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| 1 | Tailoring strength-ductility balance of caliber-rolled AZ31 Mg alloy through subsequent annealing显示文摘Recently,multi-pass caliber rolling has been shown to be effective for Mg alloys.This study investigated the effect of subsequent annealing on the mechanical properties of a caliber-rolled AZ31 Mg alloy to modulate the strength-ductility relationship.This annealing gave rise to different trends in mechanical properties depending on the temperature regime.Low-temperature annealing(T≤473 K)exhibited a typical trade-off relationship,where an increase in annealing temperature resulted in increased ductility but decreased strength and hardness.Such a heat treatment did not degrade the high strength-ductility balance of the caliber-rolled alloy,suggesting that the mechanical properties could be tailored for different potential applications.In contrast,high-temperature annealing(T>473 K)caused a simultaneous deterioration in strength,hardness,and ductility with increasing annealing temperature.These differences are discussed in terms of the varying microstructural features under the different investigated annealing regimes. | Taein Kong Byung Je Kwak Jonghyun Kim Jeong Hun Lee Sung Hyuk Park Ji Hoon Kim Young Hoon Moon Hyun Sik Yoon Taekyung Lee | 2020 | Journal of Magnesium and Alloys2020，8，1： | 10 |
| 2 | 干扰素调节因子5通过损伤胞葬作用控制动脉粥样硬化病变中的坏死核心形成显示文摘髓系细胞是动脉粥样硬化病变发展和易损斑块形成的核心。动脉吞噬细胞吸收凋亡细胞(胞葬作用)的能力受损,可促进病变生长并建立坏死核心。干扰素调节因子(interferon regulatory factor,IRF)5是髓系细胞功能的重要调节因子。该研究试图确定IRF5是否影响动脉粥样硬化病变的形成和表型。方法:通过两种互补模型,研究IRF5在动脉粥样硬化中的作用: | Seneviratne AN Edsfeldt AO Cole JE Kassiteridi C Swart M Park I Green P Khoyratty TE Saliba DG Goddard ME Sansom SN Goncalves I Krams R Udalova IA Monaco C 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，8： | 9 |
| 3 | 2-Hydroxy-3-methoxybenzoic acid attenuates mast cell-mediated allergic reaction in mice via modulation of the FcεRI signaling pathway显示文摘桅杆房间是在免疫球蛋白(Ig ) 的重要受动器房间电子 mediated 过敏反应象气喘,遗传性过敏症的皮炎和鼻炎那样。香子兰的酸,一个自然产品,显示出抗氧化剂和反煽动性的活动。在现在的学习,我们调查了 ortho 香子兰的酸的反过敏的煽动性的效果(2-hydroxy-3-methoxybenzoic 酸,卵) 那是从 Amomum xanthioides 孤立的香子兰的酸的衍生物。在老鼠过敏性模型,卵的口头的管理(2, 10, 50 mg/kg ) dose-dependently 稀释了象降低体温,组织安版本, IgE 生产和 vasodilation 那样的导致 ovalbumin 的活跃全身的过敏性和调停 IgE 的皮肤的过敏反应;卵的管理也压制了桅杆房间 degranulator 混合物 48/80-induced 过敏性。在在 vitro 的有教养的桅杆房间线 RBL-2H3 和孤立的老鼠腹桅杆房间,有卵(1-100 mol/L ) 的预告的处理 dose-dependently 由减少禁止了桅杆房间的 DNP-HSA-induced degranulation 细胞内部的免费的钙水平,并且压制了支持 inflammatory cytokines TNF-4 和 IL-4 的表示。有卵的 RBL-2H3 房间的预告的处理压制了 Lyn, Syk, Akt,和原子 factor-B 的原子 translocation 的 DNP-HSA-induced phosphorylation。在结论,卵压制桅杆由在桅杆房间的表面上高亲密关系 IgE 受体(FcRI ) 下游地堵住发信号的小径的调停房间的过敏煽动性的反应。 | Yeon-Yong KIM In-Gyu JE Min Jong KIM Byeong-Cheol KANG Young-Ae CHOI Moon-Chang BAEK Byungheon LEE Jin Kyeong CHOI Hae Ran PARK Tae-Yong SHIN Soyoung LEE Seung-Bin YOON Sang-Rae LEE Dongwoo KHANG Sang-Hyun KIM | 2017 | Acta Pharmacologica Sinica2017，38，1： | 8 |
| 4 | Improved tensile properties of AZ31 Mg alloy subjected to various caliber-rolling strains显示文摘A multi-pass caliber rolling has attracted attentions as an alternative to severe plastic deformation processes.The present study enhanced strength and ductility of AZ31 Mg alloy simultaneously through the application of caliber rolling.The improving trends in tensile properties were interpreted with various caliber-rolling strains.The oval/circular-shaped calibers imposed a high plastic strain at the center of crosssection,leading to effective grain refinement to submicron scale.This work also confirmed the texture randomizing effect of caliber rolling.Such microstructural evolutions gave rise to the fabrication of high-strength material.Moreover,the caliber-rolled AZ31 Mg alloys exhibited an improvement in ductility as compared to the as-received sheet-rolled material.This was discussed in terms of activation of non-basal slip systems and suppression of mechanical twinning.This study successfully proved the possibility of caliber rolling to produce a bulk Mg rod with enhanced tensile properties. | Jeong Hun Lee Byung Je Kwak Taein Kong Sung Hyuk Park Taekyung Lee | 2019 | Journal of Magnesium and Alloys2019，7，3： | 7 |
