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| 1 | Targeting the untargetable KRAS in cancer therapy显示文摘RAS is one of the most well-known proto-oncogenes. Its gain-of-function mutations occur in approximately 30% of all human cancers. As the most frequently mutated RAS isoform, KRAS is intensively studied in the past years. Despite its well-recognized importance in cancer malignancy,continuous efforts in the past three decades failed to develop approved therapies for KRAS mutant cancer. KRAS has thus long been considered to be undruggable. Encouragingly, recent studies have aroused renewed interest in the development of KRAS inhibitors either directly towards mutant KRAS or against the crucial steps required for KRAS activation. This review summarizes the most recent progress in the exploration of KRAS-targeted anticancer strategies and hopefully provides useful insights for the field. | Pingyu Liu Yijun Wang Xin Li | 2019 | Acta Pharmaceutica Sinica B2019，9，5： | 33 |
| 2 | Cobalt single atom site catalysts with ultrahigh metal loading for enhanced aerobic oxidation of ethylbenzene显示文摘The oxidation of hydrocarbons to produce high value-added compounds(ketones or alcohols)using oxygen in air as the only oxidant is an efficient synthetic strategy from both environmental and economic views.Herein,we successfully synthesized cobalt single atom site catalysts(Co SACs)with high metal loading of 23.58 wt.%supported on carbon nitride(CN),which showed excellent catalytic properties for oxidation of ethylbenzene in air.Moreover,Co SACs show a much higher turn-over frequency(19.6 h^(−1))than other reported non-noble catalysts under the same condition.Comparatively,the as-obtained nanosized or homogenous Co catalysts are inert to this reaction.Co SACs also exhibit high selectivity(97%)and stability(unchanged after five runs)in this reaction.DFT calculations reveal that Co SACs show a low energy barrier in the first elementary step and a high resistance to water,which result in the robust catalytic performance for this reaction. | Yu Xiong Wenming Sun Yunhu Han Pingyu Xin Xusheng Zheng Wensheng Yan Juncai Dong Jian Zhang Dingsheng Wang Yadong Li | 2021 | Nano Research2021，14，7： | 20 |
| 3 | Spatiotemporal Variations and Influencing Factors Analysis of PM_(2.5) Concentrations in Jilin Province,Northeast China显示文摘High PM_(2.5) concentrations and frequent air pollution episodes during late autumn and winter in Jilin Province have attracted attention in recent years. To describe the spatial and temporal variations of PM_(2.5) concentrations and identify the decisive influencing factors, a large amount of continuous daily PM_(2.5) concentration data collected from 33 monitoring stations over 2-year period from 2015 to 2016 were analyzed. Meanwhile, the relationships were investigated between PM_(2.5) concentrations and the land cover, socioeconomic and meteorological factors from the macroscopic perspective using multiple linear regressions(MLR) approach. PM_(2.5) concentrations across Jilin Province averaged 49 μg/m^3, nearly 1.5 times of the Chinese annual average standard, and exhibited seasonal patterns with generally higher levels during late autumn and over the long winter than the other seasons. Jilin Province could be divided into three kinds of sub-regions according to 2-year average PM_(2.5) concentration of each city. Most of the spatial variation in PM_(2.5) levels could be explained by forest land area, cultivated land area, urban greening rate, coal consumption and soot emissions of cement manufacturing. In addition, daily PM_(2.5) concentrations had negative correlation with daily precipitation and positive correlation with air pressure for each city, and the spread and dilution effect of wind speed on PM_(2.5) was more obvious at mountainous area in Jilin Province. These results indicated that coal consumption, cement manufacturing and straw burning were the most important emission sources for the high PM_(2.5) levels, while afforestation and urban greening could mitigate particulate air pollution. Meanwhile, the individual meteorological factors such as precipitation, air pressure, wind speed and temperature could influence local PM_(2.5) concentration indirectly. | WEN Xin ZHANG Pingyu LIU Daqian | 2018 | Chinese Geographical Science2018，28，5： | 6 |
| 4 | Green Development for Supporting Sustainability of Northeast China:Performance Quantification,Spatio-temporal Dynamics and Implications显示文摘Green development is the cognition of geography to human-nature nexus under the background of the new era.As China is facing various eco-environment problems,green development has become a key approach towards ecological progress,and it is ultimately an explicit means to respond to support sustainable development in China.Quantifying green development performance is essential to track efforts towards sustainability and guide policymakers.However,applying the balanced property of’Economy-Ecology-Society’of green development to its performance assessment is rarely discussed.Here we elaborated the connotation of green development and developed a quantification model with coupling coordination degree to assess green development performance of the largest old industrial base of China,Northeast China.We found that the green development performance has been improved from a score of 0.443 in 2003 to 0.530 in 2019 but the disparities of green development performance were enlarging over time,especially for the cities in Heilongjiang.A positive spatial autocorrelation phenomenon of green development performance was confirmed,and Low-Low clusters in the northeastern Heilongjiang and High-High clusters in the central-eastern Liaoning were discovered.This study suggests the need to track the spatio-temporal dynamics of green development performance to provide references for achieving sustainable development goals in northeast China and other regions. | FAN Weiguang ZHANG Pingyu TONG Lianjun LI Chenggu LI Xin LI Jing MA Zuopeng | 2022 | Chinese Geographical Science2022，32，3： | 0 |
| 5 | MicroRNA-181a is elevated by 10-hydroxycamptothecin and represses lung carcinoma progression by downregulating FOXP1显示文摘Tumor progression is usually characterized by proliferation,migration,and angiogenesis,which is essential for supplying both nutrients and oxygen to the tumor cells.Therefore,targeting angiogenesis has been considered a promising therapeutic strategy for cancer prevention and treatment.In the present study,we demonstrated that in addition to suppressing lung cancer cell proliferation and migration in vitro,10-hydroxycamptothecin(10-HCPT)is also capable of inhibiting angiogenesis in vivo with a miR-181a-dependent manner.Mechanistically,by upregulating miR-181a,which in turn downregulating FOXP1,10-HCPT can inhibit the PI3K/Akt/ERK signaling pathwaymediated angiogenesis.Furthermore,reduced levels of miR-181a have been found in both lung cancer cell lines and xenograft with concurrently elevated levels of FOXP1,VEGF,bFGF,and HDGF.Consistent with the findings from the in vitro experiments,miR-181a impairs neovascularization in our xenograft model.In summary,our findings have not only established the anti-oncogenic role of miR-181a in lung cancer angiogenesis but also suggest that 10-HCPT could be a potential therapeutic reagent for lung cancer treatment. | LI PAN WENTING YI DONGMIN LIANG YULONG ZHAO RANRAN WANG PINGYU WANG YOUJIE LI JIAXUAN XIN YUNFEI YAN SHUYANG XIE | 2022 | BIOCELL2022，46，2： | 0 |
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