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| 1 | Current understanding of the molecular mechanisms in Parkinson's disease:Targets for potential treatments显示文摘Gradual degeneration and loss of dopaminergic neurons in the substantia nigra,pars compacta and subsequent reduction of dopamine levels in striatum are associated with motor deficits that characterize Parkinson’s disease(PD).In addition,half of the PD patients also exhibit frontostriatal-mediated executive dysfunction,including deficits in attention,short-term working memory,speed of mental processing,and impulsivity.The most commonly used treatments for PD are only partially or transiently effective and are available or applicable to a minority of patients.Because,these therapies neither restore the lost or degenerated dopaminergic neurons,nor prevent or delay the disease progression,the need for more effective therapeutics is critical.In this review,we provide a comprehensive overview of the current understanding of the molecular signaling pathways involved in PD,particularly within the context of how genetic and environmental factors contribute to the initiation and progression of this disease.The involvement of molecular chaperones,autophagy-lysosomal pathways,and proteasome systems in PD are also highlighted.In addition,emerging therapies,including pharmacological manipulations,surgical procedures,stem cell transplantation,gene therapy,as well as complementary,supportive and rehabilitation therapies to prevent or delay the progression of this complex disease are reviewed. | Panchanan Maiti Jayeeta Manna Gary L.Dunbar | 2017 | Translational Neurodegeneration2017，6，1： | 27 |
| 2 | Nitric oxide mediated Staphylococcus aureus pathogenesis and protective role of nanoconjugated vancomycin显示文摘Objective:To investigate the relation between fruit seeds,plants residuals and appendicitis. Methods:Among cases that underwent appendectomy,the appendicitis cases having fruit seeds and undigested plant residuals in their etiology were examined retrospectively.Also, histopathological features,age,sex,and parameters of morbidity and mortality were used. Results:Fruit seed was found in one case(0.05%) with presence of pus in appendix lumen, undigested plant residuals in 7 cases(0.35%).It was determined that there were appendix inflammation in 2 of the plant residuals cases,while there were obstruction and lymphoid hyperplasia in the appendix lumen of 5 cases.No mortality was observed.Conclusions:The ratio of acute appendicitis caused by plants is minimal among all appendectomised patients, but avoidence of eating undigested fruit seeds and chewing plants well may help to prevent appendicitis. | Subhankari Prasad Chakraborty Santanu Kar Mahapatra Sumanta Kumar Sahu Sourav Chattopadhyay Panchanan Pramanik Somenath Roy | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，2： | 4 |
| 3 | Antioxidative effect of folate-modified chitosan nanoparticles显示文摘Objective:To evaluate the potency of carboxymethyl chitosan-2,2' ethylenedioxy bisethylamine-folate(CMC-EDBE-FA) on tissue injury,antioxidant status and glutathione system in tissue mitochondria and serum against nicotine-induced oxidative stress in mice.Methods: CMC-EDBE-FA was prepared on basis of carboxymethyl chitosan tagged with folic acid by covalently linkage through 2,2' ethylenedioxy bis-ethylamine.Animals were divided into four groups,i.e.,control,nicotine(1 mg/kg bw/day),CMC-EDBE-FA(1 mg/kg bw/day) and nicotine(1 mg/kg bw/day) and CMC-EDBE-FA(1 mg/kg bw/day) for 7 days.Levels of lipid peroxidation, oxidized glutathione level,antioxidant enzyme status and DNA damage were observed and compared.Results:The significantly increase of lipid peroxidation,oxidized glutathione levels and DNA damage was observed in nicotine treated group as compared with control group;those were significantly reduced in CMC-EDBE-FA supplemented group.Moreover,significantly reduced antioxidant status in nicotine treated group was effectively ameliorated by the supplementation of CMC-EDBE-FA.Only CMC-EDBE-FA treated groups showed no significant change as compared with control group;rather than it repairs the tissue damage of nicotine treated group.Conclusions:These findings suggest that CMC-EDBE-FA is non-toxic and ameliorates nicotine-induced toxicity. | Subhankari Prasad Chakraborty Santanu Kar Mahapatra Sumanta Kumar Sahu Panchanan Pramanik Somenath Roy | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，1： | 3 |