| 5 | Machining characteristics of complex prism pattern on electroplated roll by copper显示文摘The BLU (back light unit) is the core component of the LCD for notebook, mobile-phone, navigation, as well as large sized TV, PID (public information display), etc. In order to enhance optical efficiency of LCD, optical films with the uniform prism patterns have been used for BLU by stacking two films up orthogonally. In this case, light interference-phenomenon occurred such as Morie, wet-out, u-turning, etc. It caused several problems such as low brightness, spots and stripes in LCD. Recently, the high-luminance micro complex prism patterns are actively studied to avoid the light interference-phenomenon and enhance the optical efficiency. In this study, the roll master to manufacture complex micro prism pattern film was machined by using the high precision lathe. The machined patterns on the roll master were 50, 45, 40, 35, 30, 25, 20, 15, 10 and 5 μm in the pitch with 25.0, 22.5, 20.0, 17.5, 15.0, 12.5, 10.0, 7.5, 5.0 and 2.5 μm in the peak height, respectively. The roll was 2 000 mm in length and 320 mm in diameter. The electroplated roll by copper and the natural single crystal diamond tool was used for machining the patterns. The cutting force was measured and analyzed for each cutting condition by using the dynamometer. The chips and the surfaces after being machined were analyzed by SEM and microscope. | Tae-Jin JE Sang-Cheon PARK Kang-Won LEE Yeong-Eun YOO Doo-Sun CHOI Kyung-Hyun WHANG Myung-Chang KANG | 2009 | 中国有色金属学会会刊:英文版2009，19，B09： | 4 |
| 6 | Improvement of machining quality of copper-plated roll mold by controlling temperature variation显示文摘Micro prism film used in LCD industry can be manufactured by roll to roll method with copper-plated roll mold. As copper-plated roll mold is getting larger, pitch error is getting severer. The pitch error drops the quality of micro prism film. The main cause of the pitch error was investigated during machining large roll mold whose machined length was 1 200 mm. The temperature of machining system was elevated during machining roll mold, and this elevation induced thermal expansion of the system. The temperature variation around the roll mold also made thermal expansion of the roll mold. The amount of thermal expansion had strong relationship to the amount of pitch error. Therefore, the roll mold was machined after warming-up of machining system and precise temperature controller around copper-plated roll mold was installed, which minimized the temperature variation. Finally, precise micro prism patterns without pitch error were machined on the large roll mold. | Tae-Jin JE Eun-Chae JEON Sang-Cheon PARK Doo-Sun CHOI Kyung-Hyun WHANG Myung-Chang KANG | 2011 | Transactions of Nonferrous Metals Society of China2011，21，A01： | 4 |
| 7 | Effects of exogenous recombinant human bone morphogenic protein-7 on the corneal epithelial mesenchymal transition and fibrosis显示文摘AIM:To evaluate the effect of exogenous recombinant human bone morphogenic protein-7(rhBMP-7)on transforming growth factor-β(TGF-β)-induced epithelial mesenchymal cell transition(EMT)and assessed its antifibrotic effect via topical application.METHODS:The cytotoxic effect of rhBMP-7 was evaluated and the EMT of human corneal epithelial cells(HECEs)was induced by TGF-β. HECEs were then cultured in the presence of rhBMP-7 and/or hyaluronic acid(HA). EMT markers,fibronectin,E-cadherin,α-smooth