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| 1 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017,17,27: | 3 |
| 2 | 牙本质胞外基质对人血管内皮细胞增殖的影响显示文摘目的 :探讨牙本质胞外基质成分 (dentineextracellularmatrixcomponents,DM)对血管内皮细胞增殖的影响。方法 :用 10 0 g/LEDTA ,在pH 7.2和蛋白酶抑制剂存在的条件下 ,从健康人牙中提取DM。第 3代人脐静脉内皮细胞 (humanumbilicalveinendothelialcell,HUVEC) ,在含有不同浓度DM培养液中培养 8d ,每 2天计数 1次 ,绘制生长曲线。并对第 8天对照 (不含DM培养 )与实验组的细胞数进行Mann -Whitney统计分析。结果 :HUVEC在DM浓度为 0 .0 0 0 1、0 .0 0 1和 0 .0 1mg/mL的培养液中培养时较对照分别增长了 4 9% (P =0 .0 0 0 6 )、2 1%和 9% ,在DM浓度为 0 .1和 1mg/mL时 ,减少 2 2 %和 74 % (P =0 .0 0 0 3)。 结论 :DM对血管内皮细胞增殖具有计量依赖型影响效应。低浓度DM可刺激内皮细胞的增殖 ,而高浓度DM则可抑制该细胞的增殖。提示 :这一计量依赖型效应可能正是牙髓损伤后造成局部不同的血管形成方式 ,并最终导致不同修复结果的原因。 | 张蓉 Gay Smith Alastair J Sloan Paul R Cooper 赵守亮 Athony J Smith | 2004 | 牙体牙髓牙周病学杂志2004,14,6: | 2 |
| 3 | 成人2型糖尿病不同筛查及预防策略成本效益分析显示文摘目的 比较针对2型糖尿病预防及治疗的4种筛查策略及随后予以的干预措施:(a)筛查2型糖尿病患者使其能接受早期检查及治疗,(b)筛查2型糖尿病和糖耐量受损患者,对糖耐量受损的人群予以生活方式干预以延缓或预防糖尿病的发生,(c)同(b)但予以药物干预措施,(d)不筛查。
设计 成本效益决策分析建立在对概率的发展和评估基础上,是从筛查到死亡的综合性经济决策分析模型。
研究对象 一组假设人群,筛查时年龄45岁,高于平均糖尿病风险水平。
数据来源 电子书目数据库收录的已发表的临床试验和流行病学研究;补充数据分别来自英国和威尔士健康统计署、风险筛查(STAR)研究和ADDITION研究的Leicester部分。
方法 建立一种决策树/Markov混合模型,以模拟每一种筛查策略的长期效用,包括临床和成本效益终点。该模型假设水平跨度为50年时间,其成本效益折损率为3.5%。采用敏感度分析以验证模型假设及确定哪种模型数据输入对结果的影响最大。
结果 与不筛查策略比较,筛查2型糖尿病、筛查糖尿病和糖耐量受损并予以生活方式干预、筛查糖尿病和糖耐量受损并予以药物干预治疗3种策略,每获得一个质量调整生命年(QALY)估计所需成本分别为(每年成本效益贴现率为3.5%)14150英镑(17560欧元;27860美元)、6242英镑和7023英镑。在支付意愿阈值为20000英镑时,各主动筛查策略通过干预产生的成本效益概率分别为49%,93%和85%。
结论 对年龄45岁、高于平均风险水平的人群进行2型糖尿病和糖耐量受损的筛查,并对糖耐量受损人群予以适当的干预似乎具有很好的成本效益。单独筛查糖尿病而不对糖耐量受损人群予以干预的策略具有的成本效益仍不确定,需要进一步研究确定早期检测糖尿病的作用。 | Clare L Gillies Paul C Lambert Keith R Abrams Alex J Sutton Nicola J Cooper Ron T Hsu Melanie J Davies Kamlesh Khunti 张晓梅(译) 纪立农(校) | 2008 | 英国医学杂志中文版2008,11,5: | 1 |
| 4 | Subgroups of patients with cancer with different symptom experiences and quality - of - life out- comes : A cluster analysis 显示文摘 | Miaskowski C Cooper BA Paul SM | 2006 | Oncol Nurs Forum2006,33,5: | 1 |
| 5 | A three-phase study to develop and validate a Chinese coping strategies scales in Greater China显示文摘 | Oi-ling Siu Paul E. Spector Cary L. Cooper | 2006 | Personality and Individual Differences2006,,3: | 1 |
| 6 | 11β-Hydroxysteroid Dehydrogenase 1: Translational and Therapeutic Aspects显示文摘 | Laura L. Gathercole Gareth G. Lavery Stuart A. Morgan Mark S. Cooper Alexandra J. Sinclair Jeremy W. Tomlinson Paul M. Stewart | 2013 | Endocrine Reviews2013,,4: | 1 |
| 7 | A review of the design and performance of vertical flow and hybrid reed bed treatment systems 显示文摘 | Paul Cooper | 1999 | Water Science and Technology1999,40,3: | 1 |
| 8 | The Unique Characteristics of “Upper” Lumbar Disc Herniations显示文摘 | Scott P. Sanderson John Houten Thomas Errico David Forshaw Joel Bauman Paul R. Cooper | 2004 | Neurosurgery2004,,2: | 1 |
| 9 | Total synthesis of a functional designer eukaryotic chromosome 显示文摘 | Annaluru N Muller H Mitchell L A Ramalingam S Stracquadanio G Richardson S M Dymond J S Kuang Z Scheifele L Z Cooper E M Cai Y Z Zeller K Agmon N Han J S Hadjithomas M Tullman J Caravelli K Cirelli K Guo Z Y London V Yeluru A Murugan S Kandavelou K Agier N Fischer G Yang K Martin J A Bilgel M Bohutski P Boulier K M Capaldo B J Chang J Charoen K Choi W J Deng P Dicarlo J E Doong J Dunn J Feinberg J I Fernandez C Floria C E Gladowski D Hadidi P Ishizuka I Jabbari J Lau C Y L Lee P A Li S Lin D Linder M E Ling J Liu J Liu J London M Ma H Mao J Mcdade J E Mcmillan A Moore A M Oh W C Ouyang Y Patel R Paul M Paulsen L C Qiu J Rhee A Rubashkin M G Soh I Y Sotuyo N E Srinivas V Suarez A Wong A Wong R Xie W R Xu Y J Yu A T Koszul R Bader J S Boeke J D Chandrasegaran S | 2014 | Science2014,344,6179: | 1 |
