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| 1 | Targeting the untargetable KRAS in cancer therapy显示文摘RAS is one of the most well-known proto-oncogenes. Its gain-of-function mutations occur in approximately 30% of all human cancers. As the most frequently mutated RAS isoform, KRAS is intensively studied in the past years. Despite its well-recognized importance in cancer malignancy,continuous efforts in the past three decades failed to develop approved therapies for KRAS mutant cancer. KRAS has thus long been considered to be undruggable. Encouragingly, recent studies have aroused renewed interest in the development of KRAS inhibitors either directly towards mutant KRAS or against the crucial steps required for KRAS activation. This review summarizes the most recent progress in the exploration of KRAS-targeted anticancer strategies and hopefully provides useful insights for the field. | Pingyu Liu Yijun Wang Xin Li | 2019 | Acta Pharmaceutica Sinica B2019，9，5： | 33 |
| 2 | Cobalt single atom site catalysts with ultrahigh metal loading for enhanced aerobic oxidation of ethylbenzene显示文摘The oxidation of hydrocarbons to produce high value-added compounds(ketones or alcohols)using oxygen in air as the only oxidant is an efficient synthetic strategy from both environmental and economic views.Herein,we successfully synthesized cobalt single atom site catalysts(Co SACs)with high metal loading of 23.58 wt.%supported on carbon nitride(CN),which showed excellent catalytic properties for oxidation of ethylbenzene in air.Moreover,Co SACs show a much higher turn-over frequency(19.6 h^(−1))than other reported non-noble catalysts under the same condition.Comparatively,the as-obtained nanosized or homogenous Co catalysts are inert to this reaction.Co SACs also exhibit high selectivity(97%)and stability(unchanged after five runs)in this reaction.DFT calculations reveal that Co SACs show a low energy barrier in the first elementary step and a high resistance to water,which result in the robust catalytic performance for this reaction. | Yu Xiong Wenming Sun Yunhu Han Pingyu Xin Xusheng Zheng Wensheng Yan Juncai Dong Jian Zhang Dingsheng Wang Yadong Li | 2021 | Nano Research2021，14，7： | 20 |
| 3 | 2020 Roadmap on gas-involved photo-and electro-catalysis显示文摘Green reactions not only provide us chemical products without any pollution,but also offer us the viable technology to realize difficult tasks in normal conditions.Photo-,photoelectro-,and electrocatalytic reactions are indeed powerful tools to help us to embrace bright future.Especially,some gas-involved reactions are extremely useful to change our life environments from energy systems to liquid fuels and cost-effective products,such as H2 evolution(H2 production),02 evolution/reduction,CO2 reduction,N2 reduction(or N2 fixation) reactions.We can provide fuel cells clean H2 for electric vehicles from H2 evolution reaction(HER),at the same time,we also need highly efficient 02 reduction reaction(ORR) in fuel cells for improving the reaction kinetics.Moreover,we can get the clean oxidant O2 from water through O2 evolution reaction(OER),and carry out some reactions without posing any pollution to reaction systems.Furthermore,we can translate the greenhouse gas CO2 into useful liquid fuels through CO2 reduction reaction(CRR).Last but not the least,we can get ammonia from N2 reduction reaction(NRR),which can decrease energy input compared to the traditional Hubble process.These reactions,such as HER,ORR,OER,CRR and NRR could be realized through solar-,photoelectro-and electro-assisted ways.For them,the catalysts used play crucial roles in determining the efficiency and kinds of products,so we should consider the efficiency of catalysts.However,the cost,synthetic methods of catalysts should also be considered.Nowadays,significant progress has been achieved,however,many challenges still exist,reaction systems,catalysts underlying mechanisms,and so on.As extremely active fields,we should pay attention to them.Under the background,it has motivated us to contribute with a roadmap on ’GasInvolved Photo-and Electro-Catalysis’. | Yulu Yang Yang Tang Haomin Jiang Yongmei Chen Pingyu Wan Maohong Fan Rongrong Zhang Sana Ullah Lun Pan Ji-Jun Zou Mengmeng Lao Wenping Sun Chao Yang Gengfeng Zheng Qiling Peng Ting Wang Yonglan Luo Xuping Sun Alexander S.Konev Oleg V.Levin Panagiotis Lianos Zhuofeng Hu Zhurui Shen Qinglan Zhao Ying Wang Nadia Todorova Christos Trapalis Matthew V.Sheridan Haipeng Wang Ling Zhang Songmei Sun Wenzhong Wang Jianmin Ma | 2019 | Chinese Chemical Letters2019，30，12： | 1 |