muscle actin(α-SMA),and matrix metaloproteinase-9(MMP-9),were evaluated. The level of corneal fibrosis and the reepithelization rate were evaluated using a rabbit keratectomy model. Expression of α-SMA in keratocytes were quantified following treatment with different concentrations of rhBMP-7.RESULTS:Treatment with rhBMP-7 attenuated TGF-β-induced EMT in HECEs. It significantly attenuated fibronectin secretion(31.6%; P<0.05),the α-SMA protein level(72.2%; P<0.01),and MMP-9 expression(23.6%,P<0.05)in HECEs compared with cells grown in the presence of TGF-β alone. E-cadherin expression was significantly enhanced(289.7%; P<0.01)in the presence of rhBMP-7. Topical application of rhBMP-7 combined with 0.1% HA significantly reduced the amount of α-SMA^+ cells by 43.18%(P<0.05)at a concentration of 2.5 μg/mL and by 47.73%(P<0.05)at 25 μg/mL,compared with the control group,without disturbing corneal reepithelization.CONCLUSION:rhBMP-7 attenuates TGF-β-induced EMT in vitro,and topical application of rhBMP-7 reduces keratocyte myodifferentiation during the early wound healing stages in vivo without hindering reepithelization. Topical rhBMP-7 application as biological eye drops seems to be feasible in diseases involving TGF-β-related corneal fibrosis with corneal reepithelization disorders. | Jin Kwon Chung Shin Ae Park Hee Sun Hwang Kwang Sung Kim Yang Je Cho Yong Sung You Young Sik Kim Ju Woong Jang Sung Jin Lee | 2017 | International Journal of Ophthalmology(English edition)2017，10，3： | 3 |
| 8 | The biochemical efficacy of primary cryoablation combined with prolonged total androgen suppression compared with radiotherapy on high-risk prostate cancer: a 3-year pilot study显示文摘为了在高风险的前列腺癌症,联合本地治疗的一条综合途径和雄激素剥夺治疗(ADT ) 的管理获得有益的效果,被使用。我们比较了在与与 ADT 相结合的延长 ADT 和放射相结合的前列腺(CSAP ) 的主要 cryosurgical 脱离之间的生物化学的回答,它是在高风险的疾病的确定的形式。收到的 CSAP 在治疗以后与 ADT 相结合 3 个月在前并且直到 24 个月的 33 个高风险的病人的一个总数。这个耐心的组与另外一个被匹配为 ADT 与一样的协议经历了三维的保角的放射治疗(3D-CRT ) 的 33 个病人。生物化学的复发(BCR ) 被美国社会为治疗学的放射肿瘤学(ASTRO ) 估计 0.5 ng mL 的定义,菲尼克斯定义和前列腺特定的抗原(PSA ) 截止 ? 1。中部的后续是为 CSAP + ADT 的 11.9 个月组织的 61.0 卤和为 3D-CRT + ADT 的 15.8 个月组织的 86.0 卤。在 CSAP 组,包括 rectourethral 管和不能自制的主要复杂并发症没被注意。在 CSAP + ADT 组, 57.0% 用 ASTRO 定义有 BCR, 21.2% 使用菲尼克斯定义并且 54.5% 使用 0.5 ng mL 的 PSA 截止 ? 1。在 3D-CRT + ADT 组, 54.5% , 21.2% 和 54.5% 分别地用 ASTRO,菲尼克斯和 PSA 定义有 BCR。在 CSAP + ADT 组, BCR 免费的幸存(BRFS ) 是 54 卤用 ASTRO 定义的 10 个月, 65 卤用菲尼克斯定义的 5 个月和 51 卤用 0.5 ng mL 的 PSA 截止的 4 个月 ? 1。在 3D-CRT + ADT 组, BRFS 是 68 卤 12, 93 卤 19 和 70 卤分别地使用 ASTRO,菲尼克斯和 PSA 定义的 18 个月。由木头等级测试,为每个组的 BRFS 价值不是统计上不同的。这中间术语的结果显示与延长 ADT 相结合的主要 CSAP 在高风险的前列腺癌症与放射疗法相比提供平行生物化学的回答。 | Young Hwii Ko Seok Ho Kang Young Je Park Hong Seok Park Du Geon Moon Jeong Gu Lee Duck Ki Yoon Je Jong Kim Jun Cheon | 2010 | Asian Journal of Andrology2010，12，6： | 3 |
| 9 | 心脏病及非心脏病患者降低舒张压的效果:收缩压干预试验结果分析显示文摘收缩压和舒张压低于何种阈值时心血管事件增多仍然不明确。应用收缩压干预试验(systolic blood pressure intervention trial,SPRINT)的数据,研究者评估了1519例心血管病患者和7574位非心血管病者的收缩压和舒张压与心血管事件之间的关系。 | 刘青 叶鹏 Khan NA Rabkin SW Zhao Y McAlister FA Park JE Guan M Chan S Humphries KH | 2018 | 中华高血压杂志2018，26，6： | 3 |
| 10 | Sequential disruption of ALV host receptor genes reveals no sharing of receptors between ALV subgroups A, B, and J显示文摘Background: Previously, we showed that targeted disruption of viral receptor genes in avian leukosis virus(ALV)subgroups using clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9))-based genome editing confers resistance to ALV subgroups B and J. Here, we used the same strategy to target the receptor expressed by ALV subgroup A(TVA) and generate chicken cells resistant to infection by this virus.Results: CRISPR/Cas9-based disruption of exon 2 within the tva gene of DF-1 fibroblasts conferred resistance to infection by ALV subgroup A regardless of whether frameshift mutations were introduced during