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| 1 | Mesenchymal stem cell therapy in retinal and optic nerve diseases: An update of clinical trials显示文摘Retinal and optic nerve diseases are degenerative ocular pathologies which lead to irreversible visual loss. Since the advanced therapies availability, cell-based therapies offer a new all-encompassing approach. Advances in the knowledge of neuroprotection, immunomodulation and regenerative properties of mesenchymal stem cells(MSCs) have been obtained by several preclinical studies of various neurodegenerative diseases. It has provided the opportunity to perform the translation of this knowledge to prospective treatment approaches for clinical practice. Since 2008, several first steps projecting new treatment approaches, have been taken regarding the use of cell therapy in patients with neurodegenerative pathologies of optic nerve and retina. Most of the clinical trials using MSCs are in Ⅰ/Ⅱ phase, recruiting patients or ongoing, and they have as main objective the safety assessment of MSCs using various routes of administration. However, it is important to recognize that, there is still a long way to go to reach clinical trials phase Ⅲ-Ⅳ. Hence, it is necessary to continue preclinical and clinical studies to improve this new therapeutic tool. This paper reviews the latest progress of MSCs in human clinical trials for retinal and optic nerve diseases. | Sonia Labrador-Velandia María Luz Alonso-Alonso Sara Alvarez-Sanchez Jorge González-Zamora Irene Carretero-Barrio José Carlos Pastor Iván Fernandez-Bueno Girish Kumar Srivastava | 2016 | World Journal of Stem Cells2016，8，11： | 5 |
| 2 | Cataract surgery with toric intraocular lens implantation in patients with high corneal astigmatism显示文摘 | Nienke Visser Ramón Ruíz-Mesa Francisco Pastor No?l J.C. Bauer Rudy M.M.A. Nuijts Robert Montés-Micó | 2011 | Journal of Cataract & Refractive Surgery2011，，8： | 2 |
| 3 | PD-L2 is expressed on activated human T cells and regulates their function显示文摘 | Messal N Serriari NE Pastor S | 2011 | Mol Immunol2011，48，1516： | 1 |
| 4 | Potential applications of laecase in the food industry显示文摘 | Minussi R C Pastore G M Dura N | 2002 | Trends in Food Science & Technology2002，13，： | 1 |
| 5 | Enzyme therapy in type I Gaucher disease : comparative efficacy of mannose-terminated , glucocerebrosidase from natural and recombinant sources 显示文摘 | GRABOWSKI G A BARTON N W PASTORES G | 1995 | Ann Intern Med1995，122，1： | 1 |
| 6 | Aquaporin 9 Expression along the Male Reproduction Tract 显示文摘 | Pastor - Soler N Bagnis C Sabolic I | 2001 | Biol Reprod2001，65，： | 1 |
| 7 | Therapeutic goals in the treatment of Gaucher disease显示文摘 | Pastores GM Weinreb N J Aerts H | 2004 | Semin Hematol2004，41，45： | 1 |
| 8 | Mechanization process in the production of mescal 显示文摘 | Hector M Duran-Garcia Emilio J Gonzalez- Galv a n Pastor Matadamas-Ort i z | 2007 | Journal of Food Agriculture & Environment2007，5，34： | 1 |
| 9 | Expression of aquaporin 9 in the adult rat epididymal epithelium is modulated by androgens 显示文摘 | Pastor - Soler N Isnard - Bagnis C Herak - Kramberger C | 2002 | Biol Reprod2002，66，： | 1 |
| 10 | Open tension-free hernioplasty using a novel lightweight self-gripping mesh:medium-term experience from two institutions显示文摘 | Pedano N Pastor C Arredondo J | | 0，，02： | 1 |
| 11 | Synthesis of epothi- lones A and B in solid and solution phase显示文摘 | Nicolaou KC Winssinger N Pastor J | 1997 | Nature1997，387，6630： | 1 |
| 12 | Development of a method for the analysis of seven banned azo-dyes in chilli and hot chilli food samples by pressurised liquid extraction and liquid chromatography with electrospray ionization-tandem mass spectrometry显示文摘 | Pardo O Yusa V Leon N Pastor A | | 0，，1： | 1 |
| 13 | Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients显示文摘 | Lopez-Lazaro M Pastor N Azrak S S | 2005 | J Nat Prod2005，68，11： | 1 |
| 14 | Bench scale laboratory tests to analyze non-linear flow in fractured media显示文摘 | CHERUBINI CI GIASI C I PASTORE N | 2012 | Hydrology and Earth System Sciences2012，16，8： | 1 |
| 15 | Bone mineralization defects and vitamin D deficiency:histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675 patients显示文摘 | Priemel M von Domarus C Klatte TO Kessler S Schlie J Meier S Proksch N Pastor F Netter C Streichert T Püschel K Amling M | | 0，，： | 1 |
| 16 | Cataract surgery with toric intraocular lens implantation in patients with high corneal astigmatism显示文摘 | Visser N Ruíz-Mesa R Pastor F | | 0，，8： | 1 |
| 17 | Synthe- sis of epothilones A and B in solid and solution phase显示文摘 | NICOLAOU K C WINSSINGER N PASTOR J | 1997 | Nature1997，387，6630： | 1 |
| 18 | Enzymatic synthesis of short chain citronellyl esters by a new lipase from Rhizopus sp显示文摘 | Gabriela Alves Macedo Maria Mercedez Soberón Lozano Gláucia Maria Pastore | 2003 | Electronic Journal of Biotechnology2003，，6： | 1 |
| 19 | Sewage sludge management for phosphorus recovery as struvite in EBPR wastewater treatment plants显示文摘 | Pastor L Marti N Bouzas A | 2008 | Bioresouree Technology2008，99，11： | 1 |
| 20 | Open tension-free hemioplasty using a novel lightweight self-gripping mesh: medium-term experience from two institutions 显示文摘 | Pedano N Pastor C Arredondo J | 2012 | Langenbecks Arch Surg2012，397，2： | 1 |
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