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| 1 | 二甲双胍与吡格列酮两种2型糖尿病药物在亲水作用色谱上的保留机理研究(英文)显示文摘二甲双胍和吡格列酮是治疗2型糖尿病的常见药物,经常用于同一复方制剂。制药和临床领域常要求同时测定这两种药物。亲水作用色谱近来在医药分析领域展现出良好的前景。本文通过研究流动相的有机溶剂含量、pH值和缓冲盐浓度等参数对色谱保留的影响,从而尝试揭示两种药物在亲水性硅胶柱上的分离机理。流动相中甲醇的增加会导致二甲双胍的保留因子的增加。流动相pH值比较低时,二甲双胍的保留因子会随着pH值升高而增加,而当pH值>6.09,其反而会随着pH值的升高而下降。吡格列酮的保留因子几乎不受甲醇比例和pH值的影响。缓冲盐浓度对两种药物的保留因子几乎都没有影响。因此,对于二甲双胍,亲水作用是主要的保留机理,静电作用和氢键也起到了重要作用。对于吡格列酮,亲水作用是支配性的。经过优化的亲水作用色谱方法可成功地应用到分离测定两种药物在2型糖尿病复方药物中的含量。 | 鲁肖飞 Caroline Martin 戚忠林 Pari Samani Zemen Berhe Dominic B Siaw Shyam K Pahari 左跃钢 | 2019 | 分析科学学报2019，35，6： | 4 |
| 2 | Morphological and bond strength evaluation of different resin cements to root dentin显示文摘 | Bitter K Paris S Pfuertner C | 2009 | Eur J Oral Sci2009，117，3： | 1 |
| 3 | Antihyperlipidemic effect of chlorogenic acid and tetrahydrocureumin in rats subjected to dia- betogenic agents 显示文摘 | K Karthikesan L Pari V P Menon | 2010 | Chemico Biological Interact2010，188，3： | 1 |
| 4 | Hesperetin protects against oxi- dative stress related hepatic dysfunction by cadmium in rats显示文摘 | Pari L Shagirtha K | 2012 | Experimental and Toxicologic Pathology2012，64，5： | 1 |
| 5 | Channel Order Estimation via Sample Sorting显示文摘 | Wood S G Paris B P Nelson J K | 2011 | IEEE Trans on Signal Processing2011，45，2： | 1 |
| 6 | A highly sensitive quantitative Real-time PCR assay based on the groEL gene of contemporary Thai strains of Orientia tsutsugamushi显示文摘 | Paris DH Aukkanit N Jenjaroen K | | 0，，： | 1 |
| 7 | A highly sensitive quantitative real-time PCR assay based on the groEL gene of contemporary Thai stains of Orientia tsutsugamushi 显示文摘 | Paris DH Aulkkanit N Jenjaroen K | 2009 | Clin Microbiol Infect2009，15，： | 1 |
| 8 | Olig2 expression, GFAP, p53 and 1 p loss analysis contribute to glioma subclassification显示文摘 | Mokhtari K Paris S Aguirre-Cruz L | 2005 | Neuropathol Appl Neurobiol2005，31，1： | 1 |
| 9 | Analytical approach to river regime 显示文摘 | WHITE W K BETTESS R PARIS E | 1982 | Journal of Hydraulic Division Proceedings : America Society of Civil1982，108，10： | 1 |
| 10 | A comprehensive review of solid particle erosion model- ing for oil and gas wells and pipelines applications 显示文摘 | PARIS M NAJMI K NAJAFIFARD F | 2014 | Journal of Natural Gas Science and Engineer- ing2014，21，： | 1 |
| 11 | Combination docetaxel(Taxotere),flurouracil,and leucovorin(TFL),as first-line chemotheraphy in advanced gastric cancer:a Hellnic Cooperative Oncology Group phase Ⅱ study显示文摘 | Pavlos P Dimitrios T Paris K | 2006 | Gastric Cancer2006，9，1： | 1 |
| 12 | Endometriosis-associated infertility: a decadeg trend study of women from the Estrie region of Quebec, Canada 显示文摘 | Paris K Aris A | 2010 | Gynecol Endocrinol2010，26，11： | 1 |
| 13 | Post-endodontic restora- tions with adhesively luted fiber-reinforced composite post sys- tems: a review 显示文摘 | BITYER K PARIS MARTUS P | 2004 | 31 ( 12 ):840-8482004，31，12： | 1 |
| 14 | Self-adjusting nasal continuous positive airway pressure therapy based on measurement of impedance: a comparison of two different maximum pressure levers显示文摘 | RANDERATH WJ PARYS K FELDMEYER F | 1999 | Chest1999，116，： | 1 |
| 15 | Compostive modeling for adaptive shor-Term LoadForecasting显示文摘 | PARK J H PARY Y M LEE K Y | 1991 | IEEE Trans on Power Systems1991，6，2： | 1 |
| 16 | Skin Inflammation Inducedby the Synergistic Action of IL-17A,IL-22,Onco-statin M,IL-1{alpha},and TNF-{alpha}Recapitulates Some Features of Psoria-sis显示文摘 | Guilloteau K Paris I Pedretti N | 2010 | J Immunol2010，，： | 1 |
| 17 | A Confocal Laser Scanning Micro- scope investigation of different dental adhesives bonded to root canal dentine 显示文摘 | Bitter K Paris S Martus P | 2004 | Int Endod J2004，37，12： | 1 |
| 18 | Service load fatigue damage-a historical perspective显示文摘 | Paris P C Tada H Donald J K | | 0，，： | 1 |
| 19 | Comparison of delamination characterization for IM7/8552 compos ite woven and tape laminates显示文摘 | Paris I Minguet P J O'Brien T K | 2003 | Composite Materi- als : Testing and Design2003，14，： | 1 |
| 20 | A highly sensitive quantitative real-time PCR assay based on the groEL gene of contemporary Thai stains of Orientia tsutsugamushi显示文摘 | Paris DH Aulkkanit N Jenjaroen K | | 0，，05： | 1 |
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