editing. Conversely,overexpression of the wild-type TVA receptor(wtTVA) by tva-modified DF-1 clones restored susceptibility to ALV subgroup A. The results confirm that exon 2, which contains the low-density lipoprotein receptor class A domain of TVA, is critical for virus entry. Furthermore, we sequentially modified DF-1 cells by editing the tva, tvb, and Na^+/H^+ exchange 1(chNHE1) genes, which are the specific receptors for ALV subgroups A, B, and J, respectively.Conclusions: Simultaneous editing of multiple receptors to block infection by different subgroups of ALV confirmed that ALV subgroups A, B, and J do not share host receptors. This strategy could be used to generate cells resistant to multiple viral pathogens that use distinct receptors for cell entry. | Hong Jo Lee Kyung Je Park Kyung Youn Lee Yongxiu Yao Venugopal Nair Jae Yong Han | 2019 | Journal of Animal Science and Biotechnology2019，10，2： | 3 |
| 11 | Room-temperature sputtered electrocatalyst WSe2 nanomaterials for hydrogen evolution reaction显示文摘The low-temperature physical vapor deposition process of atomically thin two-dimensional transition metal dichalcogenide(2D TMD) has been gaining attention owing to the cost-effective production of diverse electrochemical catalysts for hydrogen evolution reaction(HER) applications. We, herein, propose a simple route toward the cost-effective physical vapor deposition process of 2D WSe2 layered nanofilms as HER electrochemical catalysts using RF magnetron sputtering at room temperature(<27℃). By controlling the variable sputtering parameters, such as RF power and deposition time, the loading amount and electrochemical surface area(ECSA) of WSe2 films deposited on carbon paper can be carefully determined. The surface of the sputtered WSe2 films are partially oxidized, which may cause spherical-shaped particles. Regardless of the loading amount of WSe2, Tafel slopes of WSe2 electrodes in the HER test are narrowly distributed to be ~120–138 mV dec-1, which indicates the excellent reproducibility of intrinsic catalytic activity. By considering the trade-off between the loading amount and ECSA, the best HER performance is clearly observed in the 200 W-15 min sample with an overpotential of 220 mV at a current density of 10 mA cm-2. Such a simple sputtering method at low temperature can be easily expanded to other 2D TMD electrochemical catalysts, promising potentially practical electrocatalysts. | Jae Hyeon Nam Myeong Je Jang Hye Yeon Jang Woojin Park Xiaolei Wang Sung Mook Choi Byungjin Cho | 2020 | Journal of Energy Chemistry2020，29，8： | 3 |
| 12 | Knockdown of β-catenin controls both apoptotic and autophagic cell death through LKB1/AMPK signaling in head and neck squamous cell carcinoma cell lines显示文摘 | Hyo Won Chang Yoon Se Lee Hae Yun Nam MyoungWol Han Hyo Jung Kim So Young Moon HyesungJeon Jung Je Park Thomas E. Carey Sung Eun Chang Seong Who Kim Sang Yoon Kim | 2012 | Cellular Signalling2012，，： | 2 |
| 13 | Wear characteristics of Ⅴ shape diamond tool for micro prism pattern with Al alloys显示文摘The ultra-precision machining process using a single crystal diamond tool has been mainly used for machining molds of optical components.Since the micro patterns of various shapes having excellent surface roughness can be machined by using ultra-precision machine tools,the micro pattern on a large light guide plate (LGP) is mainly machined using a diamond tool.The tool wear occurs due to long machining distances and time while machining a large-area LGP mold.The deformation and dimensional error of micro pattern are caused by tool wear,as a result,the light efficiency of LGP declines.The characteristics of tool wear should be analyzed in order to precisely machine large-area LGP mold from all sorts of materials.The experiments were performed in order to compare wear characteristics of a V90° diamond tool using Al3003,5052,6061 and 7075.The prism pattern of depth 10 μm was machined in order to analyze characteristics of tool wear according to machining distances (0.5,1 and 1.5 km).The effects of tool wear on pattern shape were analyzed by applying overlapped cutting depths (Rough machining is (10+8+7) μm and Finish machining is (5+3+2+1) μm) by continuously machining a prism pattern of W shape of 25 μm in depth. | Eun-Suk PARK Tae-Jin JE Hwan-Jin CHOI Eun-Chae JEON Myung-Chang KANG | 2012 | 中国有色金属学会会刊:英文版2012，22，S3： | 2 |
