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| 1 | 北祁连山西段熬油沟蛇绿岩SHRIMP分析结果及其地质意义显示文摘本文通过对北祁连山西段熬油沟蛇绿岩中辉绿岩岩墙中的锆石 SHRIMP法年龄的测定 ,确定出熬油沟蛇绿岩形成于中元古代早期 (约 1777Ma) ,这是迄今为止我国发现的最古老的蛇绿岩。该年龄测定的结果还暗示了本区在 146 6 Ma和5 0 7Ma各有一次地质事件 ,前者可能代表了中元古代早期的洋盆闭合的下限年龄 ,后者代表一次加里东期区域变质事件 ,并且本区可能还存在未出露的新太古代结晶基底 (2 5 6 1Ma)。 | 张招崇 周美付 Paul T ROBINSON 毛景文 杨建民 左国朝 | 2001 | 岩石学报2001，17，2： | 42 |
| 2 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 3 | 都兰花岗岩锆石SHRIMP定年及柴北缘超高压带花岗岩年代学格架显示文摘柴北缘超高压带东端都兰地区花岗岩锆石SHRIMP U-Pb定年结果表明,野马滩东岩体的年龄为(406.6±3.5)Ma,巴立给哈滩西岩体的年龄分别为(407.3±4.3)和(397±6)Ma,水文站北岩体的年龄分别为(404.5±4.0)和(397.0±3.7)Ma,水文站南岩体的年龄为(380.5±5.0)Ma,察察公麻岩体的年龄分别为(382.5±3.6)和(372.5±2.8)Ma.从年龄上看,这些花岗岩明显地分为两期:早期的为407-397 Ma,晚期的为383-373 Ma.它们主要为准铝质-弱过铝质的石英闪长岩、花岗闪长岩和二长花岗岩.岩石地球化学研究表明,大多数样品为钙碱性系列,少数样品为钙性或碱钙性系列,其中,早期花岗岩的87Sr/86Sr比值(0.7082-0.7110)和模式年龄(T2DM=1.41-1.90 Ga)高于晚期花岗岩(0.7072-0.7091,T2DM=1.07-1.38 Ga),但晚期花岗岩的εNd(t)值(0.6- -3.0)高于早期花岗岩(-3.2- -9.3),表明早期花岗岩可能起源于早中元古代的大陆壳;而晚期花岗岩起源于晚中元古代玄武质地壳.结合区域地质构造特征,可以认为,早期花岗岩的形成与俯冲板块的断离并折返有关,而晚期花岗岩的形成与造山带岩石圈地幔拆沉作用有关. | 吴才来 郜源红 李兆丽 雷敏 秦海鹏 李名则 刘春花 Ronald B FROST Paul T ROBINSON Joseph L WOODEN | 2014 | 中国科学:地球科学2014，44，10： | 27 |
| 4 | Dur’ngoi Ophiolite in East Kunlun, Northeast Tibetan Plateau: Evidence for Paleo-Tethyan Suture in Northwest China显示文摘The A’nyemaqen (阿尼玛卿) ophiolite belt along the southern margin of the East Kunlun (昆仑) Mountains marks the suture formed by the closure of paleo-Tethys. The Dur’ngoi ophiolite in the eastern part of this belt consists of meta-peridotite, mafic-ultramafic cumulates, sheeted dikes and basaltic lavas. The meta-peridotites consist of dunite, harzburgite, lherzolite, feldspar-bearing lherzolite and garnet-bearing lherzolite and contain residual spinel with Cr# [100×Cr/(Cr+Al)] ranging from 30 to 57 and Mg# [100×Mg/(Mg+Fe2+)] ranging from 50 to 75, indicating an Aland Mg-rich series. The meta-peridotites have a relatively narrow range of composition with Mg# of 89.2–92.6, Al2O3 contents of (1–4) wt.% and slightly depleted chondrite normalized REE patterns, indicating that they represent relict mantle material that has undergone intermediate to low degrees of partial melting. Garnets in the lherzolite are andradite, enriched in Ca and Fe and depleted in Mg and Al (And=95–97, Pyr=0.3–5, Gro=0–3), indicating a metamorphic origin. The cumulate rocks mainly consist of dunite, wehrlite, pyroxenite and gabbro. A well-layered gabbro-pyroxenite complex is defined by modal variations in plagioclase and pyroxene. Blocks of garnet-pyroxenite or rodingite are locally present in the meta-peridotites. Garnets in the cumulate rocks are grossular (Gro=69–90, And=9–19, Br=1–12), also metamorphic origin. The diabase dikes are moderately depleted in LREE [(La/Sm)N=0.5–0.8] and HREE resulting in slightly convex chondrite-normalized patterns with slightly positive Eu anomalies (δEu=1.1–1.3). The basaltic lavas have REE patterns similar to those of MORB with (La/Sm)N ratios of 0.5–1 and small negative Eu anomalies. They appear to have been derived from a depleted mantle source and to have undergone little or no differentiation during crystallization. SHRIMP U-Pb dating of zircons from the basalts yields 206Pb/238U ages of 276–319 Ma (average 308.0±4.9 Ma). The Dur’ngoi ophiolite is interpreted as a dismembered fragment of paleo-oceanic crust emplaced during closure of the paleo-Tethyan Ocean basin. Three other suites of oceanic lavas are recognized in the area: island arc volcanic (IAV) rocks, possible back arc basin (BAB) basalts and possible post-collisional volcanic (PCV) and plutonic rocks. The distribution of these rocks suggests north-directed subduction. Opening of the