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您的检索式：作者名="Patrick Hamel"
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| 1 | AB046. The retinoblastoma model for translational research显示文摘Background:Our national collaborative research initiative is proposing to develop a common infrastructure for Rb research.We are proposing a novel in vivo Rb model using human Rb cells line.Methods:The rabbit model has advantages over the mouse models:(I)the larger eye size of rabbits,similar to the human infant eye,permits a more accurate injection of the drugs and evaluation of methods of targeted intraocular drug delivery;(II)the rabbit model demonstrated similar fundus appearance and pathologic features to human Rb,including vitreous seeds of viable tumor when the retinal tumor is mid-sized,which are usually found in the late stage in mouse models.The lack of ability to eliminate vitreous seeds is a major reason of current treatment failures in Group C and D tumors;therefore,the rabbit model of Rb may be used as a model to evaluate the effectiveness and various routes of drug delivery.Results:This is an implementation of an infrastructure for evaluating therapeutic targets.In addition,this finding enables a variety of pharmacokinetic studies,pharmacodynamic and toxicology studies for new therapeutic agents.Conclusions:This infrastructure meets the growing concern of practitioners and researchers in the field.The common facility is easily accessible to all VHRN members on request,including requests from other sectors. | Pierre Hardy Chung Yang Rosanne Superstein Mike P.Sapieha Patrick Hamel | 2018 | Annals of Eye Science2018，，1： | 0 |
| 2 | French Spine Surgery Society guidelines for management of spinal surgeries during COVID-19 pandemic显示文摘Since the outbreak of coronavirus disease 2019(COVID-19)in December 2019 in China,various measures have been adopted in order to attenuate the impact of the virus on the population.With regard to spine surgery,French physicians are devoted to take place in the national plan against COVID-19,the French Spine Surgery Society therefore decided to elaborate specific guidelines for management of spinal disorders during COVID-19 pandemic in order to prioritize management of patients.A three levels stratification was elaborated with Level I:Urgent surgical indications,Level II:Surgical indications associated to a potential loss of chance for the patient and Level III:Non-urgent surgical indications.We also report French experience in a COVID-19 cluster region illustrated by two clinical cases.We hope that the guidelines formulated by the French Spine Surgery Society and the experience of spine surgeons from a cluster region will be helpful in order optimizing the management of patients with urgent spinal conditions during the pandemic. | Solène Prost Yann Philippe Charles Jérome Allain Jean-Luc Barat Henri d'Astorg Manuel Delhaye Chistophe Eap Fahed Zairi Pierre Guigui Brice Ilharreborde Jean Meyblum Jean-Charles Le Huec Nicolas Lonjon Guillaume Lot Olivier Hamel Guillaume Riouallon Stéphane Litrico Patrick Tropiano Benjamin Blondel | 2020 | World Journal of Clinical Cases2020，8，10： | 0 |
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