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| 1 | Early treadmill exercise increases macrophage migration inhibitory factor expression after cerebral ischemia/reperfusion显示文摘The neuroprotective function of macrophage migration inhibitory factor(MIF) in ischemic stroke was rarely evaluated.This study aimed to investigate the effects of early treadmill exercise on recovery from ischemic stroke and to determine whether these effects are associated with the expression levels of MIF and brain-derived neurotrophic factor(BDNF) in the ischemic area.A total of 40 male Sprague-Dawley rats were randomly assigned to the ischemia and exercise group [middle cerebral artery occlusion(MCAO)-Ex,n = 10),ischemia and sedentary group(MCAO-St,n = 10),sham-surgery and exercise group(Sham-Ex,n= 10),or sham-surgery and sedentary group(Sham-St,n = 10).The MCAO-Ex and MCAO-St groups were subjected to MCAO for 60 minutes,whereas the Sham-Ex and Sham-St groups were subjected to an identical operation without MCAO.Rats in the MCAO-Ex and Sham-Ex groups then ran on a treadmill for 30 minutes once a day for 5 consecutive days.After reperfusion,the hanging time tested by the wire hang test was longer and the relative fractional anisotropy determined by MRI was higher in the peri-infarct region of the MCAO-Ex group compared with the MCAO-St group.The expression levels of MIF and BDNF in the peri-infarct region were upregulated in the MCAO-Ex group.Increased MIF and BDNF levels were positively correlated with relative fractional anisotropy changes in the peri-infarct region.There was no significant difference in the levels of MIF and BDNF in the peri-infarct region between the Sham-Ex and Sham-St groups.Our study demonstrated that early exercise(initiated 48 hours after the MCAO) could improve motor and neuronal recovery after ischemic stroke.Furthermore,the increased levels of MIF and BDNF in the peri-infarct region(penumbra) may be one of the mechanisms of enhanced neurological function recovery.All experiments were approved by the Institutional Animal Care and Use Committee in Asan Medical Center in South Korea(2016-12-126). | Min Cheol Chang Chae Ri Park Seung Hwa Rhie Woo Hyun Shim Dae Yul Kim | 2019 | Neural Regeneration Research2019，14，7： | 7 |
| 2 | SUPPRESSOR OF VARIEGATION4, a New var2 Suppressor Locus, Encodes a Pioneer Protein that Is Required for Chloroplast Biogenesis显示文摘VAR2 是不可分的 thylakoid 膜蛋白质和在初核质和优核质的 metalloproteases 的万用的 FtsH 班的一个成员。在 VAR2 地点的后退的变化产生与正常出现的叶绿体与反常质体和绿部门包含白部门的使成杂色的植物(var2 ) 。在孤立 var2 上色的秒地点 suppressors 的一个持续努力,我们在这报告 ems2505 描绘,在 At4g28590 由于一个错误感觉变化有带绿色的显型的一个 suppressor 种类,为先驱蛋白质的基因。我们指明了这基因 SVR4 (为 VARIEGATION4 的 SUPPRESSOR ) 并且在 ems2505 的变异的等位基因作为 svr4-1。我们证明 SVR4 位于叶绿体并且 svr4-1 单身者异种关于叶绿体解剖和 thylakoid 膜蛋白质累积是正常的。然而,他们平常地在光化学的几个方面被损害并且提高了非光化学的熄灭(NPQ ) 能力。SVR4 的 T-DNA 插入等位基因, svr4-2,由于叶绿体开发的早阻塞是幼苗致命的。我们断定 SVR4 为叶绿体生物的续生说是必要的,并且假设那 SVR4 调停控制 NPQ 的 thylakoid 结构或功能的某方面。我们建议在 suppressor 紧张, VAR2 的缺乏引起的 photoinhibitory 压力被减少的 SVR4 活动引起的提高的 NPQ 能力在叶绿体开发早改善。这将导致能克服必要的阀值避免相片损坏并且从而发展成功能的叶绿体的叶绿体的数字的增加。 | Fei Yu ung-Soon Park Xiayan Liu Andrew Foudree Aigen Fu Marta Powikrowska Anastassia Khrouchtchova Poul Erik Jensen Jillian N. Kriger Gordon RI Gray Steven R. Rodermel | 2011 | Molecular Plant2011，4，2： | 5 |
| 3 | Early Intrapulmonary Recurrence After Pulmonary Metastasectomy Related to Colorectal Cancer显示文摘 | Mi Ri Hwang Ji Won Park Dae Yong Kim Hee Jin Chang Sun Young Kim Hyo Seong Choi Moon Soo Kim Jae Ill Zo Jae Hwan Oh | 2010 | The Annals of Thoracic Surgery2010，，2： | 2 |
