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| 1 | 42,573 cases of hepatectomy in China: a multicenter retrospective investigation显示文摘Hepatectomy is currently routinely performed in most hospitals in China. China owns the largest population of liver diseases and the biggest number of liver resection cases. A nationwide multicenter retrospective investigation involving 112 hospitals was performed, and focused on liver resection for patients with hepatocellular carcinoma(HCC). 42,573 cases of hepatectomy were enrolled, and 18,275 valid cases of liver resection for HCC patients were selected for statistical analysis. The epidemiology of HCC, distribution of hepatectomy, postoperative complications and prognosis were finally analyzed. In the 18,275 HCC patients,81% had hepatitis B virus infection and 10% had hepatitis C virus infection. 38% of the HCC patients had normal Alphafetoprotein(AFP) level, and other 35% had an AFP level lower than 400 ng mL^(-1). In the study period, 97% of the hepatectomy for HCC were treated with open surgery, and 23.81% had vascular exclusion techniques. The operation time was(191.7±105.6) min,the blood loss was(546.0±562.8) m L, and blood transfusion was(543.0±1,035.2) m L. The median survival for HCC patients was 631 days, with 1-, 3-, and 5-year overall survival of 73.2%, 28.8% and 19.6%, respectively. Liver cirrhosis, multiple nodules,tumor thrombosis and high AFP level were risk factors that affect postoperative survival. | Binhao Zhang Bixiang Zhang Zhiwei Zhang Zhiyong Huang Yifa Chen Minshan Chen Ping Bie Baogang Peng Liqun Wu Zhiming Wang Bo Li Jia Fan Lunxiu Qin Ping Chen Jingfeng Liu Zhe Tang Jun Niu Xinmin Yin Deyu Li Songqing He Bin Jiang Yilei Mao Weiping Zhou Xiaoping Chen | 2018 | Science China(Life Sciences)2018，61，6： | 39 |
| 2 | Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China显示文摘Enterovirus 71(EV71),one of the major causative agents for hand-foot-and-mouth disease(HFMD),has caused more than 100 deaths among Chinese children since March 2008.The EV71 genome encodes an RNAdependent RNA polymerase(RdRp),denoted 3D^(pol),which is central for viral genome replication and is a key target for the discovery of specific antiviral therapeutics.Here we report the crystal structures of EV71 RdRp(3D^(pol))and in complex with substrate guanosine-5'-triphosphate and analog 5-bromouridine-5'-triphosphate best to 2.4Åresolution.The structure of EV71 RdRp(3D^(pol))has a wider open thumb domain compared with the most closely related crystal structure of poliovirus RdRp.And the EV71 RdRp(3D^(pol))complex with GTP or Br-UTP bounded shows two distinct movements of the polymerase by substrate or analogue binding.The model of the complex with the template:primer derived by superimposition with foot-and-mouth disease virus(FMDV)3D/RNA complex reveals the likely recognition and binding of template:primer RNA by the polymerase.These results together provide a molecular basis for EV71 RNA replication and reveal a potential target for anti-EV71 drug discovery. | Yang Wu Zhiyong Lou Yi Miao Yue Yu Hui Dong Wei Peng Mark Bartlam Xuemei Li Zihe Rao | 2010 | Protein & Cell2010，1，5： | 30 |
| 3 | Gold nanorods together with HSP inhibitor-VER-155008 micelles for colon cancer mild-temperature photothermal therapy显示文摘Enhancing the heat-sensitivity of tumor cells provides an alternative solution to maintaining the therapeutic outcome of photothermal therapy(PTT). In this study, we constructed a therapeutic system, which was composed of methoxy-polyethylene-glycol-coated-gold-nanorods(MPEG-AuN R) and VER-155008-micelles, to evaluate the effect of VER-155008 on the sensitivity of tumor cells to heat, and further investigate the therapeutic outcome of MPEG-AuN R mediated PTT combined with VER-155008-micelles. VER-155008-micelles downregulate the expression