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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Perforin,granzyme B,and FasL expression by peripheral blood T lymphoeytes in emphysema 显示文摘 | Morissette MC Parent J Milot J | 2007 | Respir Res2007，8，： | 1 |
| 3 | New microsatellite markers for the snow crab Chionoecetes opilio (Brachyura:Majidae) 显示文摘 | Puebla O Parent E Svigny J | 2003 | Molecular Ecology Notes2003，3，4： | 1 |
| 4 | Blunted responses to vasoconstrictors in mesenteric vasculature but not in portal vein of spontaneously hypertensive rats treated with relaxin显示文摘 | Massicotte G Parent A St-Louis J | 1989 | Proc Soc Exp Biol Med1989，190，3： | 1 |
| 5 | Interverte-bral disk disease in dogs with signs of back pain alone:25cases(1986-1993)显示文摘 | Sukhiani H R Parent J M Atilola M A O | 1996 | Journal of the American Veterinary Medi-cal Association1996，209，： | 1 |
| 6 | Bayesian POT modeling for historical data 显示文摘 | Parent E Bernier J | 2003 | Journal of Hydrology2003，274，： | 1 |
| 7 | Influence of specific energy on the properties of hydroentangled nonwoven pabrics 显示文摘 | Connolly T J Parent L R | 1993 | Nonwovens Conference1993，，1： | 1 |
| 8 | MRI signal distribution within the intcrvertcbral disc as a biomarker of adolescent idiopathic scoliosis and spondylolisthesis显示文摘 | Gervais J Pcrie D Parent S | 2012 | BMC Musculoskelet Disord2012，13，： | 1 |
| 9 | Layered construction for deformable animated characters 显示文摘 | Chadwick J E Haumann D R Parent R E | 1989 | ACM Siggraph Com- puter Gra-phics1989，23，3： | 1 |
| 10 | Comparison of the bi- omechanical 3D efficiency of different brace designs for the treatment of scoliosis using a finite element model显示文摘 | Clin J Aubin CE Parent S ei al | 2010 | Eur Spine J2010，19，7： | 1 |
| 11 | An Active Range-gated Near-IR TV system for All-weather Surveillance 显示文摘 | Kevin J Snell Andre Parent | 1997 | SPIE1997，2935，： | 1 |
| 12 | Use of maximum entropy spectral analysis to improve ship detection by the over-the-horizon radar显示文摘 | Bourdillon A Gouthier F Parent J | 1987 | Radio Science1987，22，2： | 1 |
| 13 | Human type Ⅶ collagen : CDNA cloning and chromosomal mapping of the gene 显示文摘 | Parente MG Chung LC Ryynanen J | 1991 | Proc Natl Acad Sci USA1991，88，16： | 1 |
| 14 | Shape transformation for polyhedral objects 显示文摘 | Kent J 1L Carlson W E Parent R E | 1992 | Computer Graphics (ACM)1992，26，2： | 1 |
| 15 | Biomechanical model- ing of brace treatment of scoliosis:effects of gravitational loads显示文摘 | Clin J Aubin CE Parent S9 | 2011 | Med Biol Eng Comput2011，49，7： | 1 |
| 16 | Neurophysiological field potent ial analysis by microcomputers显示文摘 | Mayhew W Parent A | 1982 | J of Neurosci Methods1982，5，： | 1 |
| 17 | Synthesis of graft copolymer derivatives of brominated poly (isobutylene-co-isoprene) 显示文摘 | Mclean J K Sergio A Parent J S | 2007 | European Polymer Journal2007，43，： | 1 |
| 18 | An active range-gated near IRTV system for all-weather surveillance 显示文摘 | Kevin J Snell Andre Parent Marc Levesque | 1997 | Proc SPIE1997，2935，： | 1 |
| 19 | Experimental evaluation of clad metallic buffer rods for high temperature ultrasonic measurements显示文摘 | Legoux J G Parent L | 1999 | NDT & E International1999，33，2000： | 1 |
| 20 | New brace de- sign combining CAD/ CAM and biomechanical simulation for the treatment of adolescent idiopathic scoliosis显示文摘 | Desbiens-Blais F Clin J Parent S9 | 2012 | Clin Biomech(Bristol Avon)2012，27，10： | 1 |
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