| 4 | Safe drug treatment and procedure for herpes zoster in pregnancy:a case report显示文摘To the Editor:A first infection of varicella-zoster virus(VZV)during pregnancy can cause serious systemic disease to both mother and the fetus.Despite this maternal herpes zoster(HZ)does not increase fetal mortality,and the transmission of varicella-zoster virus to the fetus rarely occurs.Although HZ infection has a minimal effect on the fetus,maternal HZ can cause significant complications for the mother. | Ji Yeong Kim You Ri Ko Sung Eun Sim Sua Oh Mi Hyeon Lee Hue Jung Park | 2020 | Chinese Medical Journal2020，，16： | 2 |
| 5 | Cancer-associated fibroblast-derived secreted phosphoprotein 1 contributes to resistance of hepatocellular carcinoma to sorafenib and lenvatinib显示文摘Background:Cancer-associated fibroblasts(CAFs)play an important role in the induction of chemo-resistance.This study aimed to clarify the mechanism underlying CAF-mediated resistance to two tyrosine kinase inhibitors(TKIs),sorafenib and lenvatinib,and to identify a novel therapeutic target for overcoming TKI resistance in hepatocellular carcinoma(HCC).Methods:We performed a systematic integrative analysis of publicly available gene expression datasets and whole-transcriptome sequencing data from 9 pairs of CAFs and para-cancer fibroblasts isolated from human HCC and para-tumor tissues,respectively,to identify key molecules that might induce resistance to TKIs.We then performed in vitro and in vivo experiments to validate selected targets and related mechanisms.The associations of plasma secreted phosphoprotein 1(SPP1)expression levels before sorafenib/lenvatinib treatment with progression-free survival(PFS)and overall survival(OS)of 54 patients with advanced HCC were evaluated using Kaplan-Meier and Cox regression analysis.Results:Bioinformatic analysis identified CAF-derived SPP1 as a candidate molecule driving TKI resistance.SPP1 inhibitors reversed CAF-induced TKI resistance in vitro and in vivo.CAF-derived SPP1 activated rapidly accelerated fibrosarcoma(RAF)/mitogen-activated protein kinase(MAPK)and phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)/mammalian target of rapamycin(mTOR)through the integrin-protein kinase C-alpha(PKCα)signaling pathway and promoted epithelial-to-mesenchymal transition(EMT).A high plasma SPP1 level before TKI treatment was identified as an independent predictor of poor PFS(P=0.026)and OS(P=0.047)in patients with advanced HCC after TKI treatment.Conclusions:CAF-derived SPP1 enhances TKI resistance in HCC via bypass activation of oncogenic signals and EMT promotion.Its inhibition represents a promising therapeutic strategy against TKI resistance inHCC.Moreover,plasma SPP1 level before TKI treatment represents a potential biomarker for treatment response prediction. | JungWoo Eun Jung Hwan Yoon Hye Ri Ahn Seokhwi Kim Young Bae Kim Su Bin Lim Won Park TaeWook Kang Geum Ok Baek Moon Gyeong Yoon Ju A Son Ji HyangWeon Soon Sun Kim Hyo Jung Cho Jae Youn Cheong | 2023 | Cancer Communications2023，43，4： | 2 |
| 6 | Prognostic Impact of Circumferential Resection Margin in Rectal Cancer Treated with Preoperative Chemoradiotherapy显示文摘 | Mi Ri Hwang Ji Won Park Sohee Park Hyekyoung Yoon Dae Yong Kim Hee Jin Chang Sun Young Kim Sung Chan Park Hyo Seong Choi Jae Hwan Oh Seung-Yong Jeong | 2014 | Annals of Surgical Oncology2014，，4： | 2 |