of heat shock proteins and attenuate the heat-resistance of tumor cell. The survival of HCT116 cells treated with VER-155008-micelles under 45 ℃ is equal to that treated with high temperature hyperthermia(55 ℃) in vitro. Furthermore, we proved either the MPEG-AuN R or VER-155008-micelles can be accumulate in the tumor site by photoacoustic imaging and fluorescent imaging. In vivo anti-cancer evaluation showed that tumor size remarkably decreased(smaller than 100 mm^3 or vanished) when treated with combing 45℃ mild PTT system, which contrasted to the tumor size when treated with individual 45℃ mild PTT(around 500nm^3) or normal saline as control(larger than 2000 nm^3). These results proved that the VER-155008-micelles can attenuate the heat-resistance of tumor cells and enhance the therapeutic outcome of mild-temperature photothermal therapy. | Xichuan Tang Liwei Tan Kun Shi Jinrong Peng Yao Xiao Wenting Li Lijuan Chen Qian Yang Zhiyong Qian | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 12 |
| 4 | Ginsenoside Rh2 inhibits proliferation and induces apoptosis in human leukemia cells via TNF-~ signaling pathway显示文摘人参皂甙 Rh2,从人参属人参提取的 triterpene saponin,对多重癌症的展览药理学活动。然而,人参皂甙 Rh2 的 anticancer 机制是不清楚的。在这研究,我们发现人参皂甙 Rh2 有效地禁止生长并且导致 HL-60 房间的 apoptosis。用 microarray 技术,我们发现了那个肿瘤坏死因素 --(TNF-) 清楚地是起来调整的。而且, anti-TNF- 抗体经由 caspase-8, caspase-9,和 caspase-3 激活的抑制减轻了导致 Rh2 的 HL-60 房间 apoptosis。另外, TNF- 起来规定也在另外的对待 Rh2 的癌症房间线被观察。这些结果证明 TNF- 在人参皂甙起一个关键作用导致 Rh2 的房间 apoptosis。 | Jingjia Huang Kunjian Peng Linghao Wang Bin Wen Lin Zhou Tiao Luo Min Su Jijia Li Zhiyong Luo | 2016 | Acta Biochimica et Biophysica Sinica2016，48，8： | 11 |
| 5 | Molecular mapping of QTLs for root response to phosphorus deficiency at seedling stage in wheat (Triticum aestivum L.)显示文摘Phosphorus (P) deficiency in the soil is one of the major abiotic stresses that limit plant growth and crop productivity throughout the world. Development of cultivars with improved P-deficiency tolerance is an efficient strategy for sustainable agriculture. Plant roots play an important role in crop growth and development, especially in nutrient uptake and improvement of P-efficiency. Mapping quantitative trait loci (QTLs) for root traits and their response to low P stress at seedling stage will facilitate the development of P-efficient wheat cultivars. In this study, 30 QTLs (LOD>2.0) were mapped for the three root traits, such as root length, root number and root dry matter under different P supply conditions and their response to P-stress. These QTLs were distributed on 14 chromosomes, with each of the 5 QTLs explaining more than 10% phenotype variance. Analyses showed that root traits and their response to P-deficiency were controlled by different QTLs. In addition, alleles with positive effects were separated on both parents, and wheat cultivars with improved P-efficiency could be developed by accumulating these positive effect alleles together. | Li Zhenxing Ni Zhongfu Peng Huiru Liu Zhiyong Nie Xiuling Xu Shengbao Liu Gang Sun Qixin | 2007 | Progress in Natural Science:Materials International2007，17，10： | 8 |
| 6 | Plasma membrane proteome analysis of the early effect of alcohol on liver: implications for alcoholic liver disease显示文摘在人,酒精的在消费上能导致严肃的肝疾病。在肝疾病上检验酒精的早效果,老鼠被给足够的乙醇开发肝肝硬化。在纤维变性的发作前的老鼠在这个工作被学习。肝的血浆膜(下午) 被提取由两次蔗糖密度坡度 centrifugation。从对待乙醇的老鼠和控制的下午的 proteome 侧面为相对、绝对的 quantitation (iTRAQ ) 用二维的胶化电气泳动(2-DE ) 和等压的标签被分析技术。乙醇处理改变了 15 不同的肝蛋白质的数量:他们中的 10 个被 2-DE 检测并且 5 由 iTRAQ。角质素 8 被两个方法检测。这些差别的基因本体论分析检测了显示的蛋白质他们的那个大多数涉及象有约束力的活动那样的重要房间函数(包括离子, DNA, ATP 绑定,等等) ,房间结构,或酶活动。在这些之中, annexin A2,角质素 8,和角质素 18 进一步用西方的污点分析被验证, annexin A2 被 immunohistochemistry 验证。我们的结果建议酒精有潜力由在 PM 改变几相关蛋白质的表示层次影响房间结构,粘附和酶活动。就我们的知识而言,这是第一次在肝下午 proteome 上学习酒精的效果,它可能对理解导致白酒的肝疾病的可能的机制有用。 | Lijun Zhang Xiaofang Jia Yanling Feng Xia Peng Zhiyong Zhang Wenjiang Zhou Zhanqing Zhang Fang Ma Xiaohui Liu Ye Zheng Pengyuan Yang Zhenghong Yuan | 2011 | Acta Biochimica et Biophysica Sinica2011，43，1： | 8 |
