4篇
您的检索式：作者名="Patrick Emond"
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| 1 | Analysis of the National Institute of Neurological Disorders and Stroke Tissue Plasminogen Activator Studies Following European Cooperative Acute Stroke Study III Patient Selection Criteria显示文摘 | Thomas M. Hemmen Karen S. Rapp Jennifer A. Emond Rema Raman Patrick D. Lyden | 2010 | Journal of Stroke and Cerebrovascular Diseases2010，，4： | 1 |
| 2 | Synthesis and biological evaluation of a series of flavone derivatives as potential radioligands for imaging the multidrug resistance-associated protein 1 (ABCC1/MRP1)显示文摘 | Sylvie Mavel Branko Dikic Somchit Palakas Patrick Emond Ivan Greguric Adrienne Gomez de Gracia Filomena Mattner Manuel Garrigos Denis Guilloteau Andrew Katsifis | 2005 | Bioorganic & Medicinal Chemistry2005，，5： | 1 |
| 3 | Autism Spectrum Disorder and Autistic Traits in the Avon Longitudinal Study of Parents and Children: Precursors and Early Signs显示文摘 | Patrick F. Bolton Jean Golding Alan Emond Colin D. Steer | 2012 | Journal of the American Academy of Child & Adolescent Psychiatry2012，，3： | 1 |
| 4 | A multiplatform metabolomic approach to characterize fecal signatures of negative postnatal events in chicks: a pilot study显示文摘Background: Negative experiences in early life can induce long-lasting effects on the welfare, health, and performance of farm animals. A delayed placement of chicks in rearing houses has negative effects on their performance, and results in fecal-specific odors detectable by rats. Based on this observation, the volatile organic compounds(VOCs) and metabolites from the feces of 12-day-old chickens were screened for early markers of response to negative events using gas-chromatography and liquid-chromatography coupled with mass spectrometry(GC-MS, LC-HRMS).Results: The low reproducibility of solid-phase micro-extraction of the VOCs followed by GC-MS was not suitable for marker discovery, in contrast to liquid extraction of metabolites from freeze-dried feces followed by GC-MS or LC-HRMS analysis. Therefore, the fecal metabolome from 12-day-old chicks having experienced a normal or delayed placement were recorded by GC-MS and LC-HRMS in two genotypes from two experiments. From both experiments, 25 and 35 metabolites, respectively explaining 81% and 45% of the difference between delayed and control chickens, were identified by orthogonal partial least-squares discriminant analysis from LC-HRMS and GC-MS profiling.Conclusion: The sets of molecules identified will be useful to better understand the chicks’ response to negative events over time and will contribute to define stress or welfare biomarkers. | Stéphane Beauclercq Antoine Lefèvre Frédéric Montigny Anne Collin Sophie Tesseraud Christine Leterrier Patrick Emond Laurence A.Guilloteau | 2019 | Journal of Animal Science and Biotechnology2019，10，2： | 0 |
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