| 14 | Development of novel gene carrier using modified nano hydroxyapatite derived from equine bone for osteogenic differentiation of dental pulp stem cells显示文摘Hydroxyapatite(HA)is a representative substance that induces bone regeneration.Our research team extracted nanohydroxyapatite(EH)from natural resources,especially equine bones,and developed it as a molecular biological tool.Polyethylenimine(PEI)was used to coat the EH to develop a gene carrier.To verify that PEI is well coated in the EH,we first observed the morphology and dispersity of PEI-coated EH(pEH)by electron microscopy.The pEH particles were well distributed,while only the EH particles were not distributed and aggregated.Then,the existence of nitrogen elements of PEI on the surface of the pEH was confirmed by EDS,calcium concentration measurement and fourier transform infrared spectroscopy(FT-IR).Additionally,the pEH was confirmed to have a more positive charge than the 25 kD PEI by comparing the zeta potentials.As a result of pGL3 transfection,pEH was better able to transport genes to cells than 25 kD PEI.After verification as a gene carrier for pEH,we induced osteogenic differentiation of DPSCs by loading the BMP-2 gene in pEH(BMP-2/pEH)and delivering it to the cells.As a result,it was confirmed that osteogenic differentiation was promoted by showing that the expression of osteopontin(OPN),osteocalcin(OCN),and runt-related transcription factor 2(RUNX2)was significantly increased in the group treated with BMP-2/pEH.In conclusion,we have not only developed a novel nonviral gene carrier that is better performing and less toxic than 25 kD PEI by modifying natural HA(the agricultural byproduct)but also proved that bone differentiation can be effectively promoted by delivering BMP-2 with pEH to stem cells. | Myung Chul Lee Hoon Seonwoo Kyoung Je Jang Shambhavi Pandey Jaewoon Lim Sangbae Park Jae Eun Kim Yun-Hoon Choung Pankaj Garg Jong Hoon Chung | 2021 | Bioactive Materials2021，6，9： | 2 |
| 15 | Free radical scavenging activities of different deacetylated chitosans using an ESR spectrometer显示文摘 | Park P J Je J Y Kim S W | 2004 | Carbohydrate Polymer2004，55，： | 1 |
| 16 | Angiotensin I converting enzyme (ACE) inhibitory peptide derived from the sauce of fermented blue mussel,Mytilus edulis显示文摘 | Jae-Young Je Pyo-Jam Park Hee-Guk Byun | 2005 | Bioresource Technology2005，96，： | 1 |
| 17 | The vascular endothelial growth factor(VEGF)isoforms:differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrixbound VEGF显示文摘 | Park JE Keller GA Ferrara N | 1993 | Mol Biol Med1993，4，1： | 1 |
| 18 | DNA Ploidy and proliferation activty (s-phase) in childhood soft-tissue sarcomas:their value as prognosis indicators显示文摘 | Niggi FK Powell JE Parkes SE | 1994 | Br J Cancer1994，69，6： | 1 |
| 19 | A phase Ⅱ study of oxaliplatin in combination with doxorubicin as first-line systemic chemotherapy in patients with inoperable hepatocellular carcinoma显示文摘 | Uhm JE Park JO Lee J | 2009 | Cancer Chemother Pharmacol2009，63，5： | 1 |
| 20 | Anti - inflammatory activity of mul- berry leaf extract through inhibition of NF - KB 显示文摘 | Park E Lee S Lee JE | 2013 | Journal of Functional Foods2013，5，1： | 1 |
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