| 4 | Production of diacylglycerol - mixture of regioisomers with high purity by two - step enzymatic reactions combined with molecular distillation 显示文摘 | ZHENG Pingyu XU Yang WANG Weifei | 2014 | J Am Oil Chem Soc2014，91，2： | 1 |
| 5 | Kinetics of natural rubber vulcanization in the end stage of curing period 显示文摘 | Wang Pingyue Qian Honglian Yu Heping | 2006 | Journal of Applied Polymer Science2006，101，： | 1 |
| 6 | Preparation of porous super-hydrophobic and super-oleophilic polyvinyl chloride surface with corrosion resistance property显示文摘 | Yingke Kang Jinyan Wang Guangbin Yang Xiujuan Xiong Xinhua Chen Laigui Yu Pingyu Zhang | 2011 | Applied Surface Science2011，，3： | 1 |
| 7 | Production of Diacylglycerol-Mixture of Regioisomers with High Purity by Two-Step Enzymatic Reactions Combined with Molecular Distillation显示文摘 | Pingyu Zheng Yang Xu Weifei Wang Xiaoli Qin Zhengxiang Ning Yonghua Wang Bo Yang | 2014 | Journal of the American Oil Chemists’ Society2014，，2： | 1 |
| 8 | Location analysis of retail stores in Changchun, China: A street centrality perspective显示文摘 | Fahui Wang Chen Chen Chunliang Xiu Pingyu Zhang | 2014 | Cities2014，，： | 1 |
| 9 | De novo assembly of the seed transcriptome and search for potential EST-SSR markers for an endangered, economically important tree species: Elaeagnus mollis Diels显示文摘Seeds of Elaeagnus mollis(Elaeagnaceae) produce an edible oil and contain more vitamin E(Ve) than major oil-seed crops. Despite its economic value, there is no information on its genome sequence. Here, we used the Illumina platform to determine the seed transcriptome of E.mollis to identify the genes related to Ve biosynthesis and potential simple sequence repeat(SSR) markers. In total, 100,999 unigenes were obtained with an average length of 605 bp and N50 of 985 bp. Of these unigenes,52,256(51.7%) were annotated in at least one public database(NT, NR, PFAM, Swiss Prot, KOG, KO, and GO)in searches using blastn/x. The unigene annotation identified 15 unigenes encoding six enzymes(GGR, HPPD,HPT/VTE2, MPBQ-MT/VTE3, TC/VTE1, and c-TMT/VTE4) putatively involved in Ve biosynthesis. In addition,16,810 SSRs distributed in 14,057 unigenes were mined.Of these, 2820, 583, and 3423 SSRs were located in the 50–UTR, coding sequence(CDS), and 30–UTR regions,respectively, while the remaining 9984 SSRs had undetermined physical locations. The largest group of repeat motifs comprised mononucleotide repeats(70.76%), followed by dinucleotide(15.59%) and trinucleotide(12.10%)repeats. AG/CT(8.69%) and AAG/CTT(4.15%) were the main dinucleotide and trinucleotide repeats, respectively.Furthermore, 9597 SSR-specific primer pairs were designed. Among 100 primer pairs selected randomly to determine their usefulness, 53 proved to be efficient. To the our best of knowledge, this work is the first study of the E. mollis transcriptome and constitutes valuable genomics data for future genetic engineering studies to alter the amount of Ve. The identified potential EST-SSR markers can be used for population genetics studies and assistedbreeding of E. mollis. | Yulin Liu Siqiao Li Yunying Wang Pingyu Liu Wenjing Han | 2020 | Journal of Forestry Research2020，31，3： | 1 |
| 10 | Facile and fast template removal frommesoporous MCM-41 molecular sieve using dielectric-barrierdischarge plasma 显示文摘 | Liu Yuan Pan Yunxiang Wang Zhoujun Kuai Pingyu Liu Changjun | 2010 | Catalysis Communications ?2010，11，： | 1 |
| 11 | Location analysis of retail stores in Changchun, China: A street centrality perspective显示文摘 | Fahui Wang Chen Chen Chunliang Xiu Pingyu Zhang | 2014 | Cities2014，，： | 1 |
| 12 | Characterization of the aging behavior of raw epoxidized natural rubber with a rubber processing analyzer显示文摘 | Wang Pingyue Qian Honglian Yang Chunliang | 2006 | Journal of Applied Polymer Science2006，100，12： | 1 |
| 13 | Analysis and control for a bioinspired multi-legged soft robot显示文摘Untethered soft miniature robots are considered to have a wide range of applications in biomedical field.However,researchers today still have not reached a consensus on its configuration design and actuation method.Here,inspired by the tentacles of a certain kind of echinodermata,we propose a soft multi-legged robot with a total weight of 0.26 g capable of multiple locomotion modes.Based on the magnetic field distribution of a square permanent magnet,we qualitatively analyze the motion mechanism of the robot.Finally,we carried out relevant experimental research.The research shows that the robot can move forward,backward,steering and cross obstacles under the control of the magnetic field,and can combine these abilities to navigate the maze. | Danying Sun Jingyu Zhang Qin Fang Pingyu Xiang Yanan Xue Yue Wang Rong Xiong Haojian Lu | 2022 | Biomimetic Intelligence & Robotics2022，2，1： | 1 |