| 7 | The Influence of Extractable Organic Matter on Pore Development in the Late Triassic Chang 7 Lacustrine Shales, Yanchang Formation, Ordos Basin, China显示文摘To investigate the influence of extractable organic matter(EOM) on pore evolution of lacustrine shales, Soxhlet extraction, using dichloromethane, was performed on a series of Chang 7 shale samples(Ordos Basin, China) with vitrinite reflectance of 0.64% to 1.34%. Low-pressure gas adsorption experiments were conducted on the samples before and after extraction. The pore structure parameters were calculated from the gas adsorption data. The results show complex changes to the pore volumes and surface areas after extraction. The pore development of both the initial and extracted samples is strongly controlled by total organic carbon(TOC) content. Micropores developed mainly in organic matter(OM), while mesopores and macropores predominantly developed in fractions other than OM. The influence of EOM on micropores is stronger than on mesopores and macropores. Organic solvents with a higher boiling point should be used to explore the effect of EOM on pore structure in the future. | HAN Hui LIU Pengwei DING Zhengang SHI Pitong JIA Jianchao ZHANG Wei LIU Yan CHEN Shijia LU Jungang Chen Kang PENG Xudong WANG Zhiyong XIAO Shuqi GAO Yuans | 2018 | Acta Geologica Sinica(English Edition)2018，92，4： | 8 |
| 8 | ZBP1(DAI/DLM-1) promotes osteogenic differentiation while inhibiting adipogenic differentiation in mesenchymal stem cells through a positive feedback loop of Wnt/β-catenin signaling显示文摘The lineage specification of mesenchymal stem/stromal cells(MSCs) is tightly regulated by a wide range of factors. Recently, the versatile functions of ZBP1(also known as DAI or DLM-1) have been reported in the blood circulation and immune systems.However, the biological function of ZBP1 during the lineage specification of MSCs is still unknown. In the present study, we found that ZBP1 was upregulated during osteogenesis but downregulated during adipogenesis in mouse bone marrow-derived MSCs(m BMSCs). ZBP1 was highly expressed in osteoblasts but expressed at a relatively low level in marrow adipocytes. Knockdown of ZBP1 inhibited alkaline phosphataseactivity, extracellular matrix mineralization, and osteogenesis-related gene expression in vitro and reduced ectopic bone formation in vivo. Knockdown of ZBP1 also promoted adipogenesis in MSCs in vitro. Conversely, the overexpression of ZBP1 increased the osteogenesis but suppressed the adipogenesis of MSCs. When the expression of ZBP1 was rescued, the osteogenic capacity of ZBP1-depleted m BMSCs was restored at both the molecular and phenotypic levels.Furthermore, we demonstrated that ZBP1, a newly identified target of Wnt/β-catenin signaling, was required for β-catenin translocation into nuclei. Collectively, our results indicate that ZBP1 is a novel regulator of bone and fat transdifferentiation via Wnt/β-catenin signaling. | Xuefeng Zhao Liang Xie Zhiyong Wang Jiongke Wang Hao Xu Xianglong Han Ding Bai Peng Deng | 2020 | Bone Research2020，8，2： | 8 |
| 9 | High-performance doping-free carbon-nanotube-based CMOS devices and integrated circuits显示文摘Ballistic n-type carbon nanotube(CNT)-based field-effect transistors(FETs) have been fabricated by contacting semiconducting single-walled CNTs(SWCNTs) using Sc or Y.The n-type CNT FETs were pushed to their performance limits through further optimizing their gate structure and insulator.The CNT FETs outperformed n-type Si metal-oxide-semiconductor(MOS) FETs with the same gate length and displayed better downscaling behavior than the Si MOS FETs.Together with the demonstration of ballistic p-type CNT FETs using Pd