| 7 | Comparison of Endoscopic Papillary Balloon Dilation and Sphincterotomy in Young Patients with CBD Stones and Gallstones显示文摘 | Yu Ri Seo Jong Ho Moon Hyun Jong Choi Dong Choon Kim Ji Su Ha Tae Hoon Lee Sang-Woo Cha Young Deok Cho Sang-Heum Park Sun-Joo Kim | 2014 | Digestive Diseases and Sciences2014，，5： | 2 |
| 8 | Papillary balloon dilation is not itself a cause of post‐endoscopic retrograde cholangiopancreatography pancreatitis; results of anterograde and retrograde papillary balloon dilation显示文摘 | Yu Ri Seo Jong Ho Moon Hyun Jong Choi Dong Choon Kim Tae Hoon Lee Sang‐Woo Cha Young Deok Cho Sang‐Heum Park Sun‐Joo Kim | 2013 | J Gastroenterol Hepatol2013，，8： | 2 |
| 9 | Inhibition of Histone Deacetylation Blocks Cardiac Hypertrophy Induced by Angiotensin II Infusion and Aortic Banding显示文摘 | Hae Jin Kee Il Suk Sohn Kwang Il Nam Jong Eun Park Yong Ri Qian Zhan Yin Youngkeun Ahn Myung Ho Jeong Yung-Jue Bang Nacksung Kim Jong-Keun Kim Kyung Keun Kim Jonathan A. Epstein Hyun Kook | 2006 | Circulation2006，，1： | 2 |
| 10 | Chemical and functional components in different parts of rough rice ( Oryza sativa L.) before and after germination显示文摘 | Hyun Young Kim In Guk Hwang Tae Myoung Kim Koan Sik Woo Dong Sik Park Jae Hyun Kim Dae Joong Kim Junsoo Lee Youn Ri Lee Heon Sang Jeong | 2012 | Food Chemistry2012，，1： | 2 |
| 11 | Bone regeneration in critical size defects by cell-mediated BMP-2 gene transfer: a comparison of adenoviral vectors and liposomes显示文摘 | Park J Ries J Gelse K | 2003 | Gene Ther2003，10，13： | 1 |
| 12 | Bone regeneration in crit-ical size defects by cell-mediated BMP-2 gene transfer : acomparison of adenoviral vectors and liposomes显示文摘 | Park J Ries J Gelse K | 2003 | GeneTher2003，10，13： | 1 |
| 13 | Aktl induces extracellular matrix invasion and matrix metalloproteinase-2 activity in mouse mammary epithelial cells显示文摘 | Park BK Zeng X Glazer RI | 2001 | Cancer Res2001，61，20： | 1 |
| 14 | Iodine 125 seed implantation as an adjunct to surgery in advanced recurrent squamous cell Cancer of the head and neck显示文摘 | Park RI Liberman FZ Lee DJ | 1991 | Laryngoscope1991，101，： | 1 |
| 15 | Bone regeneration in critical size defects by cell-mediated BMP-2 gene transfer: a comparision of adeno-viral vectors and liposomes显示文摘 | Park J Ries J Gelse K | 2003 | Gene Ther2003，10，13： | 1 |
| 16 | Dynamic adjust of container stacking policy in an automated container terminal 显示文摘 | Taejin Park Ri Choe Young Hun Kim Kwang Ryel Ryu | 2011 | Interuational Journal of Production Economics2011，133，： | 1 |
| 17 | Endosonographic features of esophageal granular cell tumors using a high-frequency catheter probe显示文摘 | Dong Uk Kim Gwang Ha Kim Dong Yup Ryu Dong Gun Lee Jae Hoon Cheong Bong Eun Lee Geun Am Song Do Youn Park Na Ri Shin Hoseok I Mitsuhiro Kida | 2011 | Scandinavian Journal of Gastroenterology2011，，2： | 1 |
| 18 | Bone regeneration in critieal size detects by cell-mediated BMP-2 gene transfer:a comparison of adenoviral vectors and liposomes显示文摘 | Park J Ries J Gelse K | 2003 | Gene Ther2003，10，： | 1 |
| 19 | Bone regeneration in critical size defects by ceU-mediated BMP-2 gene transfer: a comparison of adenoviral vectors and liposomes 显示文摘 | Park J Ries J Gelse K | 2003 | Gene Ther2003，10，13： | 1 |
| 20 | Differential scan- ning calorimetry of phenolic formaldehyde resins cure - accelerated by carbonates 显示文摘 | Byung - Dae Park Bernard Ried Ernest W | 1999 | Polymer1999，40，7： | 1 |
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