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| 1 | Chemical screen identifies a geroprotective role of quercetin in premature aging显示文摘Aging increases the risk of various diseases. The main goal of aging research is to find therapies that attenuate aging and alleviate aging-related diseases. In this study, we screened a natural product library for geroprotective compounds using Werner syndrome (WS) human mesenchymal stem cells (hMSCs), a premature aging model that we recently established. Ten candidate compounds were identified and quercetin was investigated in detail due to its leading effects. Mechanistic studies revealed that quercetin alleviated senescence via the enhancement of cell proliferation and restoration of heterochromatin architecture in WS hMSCs. RNA-sequencing analysis revealed the transcriptional commonalities and differences in the geroprotective effects by quercetin and Vitamin C. Besides WS hMSCs, quercetin also attenuated cellular senescence in Hutchinson-Gilford progeria syndrome (HGPS) and physiological-aging hMSCs. Taken together, our study identifies quercetin as a geroprotective agent against accelerated and natural aging in hMSCs, providing a potential therapeutic intervention for treating age-associated disorders. | Lingling Geng Zunpeng Liu Weiqi Zhang Wei Li Zeming Wu Wei Wang Ruotong Ren Yao Su Peichang Wang Liang Sun Zhenyu Ju Piu Chan Moshi Song Jing Qu Guang-Hui Liu | 2019 | Protein & Cell2019，10，6： | 13 |
| 2 | A survey of Blockchain consensus algorithms:mechanism,design and applications显示文摘In 2008,Blockchain was introduced to the world as the underlying technology of the Bitcoin system.After more than a decade of development,various Blockchain systems have been proposed by both academia and industry.This paper focuses on the consensus algorithm,which is one of the core technologies of Blockchain.In this paper,we propose a unified consensus algorithm process model that is suitable for Blockchains based on both the chain and directed acyclic graph(DAG)structure.Subsequently,we analyze various mainstream Blockchain consensus algorithms and classify them according to their design in different phases of the process model.Additionally,we present an evaluation framework of Blockchain consensus algorithms and then discuss the security design principles that enable resistance from different attacks.Finally,we provide some suggestions for selecting consensus algorithms in different Blockchain application scenarios. | Xiang FU Huaimin WANG Peichang SHI | 2021 | Science China(Information Sciences)2021，64，2： | 11 |
| 3 | Review of Chinese atmospheric science research over the past 70 years: Atmospheric physics and atmospheric environment显示文摘Since the founding of the People’s Republic of China 70 years ago,the subject of atmospheric physics and atmospheric environment has developed rapidly in China,providing important support for the development of atmospheric science and guarantee for the development of national economy.In this paper,the general advancement of atmospheric physics and atmospheric environment in last 70 years was described.The main research progress of atmospheric physics and atmospheric environment in the past 40 years of reform and opening-up was reviewed,the outstanding research achievements since the 21 st century were summarized,the major problems and challenges are pointed out,and the key directions and suggestions for future development are put forward. | Tijian WANG Taichang GAO Hongsheng ZHANG Maofa GE Hengchi LEI Peichang ZHANG Peng ZHANG Chunsong LU Chao LIU Hua ZHANG Qiang ZHANG Hong LIAO Haidong KAN Zhaozhong FENG Yijun ZHANG Xiushu QIE Xuhui CAI Mengmeng LI Lei LIU Shengrui TONG | 2019 | Science China Earth Sciences2019，62，12： | 5 |
| 4 | A new approach to fuzzy dynamic fault tree analysis using the weakest n-dimensional t-norm arithmetic显示文摘Dynamic fault tree analysis is widely used for the reliability analysis of the complex system with dynamic failure characteristics. In many circumstances, the exact value of system reliability is difficult to obtain due to absent or insufficient data for failure probabilities or failure rates of components. The traditional fuzzy operation arithmetic based on extension principle or interval theory may lead to fuzzy accumulations. Moreover, the existing fuzzy dynamic fault tree analysis methods are restricted to the case that all system components follow exponential time-to-failure distributions. To overcome these problems, a new fuzzy dynamic fault tree analysis approach based on the weakest n-dimensional t-norm arithmetic and developed sequential binary decision diagrams method is proposed to evaluate system fuzzy reliability. Compared with the existing approach,the proposed method can effectively reduce fuzzy cumulative and be applicable to any time-tofailure distribution type for system components. Finally, a case study is presented to illustrate the application and advantages of the proposed approach. | Ge JIANG Hongjie YUAN Peichang LI Peng LI | 2018 | Chinese Journal of Aeronautics2018，31，7： | 4 |