contacts,this technological advance is a step toward the doping-free fabrication of CNT-based ballistic complementary metal-oxide-semiconductor(CMOS) devices and integrated circuits.Taking full advantage of the perfectly symmetric band structure of the semiconductor SWCNT,a perfect SWCNT-based CMOS inverter was demonstrated,which had a voltage gain of over 160.Two adjacent n-and p-type FETs fabricated on the same SWCNT with a self-aligned top-gate realized high field mobility simultaneously for electrons(3000 cm2 V-1 s-1) and holes(3300 cm2 V-1 s-1).The CNT FETs also had excellent potential for high-frequency applications,such as a high-performance frequency doubler. | ZHANG ZhiYong WANG Sheng PENG LianMao | 2012 | Chinese Science Bulletin2012，57，2： | 7 |
| 10 | Insight into the Ebola virus nucleocapsid assembly mechanism: crystal structure of Ebola virus nucleoprotein core domain at 1.8 A resolution显示文摘 | Shishang Dong Peng Yang Guobang Li Baocheng Liu Wenming Wang Xiang Liu Boran Xia Cheng Yang Zhiyong Lou Yu Guo Zihe Rao | 2015 | Protein & Cell2015，6，5： | 6 |
| 11 | Performance projections for ballistic carbon nanotube FinFET at circuit level显示文摘为碳 nanotube (CNT ) 的新奇三维的设备结构鳍地效果晶体管(FinFET ) 被建议并且评估。我们包括繁殖延期,全部的力量驱散,和精力延期产品(电子数据处理) 用三个表演度量标准在电路水平在一个 22-nm 节点与 Si FinFET 相比评估了 CNT FinFET 的潜力。与 Si FinFET 相比, CNT FinFET 处于在更高全部的功率驱散从它的几乎更大的当前的密度而且结果产生的速度和电子数据处理介绍明显的优点,特别在低阀值电压(V th = 1/3V dd ) 。在 V th 能有效地贡献漏电流和力量驱散的重要抑制,然后明显的优化处于速度与可接受的牺牲在 EDP 被获得。特别地,有优化阀值电压的 CNT FinFETs 能在低供应电压下面在 Si FinFETs 上提供约 50 次的一个电子数据处理优点(V dd = 0.4 V ) ,为 CNT 基于 FinFET 的集成电路建议大潜力。 | Panpan Zhang Chenguang Qiu Zhiyong Zhang Li Ding Bingyan Chen Lianmao Peng | 2016 | Nano Research2016，9，6： | 6 |
| 12 | Realization of low contact resistance close to theoretical limit in graphene transistors显示文摘认识到在 graphene 和金属电极之间的低接触抵抗为造高效的 graphene 设备仍然是著名挑战。在这个工作,我们试图在 graphene 晶体管减少接触抵抗并且进一步探索在 graphene 和金属接触之间的抵抗限制。在房间温度的 Pd/graphene 接触抵抗在 100 ?? 下面被减少 ? ?? 汣獡 ? 愢瀭畬 ? 汰獵?? 猯'T ￣慮潮慰瑲捩敬 ? 敤潣慲整 ? 湯吠佩猼'T 挠慬獳∽ ? 汰獵瀭畬 ? 资 ? ?? 渠湡景扩牥 ? 湥 'L 敬 ? 桴 ? ?捣獥晳汵椠瑮来慲楴湯漠 ? 桴 ? 楢慮祲挠浯潰楳整椠瑮 ? 慢瑴牥敩 ? 潴愠摤敲獳猠牴 ' 壮霊 `? 瑳 'L 汩瑩 ? 湡 ? 潬 ? 慣慰楣吗? | Hua Zhong Zhiyong Zhang Bingyan Chen Haitao Xu Dangming Yu Le Huang Lianmao Peng | 2015 | Nano Research2015，8，5： | 5 |
| 13 | Large-area growth of ultra-high-density single-walled carbon nanotube arrays on sapphire surface显示文摘获得高密度的、大区域的围单人赛的碳 nanotube (SWNT ) 的可伸缩的途径穿的 A 为在实际电子设备认识到 SWNT 的完整的潜力是必要的;这仍然是大挑战。这里,我们由联合特洛伊催化剂在蓝宝石表面上为 ultra-high-density SWNT 数组的大区域的生长报导一个改进合成方法(免除了底层,保证超离频密度) 与瞬间 nanoparticles (在表面上装载了,稳定释放特洛伊催化剂) 作为合作催化剂。稠密、非常排列的 SWNT 盖住全部底层,本地密度象 160 tubes/m 一样高。在如此的数组上造的地效果晶体管(联邦货物税) 在排水管来源电压给了 488 A/m 的产量电流密度(V ds )= 门来源电压(V gs )=2 V,相应于在传导力上每 244 S/m 的宽度。这些结果在 SWNT 的控制结构的生长证实特洛伊瞬间催化剂的潜在的应用的宽范围。 | Lixing Kang Yue Hu Hua Zhong Jia Si Shuchen Zhang Qiuchen Zhao Jingjing Lin Qingwen Li Zhiyong Zhang Lianmao Peng Jin Zhang | 2015 | Nano Research2015，8，11： | 5 |
| 14 | Mechanism and technology study of collaborative support with long and short bolts in large-deformation roadways显示文摘Common short bolts of equal length are widely used to support the roofs of roadways in coal mines.However, they are insufficient to keep the roof stable against large deformations, so docking long bolts with high levels of elongation that can adapt to large deformations of the surrounding rock have been adopted. This paper proposes a collaborative support method that uses long and short bolts. In this study,the mechanism of docking long bolts and collaborative support was studied. Numerical simulation, similarity simulation, and field testing were used to analyze the distribution law of the displacement, stress,and plastic failure in the surrounding rock under different support schemes. Compared with the equal-length short bolt support, the collaborative support changed the maximum principal stress of the shallow