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| 1 | Advances and Trends on Tube Bending Forming Technologies显示文摘作为有庞大的数量和差异的一个种关键部件,弄弯的试管部分从材料和结构方面为无足轻重的人和高张力产品满足增加的需要。弄弯的试管广泛地在象航空,太空,造船,汽车,精力和护理那样的许多高端工业被使用了。弯曲的试管成为了为小产品形成生产技术的钥匙之一。经由把特征和多重缺点弄弯的分析,在试管弯曲探索普通问题上的进展在穹隆之内面关于起皱的不稳定性被总结,墙变瘦(裂开) 在拱背, springback 现象,剖面图变丑,形成的限制和过程 / 工具设计 / 优化。一些当前发达的弯曲技术以他们的优点和限制被考察。最后,鉴于高效的建筑群的迫切要求,在航空与 difficult-to-deform 和小材料把试管部件弄弯,太空域,发展趋势和相应挑战为认识到把变丑弄弯的精确、高效率的试管被介绍。 | YANG He LI Heng ZHANG Zhiyong ZHAN Mei LIU Jing LI Guanjun | 2012 | Chinese Journal of Aeronautics2012，25，1： | 86 |
| 2 | Dual function of Arabidopsis A TAF1 in abiotic and biotic stress responses显示文摘NAC 家庭基因编码涉及多样的生物过程的植物特定的抄写因素。在这研究, Arabidopsis NAC 基因 ATAF1 被发现被干旱导致,高咸度, abscisic 酸(骆驼毛的织物) ,甲基 jasmonate,机械伤害,并且 Botrytis cinerea 感染。ATAF1 的重要正式就职在受到干旱或高咸度的骆驼毛的织物缺乏的变异的 aba2 被发现,揭示表示的骆驼毛的织物无关的机制。Arabidopsis ATAF1-overexpression 线显示了许多改变的显型,包括侏儒症和短主要的根。而且,在 vivo,实验显示 ATAF1 是真正的管理者 modulating 植物对许多不能生活的压力和 necrotrophic 病原体感染的回答。在 Arabidopsis 的 ATAF1 的 Overexpression 增加了植物敏感到骆驼毛的织物,盐,和氧化压力。特别, ATAF1 overexpression 种,然而并非异种排队显示出的显著地提高的植物忍耐到干旱。另外, ATAF1 overexpression 提高了植物危险性到 necrotrophic 病原体 B。cinerea,但是没改变 P 的无毒害或剧毒的紧张引起的疾病症状。syringae pv 西红柿 DC3000。转基因的植物 overexpressing ATAF1 对氧化应力过分敏感,建议反应的氧中介可能与响应病原体和不能生活的压力的调停 ATAF1 的发信号有关。 | Yaorong Wu Zhiyong Deng Jianbin Lai Yiyue Zhang Cuiping Yang Bojiao Yin Qingzhen Zhao Ling Zhang Yin Li Chengwei Yang Qi Xie | 2009 | Cell Research2009，19，11： | 56 |
| 3 | 42,573 cases of hepatectomy in China: a multicenter retrospective investigation显示文摘Hepatectomy is currently routinely performed in most hospitals in China. China owns the largest population of liver diseases and the biggest number of liver resection cases. A nationwide multicenter retrospective investigation involving 112 hospitals was performed, and focused on liver resection for patients with hepatocellular carcinoma(HCC). 42,573 cases of hepatectomy were enrolled, and 18,275 valid cases of liver resection for HCC patients were selected for statistical analysis. The epidemiology of HCC, distribution of hepatectomy, postoperative complications and prognosis were finally analyzed. In the 18,275 HCC patients,81% had hepatitis B virus infection and 10% had hepatitis C virus infection. 38% of the HCC patients had normal Alphafetoprotein(AFP) level, and other 35% had an AFP level lower than 400 ng mL^(-1). In the study period, 97% of the hepatectomy for HCC were treated with open surgery, and 23.81% had vascular exclusion techniques. The operation time was(191.7±105.6) min,the blood loss was(546.0±562.8) m L, and blood transfusion was(543.0±1,035.2) m L. The median survival for HCC patients was 631 days, with 1-, 3-, and 5-year overall survival of 73.2%, 28.8% and 19.6%, respectively. Liver cirrhosis, multiple nodules,tumor thrombosis and high AFP level were risk factors that affect postoperative survival. | Binhao Zhang Bixiang Zhang Zhiwei Zhang Zhiyong Huang Yifa Chen Minshan Chen Ping Bie Baogang Peng Liqun Wu Zhiming Wang Bo Li Jia Fan Lunxiu Qin Ping Chen Jingfeng Liu Zhe Tang Jun Niu Xinmin Yin Deyu Li Songqing He Bin Jiang Yilei Mao Weiping Zhou Xiaoping Chen | 2018 | Science China(Life Sciences)2018，61，6： | 39 |
| 4 | How many sutures in the southern Central Asian Orogenic Belt:Insights from East Xinjiang-West Gansu(NW China)?显示文摘How ophiolitic mèlanges can be defined as sutures is controversial with regard to accretionary orogenesis and continental growth.The Chinese Altay,East junggar,Tianshan,and Beishan belts of the southern Central Asian Orogenic Belt(CAOB) in Northwest China,offer a special natural laboratory to resolve this puzzle.In the Chinese Altay,the Erqis unit consists of ophiolitic melanges and coherent assemblages,forming a Paleozoic accretionary complex.At least two ophiolitic melanges(Armantai,and Kelameili) in East Junggar,characterized by imbricated ophiolitic melanges,Nb-enriched basalts,adakitic rocks and volcanic rocks,belong to a Devonian-Carboniferous intra-oceanic island arc with some Paleozoic ophiolites,superimposed by