratory procedures. | Taner Ozgurtas Sercan Tekin Fatih Yesildal Umut Karaca Fevzi Nuri Aydin Muhammed Talha Ugurlu Mehmet Ozler Hakan Durukan | 2016 | International Journal of Ophthalmology(English edition)2016，9，9： | 1 |
| 10 | Multi-product newsvendor problem with value-at-risk considerations 显示文摘 | Ozler A Tan B Karaesmen F | 2009 | International Journal of Production Economics2009，117，2： | 1 |
| 11 | An atypically located large subchondral cyst in an osteoarthritic hip joint:a case report显示文摘 | Giiven M Ozler T Kocadal O | 2013 | J Med Case Rep2013，7，： | 1 |
| 12 | The protective effects of ozone therapy in a rat model of acetaminophen-induced liver injury显示文摘 | Husamettin Gul Bulent Uysal Erdinc Cakir Halil Yaman Enis Macit Ali Osman Yildirim Yusuf Emrah Eyi Umit Kaldirim Emin Oztas Emin Ozgur Akgul Tuncer Cayci Mehmet Ozler Turgut Topal Sukru Oter Ahmet Korkmaz Mehmet Toygar Suzi Demirbag | 2012 | Environmental Toxicology and Pharmacology2012，，1： | 1 |
| 13 | Effects of estrogen,estrogen/ progesteron combination and genistein treatments on oxidant/antioxidant status in the brain of ovariectomized rats 显示文摘 | Evsen MS Ozler A Gocmez C | 2013 | Eur Rev Med Phamlacol Sci2013，17，14： | 1 |
| 14 | Efficacy of melatonin, mcr- captoethylguanidine and 1400W in doxorubicin- and trastuzumab- induced cardiotoxicity 显示文摘 | Ozturk M Ozler M Kurt YG | 2011 | J Pineal Res2011，50，1： | 1 |
| 15 | Multi- product news- vendor problem with value- at- risk considerations 显示文摘 | Ozler A Tan B Karaesmen F | 2009 | International Journal of Production Economics2009，117，2： | 1 |
| 16 | Crime and local inequality in South显示文摘 | Demombynes G Ozler B | 2005 | Journal of Development Economics2005，76，2： | 1 |
| 17 | CD147 expression in uterine smooth muscle tumors, and its potential role as a diagnostic and prognostic marker in patients with leiomyosarcoma 显示文摘 | Ozler A Evsen M S Turgut A | 2014 | J Exp Ther Oncol2014，10，4： | 1 |
| 18 | Serum levels of the adipokines, free fatty acids, and oxidative stress markers in obese and non-obese preeclamptic patients 显示文摘 | TURGUT A OZLER A GORUK N Y et at | 2015 | Clin Exp ObstetGynecol2015，42，4： | 1 |
| 19 | Alteration of peripheral blood cells in tubal ectopic pregnancy显示文摘 | Turgut A Sak M E Ozler A | 2013 | Ginekol Pal2013，84，3： | 1 |
| 20 | Zinc deficiency in patients with recurrent aphthous stomati- tis: a pilot study 显示文摘 | Ozler GS | 2014 | J Laryngol Oto12014，128，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员