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| 1 | Different profile of cytokine synthesis according to the severity of acute pancreatitis显示文摘AIM: To evaluate the cellular synthetic ability of cytokines involved in pro- and anti-inflammatory reactions in patients with AP.METHODS: Sixty-seven patients with AP (16 severe,51 mild) and 10 controls were included in the study.Cultures of whole blood were performed in samples obtained within the first 72 h from the onset of pain.Serum levels of interleukins (IL) 6, 8, 10, and TNF-α were measured at baseline and in the supernatant of cultures with (functional reserve) or without stimulation with phytohemaglutinin.RESULTS: Basal levels of cytokines were significantly higher in patients with severe AP. A significant increase of all pro-inflammatory cytokines vs basal levels was observed in the supernatant after 24 h of whole blood cultures in patients, but not in controls. In contrast, IL-10 increased significantly in the supernatant of cultures only in patients with mild AP. Cells showed a statistically significant functional reserve for all IL in patients with mild, but only for pro-inflammatory cytokines in patients with severe AP.CONCLUSION: A marked activation of immune system may be observed in patients with AP, being balanced between pro- and anti-inflammatory cytokines in patients with mild but not severe AP. A reduced functional reserve for the synthesis of IL-10 may be observed in patients with severe AP, which might lead to a worst prognosis. | Raquel Laveda Juan Martínez Carlos Mu■oz Juan Carlos Penalva Jesus Sáez Germán Belda Salvador Navarro Faust Feu Anton Mas José Ma Palazón José Sánchez-Payá José Such Miguel Pérez-Mateo | 2005 | World Journal of Gastroenterology2005，11，34： | 24 |
| 2 | MADS-box gene evolution beyond flowers:expression in pollen,endosperm,guard cell,and trichomes显示文摘 | ALVARZ-BUYLLA E R LILJEGREN S J PALAZ S GOLD S E BURGEFF C DITFA G S VERGARA-SILVA F YANOFSKY M F | 2000 | Plant J2000，24，： | 1 |
| 3 | Acute and chronic hemodynamic changes after propranolol in patients with cirrhosis under primary and secondary prophylaxis of variceal bleeding: a pilot study显示文摘 | Enrique de-Madaria José María Palazón Flavia Tamara Hernández José Sánchez-Paya Pedro Zapater Javier Irurzun Francisco de Espa?a Sonia Pascual José Such Laura Sempere Fernando Carnicer Antonio García-Herola Jaime Valverde Miguel Pérez-Mateo | 2010 | European Journal of Gastroenterology & Hepatology2010，，5： | 1 |
| 4 | Detection and identification of bacterial DNA in patients with cirrhosis and culture-negative, nonneutrocytic ascites显示文摘 | José Such Rubén Francés Carlos Mu?oz Pedro Zapater Juan A. Casellas Ana Cifuentes Francisco Rodr??guez-Valera Sonia Pascual Javier Sola-Vera Fernando Carnicer Francisco Uceda José M. Palazón Miguel Pérez-Mateo | 2002 | Hepatology2002，，1： | 1 |
| 5 | Recent developments in high performance computing for remote sensing: a review显示文摘 | LEE C A GASSTER S D PALAZE A | 2011 | IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing2011，4，3： | 1 |
| 6 | A comparison of two different dosages of somatostatin combined with sclerotherapy for the treatment of acute esophageal variceal bleeding:aprospective randomized trial显示文摘 | PALAZN J M SUCH J SNCHEZ-PAYJ | 2006 | Rev Esp Enferm Dig2006，98，： | 1 |
| 7 | A sequential study of serum bacterial DNA in patients with advanced cirrhosis and ascites显示文摘 | Rubén Francés Susana Benlloch Pedro Zapater José M. González Beatriz Lozano Carlos Mu?oz Sonia Pascual Juan A. Casellas Francisco Uceda José M Palazón Fernando Carnicer Miguel Pérez‐Mateo José Such | 2004 | Hepatology2004，，2： | 1 |
| 8 | Detection and identification of bacterial DNA in patients with cirrhosis and culture-negative, nonneutrocytic ascites显示文摘 | José Such Rubén Francés Carlos Mu?oz Pedro Zapater Juan A. Casellas Ana Cifuentes Francisco Rodr??guez-Valera Sonia Pascual Javier Sola-Vera Fernando Carnicer Francisco Uceda José M. Palazón Miguel Pérez-Mateo | 2002 | Hepatology2002，，1： | 1 |
| 9 | MADS- box gene evolution beyond flowers: expression in pollen, endo- sperm, guard cells, roots and trichomes 显示文摘 | Alvarez-Buylla E R Liljegren S J Palaz S | 2000 | The Plant Jour- nal2000，24，： | 1 |
| 10 | MADS-box gene evolution beyond flowers: expression inpollen, endosperm, guard cells, roots and trichomes显示文摘 | Alvarez-Buylla E R Liljegren S J Palaz S | 2000 | The Plant Journal2000，24，： | 1 |
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