Permian arc volcanism.In the Tianshan,ophiolitic melanges like Kanggurtag,North Tianshan,and South Tianshan occur as part of some Paleozoic accretionary complexes related to amalgamation of arc terranes.In the Beishan there are also several ophiolitic melanges,including the Hongshishan,Xingxingxia-Shibangjing,Hongliuhe-Xichangjing,and Liuyuan ophiolitic units.Most ophiolitic melanges in the study area are characterized by ultramafic,mafic and other components,which are juxtaposed,or even emplaced as lenses and knockers in a matrix of some coherent units.The tectonic settings of various components are different,and some adjacent units in the same melange show contrasting different tectonic settings.The formation ages of these various components are in a wide spectrum,varying from Neoproterozoic to Permian.Therefore we cannot assume that these ophiolitic melanges always form in linear sutures as a result of the closure of specific oceans.Often the ophiolitic components formed either as the substrate of intra-oceanic arcs,or were accreted as lenses or knockers in subduction-accretion complexes.Using published age and paleogeographic constraints,we propose the presence of (1) a major early Paleozoic tectonic boundary that separates the Chinese Altay-East Junggar multiple subduction systems of the southern Siberian active margin from those of the northern Tarim;and (2) a major Permian suture zone that separates the Tianshan-Beishan from the northern active margin of the Tarim Craton.These new observations and interpretations have broad implications for the architecture and crustal growth of central Asia and other ancient orogens as well. | Wenjiao Xiao Chunming Han Wei Liu Bo Wan Ji'en Zhang Songjian Ao Zhiyong Zhang Dongfang Song Zhonghua Tian Jun Luo | 2014 | Geoscience Frontiers2014，5，4： | 31 |
| 5 | SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2显示文摘 | Huize Pan Di Guan Xiaomeng Liu Jingyi Li Lixia Wang Jun Wu Junzhi Zhou Weizhou Zhang Ruotong Ren Weiqi Zhang Ying Li Jiping Yang Ying Hao Tingting Yuan Guohong Yuan Hu Wang Zhenyu Ju Zhiyong Mao Jian Li Jing Qu FuchouTang Guang-Hui Liu | 2016 | Cell Research2016，26，2： | 32 |
| 6 | Contribution of Toll-like receptors to the control of hepatitis B virus infection by initiating antiviral innate responses and promoting specific adaptive immune responses显示文摘适应免疫在肝炎 B 的控制起一个关键作用,这很好被接受病毒(HBV ) 感染。相反,天生的免疫的贡献仅仅在最近的年里收到了注意。像使用费的受体(TLR ) 察觉到联系病原体的分子模式并且激活抗病毒的机制,包括细胞内部的抗病毒的小径和抗病毒的受动器干扰素(IFN ) 和支持 inflammatory cytokines 的生产。从在 vitro 并且在 vivo 模型的试验性的结果证明了 TLR 调停细胞的发信号的小径和抗病毒的 cytokines 的生产的激活,导致 HBV 复制的抑制。然而, HBV 感染在主人房间和下游地表明小径的激活的封锁上与 TLR 表示的 downregulation 被联系。在主要 HBV 感染, TLR 可以减慢 HBV 感染,但是仅仅间接地作出贡献到病毒的清理。重要地, TLR 可以在 vivo 调制 HBV 特定的 T 房间和 B 房间回答,它为 HBV 感染的结束是必要的。因此, TLR 收缩筋正在答应候选人为长期的 HBV 感染的处理充当 immunomodulators。抗病毒的处理可以在长期的 HBV 感染恢复 TLR 表示和功能并且可以基于 TLR 激活增加治疗学的途径的功效。有抗病毒的治疗和 TLR 激活的联合治疗学的策略能便于 HBV 特定的有免疫力的回答的恢复并且从而,在长期地感染的 HBV 病人完成病毒的清理。 | Zhiyong Ma Ejuan Zhang Dongliang Yang Mengji Lu | 2015 | Cellular & Molecular Immunology2015，12，3： | 22 |
| 7 | Cationic nanocarriers induce cell necrosis through impairment of Na^+/K^+-ATPase and cause subsequent inflammatory response显示文摘有积极表面费用的 Nanocarriers 以他们限制了他们的临床的应用的毒性著名。位于他们的毒性下面的机制例如煽动性的反应的正式就职,仍然保持大部分未知。在我们发现了 cationic nanocarriers 的那注射的现在的学习,包括 cationic liposomes, PEI,和 chitosan,导致了坏死的房间的快速的外观。cationic nanocarriers 导致的房间坏死依赖于他们的积极表面费用,但是不要求 RIP1 和 Mlkl。相反,细胞内部的 Na + 超载被发现伴随房间死亡。在文化媒介或有 Na +/K+-ATPase 阳离子绑定地点禁止者 ouabain 的房间的预告的处理的 Na + 的弄空,从房间坏死的保护的房间。而且,有 cationic nanocarriers 的处理在 vitro 并且在 vivo 禁止了 Na +/K+-ATPase 活动。计算模拟证明 cationic 搬运人能与 Na +/K+-ATPase 的阳离子绑定地点交往。有 ouabain 的小剂量的老鼠 pretreated 在 cationic nanocarriers 的致命的剂量的注射以后显示出改进幸存。进一步的分析建议 cationic nanocarriers 和 mitochondrial DNA 的产生的漏导致的那房间坏死能在 vivo 触发严重发炎,它被包含 TLR9 并且 MyD88 发信号的一条小径调停。一起拿,我们的结果揭示由此的新奇机制 cationic nanocarriers 通过和 mitochondrial 的随后的暴露的和 Na +/K+-ATPase, 的相互作用导致尖锐房间坏死是的联系损坏的分子的模式调停的一个关键事件煽动性的回答。我们的学习为评估 nanocarriers 的 biocompatibility 并且为药交货设计更好、更安全的有重要含意。 | Xiawei Wei Bin Shao Zhiyao He Tinghong Ye Min Luo Yaxiong Sang Xiao Liang Wei Wang Shuntao Luo Shengyong Yang Shuang Zhang Changyang Gong Maling Gou Hongxing Deng Yinglan Zhao Hanshuo Yang Senyi Deng Chengjian Zhao Li Yang Zhiyong Qian Jiong Li Xun Sun Jiahuai Han Chengyu Jiang Min Wu Zhirong Zhang | 2015 | Cell Research2015，25，2： | 21 |