roof from tensile stress to compressive stress, and the minimum principal stress of the roof significantly increased. The stress concentration degree of the anchorage zone clearly increased. The deformation of the roof and the two sides was greatly reduced, and the subsidence shape of the shallow roof changed from serrated to a smooth curve. The roof integrity was enhanced, and the roof moved down as a whole. Plastic failure significantly decreased, and the plastic zone of the roof was within the anchorage range. The similarity simulation results showed that, under the maximum mining stress,the roof collapsed with the equal-length short bolt support but remained stable with the collaborative support. The collaborative support method was successfully applied in the field and clearly improved the stability of the surrounding rock for a large deformation roadway. | Yu Hui Niu Zhiyong Kong Linggen Hao Caicheng Cao Peng | 2015 | International Journal of Mining Science and Technology2015，25，4： | 5 |
| 15 | Tree ring-dated fluctuation history of Midui glacier since the Little Ice Age in the southeastern Tibetan Plateau显示文摘Fluctuation history of Midui glacier in the southeastern Tibet since the Little Ice Age(LIA) was reconstructed by the dating of lateral and terminal moraines using tree rings.Four conversions of glacier advance/stabilization to retreat were identified at around 1767,1875,1924 and 1964.The glacier reached its LIA maximum position at 1767.The fluctuations are consistent with those of other glaciers from the Tibetan Plateau,the Rockies and the Alps,suggesting high spatial coherency of glacier fluctuations in the Northern Hemisphere.Comparison with the summer temperature reconstruction in the southeastern Tibetan Plateau indicated that the Midui glacier fluctuation may be related to temperature variation on the centennial timescale.On the decadal scale,the fluctuation could correspond to cold/warm variation with an 8-year lag on average. | XU Peng ZHU HaiFeng SHAO XueMei YIN ZhiYong | 2012 | Science China Earth Sciences2012，55，4： | 5 |
| 16 | A MITE insertion into the 3′-UTR regulates the transcription of TaHSP16.9 in common wheat显示文摘Miniature inverted-repeat transposable elements(MITEs) are a type of DNA transposon frequently inserted into promoters, untranslated regions(UTR), introns, or coding sequences of genes. We found a 276-bp tourist-like MITE insertion in the 3′-UTR of a 16.9 k Da small heat shock protein gene(TaH SP16.9-3A) on chromosome 3A of common wheat. Haplotype analysis revealed two haplotypes, s HSP-W(wild type without MITE insertion) and s HSP-M(mutant with MITE insertion), present in wheat germplasm. Both semiquantitative PCR and quantitative real-time PCR analyses showed increased transcription levels of TaH SP16.9-3A in s HSP-M compared with those of s HSP-W after heat treatment at 42 °C. It appeared that the MITE insertion into the 3′-UTR enhances the transcription of TaH SP16.9-3A. | Jingting Li Zhenzhong Wang Huiru Peng Zhiyong Liu | 2014 | The Crop Journal2014，2，6： | 5 |
| 17 | 水稻叶片上表面气孔特征的变异显示文摘用硅胶压印技术观测水稻叶片正面的气孔密度、大小和开度,所得数据用GIMMS计算机软件绘制成气孔特征分布等值图。结果表明:不同取样时间气孔开度变异甚大;在叶片不同部位,以叶片中部的气孔开度较大,叶片基部的气孔开度较小;叶片顶部和边缘的气孔开度因测定时间而异。气孔大小和密度的分布也有很大的不均一性:叶片边缘气孔分布最多,叶片顶部气孔分布最少;保卫细胞则以叶片顶部的最大,叶片边缘的最小。讨论了试验结果对气孔生理研究的意义。 | 杨建昌 王志琴 朱庆森 Weyers J D B Peng Zhiyong | 1996 | 江苏农学院学报1996，17，3： | 5 |