A’nyemaqen oceanic basin started at least as early as Late Carboniferous (308 Ma) and the basin probably closed during the Early Triassic. The IAV formed in Late Permian (260 Ma), the BAB in Early–Middle Triassic, and the PCV in Late Triassic. Several large scale, ductile, sinistral strike-slip fault zones, extending hundreds to thousands kilometers, formed along or north of the suture during the Early–Late Triassic, e.g., they are the south margin fault zone of East Kunlun (200–220 Ma), the Altyn Tagh fault (220–230 Ma), and the North Qaidam fault zone (240–250 Ma). These strike-slip faults were probably generated by oblique subduction and closure of the paleo-Tethyan Ocean basin, possibly during exhumation of the subducted plate or uplift of the overriding plate, coincident with post-collisional magmatism. | 杨经绥 史仁灯 吴才来 王希斌 Paul T Robinson | 2009 | Journal of China University of Geosciences2009，20，2： | 26 |
| 5 | Zircon SHRIMP U-Pb dating of granites from Dulan and the chronological framework of the North Qaidam UHP belt, NW China显示文摘Zircon SHRIMP dating of granites from Dulan,east segment of North Qaidam UHP belt shows that they are 406.6±3.5 Ma for Yematan-E,407.3±4.3 and 397±6 Ma for Balijiehatan-W,404.5±4.0 and 397.0±3.7 Ma for Shuiwenzhan-N,380.5±5.0 Ma for Shuiwenzhan-S,382.5±3.6 and 372.5±2.8 Ma for Chachagongma.These granites from Dulan represent the products of the third and fourth periods of Paleozoic magmatism in North Qaidam.Geochemically,the granitoids with metalumious to weak peratuminous are quartz diorite,granodiorite,and granite in composition and mainly belong to calc-alkaline series,a few samples to calc or alkali-calc series.The third period of granites is a rock association of granodiorite+granite,with initial 87Sr/86Sr ratios from 0.7082 to 0.7110 and T2DM model ages from 1.41–1.90 Ga;and the fourth period of granites is a rock association of quartz diorite+granodiorite+granite,with initial 87Sr/86Sr ratios from 0.7072 to 0.7091 and T2DM model ages from 1.07–1.38 Ga.Therefore,the third period of granites has higher initial 87Sr/86Sr ratios and T2DM model ages.On the contrary,the fourth period of granites has Nd(t)values from 0.6 to-3.0,higher than that of the third granite with Nd(t)values-3.2 to-9.3.Thus,the data comparison indicates that the third granites may derive from Paleo-proterzoic continental crust with mantle material whereas the fourth granites may derive from the Meso-proterzoic basalt crust with continental material.Combined with regional geology,we thought that the third granites were formed relative to plate exhumation and the fourth granites to delamination of the lithospheric mantle. | WU CaiLai GAO YuanHong LI ZhaoLi LEI Min QIN HaiPeng LI MinZe LIU ChunHua Ronald B FROST Paul T ROBINSON Joseph L WOODEN | 2014 | Science China Earth Sciences2014，57，12： | 21 |
| 6 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 7 | Sporadic versus hereditary gastrinomas of the duodenum and pancreas: Distinct clinico-pathological and epidemiological features显示文摘Gastrinomas are defined as gastrin secreting tumors that are associated with Zollinger-Ellison syndrome (ZES). ZES is characterized by elevated fasting gastrin serum levels, positive secretin stimulation test and clinical symptoms such as recurrent peptic ulcer disease, gastroesophageal re?ux disease and occasional diarrhea. Genetically, nonhereditary (sporadic) gastrinomas are distinguished from hereditary gastrinomas, which are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome. In general, duodenal gastrinomas are small and solitary if they are sporadic and multiple as well as hereditary. The sporadic