| 8 | Anatomy of composition and nature of plate convergence: Insights for alternative thoughts for terminal India-Eurasia collision显示文摘The pattern and timing of collision between India and Eurasia have long been a major concern of the international community. However, no consensus has been reached hitherto. To explore and resolve the disagreements in the Himalayan study,in this paper we begin with the methodology and basic principles for the anatomy of composition and nature of convergent margins,then followed by an effort to conduct a similar anatomy for the India-Eurasia collision. One of the most common patterns of plate convergence involves a passive continental margin, an active continental margin and intra-oceanic basins together with accreted terranes in between. The ultimate configuration and location of the terminal suture zone are controlled by the basal surface of the accretionary wedge, which may show fairly complex morphology with Z-shape and fluctuant geometry. One plausible method to determine the terminal suture zone is to dissect the compositions and structures of active continental margins. It requires a focus on various tectonic elements belonging to the upper plate, such as accretionary wedges, high-pressure(HP)-ultra-high-pressure(UHP) metamorphic rocks, Barrovian-type metamorphic rocks and basement nappes, together with superimposed forearc basins.Such geological records can define the extreme limits and the intervening surface separating active margin from the passive one,thus offering a general sketch for the surface trace of the terminal suture zone often with a cryptic feature. Furthermore, the occurrence of the cryptic suture zone in depth may be constrained by geophysical data, which, in combination with outcrop studies of HP-UHP metamorphic rocks, enables us to outline the terminal suture zone. The southern part of the Himalayan orogen records complicated temporal and spatial features, which are hard to be fully explained by the classic 'two-plate-one-ocean' template,therefore re-anatomy of the compositions and nature for this region is necessitated. Taking advantage of the methodology and basic principles of plate convergence anatomy and synthesizing previous studies together with our recent research, we may gain new insights into the evolution of the Himalayan orogeny.(1) The Yarlung-Zangbo ophiolite is composed of multiple tectonic units rather than a single terminal suture zone, and a group of different tectonic units were juxtaposed against each other in the backstop of the Gangdese forearc.(2) The Tethyan Himalayan Sequence(THS) contains mélanges with typical block-in-matrix structures, uniform southwards paleocurrents and age spectra of detrital zircons typical of Eurasia continent. All of these facts indicate that the THS belonged to Eurasia plate before the terminal collision, emplaced in the forearc of the Gangdese arc.(3) The Greater Himalayan Crystalline Complex(GHC) and Lesser Himalayan Sequence(LHS) comprise complex components including eclogites emplaced into the GHC and the upper part of the LHS. Judging from the fact that HP-UHP metamorphic rocks are exhumed and emplaced in the upper plate, the GHC and the upper part of the LHS where eclogite occur should be assigned to the upper plate, lying above the terminal subduction zone surface. It is the very surface along which the continuous subduction of the India subcontinent occurred, therefore acting as the terminal, cryptic suture. From the suture further southward, the bulk rock associations of the LHS and Sub-Himalayan Sequence(Siwalik) show little affinity of mélange, probably belonging to the foreland system of the India plate. By the anatomy of tectonic features of all the tectonic units in the Himalayan orogen as well as the