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| 1 | Para-aortic lymph node involvement should not be a contraindication to resection of pancreatic ductal adenocarcinoma显示文摘BACKGROUND Para-aortic lymph nodes(PALN)are found in the aortocaval groove and they are staged as metastatic disease if involved by pancreatic ductal adenocarcinoma(PDAC).The data in the literature is conflicting with some studies having associated PALN involvement with poor prognosis,while others not sharing the same results.PALN resection is not included in the standard lymphadenectomy during pancreatic resections as per the International Study Group for Pancreatic Surgery and there is no consensus on the management of these cases.AIM To investigate the prognostic significance of PALN metastases on the oncological outcomes after resection for PDAC.METHODS This is a retrospective cohort study of data retrieved from a prospectively maintained database on consecutive patients undergoing pancreatectomies for PDAC where PALN was sampled between 2011 and 2020.Statistical comparison of the data between PALN+and PALN-subgroups,survival analysis with the Kaplan-Meier method and risk analysis with univariable and multivariable time to event Cox regression analysis were performed,specifically assessing oncological outcomes such as median overall survival(OS)and disease-free survival(DFS).RESULTS 81 cases had PALN sampling and 17(21%)were positive.Pathological N stage was significantly different between PALN+and PALN-patients(P=0.005),while no difference was observed in any of the other characteristics.Preoperative imaging diagnosed PALN positivity in one case.OS and DFS were comparable between PALN+and PALN-patients with lymph node positive disease(OS:13.2 mo vs 18.8 mo,P=0.161;DFS:13 mo vs 16.4 mo,P=0.179).No difference in OS or DFS was identified between PALN positive and negative patients when they received chemotherapy either in the neoadjuvant or in the adjuvant setting(OS:23.4 mo vs 20.6 mo,P=0.192;DFS:23.9 mo vs 20.5 mo,P=0.718).On the contrary,when patients did not receive chemotherapy,PALN disease had substantially shorter OS(5.5 mo vs 14.2 mo;P=0.015)and DFS(4.4 mo vs 9.8 mo;P<0.001).PALN involvement was not identified as an independent predictor for OS after multivariable analysis,while it was for DFS doubling the risk of recurrence.CONCLUSION PALN involvement does not affect OS when patients complete the indicated treatment pathway for PDAC,surgery and chemotherapy,and should not be considered as a contraindication to resection. | Rupaly Pande Shafiq Chughtai Manish Ahuja Rachel Brown David C Bartlett Bobby V Dasari Ravi Marudanayagam Darius Mirza Keith Roberts John Isaac Robert P Sutcliffe Nikolaos A Chatzizacharias | 2022 | World Journal of Gastrointestinal Surgery2022，14，5： | 2 |
| 2 | Time dependent multilaminate model of rocks-a numerical study of deformation and failure of rock masses显示文摘 | ZIENKIEWICZ O C PANDE G N | 1977 | International Journal for Numerical and Analytical Methods in Geomechanics1977，，1： | 1 |
| 3 | An ironhomeostasis regulatory circuit with reciprocal roles inCandida albicans commensalism and pathogenesis显示文摘 | Chen C Pande K French SD | 2011 | Cell Host and Microbe2011，10，2： | 1 |
| 4 | Finite elements in geomechanics 显示文摘 | Zienkiewiez O C Pande G N | 1978 | Gudehus G ASME1978，21，： | 1 |
| 5 | Performance Evaluation and Design Trade-Offs for Network on Chip Interconnect Architectures显示文摘 | Pande P P Grecu C Jones M | 2005 | IEEE Trans on Computers2005，54，8： | 1 |
| 6 | Addition of probiotics to nor- floxacin does not improve efficacy in the prevention of sponta- neous bacterial peritonitis:a double-blind placebo-controlled randomized-controlled trim 显示文摘 | Pande C Kumar A Sarina SK | 2012 | Eur J Gastroenterol Hepa- tol2012，24，： | 1 |
| 7 | Yield stress of fine grained materials 显示文摘 | Masumura R A Hazzledine P M Pande C S | 1998 | Acta Metallurgica Inc1998，46，13： | 1 |
| 8 | Strain Hardening in FCC Metals and Alloys显示文摘 | Pande C S | 2001 | Materials Science and Engineering: A2001，309，： | 1 |
| 9 | Diffusion and excessvacancy production in Cu-Ni laminates 显示文摘 | MASUMURA R RATH B PANDE C | 2003 | Materials Scienceand Engineering: A2003，346，1： | 1 |
| 10 | Fractal characterization of fractured surfaces显示文摘 | PANDE C S RICHARDS L R LONAT N | 1987 | Acta Metall1987，35，7： | 1 |
| 11 | Overlay models in time-dependent nonlinear analysis显示文摘 | Pande G N Owen D R J Zienkiwicz O C | 1977 | Computers & Structures1977，7，： | 1 |
| 12 | Design development and testing of a solar PV pump based drip system for orchards显示文摘 | Pande P C Singh A K Ansari S | 2003 | Renewable2003，2003，28： | 1 |
| 13 | Enzymatic synthesis of trans-free structured margarine fat analogs with high stearate soybean oil and palm stearin and their characterization显示文摘 | Pande G Akoh C C | 2013 | LWT-Food Science and Technology2013，50，1： | 1 |
| 14 | Yield stress of nanocrystalline materials: Role of grain-boundary dislocations, triple junctions and eoble creep显示文摘 | GUTKIN M Y OVID'KO I A PANDE C S | 2004 | Philosophical Magazine2004，84，9： | 1 |
| 15 | Performance evaluationand design trade-offs for network-on-chip interconnectarchitectures显示文摘 | Pande P P Grecu C Jones M | 2005 | IEEE Transactions on Computers2005，54，8： | 1 |
| 16 | Highly stable glycosylated serine protease from the medicinal plant Euphorbia milii显示文摘 | Yadav S C Pande M Jagannadham M | 2006 | Phytochemistry2006，67，14： | 1 |
| 17 | Plant availabili- ty of nickel as influenced by farmyard manure and its critical toxic limits in french bean显示文摘 | PANDE J SRIVASTAVA P C SINGH S K | 2012 | Journal of Plant Nutrition2012，35，： | 1 |
| 18 | Yield stress of fine grained materials显示文摘 | MASUMURA R A HAZZLEDINE P M PANDE C S | 1998 | Acta Materialia1998，46，13： | 1 |
| 19 | Chlorination of natural rubber in solution with gaseous chlorine显示文摘 | Ramakrishnan C S Raghunath D Pande J B | 1953 | Rub Chem Tech1953，，26： | 1 |
| 20 | Effect of annealing twins on Hall-Perch relation in polycrystalline materials显示文摘 | PANDE C S RATH B B IMAN M A | 2004 | Mater Sci Eng A2004，367，： | 1 |
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