gastrinomas occur in the duodenum or in the pancreas while the hereditary gastrinomas almost all occur in the duodenum. Our series of 77 sporadic duodenal neuroendocrine tumors (NETs) includes 18 patients (23.4%) with gastrinomas and ZES. Of 535 sporadic NETs in the pancreas collected from the NET archives of the departments of pathology in Zürich, Switzerland, and Kiel, Germany, 24 patients (4.5%) suffered from sporadic pancreatic gastrinomas and ZES. These NETs have to be distinguished fromtumors with immunohistochemical positivity for gastrin but without evidence of ZES. An additional 19 patients suffered from MEN1 and ZES. These patients showed exclusively duodenal gastrinomas, but not pancreatic gastrinomas. The prognosis of sporadic and MEN1- associated duodenal gastrinomas is better than that of pancreatic gastrinomas, since they progress slowly to liver metastasis. In summary, sporadic and MEN1- associated gastrinomas in the duodenum and pancreas show different clinico-pathological and genetic features. The incidence of sporadic duodenal gastrin-producing tumors is increasing, possibly due to optimized diagnostic procedures. In contrast, pancreatic MEN1- associated gastrinomas seem to be extremely rare. A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functionally inactive NETs expressing gastrin, but not as gastrinomas. | Martin Anlauf Nele Garbrecht Tobias Henopp Anja Schmitt Regina Schlenger Andreas Raffel Markus Krausch Oliver Gimm Claus F Eisenberger Wolfram T Knoefel Henning Dralle Paul Komminoth Philipp U Heitz Aurel Perren Günter Klppel | 2006 | World Journal of Gastroenterology2006，12，34： | 7 |
| 8 | Comparison of esophageal capsule endoscopy and esophagogastroduodenoscopy for diagnosis of esophageal varices显示文摘AIM: To investigate the utility of esophageal capsule endoscopy in the diagnosis and grading of esophageal varices. METHODS: Cirrhotic patients who were undergo-ing esophagogastroduodenoscopy (EGD) for variceal screening or surveillance underwent capsule endos-copy. Two separate blinded investigators read each capsule endoscopy for the following results: variceal grade, need for treatment with variceal banding or prophylaxis with beta-blocker therapy, degree of portal hypertensive gastropathy, and gastric varices. RESULTS: Fifty patients underwent both capsule and EGD. Forty-eight patients had both procedures on the same day, and 2 patients had capsule endoscopy within 72 h of EGD. The accuracy of capsule endos- copy to decide on the need for prophylaxis was 74%, with sensitivity of 63% and specificity of 82%. Inter-rater agreement was moderate (kappa = 0.56). Agree-ment between EGD and capsule endoscopy on grade of varices was 0.53 (moderate). Inter-rater reliability was good (kappa = 0.77). In diagnosis of portal hyper-tensive gastropathy, accuracy was 57%, with sensitiv-ity of 96% and specificity of 17%. Two patients had gastric varices seen on EGD, one of which was seen on capsule endoscopy. There were no complications from capsule endoscopy.CONCLUSION: We conclude that capsule endoscopy has a limited role in deciding which patients would benefit from EGD with banding or beta-blocker thera-py. More data is needed to assess accuracy for staging esophageal varices, PHG, and the detection of gastric varices. | Catherine T Frenette John G Kuldau Donald J Hillebrand Jill Lane Paul J Pockros | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 9 | High-density SNP-based genetic maps for the parents of an outcrossed and a selfed tetraploid garden rose cross, inferred from admixed progeny using the 68k rose SNP array显示文摘Dense genetic maps create a base for QTL analysis