| 4 | Nanoconjugated vancomycin: new opportunities for the development of anti-VRSAagents显示文摘 | Subhankari Prasad Chakraborty Sumanta Kumar Sahu Santanu Kar Mahapatra Susmita Santra Manjusri Bal Somenath Roy Panchanan Pramanik | 2010 | Nanotechnology2010，，10： | 3 |
| 5 | High altitudememory impairment is due to neuronal apoptosis in hippocam-pus,cortex and striatum显示文摘 | Panchanan M Shashi BS Birendranath M | 2008 | J Chem Neuroanat2008，36，： | 1 |
| 6 | Circannual variation in plasma vitellogenin and gonadotropin II levels in relation to annual ovarian cycle in female mrigal, Cirrhinus mrigala显示文摘 | Sudipta Maitra Raju Sahu Nirupama Trehan S.K. Garg Panchanan Nath | 2007 | Aquaculture2007，，1： | 1 |
| 7 | Hypobaric hypoxia induces oxidative stress in rat brain显示文摘 | Panchanan Maiti Shashi B. Singh Alpesh K. Sharma S. Muthuraju Pratul K. Banerjee G. Ilavazhagan | 2006 | Neurochemistry International2006，，： | 1 |
| 8 | A novel study of antibacterial activity of copper iodide nanoparticle mediated by DNA and membrane damage显示文摘 | Arindam Pramanik Dipranjan Laha Debalina Bhattacharya Panchanan Pramanik Parimal Karmakar | 2012 | Colloids and Surfaces B: Biointerfaces2012，，： | 1 |
| 9 | Impedance spectroscopy study of LaMnO 3 modified BaTiO 3 ceramics显示文摘 | Prasanta Dhak Debasis Dhak Manasmita Das Kausikisankar Pramanik Panchanan Pramanik | 2009 | Materials Science & Engineering B2009，，3： | 1 |
| 10 | Role of cholinergic markers on memory function of rats exposed to hypobaric hypoxia显示文摘 | Sangu Muthuraju Panchanan Maiti Soumya Pati Preeti Solanki Alpesh Kumar Sharma Shashi Bala Singh Dipti Prasad Govindasamy Ilavazhagan | 2011 | European Journal of Pharmacology2011，，1： | 1 |
| 11 | A chemical synthetic route for the preparation of fine-grained metal tungstate powders (M=Ca,Co,Ni,Cu,Zn)显示文摘 | Panchanan P | 2001 | Journal of the European Ceramic Society2001，21，： | 1 |
| 12 | Photooxidation of different organic dyes (RB, MO, TB, and BG) using Fe(III)-doped TiO 2 nanophotocatalyst prepared by novel chemical method显示文摘 | Tanmay K. Ghorai Soumya K. Biswas Panchanan Pramanik | 2008 | Applied Surface Science2008，，22： | 1 |
| 13 | Hypobaric hypoxia induces oxidative stress in rat brain 显示文摘 | PANCHANAN M SHASHI B S ALPESH K S | 2006 | Neurochemistry International2006，49，8： | 1 |
| 14 | Low-temperature preparation of nanocrystalline lead zirconate titanate and lead lanthanum Z zirconate titanate powders using triethanolamine显示文摘 | Rabindra N Das Amita Pathak Panchanan Pramanik | 1998 | J Am Ceram Soc1998，81，12： | 1 |
| 15 | Hypobaric hypoxia damages the hippocampal pyramidal neurons in the rat brain显示文摘 | Panchanan Maiti Shashi B. Singh S. Muthuraju Shobi Veleri G. Ilavazhagan | 2007 | Brain Research2007，，： | 1 |
| 16 | Synthesis, characterization of chitosan–tripolyphosphate conjugated chloroquine nanoparticle and its in vivo anti-malarial efficacy against rodent parasite: A dose and duration dependent approach显示文摘 | Satyajit Tripathy Sabyasachi Das Subhankari Prasad Chakraborty Sumanta Kumar Sahu Panchanan Pramanik Somenath Roy | | International Journal of Pharmaceutics (-)0，，： | 1 |
| 17 | Investigation of the catalytic efficiency of a new mesoporous catalyst SnO2/WO3towards oleic acid esterification显示文摘 | Arpita Sarkar Sudip K Ghosh Panchanan Pramanik | 2010 | Journal of Molecular Catalysis A:Chemical2010，327，： | 1 |
| 18 | Low-temperature chemical synthesis of nanocrystalline MgAl2O4 spinel powder 显示文摘 | Ranjan K P Panchanan P | 2000 | J Am Ceram Soc2000，83，7： | 1 |
| 19 | Nanocrystal- line Yttria - Stabilized Zirconia Fibers from Plant Fi- bers and their Polymer Composites显示文摘 | Rabindra N D Sanjukta N Panchanan P | 2008 | Journal of A- merican Ceramic Society2008，，3： | 1 |
| 20 | Synthesis, characterization and properties of nano-sized SrBi 2 Ta 2 O 9 ceramics prepared by chemical routes显示文摘 | Asit.B Panda Abhijit Tarafdar Panchanan Pramanik | 2003 | Journal of the European Ceramic Society2003，，10： | 1 |
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