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| 1 | Expression and anti-apoptotic mechanism of Spodoptera littoralis Nucleopolyhedrovirus P49 protein显示文摘A novel cloned Spodoptera littoralis Nucleo-polyhedrovirus (SINPV) p49 gene is able to suppress apop-tosis of insect cells Sf9 triggered by virus. The amino acid sequence of P49 expressed in baculovirus expression system is the same as predicted, indicating that the expression of P49 is correct. Metabolic labeling revealed that p49 was able to be expressed both in the early and late phases after the viral infection, and only in the late phase was the expression driven by polyhedra promoter, but the amount of expression was higher than that of wtSlNPV. In summary, the early gene of SINPV p49 as well as p35 of AcMNPV is able to be expressed in the late phase, but its promoter is weaker compared with polyhedra promoter. In vitro, P49 can be cut by Bm caspase and human caspase-3, yielding 10 and 40 ku fragments. Purified P49 blocks the substrate cleavage by Bm caspase and human caspase-3, showing that P49 inhibits downstream caspases in the apoptotic pathway. | Pei, ZF Qi, YP Liu, YL Xiao, HZ | 2002 | Chinese Science Bulletin2002，47，8： | 2 |
| 2 | PEG-lated PLGA nanoparticles as protein carriers: synthesis, preparation and biodistribution in rats显示文摘 | Pei YY Zhang XY | 2001 | J Controlled Release2001，71，2： | 1 |
| 3 | PEGylated PLGA nanopartieles as protein carriers: synthesis,preparation and biodistribution in rats显示文摘 | Li YP Pei YY Zhang XY | 2001 | J Control Release2001，71，2： | 1 |
| 4 | PEGylated polycyanoacrylate nanoparticles as tumor necrosis factoralpha carriers 显示文摘 | Li YP Pei YY Zhou ZH | 2001 | J Controlled Release2001，71，3： | 1 |
| 5 | Stealth polycyanoacrylate nanoparticles as tumor necrosis factoralpha carriers: pharmacokinetics and anti-tumor effects 显示文摘 | Li YP Pei YY Zhou ZH | 2001 | Biol Pharm Bull2001，24，6： | 1 |
| 6 | PEGylated polycyanoacrylate nanoparticles as tumor necrosis factor-α carriers 显示文摘 | Li YP Pei YY Zhou ZH | 2001 | J Controlled Release2001，71，3： | 1 |
| 7 | Constituents with radical scavenging effect from Opuntia dillenii:Structures of new Apyrones and flavonol glycoside显示文摘 | Qiu YK Chen YJ Pei YP | 2002 | Chem Pharm Bull (Tokyo)2002，50，11： | 1 |
| 8 | PEGylated polycyanoacrylate nanoparticles as tumor necrosis factor-alpha carriers 显示文摘 | Li YP Pei YY Zhou ZH | 2001 | J Controlled Release2001，71，3： | 1 |
| 9 | Stealth polycyanoacrylate nanoparticles as tumor necrosis factor-alpha carriers: pharmacokinetics and antitumor effects 显示文摘 | Li YP Pei YY Zhou ZH | 2001 | Biol Pharm Bull2001，24，6： | 1 |
| 10 | PEGylated polycyanoacrylate nanoparticles as salvicine carriers : synthesis, preparation, and in vitro characterization显示文摘 | LI YP ZHOU ZH PEI YY el al | 2001 | Acta Pharmacol Sin2001，22，7： | 1 |
| 11 | PEGylated PLGA nanoparticles as protein carriers: synthesis, preparation and biodistribution in rats显示文摘 | Li YP Pei YY Zhang XY | 2001 | J Control Release2001，71，2： | 1 |
| 12 | PEGylated polycyanoacrylate nanoparticles as tumor necrosis factor-alpha carriers显示文摘 | Li Yp Pei YY Zhou ZH | 2001 | J Controlled Release2001，71，3： | 1 |
| 13 | PEGylated PL GA nanopartieles as protein carriers : synthesis ,preparation and biodistribution in rats显示文摘 | LI YP PEI YY ZHANG XY | 2001 | J Controlled Release2001，71，2： | 1 |
| 14 | PEGylated polycyanoacrylate nanoparticles as tumor necrosis factor-alpha carriers 显示文摘 | Li YP Pei YY Zhou ZI-I | 2001 | Journal of Controlled Release2001，71，3： | 1 |
| 15 | Protective effects of hy- drogen gas on murine polyrnicrobial sepsis via reducing oxidative stress and HMGB1 release 显示文摘 | Xie KL Yu YH Pei YP | 2010 | Shock2010，34，1： | 1 |
| 16 | Pegylated nanoparticles as tumours necrosis factor-Alpha carriers显示文摘 | Li YP Pei YY Zhou ZH | 2001 | J Control Release2001，71，3： | 1 |
| 17 | Stealth polycyanoacrylate nanoparticles as tumor necrosis factor-alpha carriers: pharmacokinetics and antitumor effects显示文摘 | Li YP Pei YY Zhou ZH | 2001 | Biol Pharm Bull2001，24，6： | 1 |
| 18 | PEGylated polycyanoacrylate nanoparticles as salvicine carriers: synthesis, preparation and in vitro characterization 显示文摘 | Li YP Zhou ZH Pei YY | 2001 | Acta Pharmacol Sin2001，22，7： | 1 |
| 19 | PEGylated PLGA nanoparticles as protein carriers: synthesis, preparation and biodistribution in rats显示文摘 | Li YP Pei YY Zhang XY | 2001 | J Control Rel2001，71，： | 1 |
| 20 | PEGylated recombinant human tumor necrosis factor alpha: pharmacokinetics and anti-tumor effects 显示文摘 | Li YP Pei YY Zhou ZH | 2001 | Biol Pharm Bull2001，24，6： | 1 |
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