ages of the subduction-accretion related deformation, we conclude that the terminal India-Eurasia collision occurred after 14 Ma, the timing of the metamorphism of the eclogites emplaced into the upper plate. The development of rifts stretching in N-S direction in Tibet and tectonic events with the transition from sinistral to dextral movements in shear zones, such as the Ailaoshan fault in East Tibet, can coordinately reflect the scale and geodynamic influence of the India-Eurasia convergence zone.By conducting a detailed anatomy of the southern Himalayas, we propose a new model for the final collision-accretion of the Himalayan orogeny. Our study indicates that the anatomy of structures, composition, and tectonic nature is the key to a better understanding of orogenic belts, which may apply to all the orogenic belts around the world. We also point out that several important issues regarding the detailed anatomy of the structures, compositions and tectonic nature of the Himalayan orogeny in future. | XIAO WenJiao AO SongJian YANG Lei HAN ChunMing WAN Bo ZHANG Ji'En ZHANG ZhiYong LI Rui CHEN ZhenYu SONG ShuaiHua | 2017 | Science China Earth Sciences2017，60，6： | 20 |
| 9 | Natural Variation in CCD4 Promoter Underpins Species-Specific Evolution of Red Coloration in Citrus Peel显示文摘Carotenoids and apocarotenoids act as phytohormones and volatile precursors that influence plant development and confer aesthetic and nutritional value critical to consumer preference.Citrus fruits display considerable natural variation in carotenoid and apocarotenoid pigments.In this study,using an integrated genetic approach we revealed that a 5;c/s-regulatory change at CCD4b encoding CAROTENOID CLEAVAGE DIOXYGENASE 4b is a major genetic determinant of natural variation in C3 0 apocarotenoids responsible for red coloration of citrus peel.Functional analyses demonstrated that in addition the known role in synthesizing 3-citraurin,CCD4b is also responsible for the production of another important C3 0 apocarotenoid pigment,p-citraurinene.Furthermore,analyses of the CCD4b promoter and transcripts from various citrus germplasm accessions established a tight correlation between the presence of a putative 5'c/s-regulatory enhancer within an MITE transposon and the enhanced allelic expression of CCD4b in C3 0 apocarotenoid-rich red-peeled accessions.Phylogenetic analysis provided further evidence that functional diversification of CCD4b and naturally occurring variation of the CCD4b promoter resulted in the stepwise evolution of red peels in mandarins and their hybrids.Taken together,our findings provide new insights into the genetic and evolutionary basis of apocarotenoid diversity in plants,and would facilitate breeding efforts that aim to improve the nutritional and aesthetic value of citrus and perhaps other fruit crops. | Xiongjie Zheng Kaijie Zhu Quan Sun Weiyi Zhang Xia Wang Hongbo Cao Meilian Tan Zongzhou Xie Yunliu Zeng Junli Ye Lijun Chai Qiang Xu Zhiyong Pan Shunyuan Xiao Paul D.Fraser Xiuxin Deng | 2019 | Molecular Plant2019，12，9： | 18 |
| 10 | ‘Size effect’ related bending formability of thin-walled aluminum alloy tube显示文摘Aluminum alloy (Al-alloy) thin-walled (D/t > 20, diameter D, wall thickness t) bent tubes have attracted increasing applications in many industries with mass quantities and diverse specifications due to satisfying high strength to weigh ratio requirements of product manufacturing. However, due to nonlinear nature of bending with coupling effects of multiple factors, the similarity theory seems not applicable and there occurs a challenge for efficient and reliable evaluation of the bending formability of thin-walled tube with various bending specifications. Considering the unequal deformation and three major instabilities, the bending formability of thin-walled Al-alloy tube in changing tube sizes such as D and t are clarified via both the analytical and FE modeling/ simulations. The experiments of rotary draw bending are conducted to validate the theoretical models and further confirm 'size