| 5 | Microwave absorption by and scattering from mixed ice and liquid water spheres显示文摘 | Wang Zhenhui Zhang Peichang | 2004 | J Quantitative Spectroscopy and Radiative Transfer 83 Issues 3~42004，，： | 1 |
| 6 | The visualization ofhyperbolie patternsfrom invariant mapping method显示文摘 | Ouyang Peichang Cheng Dongsheng | 2012 | Computer & Graphics2012，36，： | 1 |
| 7 | Neuroprotective effect of morroniside on focal cerebral ischemia in rats显示文摘 | Wen Wang Jingdong Xu Lei Li Peichang Wang Xunming Ji Houxi Ai Li Zhang Lin Li | 2010 | Brain Research Bulletin2010，，5： | 1 |
| 8 | Two-tier channel estimation aided neai-capanity MIMO transceivers relying on norm-based joint transmit and receive antenna selection显示文摘 | ZHANG Peichang CHEN Sheng and HANZO L | 2015 | IEEE Transactions on Wireless Communications2015，14，1： | 1 |
| 9 | Total analytical method for Radix astragali extract usingtwo-binarymuhi-segment gradient elution liquid chromatography 显示文摘 | Xiao Hongbin Liang Xinmiao Lu Peichang | 2001 | J Separa Sci2001，24，3： | 1 |
| 10 | Proton-exchangedOH- absorption spectra of highly Zn-doped LiNbO3 with and without polarization inversion 显示文摘 | Tsai PeiChang Chia ChihTa | 2009 | Applied Physics Letters2009，94，08： | 1 |
| 11 | OH-absorption of Zn- doped LiNbO3 single crystals after proton exchange 显示文摘 | Tsai PeiChang Lu HsiuFeng | 2007 | Japanese Journal of Applied Physics2007，46，10： | 1 |
| 12 | China's forest policy for the 21st century显示文摘 | Zhaug Peichang Shao Guofan Zhao Guang | 2000 | Science2000，288，： | 1 |
| 13 | Decentralized control design and implementation for magnetic levitation systems with extended state observer显示文摘This paper focuses on control design and synthesize for a class of magnetic levitation systems,which have a decentralized control for each suspension point.Due to the existence of mechanical coupling among four suspension points,large modeling uncertainties,unpredictable disturbances during the operation,and measurement noises,becomes challenging.To estimate and compensate for the effects of lumped uncertainties,this study employs the extended state observer(ESO)in conjunction with active disturbance rejection control(ADRC).Specifically,a novel ESO is proposed that utilizes output signals and their derivatives to estimate the lumped uncertainties more accurately,which simplifies the convergence proof conditions and has well engineering performance.This article is written in honor of B.M.Chen on the occasion of his 60th birthday.Specifically,this paper is inspired by his pioneering work on composite nonlinear feedback,which combines linear feedback and nonlinear compensator to enhance system performance Chen et al.(IEEE Trans Autom Control,40:427-439,2003). | Qiang Chen Qing Yang Mingxin Liu Peichang Yu Lianchun Wang Danfeng Zhou Jie Li Ying Tan | 2023 | Control Theory and Technology2023，21，3： | 0 |
| 14 | Teegraph: trusted execution environment and directed acyclic graph-based consensus algorithm for IoT blockchains显示文摘Dear editor,Owing to the recent advancements in the field of Internet of things(Io T), the use of Io T devices has increased in every aspect of human life, such as smart cities, Internet of medical things, and Internet of vehicles [1]. Such devices gather data from the surrounding environment and communicate with each other via the Internet. However, it is difficult for such non-trustable devices to collaborate without a trusted intermediary [2]. | Xiang FU Huaimin WANG Peichang SHI Xingkong MA Xunhui ZHANG | 2022 | Science China(Information Sciences)2022，65，3： | 0 |
| 15 | Specific Order and Bisection Search Aided Joint 3D Beamforming and RIS Reflecting Optimization显示文摘In this paper,a three-node transmission model is conceived,where the base station(BS)node leverages 3D beamforming,the reconfigurable intelligent surface(RIS)node can constructively reconfigure the wireless channel,the user node only has a single antenna due to a limited price.Maximization of its downlink spectral efficiency is a joint optimization problem of three variables,namely phase-shift matrixΦof RIS,tilt angleθand beamforming vector w used in BS 3D beamforming.We solve this problem by employing the alternating optimization(AO)algorithm.But,in each iteration,a specific optimization order of firstlyΦ,secondlyθand finally w is proposed,which facilitates the search of optimalθin the way of narrowing its trust region and enabling unimodal property over the narrowed trust region.It finally results in a better combination of{Φ,θ,w}. | Hongxing He Li Li Peichang Zhang Xiaohu Tang | 2023 | China Communications2023，20，5： | 0 |
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