| 14 | Char- acterization of the aging behavior of raw epoxidized natural rubber with a rubber processing analyzer显示文摘 | Wang Pingyue Qian Honglian Yang Chunliang et at | 2006 | Applied Poly- mer Science2006，100，2： | 1 |
| 15 | A Survey on Design,Actuation,Modeling,and Control of Continuum Robot显示文摘Inthis paper,we describethe advances inthe design,actuation,modeling,and controlfield of continuum robots.After decades ofpioneering research,many innovativeve structural designandUntethered magnetic robots are agood example;its external actuationcharteristigotten a lot of interest fromacademics.Furthermoodeling,modeling approachesbased on continuunnechals after years oof research.Geometricexactcontilodeling when combined withnumerical analytic methodschtFifecodle-b realized.In the control,closed.loop and hybrid control methodscombined with sensor feedbackinformation.On the other hand,tladeg and control of continum robotseasier.The data-driven modeling technique simplifies modeling aproves anti-interference and generalization abilities.This paper discusses the current development and challenges of continum robots in the above felds and provides prospectsfor the future. | Jingyu Zhang Qin Fang Pingyu Xiang Danying Sun Yanan Xue Rui Jin Ke Qiu Rong Xiong Yue Wang Haojian Lu | 2022 | Cyborg and Bionic Systems2022，，1： | 0 |
| 16 | Metal-Free Synthesis of Benzo[a]phenanthridines from Aromatic Aldehydes,Cyclohexanones,and Aromatic Amines显示文摘A three-component synthesis of benzo[a]phenanthridines from aromatic aldehydes,cyclohexanones,and aromatic amines has been developed,which is mediated by KI/DMSO/camphorsulfonic acid to afford a variety of functionalized benzo[a]phenanthridines in satisfactory yields.The present strategy provides a biaryl motif ortho to the nitrogen atom which has the potential to be used as ligand by further modification.With the advantages of readily available starting materials,transition-metal-free conditions,gram-scale synthesis,and broad substrate scope,this three-component protocol provides an efficient approach for the preparation of diverse benzo[a]phenanthridines. | Pingyu Jiang Zhifei Shan Shanping Chen Quanyuan Wang Shuxin Jiang Haolin Zheng Guo-Jun Deng | 2022 | Chinese Journal of Chemistry2022，40，3： | 0 |
| 17 | Ultrasound-active ReCORM-AIEgen for gas and sonodynamic therapy of mycobacterium biofilms显示文摘Bacterial infection is the leading cause of many severe inflammation diseases. The development of novel and effective therapeutic approaches to counter bacterial infections, especially for drug-resistant bacteria, is essential. Herein, we have successfully developed an ultrasound-active tricarbonyl rhenium(Ⅰ) complex with tetraphenylethylene(TPE) modification(RePyTPE) for CO gas therapy and sonodynamic therapy of bacterial infections. RePy-TPE produced reactive oxygen species and released CO under ultrasound irradiation. In addition, RePy-TPE showed aggregation-induced emission in water due to the introduction of TPE, which enhanced the yield of ^(1)O_(2) generation in a biological aqueous solution. The produced ^(1)O_(2) and released CO killed mycobacterium smegmatis(M. smegmatis) and Escherichia coli(E. coli), as shown by bacterial membrane damage and biofilm elimination. Furthermore, ultrasound-active RePy-TPE perturbed the purine metabolism of the bacteria, which disturbed the biosynthesis of DNA and energy metabolism, eventually reducing the vitality of bacteria. This article provides a novel strategy for the development of ultrasound-active metal-based antibiotics. | Yue Li Haobing Wang Qitian Lin Xinyu Yu Huaiyi Huang Pingyu Zhang | 2023 | Science China Chemistry2023，66，9： | 0 |