of important traits and future implementation of marker-assisted breeding.In tetraploid rose,the existing linkage maps include<300 markers to cover 28 linkage groups(4 homologous sets of 7 chromosomes).Here we used the 68k WagRhSNP Axiom single-nucleotide polymorphism(SNP)array for rose,in combination with SNP dosage calling at the tetraploid level,to genotype offspring from the garden rose cultivar‘Red New Dawn’.The offspring proved to be not from a single bi-parental cross.In rose breeding,crosses with unintended parents occur regularly.We developed a strategy to separate progeny into putative populations,even while one of the parents was unknown,using principle component analysis on pairwise genetic distances based on sets of selected SNP markers that were homozygous,and therefore uninformative for one parent.One of the inferred populations was consistent with self-fertilization of‘Red New Dawn’.Subsequently,linkage maps were generated for a bi-parental and a self-pollinated population with‘Red New Dawn’as the common maternal parent.The densest map,for the selfed parent,had 1929 SNP markers on 25 linkage groups,covering 1765.5 cM at an average marker distance of 0.9 cM.Synteny with the strawberry(Fragaria vesca)genome was extensive.Rose ICM1 corresponded to F.vesca pseudochromosome 7(Fv7),ICM4 to Fv4,ICM5 to Fv3,ICM6 to Fv2 and ICM7 to Fv5.Rose ICM2 corresponded to parts of F.vesca pseudochromosomes 1 and 6,whereas ICM3 is syntenic to the remainder of Fv6. | Mirjana Vukosavljev Paul Arens Roeland E Voorrips Wendy P C van't Westende G D Esselink Peter M Bourke Peter Cox W Eric van de Weg Richard G F Visser Chris Maliepaard Marinus J M Smulders | 2016 | Horticulture Research2016，3，1： | 6 |
| 10 | Artificial intelligence in gastroenterology: A state-of-the-art review显示文摘The development of artificial intelligence(AI)has increased dramatically in the last 20 years,with clinical applications progressively being explored for most of the medical specialties.The field of gastroenterology and hepatology,substantially reliant on vast amounts of imaging studies,is not an exception.The clinical applications of AI systems in this field include the identification of premalignant or malignant lesions(e.g.,identification of dysplasia or esophageal adenocarcinoma in Barrett’s esophagus,pancreatic malignancies),detection of lesions(e.g.,polyp identification and classification,small-bowel bleeding lesion on capsule endoscopy,pancreatic cystic lesions),development of objective scoring systems for risk stratification,predicting disease prognosis or treatment response[e.g.,determining survival in patients post-resection of hepatocellular carcinoma),determining which patients with inflammatory bowel disease(IBD)will benefit from biologic therapy],or evaluation of metrics such as bowel preparation score or quality of endoscopic examination.The objective of this comprehensive review is to analyze the available AI-related studies pertaining to the entirety of the gastrointestinal tract,including the upper,middle and lower tracts;IBD;the hepatobiliary system;and the pancreas,discussing the findings and clinical applications,as well as outlining the current limitations and future directions in this field. | Paul T Kröner Megan ML Engels Benjamin S Glicksberg Kipp W Johnson Obaie Mzaik Jeanin E van Hooft Michael B Wallace Hashem B El-Serag Chayakrit Krittanawong | 2021 | World Journal of Gastroenterology2021，27，40： | 6 |
| 11 | 新生儿心电图判读指南(二)显示文摘 | 魏丽 周同甫 Schwartz PJ Garson A Jr Paul T | 2009 | 中华妇幼临床医学杂志(电子版)2009，5，1： | 4 |