| 10 | Retinal Microvascular Abnormalities and MRI-Defined Subclinical Cerebral Infarction: The Atherosclerosis Risk in Communities Study显示文摘 | Lawton S. Cooper Tien Y. Wong Ronald Klein A Richey Sharrett R Nick Bryan Larry D. Hubbard David J. Couper Gerardo Heiss Paul D. Sorlie | 2006 | Stroke2006,,1: | 1 |
| 11 | Percutaneous tracheostomy in critically ill patients: A prospective, randomized comparison of two techniques显示文摘 | Joseph L. Nates D. James Cooper Paul S. Myles Carlos D. Scheinkestel David V. Tuxen | 2000 | Critical Care Medicine2000,,11: | 1 |
| 12 | A brief,multidimensional,problem-solving psychotherapy outcome measure显示文摘 | Heppner P Paul Caren Cooper Amy Mulholland | 2001 | Journal of Counseling Psychology2001,48,3: | 1 |
| 13 | Early decompressive craniectomy for patients with severe traumatic brain injury and refractory intracranial hypertension—A pilot randomized trial显示文摘 | D. James Cooper Jeffrey V. Rosenfeld Lynnette Murray Rory Wolfe Jennie Ponsford Andrew Davies Paul D’Urso Vincent Pellegrino Gregory Malham Thomas Kossmann | 2008 | Journal of Critical Care2008,,3: | 1 |
| 14 | SECM characterization of Pt-Ru-W and Pt-Ru-Co ternary thin film combinatoril libraries as anode electrocatalyst for PEMFC显示文摘 | Lu Guojin Cooper James S McGinn Paul J | 2006 | Journal of Power Sources2006,161,: | 1 |
| 15 | Myocardial Recovery in Peripartum Cardiomyopathy: Prospective Comparison With Recent Onset Cardiomyopathy in Men and Nonperipartum Women显示文摘 | Leslie T. Cooper Paul J. Mather Jeffrey D. Alexis Daniel F. Pauly Guillermo Torre-Amione Ilan S. Wittstein G. William Dec Mark Zucker Jagat Narula Kevin Kip Dennis M. McNamara | 2012 | Journal of Cardiac Failure2012,,1: | 1 |
| 16 | Diffusion rate of polyethylene glycol into cell walls of red pine following vacuum impregnation显示文摘 | Dragica Jeremic Carlos Quijano-Solis Paul Cooper | 2009 | Cellulose2009,,2: | 1 |
| 17 | Thyrotropin and Thyroid Cancer Diagnosis: A Systematic Review and Dose-Response Meta-Analysis显示文摘 | Donald S. A. McLeod Karen F. Watters Anthony D. Carpenter Paul W. Ladenson David S. Cooper Eric L. Ding | 2012 | The Journal of Clinical Endocrinology & Metabolism2012,,8: | 1 |
| 18 | Cost-Effectiveness of Aspirin, Celecoxib, and Calcium Chemoprevention for Colorectal Cancer显示文摘 | Hazel Squires Paul Tappenden Katy Cooper Christopher Carroll Richard Logan Daniel Hind | 2011 | Clinical Therapeutics2011,,9: | 1 |
| 19 | Alterations of the blood–brain barrier in cerebral white matter lesions in the ageing brain显示文摘 | Julie E. Simpson Stephen B. Wharton James Cooper Catherine Gelsthorpe Lynne Baxter Gillian Forster Pamela J. Shaw George Savva Fiona E. Matthews Carol Brayne Paul G. Ince | 2010 | Neuroscience Letters2010,,3: | 1 |
| 20 | Subgroups of patients with cancer with different symptom experiences and quality - of- life outcomes : a cluster analysis 显示文摘 | Miaskowski C Cooper BA Paul SM | 2006 | Oncol Nurs Forum2006,33,5: | 1 |