effect' related bending formability. The major results show that (1) The anti-wrinkling capability of tube decreases with the larger D and smaller t, and the effect significance of t is larger than that of D even under rigid supports; (2) The wall thinning increases with the larger D and smaller t, and this tendency becomes much more obvious under rigid supports; (3) The cross-section deformation increases with the larger D and smaller t according to the analytical model obtained intrinsic relationship, while this tendency becomes opposite due to the nonlinear role of mandrel die; (4) The size factor D/t can be used as a nondimensional index to evaluate both the bending formability regarding the wall thinning and cross-section deformation. | Li Heng Yang He Zhang Zhiyong Wang Zekang | 2013 | Chinese Journal of Aeronautics2013，26，1： | 16 |
| 11 | A structural view of the antibiotic degradation enzyme NDM-1 from a superbug显示文摘Gram-negative Enterobacteriaceae with resistance to carbapenem conferred by New Delhi metallo-β-lactamase 1(NDM-1)are a type of newly discovered antibioticresistant bacteria.The rapid pandemic spread of NDM-1 bacteria worldwide(spreading to India,Pakistan,Europe,America,and Chinese Taiwan)in less than 2 months characterizes these microbes as a potentially major global health problem.The drug resistance of NDM-1 bacteria is largely due to plasmids containing the blaNDM-1 gene shuttling through bacterial populations.The NDM-1 enzyme encoded by the blaNDM-1 gene hydrolyzes β-lactam antibiotics,allowing the bacteria to escape the action of antibiotics.Although the biological functions and structural features of NDM-1 have been proposed according to results from functional and structural investigation of its homologues,the precise molecular characteristics and mechanism of action of NDM-1 have not been clarified.Here,we report the threedimensional structure of NDM-1 with two catalytic zinc ions in its active site.Biological and mass spectroscopy results revealed that D-captopril can effectively inhibit the enzymatic activity of NDM-1 by binding to its active site with high binding affinity.The unique features concerning the primary sequence and structural conformation of the active site distinguish NDM-1 from other reported metallo-β-lactamases(MBLs)and implicate its role in wide spectrum drug resistance.We also discuss the molecular mechanism of NDM-1 action and its essential role in the pandemic of drug-resistant NDM-1 bacteria.Our results will provide helpful information for future drug discovery targeting drug resistance caused by NDM-1 and related metallo-β-lactamases. | Yu Guo Jing Wang Guojun Niu Wenqing Shui Yuna Sun Honggang Zhou Yaozhou Zhang Cheng Yang Zhiyong Lou Zihe Rao | 2011 | Protein & Cell2011，2，5： | 16 |
| 12 | Accretionary processes and metallogenesis of the Central Asian Orogenic Belt:Advances and perspectives显示文摘As one of the largest Phanerozoic orogens in the world,the Central Asian Orogenic Belt(CAOB)is a natural laboratory for studies of continental dynamics and metallogenesis.This paper summarizes the research progresses of the accretionary processes and metallogenesis of the CAOB since the Peopled Republic of China was founded,and puts forward the prospect for future research.During the early period(1950s-1970s),several geological theories were applied to explain the geological evolution of Central Asia.In the early period of China's reform and opening-up,the plate tectonics theory was applied to explain the evolution of the northern Xinjiang and Xingmeng regions,and the opinion of subduction-collision between Siberian Kazakhstan and China-North Korea-Tarim plates was proposed.The idea of the Solonker-Yanbian suture zone was established.In the 1990s,the study of the CAOB entered a period of rapid development.One school of scholars including geologists from the former Soviet Union proposed a multi-block collision model for the assemblage of the CAOB.In contrast,another school of scholars,led by a Turkish geologist,Celal Sengor,proposed that the Altaids was