| 12 | Energy balance closure at FLUXNET sites显示文摘 | Kell Wilson Allen Goldstein Eva Falge Marc Aubinet Dennis Baldocchi Paul Berbigier Christian Bernhofer Reinhart Ceulemans Han Dolman Chris Field Achim Grelle Andreas Ibrom B.E Law Andy Kowalski Tilden Meyers John Moncrieff Russ Monson Walter Oechel John T | 2002 | Agricultural and Forest Meteorology2002，，1： | 4 |
| 13 | Pulmonary complications of transcatheter arterial chemoembolization for hepatocellular carcinoma显示文摘Transcatheter arterial chemoembolization(TACE) is an effective palliative intervention that is widely accepted for the management of hepatocellular carcinoma(HCC). Post-TACE pulmonary complications resulting in acute lung injury(ALI) or acute respiratory distress syndrome(ARDS) are rare events. Pulmonary complications after TACE are thought to be related to chemical injury subsequent to the migration of the infused ethiodized oil or chemotherapeutic agent to the lung vasculature, facilitated by arteriovenous(AV) shunts within the hyper-vascular HCC. We review herein the literature on pulmonary complications related to TACE for HCC. Post-TACE pulmonary complications have included pulmonary oil embolism, interstitial pneumonitis, chemical pneumonitis, ALI, ARDS, lipoid pneumonia, acute eosinophilic and neutrophilic pneumonia, bilious pleuritis, pulmonary abscess, pulmonary tumor embolism, and possibly pulmonary metastasis with HCC. The risk factors associated with post-TACE pulmonary complications identified in the literature include large hyper-vascular HCC with AV shunts, large-volume Lipiodol infusion, and embolization via the right inferior phrenic artery. However, the absence of known risk factors is not a guarantee against serious complications. An astute awareness of the potential post-TACE pulmonary complications should expedite appropriate therapeutic interventions and increase potential for early recovery. | Quan M Nhu Harry Knowles Paul J Pockros Catherine T Frenette | 2016 | World Journal of Respirology2016，6，3： | 4 |
| 14 | Chronic kidney disease after nephrectomy in patients with renal cortical tumours: a retrospective cohort study显示文摘 | William C Huang Andrew S Levey Angel M Serio Mark Snyder Andrew J Vickers Ganesh V Raj Peter T Scardino Paul Russo | 2006 | Lancet Oncology2006，，9： | 4 |
| 15 | Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales显示文摘 | C.P Wilkinson Frederick L Ferris Ronald E Klein Paul P Lee Carl David Agardh Matthew Davis Diana Dills Anselm Kampik R Pararajasegaram Juan T Verdaguer | 2003 | Ophthalmology2003，，9： | 4 |
| 16 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 17 | 农村人口亚临床动脉粥样硬化及其与冠状动脉疾病危险因素的关系显示文摘在美国〈65岁的人群中,包括无症状的个体在内,每年有超过15万的心血管事件发生。冠状动脉钙化(coronary artery calcium,CAC)是冠状动脉疾病(coronary artery disease,CAD)的亚临床指标,可提高无症状个体的危险分层。该研究旨在评估农村人口的CAC发生率,确定CAD传统危险因素和CAC评分之间的相关性。方法:2011年1月至2012年12月,研究人员对来自阿巴拉契亚中部地区无症状个体的CAC情况进行筛查,根据Agatston钙化评分将受试者分为4种CAC水平:无(CAC=0),轻度(CAC=1~99),中度(CAC=100~399)和重度(CAC≥400)。 | 刘莉 叶鹏 Mamudu HM Paul T Veeranki SP Wang L Panchal HB Budoff M | 2015 | 中华高血压杂志2015，23，8： | 3 |
| 18 | 轮胎工业用更安全的操作油显示文摘在欧洲 ,立法和公众压力正在使欧洲市场上的操作油性质发生变化。这引起欧洲橡胶行业对不使用有潜在致癌危险芳香油的新型轮胎和橡胶配方进行评述。本文对这一状况进行了研究 ,并探讨了美国市场上可能出现的动态 ,介绍了不同产品的需求量以及北美操作油和润滑基油制造不断变化的局面。 | Paul W H T Juergen E P 吴淑华 | 2002 | 轮胎工业2002，22，5： | 3 |
| 19 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 20 | ENETS Consensus Guidelines for the Management of Patients with Digestive Neuroendocrine Neoplasms: Functional Pancreatic Endocrine Tumor Syndromes显示文摘 | Jensen Robert T Cadiot Guillaume Brandi Maria L De Herder Wouter W Kaltsas Gregory Komminoth Paul Scoazec Jean-yves Salazar Ramon Sauvanet Alain Kianmanesh Reza | 2012 | Neuroendocrinology2012，，2： | 3 |
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