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| 1 | Glutamate reduces experimental intestinal hyperpermeability and facilitates glutamine support of gut integrity显示文摘AIM:To assess whether glutamate plays a similar role to glutamine in preserving gut wall integrity.METHODS:The effects of glutamine and glutamate on induced hyperpermeability in intestinal cell lines were studied.Paracellular hyperpermeability was induced in Caco2.BBE and HT-29CL.19A cell lines by adding phorbol-12,13-dibutyrate(PDB) apically,after which the effects of glutamine and glutamate on horseradish peroxidase(HRP) diffusion were studied.An inhibitor of glutamate transport(L-trans-pyrrolidine-2,4-dicarboxylic acid:trans-PDC) and an irreversible blocker(acivicin) of the extracellular glutamine to glutamate converting enzyme,γ-glutamyltransferase,were used.RESULTS:Apical to basolateral HRP flux increased significantly compared to controls not exposed to PDB (n=30,P<0.001).Glutamine application reduced hyperpermeability by 19%and 39%in the respective cell lines.Glutamate application reduced hyperpermeability by 30%and 20%,respectively.Incubation of HT29CL.19A cells with acivicin and subsequent PDB and glutamine addition increased permeability levels.Incubation of Caco2.BBE cells with trans-PDC followed by PDB and glutamate addition also resulted in high permeability levels.CONCLUSION:Apical glutamate-similar to glutaminecan decrease induced paracellular hyperpermeability.Extracellular conversion of glutamine to glutamate and subsequent uptake of glutamate could be a pivotal step in the mechanism underlying the protective effect of glutamine. | Mechteld AR Vermeulen Jeffrey de Jong Mathijs J Vaessen Paul AM van Leeuwen Alexander PJ Houdijk | 2011 | World Journal of Gastroenterology2011，17，12： | 9 |
| 2 | P53-dependent p21-mediated growth arrest pre-empts and protects HCTll6 cells from PUMA-mediated apoptosis induced by EGCG 显示文摘 | THAKUR VS RUHUL AMIN AR PAUL RK | 2010 | Cancer Lett2010，296，2： | 1 |
| 3 | HealthAgents: distributed multi-agent brain tumor diagnosis and?prognosis显示文摘 | Horacio González-Vélez Mariola Mier Margarida Julià-Sapé Theodoros N. Arvanitis Juan M. García-Gómez Montserrat Robles Paul H. Lewis Srinandan Dasmahapatra David Dupplaw Andrew Peet Carles Arús Bernardo Celda Sabine Huffel Magí Lluch-Ariet | 2009 | Applied Intelligence2009，，3： | 1 |
| 4 | Changes in lipidprofile of postmenopausal women 显示文摘 | Saha KR Rahman MM Paul AR | 2013 | Mymensingh Med J2013，22，： | 1 |
| 5 | A contributory role for activated hepatic stellate cells in the dynamics of Schistosoma japonicum egg-induced fibrosis显示文摘 | Paul BB Grant AR Malcolm KJ | 2006 | Int J Parasitol2006，36，9： | 1 |
| 6 | A sex-related difference in the neurobehavioral and hepatic effects following chronic endosulfan treatment in rats显示文摘 | Paul V Balasubramaniam E Jayakumar AR | 1995 | Eur J Pharmacol1995，293，4： | 1 |
| 7 | p53-Dependent p21-mcdiated growth arrest pre-empts and protects HCT116 cells from PUMA-mediated apoptosis induced by EGCG 显示文摘 | Thakur VS Ruhul Amin AR Paul RK | 2010 | Cartee r Lett2010，296，2： | 1 |
| 8 | Modulation of signal proteins:a plausible mechanism to explain how a potentized drug Secale Cor 30C diluted beyond Avogadro's limit combats skin papilloma in mice显示文摘 | Khuda-Bukhsh AR Bhattacharyya SS Paul S Dutta S Boujedaini N Belon P | | 0，，： | 1 |
| 9 | Review of the temporal and geographical distribution of measles virus genotypes in the prevaccine and postvaccine eras显示文摘 | Michaela AR Jennifer SR Paul AR | 2005 | Virol J2005，22，2： | 1 |
| 10 | Comparison of clinical outcomes with low-voltage(cut) versus high-voltage (coag) waveforms during hysteroscopic endometrial ablation with the rollerball:a pilot study显示文摘 | Paul TC George AV Basim AR | 2009 | J Minim Invasive Gynecol2009，16，3： | 1 |
| 11 | Short-term outcome analysis of total pelvic reconstruction with mesh:the vaginal approach显示文摘 | Shan DK Paul EM Rastinehad AR | 2004 | J Urol2004，171，1： | 1 |
| 12 | Subacute anthraeyeline cardiotoxicity 显示文摘 | Christopher LH Prudence AR Paul AG | 2006 | Heart Lung Cire2006，15，1： | 1 |
| 13 | Histone deacetylases and cancer: causes and therapies 显示文摘 | Paul AM Richard AR VictoriaMR | 2001 | Nat Reviews Cancer2001，1，12： | 1 |
| 14 | Utility of minimum clinically important difference in assessing pain,disability,and health state after transforaminal lumbar interbody fusion for degenerative lumbar spondylolisthesis显示文摘 | Parker SL Adogwa O Paul AR | 2011 | J Neurosurg Spine2011，14，5： | 1 |
| 15 | Ch itin and ch itosan poly -mer s:Ch emistr y , solubility and fiber for mation显示文摘 | Pillai CKS Paul W Sh ar ma CP | 2009 | Pr ogr essin Poly mer Science2009，34，7： | 1 |
| 16 | Characterization of a novel coronavirus associated with severe acute respiratory syndrome 显示文摘 | Paul AR Steven O Stephan SM | 2003 | Science2003，300，5624： | 1 |
| 17 | A single center comparison of coiling versus stent assisted coiling in 90 consecutive paraophthalmic region aneurysms显示文摘 | Colby GP Paul AR Radvany MG | 2012 | J Neurointerv Surg2012，4，2： | 1 |
| 18 | Bacterial diversity within the human subgingival crevice 显示文摘 | Ian K Paul WL David AR | 1999 | Proe Natl Acad Sci USA1999，96，14： | 1 |
| 19 | Long-term results of infusional 5-FU, mitomycin-C and radiation as primary management of esophageal carcinoma显示文摘 | Coia LR Engstrom PF Paul AR | 1991 | Int J Radiat Oncol Biol Phys1991，20，： | 1 |
| 20 | Review of the temporal and geographical distribution of measles virus genotupes in the pre- vaccine and postvaecine eras显示文摘 | Miehaela AR Jennifer SR Paul AR | 2005 | Virol J2005，22，2： | 1 |
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