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| 1 | Immunological roulette: Luck or something more? Considering the connections between host and environment in TB显示文摘Accurate prediction of which patient will progress from a sub-clinical Mycobacterium tuberculosis infection to active tuberculosis represents an elusive,yet critical,clinical research objective.From the individual perspective,progression can be considered to be the product of a series of unfortunate events or even a run of bad luck.Here,we identify the subtle physiological relationships that can influence the odds of progression to active TB and how this progression may reflect directed dysbiosis in a number of interrelated systems.Most infected individuals who progress to disease have apparently good immune responses,but these responses are,at times,compromised by either local or systemic environmental factors.Obvious disease promoting processes,such as tissue-damaging granulomata,usually manifest in the lung,but illness is systemic.This apparent dichotomy between local and systemic reflects a clear need to define the factors that promote progression to active disease within the context of the body as a physiological whole.We discuss aspects of the host environment that can impact expression of immunity,including the microbiome,glucocorticoid-mediated regulation,catecholamines and interaction between the gut,liver and lung.We suggest the importance of integrating precision medicine into our analyses of experimental outcomes such that apparently conflicting results are not contentious,but rather reflect the impact of these subtle relationships with our environment and microbiota. | John E Pearl Mrinal Das Andrea M Cooper | 2018 | Cellular & Molecular Immunology2018，15，3： | 3 |
| 2 | Urologic diseases in America project: urolithiasis显示文摘 | Pearle M S Calhoun E A Curhan G C | 2005 | J Urol2005，173，： | 1 |
| 3 | Prospective randomized trial comparing shock wave lithotripsy and ureteroscopy for management of distal ureteral calculi显示文摘 | Pearle M S Nadler R Bercowsky E etal | 2001 | J Urol2001，166，： | 1 |
| 4 | Prospective randomized trial comparing shock wave lithotripsy and ureteroscopy for management of distal ureteral calculi显示文摘 | Pearle MS Nadler R Bercowsky E | 2001 | J Urol2001，166，4： | 1 |
| 5 | Development of Xenopusresource centers:The national Xenopus re-source and the European Xenopus resource center显示文摘 | Pearl E J Grainger R M Guille M | 2012 | Genesis2012，50，3： | 1 |
| 6 | Laparoseopic extraperitoneal bladder diverticulectomy: initial experience 显示文摘 | Nadler R B Pearle MS MeDougall E M | 1995 | Urology1995，45，： | 1 |
| 7 | Prospective randomized trial comparing shock wave lithotripsy and ureteroscopy for management of distal ureteral calculi显示文摘 | Pearle MS Nadler R Bercowsky E | 2001 | J Urol2001，166，： | 1 |
| 8 | Inherited disorders of neurotransmitters in children and adults显示文摘 | Pearl PL Gapp PK Novotny E J | 2005 | Clin Biochem2005，38，12： | 1 |
| 9 | Prospective randomized trial comparing shock wave lithotripsy and ureteroscopy for management of distal ureteral calculi显示文摘 | Nadler R Bercowsky E | 2001 | J Urol2001，166，4： | 1 |
| 10 | Prospective randomized trial comparing shock wave lithotripsy and ureteroseopy for management of distal ureteral caleuli显示文摘 | Pearle M S Nadler R Bercowsky E | 2001 | J Urol2001，166，4： | 1 |
| 11 | Prospective randomized trial comparing shock wave lithotripsy and ureteroscopy for lower pole caliceal calculi lcm or less显示文摘 | PEARLE M S LINGEMAN J E LEVEILLEE R | 2008 | J Urol2008，179，5： | 1 |
| 12 | Pancreatic islets under attack:cellular and molecular effectors显示文摘 | Pearl Yafe M Kaminitz A Yolcu E S | 2007 | Curr Pharm Des2007，13，7： | 1 |
| 13 | The CRIT study : Anemia and blood transfusion in the crit- ically ill - current clinical practice in the United States 显示文摘 | Corwin HL Gettingar A Pearl RG Fink MP Levy MM Abra- ham E | 2004 | Crit Care Med2004，32，1： | 1 |
| 14 | IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17- response during tuberculosis but is dispene for protection and antigenspecific IFN-γ response if IL-12 p70 is available显示文摘 | Khader S A Pearl J E Sakamoto K | 2005 | J Immunol2005，175，： | 1 |
| 15 | Determination of 4-nonylphenol in effluent and sludge from sewage treatment plants显示文摘 | PEARL T E | 1995 | Anal Chem1995，67，13： | 1 |
| 16 | Prospective, random- ized trial comparing shock wave lithotripsy and ureteroscopy for lower pole caliceal calculi 1 cm or less显示文摘 | Pearle M S Lingeman J E Leveillee R | 2005 | J Urol2005，173，6： | 1 |
| 17 | IL-23 and IL-17 in the establishment of protective pulmonary CD4^ + T cell responses after vaccination and during Mycobacterium tuberculosis challenge 显示文摘 | Khader S A Bell G K Pearl J E | 2007 | Nat Immunl2007，8，4： | 1 |
| 18 | New insights and new therapies in vitiligo显示文摘 | Pearl E Grimes | 2005 | Journal of American Medical Association2005，293，6： | 1 |
| 19 | Melasma:Etiologic and therapeutic considerations显示文摘 | Pearl E Gurimes MD | 1995 | Arch Dermator1995，131，： | 1 |
| 20 | Epileptic seizures as a cause of unilateral pulmonary edema 显示文摘 | Koppel B S Pearl M Perla E | 1987 | Epilepsia1987，28，1： | 1 |
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