formed through the growth and strike-slip duplicates of a single island arc,and pointed out that the Altaids is a special type of collisional orogen.During this period,Chinese geologists carried out a lot of pioneering researches on ophiolites and high-pressure metamorphic rocks in northern China,and confirmed the main suture zones accordingly.In 1999,the concept of'Central Asian metallogenic domain'was proposed,and it became one of the three major metallogenic domains in the world.Since the 21st century,given the importance for understanding continental accretion and metallogenic mechanism,the CAOB has become the international academic forefront.China has laid out a series of scientific research projects in Central Asia.A large number of important scientific research achievements have been spawned,including the tectonic attribution of micro-continents,timing and tectonic settings of ophiolites,magmatic arcs,identification and anatomy of accretionary wedges,regional metamorphism-deformation,(ultra)high-pressure metamorphism,ridge subduction plume-plate interaction archipelagic paleogeography and spatio-temporal framework of multiple accretionary orogeny,continental growth accretionary metallogenesis,structural superposition and transformation etc.These achievements have made important international influences.There still exist the following aspects that need further study:(1)Early evolution history and subduction initiation of the Paleo-Asian Ocean;(2)The accretionary mechanism of the extroversion Paleo-Asian Ocean;(3)The properties of the mantle of the Paleo-Asian Ocean and their spatiotemporal distribution;(4)The interaction between the Paleo-Asian Ocean and the Tethys Ocean;(5)Phanerozoic continental growth mechanism and its global comparison;(6)Accretionary metallogenic mechanism of the Central Asian metallogenic domain;and(7)Continental transformation mechanism. | Wenjiao XIAO Dongfang SONG Brian FWINDLEY Jiliang LI Chunming HAN Bo WAN Ji'en ZHANG Songjian AO Zhiyong ZHANG | 2020 | Science China Earth Sciences2020，63，3： | 16 |
| 13 | Intelligent and efficient development of wireless networks:A review of cognitive radio networks显示文摘Facing the challenges on how to improve spectrum efficiency and how to realize heterogeneous network convergence in future wireless networks,a cognitive radio network(CRN) is proposed as one of the solutions.This has become a major research topic in recent years and it is timely to give an overview of the development of CRN and to summarize key issues and technologies.The fundamental concepts of CRN,including the cognitive cycle model,the network architecture,and the cognitive ability and intelligent decision functions,are introduced in detail based on recent advances.Key issues for each topic,followed with recent research on theory and method,are then classified and the industrialization developments of CRN testbeds based on TD-LTE cellular system and standards are briefly presented.Finally,conclusions are reached on the perspectives and directions of future development. | ZHANG Ping LIU Yang FENG ZhiYong ZHANG QiXun LI Qian XU Ding | 2012 | Chinese Science Bulletin2012，57，28： | 15 |
| 14 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 15 | The Qitai radio telescope显示文摘This study presents a general outline of the Qitai radio telescope(QTT)project.Qitai,the site of the telescope,is a county of Xinjiang Uygur Autonomous Region of China,located in the east Tianshan Mountains at an elevation of about 1800 m.The QTT is a fully steerable,Gregorian-type telescope with a standard parabolic main reflector of 110 m diameter.The QTT has adopted an umbrella support,homology-symmetric lightweight design.The main reflector is active so that the deformation caused by gravity can be corrected.The structural design aims to ultimately allow high-sensitivity observations from 150 MHz up to115 GHz.To satisfy the requirements for early scientific goals,the QTTwill be equipped with ultra-wideband receivers and large field-of-view multi-beam receivers.A multi-function