| 1 | Light Triggers the miRNA-Biogenetic Inconsistency for De-etiolated Seedling Survivability in Arabidopsis thaliana显示文摘The shift of dark-grown seedlings into light causes enormous transcriptome changes followed by a dramatic developmental transition.Here,we show that microRNA(miRNA)biogenesis also undergoes regulatory changes during de-etiolation.Etiolated seedlings maintain low levels of primary miRNAs(pri-miRNAs)and miRNA processing core proteins,such as Dicer-like 1,SERRATE,and HYPONASTIC LEAVES 1,whereas during de-etiolation both pri-miRNAs and the processing components accumulate to high levels.However,the levels of most miRNAs do not notably increase in response to light.To reconcile this inconsistency,we demonstrated that an unknown suppressor decreases miRNA-processing activity and light-induced SMALL RNA DEGRADING NUCLEASE 1 shortens the half-life of several miRNAs in de-etiolated seedlings.Taken together,these data suggest a novel mechanism,miRNA-biogenetic inconsistency,which accounts for the intricacy of miRNA biogenesis during de-etiolation.This mechanism is essential for the survival of de-etiolated seedlings after long-term skotomorphogenesis and their optimal adaptation to ever-changing light conditions. | Suk Won Choi Moon Young Ryu Andras Viczian Hyun Ju Jung Gu Min Kim Agustin LArce Natalia PAchkar Pablo Manavella Ulla Dolde Stephan Wenke Attila Molnar Ferenc Nagy Seok Keun Cho Seong Wook Yang | 2020 | Molecular Plant2020，13，3： | 3 |
| 3 | Residual urinary output in high body mass index individuals on chronic hemodialysis:A disregarded life vest?显示文摘AIM:To assess residual diuresis and diverse variables according to body mass index(BMI).METHODS:Cross-sectional study(n = 57),with 3groups.Group A:BMI < 25,n = 22; Group B:BMI25-30,n = 15; Group C:BMI > 30,n = 20.Diuresis,hematocrit,albumin,C-reactive protein,Malnutrition inflammatory score,Pro-BNP,Troponin T,leptin and insulin levels are expressed as median and ranges(r).RESULTS:Albumin(g/dL):GA vs GC,3.70(r2.20-4.90)vs 3.85(r3.40-4.90),P = 0.02.Diuresis(m L/d):GA690(r0-1780); GB 660(r60-1800); GC 840(r40-2840).Diuresis GA vs GC,P = 0.01.Leptin(ng/m L):GA vs GC,3.81(r0.78-69.60) vs GC,32.80(r0.78-124.50),P< 0.001.Insulin(μU/mL):GA vs GB,7(r2-44) vs 11.50(r4-38),P = 0.02; GA vs GC,7(r2-44) vs 19.5(r5-155),P = 0.0001.Troponin T and Pro-BNP levels were not different.Significant correlations:GC,Insulin-UF:ρ= 0.53; P = 0.03; Troponin T-diuresis:ρ =-0.48,P < 0.05; Pro-BNP-diuresis:ρ =-0.39,P < 0.01; Troponin T-ProB NP:ρ = 0.77,P < 0.0001; albumin-Troponin T:ρ =-0.66,P < 0.0001; albumin-ProB NP:ρ =-0.44,P < 0.05.CONCLUSION:High BMI associated positively with higher diuresis and albuminemia,and negatively with TropT and Pro-BNP.High BMI-associated better survival may be explained by better urinary output,lowering cardiovascular stress. | Hernán Trimarchi María S Ra?a Alejandra Karl José Andrews Mariana Dicugno Vanesa Pomeranz Pablo Young Mariano Forrester Mirta Alonso Fernando Lombi Alexis Muryan | 2014 | World Journal of Nephrology2014，3，4： | 1 |
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