| 18 | Preparation of Heteropoly Molybdoselenite Complex and Its Lanthanide Salts and Their Catalysis for Hydroxylation of Phenol显示文摘A heteropoly molybdoselenite complex (NH4)6[Se2Mo8O 31 ]·5H2O and its lanthanide salts Ln2[Se2Mo8O 31 ]·xH2O(Ln=La 3+ , Ce 3+ , Nd 3+ , Sm 3+ ) were synthesized and characterized with elemental analysis, IR, UV, XRD and TG-DTA. Their reactivity for hydroxylation of phenol was investigated. The results show that catalytic activity of (NH4)6[Se2Mo8O 31 ]·5H2O is higher than that of its lanthanide salts. The reaction temperatures, the reaction time, the catalyst amount, the ratio of phenol and H2O2 have influence on the phenol conversation, H2O2 selectivity and product distribution. The optimum reaction condition was obtained with orthogonal method. At optimum reaction condition which the ratio of phenol and H2O2=1∶1, reaction time is 4 h, reaction temperatures is 70 ℃ and catalyst is 10 g·mol -1 , and the conversation of phenol reaches as high as 29.65%, the product selectivity can reach 77.2% for catalyst (NH4)6[Se2Mo8O 31 ]·5H2O. | Zhang Pingyu Wang Wei Wu Jigui | 2006 | Journal of Rare Earths2006，24，2： | 0 |
| 19 | Boosting the dimensionality of frequency entanglement using a reconfigurable microring resonator显示文摘Integrated quantum frequency combs(QFCs)based on microring resonators supplies as an essential resource for expanding the Hilbert-space dimensionality for high-dimensional quantum computing and information processing.In this work,we propose and demonstrate a reconfigurable ring resonator with tunable quality factors to efficiently increase the dimensionality of frequency entanglement,simultaneously,ensuring a high on-chip pair generation rate(PGR)and coincidence-to-accidental ratio(CAR).Our method exploits the asymmetric Mach-Zehnder interferometer instead of the traditional straight waveguide as the coupler of resonators which offer a tunable external coupling coefficient to modulate the quality factor to enlarge the QFCs’bandwidth and thus increase the dimensionality of frequency entanglement.We measured the QFCs’joint spectral intensity of 28 frequency pairs under various quality factors ranging from 16.6×10^(4) to 3.4×10^(4).Meanwhile,the measured Schmidt number increased from 11.01 to 24.77,denoting a huge expansion of the Hilbert-space dimensionality from 121 to a record number of 613 dimensions,which agrees well with our theoretical calculations.In addition,the PGR and CAR-another two key parameters for high-quality QFCs-were all measured under different quality factors to verify that our method can significantly increase the Schmidt number and CAR while maintaining a high PGR.In fact,bright QFCs with a total PGR of 4.3 MHz under a 0.48 mW pump power and a mean CAR of 1578 were simultaneously obtained at the highest Schmidt number.This method is widely applicable to other material-based ring resonators and can act as a general solution for high-dimensional QFCs. | Chao Wu Qilin Zheng Yingwen Liu Yang Wang Jiangfang Ding Pingyu Zhu Shichuan Xue Miaomiao Yu Weihong Luo Kaikai Zhang Anqi Huang Mingtang Deng Junjie Wu Ping Xu | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，5： | 0 |
| 20 | On-chip multiphoton Greenberger-Horne Zeilinger state based on integrated frequency combs显示文摘One of the most important multipartite entangled states,Greenberger-Horne-Zeilinger state(GHZ),serves as a fundamental resource for quantum foundat ion test,quantum communication and quantum computation.To increase the number of entangled particles,significant experimental efforts should been invested due to the complexity of optical setup and the difficulty in maintaining the coherence condition for high-fidelity GHZ state.Here,we propose an ultra-integrated scalable on-chip GHZ state generation scheme based on frequency combs.By designing several microrings pumped by different lasers,multiple partially overlapped quantum frequency combs are generated to supply as the basis for on-chip polarization-encoded GHZ state with each qubit occupying a certain spectral mode.Both even and odd numbers of GHZ states can be engineered with constant small number of integrated components and easily scaled up on the same chip by only adjusting one of the pumnp wavelengths.In addition,we give the on-chip design of projection measurement for characterizing GHZ states and show the reconfigurability of the state.Our proposal is rather simple and feasible within the existing fabrication technologies and we believe it will boost the development of multiphoton technologies. | Pingyu Zhu Qilin Zheng Shichuan Xue Chao Wu Xinyao Yu Yang Wang Yingwen Liu Xiaogang Qiang Junjie Wu Ping Xu | 2020 | Frontiers of physics2020，15，6： | 0 |
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