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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | Paleocene-Eocene record of ophiolite obduction and initial India-Asia collision,south central Tibet显示文摘 | DING L PAUL K WAN X | 2005 | Tectonics2005，24，： | 1 |
| 3 | Novel polymeric microspheres containing norcantharidin for chemoembolization显示文摘 | Liu X Heng W S Paul | 2006 | J Control Release2006，116，1： | 1 |
| 4 | Provenance of aeoliansediment in the Taklamakan Desert of western China,in-ferred from REE and major-elemental data显示文摘 | Yang X P Zhu B Q Paul D | 2007 | QuaternaryInternational2007，175，： | 1 |
| 5 | Ketamine anesthesia during the first week of life can cause long- lasting cognitive deficits in rhesus monkeys显示文摘 | Paule MG Li M Allen RR Liu F Zou X Hotchkiss C | 2011 | Neurotoxicol Ter- atol2011，33，2： | 1 |
| 6 | A review of copper cyanide recovery technologies for the cyanidation of copper containing gold ores 显示文摘 | Dai X W Andrew Simons Paul Breuer | 2012 | Minerals Engineer- ing2012，25，1： | 1 |
| 7 | Sequence comparison of open reading frames 2 to 5 of low and high virulence United States isolates of porcine reproductive and respiratory syndrome virus显示文摘 | Meng X J Paul P S Halbur P G | 1995 | J Gen Virol1995，76，12： | 1 |
| 8 | Hybrid inter and intra wavelet scale image restoration显示文摘 | Zhang L Paul B Wu X | 2003 | Pattern Recognition2003，36，8： | 1 |
| 9 | Comparative pathogenicity of nine US porcine reproductive and respiratory syndrome virus (PRRSV) isolates in a five-week-old cesarean-derived, colostrum-deprived pig model显示文摘 | HALBUR P PAUL P MENG X | 1996 | J Vet Diagn Invest1996，8，： | 1 |
| 10 | Multiscale LMMSE-based image denoising with optimal wavelet selection显示文摘 | ZHANG L PAUL B WU X | 2005 | IEEE Trans Circuits and Systems for Video Technology2005，15，4： | 1 |
| 11 | Quantification of the re- lationship between the environment and Fusarlum head blight, Fusarium pathogen density, and mycotoxins in winter wheat in Europe 显示文摘 | Alissa B K Paul P A Xu X M etal | 2012 | Europe Plant Pathol2012，133，97： | 1 |
| 12 | Managing risks in green building supply chain显示文摘 | Patrick X W Zou Paul Conanil | 2012 | Architectural Engineering and Design Management2012，8，2： | 1 |
| 13 | Plate Tectonics and Basin Subsidence History显示文摘 | Xie X Y Paul L H | | 0，，1： | 1 |
| 14 | Finite element method based ma- chining simulation environment for analyzing part errors induced during milling of thin-walled components显示文摘 | Jitender K R Paul X | 2008 | In- ternational Journal of Machine Tools & Manufacture2008，，48： | 1 |
| 15 | Multi-degree reduction of Bezier curves using reparameterization 显示文摘 | Chen X D Ma W Y Paul J C | 2011 | Computer-Aided Design2011，43，2： | 1 |
| 16 | Experimental Investigation of the Electrical Characteristics and Initiation Dynamics of Pulsed High- Voltage Glow Discharge显示文摘 | Tian X B Chu Paul K | 2001 | Appl Phys2001，34，： | 1 |
| 17 | Conserved small protein associates with the multidrug efflux pump AcrB and differ- entially affects antibiotic resistance显示文摘 | Hobbs EC Yin X Paul B J | 2012 | Proc Nail Acad Sci U S A2012，109，16： | 1 |
| 18 | Comparative pathogenicity of nine US porcine reproductive and respiratory syndrome virus (PRRSV) isolates in a five-week-old cesarean-derived, colostrum-deprived pig model 显示文摘 | Halbur P G Paul P S Meng X J | 1996 | J Vet Diagn Invest1996，8，1： | 1 |
| 19 | Cubic B-spline curve approximation by curve unclamping显示文摘 | Chen X D Ma W Y Paul J C | 2010 | Computer-Aided Design2010，42，6： | 1 |
| 20 | Tofacitinib in colitis显示文摘 | Paul S Roblin X active ulcerative of medicine 2012 Sandborn WJ | 1959 | The New England journal1959，367，20： | 1 |
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