signal-processing system based on RFSo C and GPU processor chips will be developed.These will enable the QTT to operate in pulsar,spectral line,continuum and Very Long Baseline Interferometer(VLBI)observing modes.Electromagnetic compatibility(EMC)and radio frequency interference(RFI)control techniques are adopted throughout the system design.The QTT will form a world-class observational platform for the detection of lowfrequency(nano Hertz)gravitational waves through pulsar timing array(PTA)techniques,pulsar surveys,the discovery of binary black-hole systems,and exploring dark matter and the origin of life in the universe.The QTT will also play an important role in improving the Chinese and international VLBI networks,allowing high-sensitivity and high-resolution observations of the nuclei of distant galaxies and gravitational lensing systems.Deep astrometric observations will also contribute to improving the accuracy of the celestial reference frame.Potentially,the QTT will be able to support future space activities such as planetary exploration in the solar system and to contribute to the search for extraterrestrial intelligence. | Na Wang Qian Xu Jun Ma Zhiyong Liu Qi Liu Hailong Zhang Xin Pei Maozheng Chen Richard N.Manchester Kejia Lee Xingwu Zheng Hans J.Kärcher Wulin Zhao Hongwei Li Dongwei Li Martin Süss Matthias Reichert Zhongyi Zhu Congsi Wang Mingshuai Li Rui Li Ning Li Guljaina Kazezkhan Wenming Yan Gang Wu Lang Cui Ming Zhang Haitao Li | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，8： | 14 |
| 16 | Relationship between electrochemical characteristics and SCC of X70 pipeline steel in an acidic soil simulated solution显示文摘Stress corrosion cracking (SCC) of X70 pipeline steel in simulated solution of the acidic soil in Yingtan in China was investigated using slow strain rate test (SSRT), SEM and potentiodynamic polarization technique. Experiment results indicate that X70 steel is highly susceptible to SCC as applied potential reduces, which is manifested in loss of toughness and brittle fracture. Constant polarization current can detect the occurrence of SCC. The lower the polarization current is the sooner stress corrosion cracking occurs. The SCC mechanisms are different at varying potentials. When potential is higher than open circuit potential, anodic process controls SCC, whereas when potential is far lower than open circuit potential, cathodic process controls SCC, and between these two potential regions, a combined electrochemical process controls the SCC. Stress or strain has a synergistic effect with electrochemical reactions to accelerate the cathodic hydrogen evolution process, which makes the X70 pipeline steel to be more susceptible to SCC. | Zhiyong LIU Xiaogang LI Yingrui ZHANG Cuiwei DU Guoli ZHA | 2009 | Acta Metallurgica Sinica(English Letters)2009，22，1： | 13 |
| 17 | Molecular mechanism of SCARB2-mediatec attachment and uncoating of EV71显示文摘 | Minghao Dang Xiangxi Wang Quan Wang Yaxin Wang Jianping Lin Yuna Sun Xuemei Li Liguo Zhang Zhiyong Lou Junzhi Wang Zihe Rao | 2014 | Protein & Cell2014，5，9： | 13 |
| 18 | Effect of molybdenum content on the microstructure and corrosion behavior of FeCoCrNiMox high-entropy alloys显示文摘The effect of Mo content on the microstructure revolution and corrosion behavior of cast FeCoCrNiMox high-entropy alloys in chloride environments were investigated.Results indicate that FeCoCrNi and FeCoCrNiMo0.1 alloys are in single FCC solid solution.The precipitates form in FeCoCrNiMo0.3 and increase in FeCoCrNiMo0.6 alloys.Pitting occurs on FeCoCrNi and FeCoCrNiMo0.1 alloys while FeCoCrNiMo0.3 and FeCoCrNiMo0.6 alloys suffer from preferential localized corrosion at the regions depleted in Cr and Mo.The higher Cr2O3/Cr(OH)3 ratio and the incorporation of Mo oxides make the passive film more protective and the corrosion resistance of the FeCoCrNiMo0.1 alloy is thus enhanced.The correlation between microstructure and corrosion behavior and the corresponding corrosion mechanism were clarified. | Chunduo Dai Tianliang Zhao Cuiwei Du Zhiyong Liu Dawei Zhang | 2020 | Journal of Materials Science & Technology2020，42，11： | 13 |
