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| 1 | Genome-wide analysis identified 17 new loci influencing intraocular pressure in Chinese population显示文摘Intraocular pressure(IOP) is a major risk factor for glaucoma. Genetic determinants of intraocular pressure can provide critical insights into the genetic architecture of glaucoma and, as a result, open new avenues for therapeutic intervention. We performed a genome-wide association study and replication analysis of 8,552 Chinese participants. In the genome-wide association study, we identified 51 loci that surpassed the significance of P<9×10^(-7), and we formally replicated these loci. A combined discovery and replication meta-analysis identified 21 genome-wide loci that surpassed the genome-wide significance of P<5×10^(-8), including 4 previously reported loci: rs145063132(7 p21.2, ETV1/DGKB), rs548030386(7 q31.2, ST7 near CAV1/CAV2), rs7047871(9 p24.2, GLIS3), and rs2472494(9 q31.1, ABCA1/SLC44 A1). Of the 17 newly identified loci, five were reported to have ocular related phenotypes: PTCH2(rs7525308 in 1 p34.1), LRIF1/DRAM2(rs1282146 in 1 p13.3), COLEC11(rs201143466 in 2 p25.3),SPTBN1(rs4514918 in 2 p16.2), and CRK(rs11078446 in 17 p13.3). The genetic loci identified in this study not only increase our understanding of the genes involved in intraocular pressure but also provide important genetic markers to improve future genetic screening and drug discovery for intraocular pressure disorders. | Lulin Huang Yuhong Chen Ying Lin Pancy O.S.Tam Yilian Cheng Yi Shi Bo Gong Fang Lu Jialiang Yang Haixin Wang Yi Yin Yong Cao Dan Jiang Ling Zhong Bai Xue Jing Wang Fang Hao Dean-Yao Lee Chi-Pui Pang Xinghuai Sun Zhenglin Yang | 2019 | Science China(Life Sciences)2019，62，2： | 4 |
| 2 | H3K4me3 epigenomic landscape derived from ChIP-Seq of 1000 mouse early embryonic cells显示文摘 | Jie Shen Dongqing Jiang Yusi Fu Xinglong Wu Hongshan Guo Binxiao Feng Yuhong Pang Aaron M Streets Fuchou Tang Yanyi Huang | 2015 | Cell Research2015，25，1： | 4 |
| 3 | An integrated microfluidic device for long-term culture of isolated single mammalian cells显示文摘We developed an integrated microfluidic chip for long-term culture of isolated single cells. This polydimethylsiloxane (PDMS) based device could accurately seed each single cell into different culture chambers, and isolate one chamber from each other with monolithically integrated pneumatic valves. We optimized the culture conditions, including the frequency of medium replacement and the introduction of conditioned medium, to keep the single cells alive for 4 days. We cultured a few hundred cells in a separated chamber on the same chip to continuously supply the conditioned medium into the culture chambers for single cells. This approach greatly facilitated the growth of single cells, and created a suitable microenvironment for observing cells' autonomous process in situ without the interference of other adjacent cells. This single cell colony assay is expandable to higher throughput, fitting the needs in the studies of drug screening and stem cell differentiation. | ZHENG ChunHong CHEN Gui’E PANG YuHong HUANG YanYi | 2012 | Science China Chemistry2012，55，4： | 2 |
| 4 | Blended Teaching Mode Based on“Cloud Class+PAD Class”in the Course of Computer Graphics and Image Design显示文摘As a teaching tool,Cloud class is specially developed for teaching and learning in mobile circumstance,and the PAD(Presentation Assimilation Discussion)class acts as a creative teaching mode.The combination of Cloud class and PAD class helps build online-offline blended teaching model.In this paper,a Cloud+PAD class mode is proposed.An experiment of teaching is implemented and the practical effectiveness is evaluated and verified.The experimental results show,compared with the conventional teaching method,the proposed teaching mode is capable of creating more high-level,innovative and complex teaching content,and thereby noticeably enhancing students’learner autonomy and motivating them to develop creativity. | Yuhong Sun Shengnan Pang Baihui Yin Xiaofang Zhong | 2020 | 国际计算机前沿大会会议论文集2020，，2： | 0 |
| 5 | One-proton Knockout from ^(16)C at around 240 MeV/u显示文摘One-nucleon knockout reactions have been used to get spectroscopic factor information of unstable nuclei for decadesl[1-4],and a systematic analysis of experiment for intermediate energies of around 80 MeV/u knockout reactions based on the eikonal model indicates a strong isospin asymmetry dependence of the reduction of the extracted spectroscopic strength relative to the shell-model predictionsl[2,3]. | Zhao Yixuan Sun Yazhou Wang Shitao Sun Zhiyu Zhang Xueheng Yan Duo Pang Danyang Ma Peng Yu Yuhong Yue Ke Tang Shuwen Wang Shaoming Fang Fang Sun Yu Cheng Zehui Liu Xiangman Yang Herun Lu Chengui Duan Limin | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 6 | Terminal transfer amplification and sequencing for high-efficiency and lowbias copy number profiling of fragmented DNA samples显示文摘Dear Editor,Since its invention,next generation sequencing(NGS)has greatly facilitated biomedical research and clinical diagnosis(Sikkema-Raddatz et al.,2013).Continuous dropping of the cost further accelerated the adaptation of sequencing as a standard analytical tool,from identification of drug candidates(Walker et al.,2015)to deciphering the complex biological systems(McConnell et al.,2013). | Dongqing Jiang Xiannian Zhang Yuhong Pang Jianyun Zhang Jianbin Wang Yanyi Huang | 2019 | Protein & Cell2019，10，3： | 0 |
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