| 18 | Au-Ag alloy nanoparticles with tunable cavity for plasmon-enhanced photocatalytic H2 evolution显示文摘Au-Ag alloy nanoparticles with different cavity sizes have great potential for improving photocatalytic performance due to their tunable plasmon effect.In this study,galvanic replacement was combined with co-reduction with the reaction kinetics processes regulated to rapidly synthesize Au-Ag hollow alloy nanoparticles with tunable cavity sizes.The position of the localized surface plasmon resonance(LSPR)peak could be effectively adjusted between 490 nm and 713 nm by decreasing the cavity size of the Au-Ag hollow nanoparticles from 35 nm to 20 nm.The plasmon-enhanced photocatalytic H2 evolution of alloy nanoparticles with different cavity sizes was investigated.Compared with pure P25(TiO2),intact and thin-shelled Au-Ag hollow nanoparticles(HNPs)-supported photocatalyst exhibited an increase in the photocatalytic H2 evolution rate from 0.48μmol h^−1 to 4μmol h^−1 under full-spectrum irradiation.This improved photocatalytic performance was likely due to the plasmon-induced electromagnetic field effect,which caused strong photogenerated charge separation,rather than the generation of hot electrons. | Xuanyu Yue Juan Hou Haifeng Zhao Pengcheng Wu Yali Guo Qin Shi Long Chen Shanglong Peng Zhiyong Liu Guozhong Cao | 2020 | Journal of Energy Chemistry2020，29，10： | 4 |
| 19 | Effects of different carbon sources on the removal of ciprofloxacin and pollutants by activated sludge:Mechanism and biodegradation显示文摘This research investigated the effects of ciprofloxacin(CIP)(0.5,5,and 20 mg/L)on SBR systems under different carbon source conditions.Microbial community abundance and structure were determined by quantitative PCR and high-throughput sequencing,respectively.The biodegradation production of CIP and possible degradation mechanism were also studied.Results showed that CIP had adverse effects on the nutrient removal from wastewater.Compared with sodium acetate,glucose could be more effectively used by microorganisms,thus eliminating the negative effects of CIP.Glucose stimulated the microbial abundance and increased the removal rate of CIP by 18%–24%.The mechanism research indicated that Proteobacteria and Acidobacteria had a high tolerance for CIP.With sodium acetate as a carbon source,the abundance of nitrite-oxidizing bacterial communities decreased under CIP,resulting in the accumulation of nitrite and nitrate.Rhodanobacter and Microbacterium played a major role in nitrification and denitrification when using sodium acetate and glucose as carbon sources.Dyella and Microbacterium played positive roles in the degradation process of CIP and eliminated the negative effect of CIP on SBR,which was consistent with the improved removal efficiency of pollutants. | Yixiang Cai Zhiyong Yan Yingjuan Ou Boshang Peng Lihua Zhang Jihai Shao Yiqing Lin Jiachao Zhang | 2022 | Journal of Environmental Sciences2022，34，1： | 4 |
| 20 | Can nanoparticles and nano-protein interactions bring a bright future for insulin delivery?显示文摘Insulin therapy plays an essential role in the treatment of diabetes mellitus.However,frequent injections required to effectively control the glycemic levels lead to substantial inconvenience and low patient compliance.In order to improve insulin delivery,many efforts have been made,such as developing the nanoparticles (NPs)-based release systems and oral insulin.Although some improvements have been achieved,the ultimate results are still unsatisfying and none of insulin-loaded NPs systems have been approved for clinical use so far.Recently,nano?protein interactions and protein corona formation have drawn much attention due to their negative influence on the in vivo fate of NPs systems.As the other side of a coin,such interactions can also be used for constructing advanced drug delivery systems.Herein,we aim to provide an insight into the advance and flaws of various NPs-based insulin delivery systems.Particularly,an interesting discussion on nano?protein interactions and its potentials for developing novel insulin delivery systems is initiated. | Ting Zhang James Zhenggui Tang Xiaofan Fei Yanping Li Yi Song Zhiyong Qian Qiang Peng | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 3 |
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