| 19 | Research progress in BYDV resistance genes derived from wheat and its wild relatives显示文摘Barley yellow dwarf virus (BYDV) may cause a serious disease affecting wheat worldwide. True resistance to BYDV is not naturally found in wheat. BYDV resistance genes are found in more than 10 wild relative species belonging to the genera of Thinopyrum, Agropyron, Elymus, Leymus, Roegneria, and Psathyrostachy. Through wide crosses combining with cell culture, use of ph mutants, or irradiation, 3 BYDV resistance genes in Th. intermedium, including Bdv2, Bdv3 and Bdv4, were introgressed into common wheat background. Various wheat-Th. intermedium addition and substitution, translocation lines with BYDV-resistance were developed and characterized, such as 7D-7Ai#1 (bearing Bdv2), 7B-7Ai#1, 7D-7E (bearing Bdv3), and 2D-2Ai-2 (bearing Bdv4) translocations. Three wheat varieties with BYDV resistance from Th. intermedium were developed and released in Australia and China, respectively. In addition, wheat-Agropyron cristatum translocation lines, wheat-Ag. pulcherrimum addition and substitution lines, and a wheat-Leymus multicaulis addition line (line24) with different resistance genes were developed. Cytological analysis, morphological markers, biochemical markers, and molecu-lar markers associated with the alien chromatin carrying BYDV resistance genes were identified and applied to determine the presence of alien, chromosomes or segments, size of alien chromosome segments, and compositions of the alien chromosomes. Furthermore, some resistance-related genes, such as RGA, P450, HSP70, protein kinases, centrin, and transducin, were identified, which expressed specifi-cally in the resistance translocation lines with Bdv2. These studies lay the foundations for developing resistant wheat cultivars and unrav-eling the resistance mechanism against BYDV. | Zengyan Zhang Zhishan Lin Zhiyong Xin | 2009 | Journal of Genetics and Genomics2009，36，9： | 12 |
| 20 | Different aspects of cognitive function in adult patients with moyamoya disease and its clinical subtypes显示文摘Objective Although a few reports suggested that cognitive function impairment could be found in adult patients with moyamoya disease(MMD),there were still many aspects that are unclear.The aim of our study was to assess the cognitive function of adult patients with MMD and its clinical subtypes.Methods 49 patients with MMD and 23 healthy controls were asked to take cognitive function tests.Cognitive function tests included IQ,prospective memory(PM),immediate memory(IM),verbal fluency(VF),visual breadth,attention,retrospective memory(RM),Stroop test,Wisconsin Card Sorting Test,Trail-Making Test Part A(TMT-A)and Continuous Performance Test(CPT).Independent t-analysis,one-way analysis of variance and Pearson correlation were used to seek for differences between subgroups and the correlation between cognitive variables.results Compared with healthy controls,adult patients with MMD had a comprehensive cognitive impairment,including IQ,PM,VF,attention,RM,Stroop,CPT and TMT-A,with more serious impairment in PM and attention.PM and RM were separated,indicating that they were independent of each other.Pattern of attention was significantly different from healthy controls.Female patients were better than male patients,where significant differences in PM,IM,Stroop and WCST could be found.The haemorrhagic patients exhibited poorer in the dimension of PM and RM than the ischaemic.The headache subtype exhibited poorer than healthy controls.PM,RM,attention and executive function were moderately correlated with each other.Conclusions Adult patients with MMD had a wide range of cognitive impairment with more serious impairment in memory and attention.Differences in cognitive function existed between the different subtypes of adult MMD. | Zhiyong Shi Yu-Jie Wen Zheng Huang Le-Bao Yu Dong Zhang | 2020 | Stroke & Vascular Neurology2020，5，1： | 12 |
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