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| 1 | Effects of regulating intestinal microbiota on anxiety symptoms: A systematic review显示文摘Background Anxiety symptoms are common in mental diseases and a variety of physical disorders, especially in disorders related to stress. More and more basic studies have indicated that gut microbiota can regulate brain function through the gut-brain axis, and dysbiosis of intestinal microbiota was related to anxiety. However, there is no specific evidence to support treatment of anxiety by regulating intestinal microbiota. Aims To find evidence sup porting improvement of anxiety symptoms by regulation of intestinal microbiota. Methods This systematic review of randomised controlled trials was searched based on the following databases: PubMed, EMBASE, the Cochrane Library, OVID, Web of Knowledge, China National Knowledge Infrastructure (CNKI), Wanfang Data, VIP databases and SinoMed. The retrieval time dated back to 25 July 2018. Then we screened research literatures based on established inclusion and exclusion criteria. Quality evaluation for each included study was done using the Cochrane risk of bias and the Jadad scale. Results A total of 3334 articles were retrieved and 21 studies were included which contained 1503 subjects. In the 21 studies, 15 chose probiotics as interventions to regulate intestinal microbiota and six chose non-probiotic ways such as adjusting daily diets. Probiotic supplements in seven studies contained only one kind of probiotic, two studies used a product that contained two kinds of probiotics and the supplements used in the other five studies included at least three kinds of probiotics. In the studies that used treatment as usual plus interventions regulating intestinal flora (IRIF) as interventions (five studies), only non-probiotic ways were effective (two studies), which means 40% of studies were effective;in the studies that used IRIF alone (16 studies, 11 studies used probiotic ways and 5 studies used non-probiotic ways), 56% of studies could improve anxiety symptoms, and 80% of studies that conducted the non-probiotic interventions were effective, while 45% of studies that used probiotic supplementations had positive effects on anxiety symptoms. Overall, 11 studies showed a positive effect on anxiety symptoms by regulating intestinal microbiota, which indicated 52% of the 21 studies were effective, and there were five studies that used probiotic supplements as interventions and six used non-probiotic interventions. In addition, it should be noted that six of seven studies showed that regulation of intestinal microbiota could treat anxiety symptoms, the rate of efficacy was 86%.Conclusions We find that more than half of the studies included showed it was positive to treat anxiety symptoms by regulation of intestinal microbiota. There are two kinds of interventions (probiotic and non-probiotic interventions) to regulate intestinal microbiota, and it should be highlighted that the non-probiotic interventions were more effective than the probiotic interventions. More studies are needed to clarify this conclusion since we still cannot run meta-analysis so far. | Beibei Yang Jinbao Wei Peijun Ju Jinghong Chen | 2019 | General Psychiatry2019，32，2： | 9 |
| 2 | The involvement of N-methyI-D-aspartate receptor (NMDAR) subunit NR1 in the pathophysiology of schizophrenia显示文摘 | Peijun Ju Donghong Cui | 2016 | Acta Biochimica et Biophysica Sinica2016，48，3： | 8 |
| 3 | Achievable delay margin using LTI control for plants with unstable complex poles显示文摘We consider the achievable delay margin of a real rational and strictly proper plant, with unstable complex poles, by a linear time-invariant(LTI) controller. The delay margin is defined as the largest time delay such that, for any delay less than this value, the closed-loop stability is maintained. Drawing upon a frequency domain method, particularly a bilinear transform technique, we provide an upper bound of the delay margin, which requires computing the maximum of a one-variable function. Finally, the effectiveness of the theoretical results is demonstrated through a numerical example. | Peijun JU Huanshui ZHANG | 2018 | Science China(Information Sciences)2018，61，9： | 2 |
| 4 | Viral vectors as a novel tool for clinical and neuropsychiatric research applications显示文摘Background A viral vector is a genetically modified vector produced by genetic engineering. As pathogenic genes in the virus are completely or largely eliminated, it is safe to be widely used in multidisciplinary research fields for expressing genes, such as neuroscience, metabolism, oncology and so on. Neuroscience and psychiatry are the most closely related disciplines in either basic research or clinical research, but the application of viral vectors in neuropsychiatry has not received much attention or not been widely accepted.Aim This article will focus on the application of viral vectors in basic and clinical neuropsychiatric research.Methods By using viral vectors, scientists can perform neurological labelling, gene expression regulation and physiological manipulation for investigating phenomenon from molecular mechanisms to behaviours. At the same time, to treat mental or neurological disorders, viral vectors can be designed for gene therapy, which alter gene expression levels or repair mutated genes in the brains of patients.Perspective Viral vectors play an important role in basic research and clinical applications. To further understand brain function and prevent mental and neurological diseases, we hypothesize that viral vectors could be used along with various advanced technologies, such as sequencing and high-throughput expression analysis in the neuroscience research field. | Yao Wang Zhiwei Hu Peijun Ju Shan Yin Fujie Wang Oudong Pan Jinghong Chen | 2018 | General Psychiatry2018，31，5： | 2 |
| 5 | The Irregular Linear Quadratic Control Problem for Deterministic Case with Time Delay显示文摘This study deals with the irregular linear quadratic control problem governed by continuous time system with time delay.Linear quadratic(LQ)control for irregular Riccati equation with time delay remains challenging since the controller could not be solved from the equilibrium condition directly.The merit of this paper is that based on a new approach of‘two-layer optimization’,the controller entries of irregular case with time delay are deduced from two equilibrium conditions in two different layers,which is fundamentally different from the classical regular LQ control.The authors prove that the irregular LQ with time delay is essentially different from the regular case.Specifically,the predictive controller bases on the feedback gain matrix and the state is given in the last part.The presented conclusions are completely new to our best knowledge.Examples is presented to show the effectiveness of the proposed approach. | LI Tongxing LI Lin LEI Jing JIN Nana JU Peijun | 2021 | Journal of Systems Science & Complexity2021，34，2： | 0 |
| 6 | Deep Transcranial Magnetic Stimulation as a Potential Approach for Digital Pain Management in Patients with Psychotic Disorder显示文摘Dear Editor,Pain is a common and complex clinical problem which affects 28%-50%of the general population and is responsible for large health-related costs.People with chronic pain often develop nociceptive sensitization,having mood and anxiety disorders as comorbidities.Sustained pain may alter the processing of affective information in the brain,thereby inducing anxio-depressive disorders. | Peijun Ju Di Zhao Cuizhen Zhu Yongjun Zheng Shiyu Peng Haisu Wu Beibei Yang Zhenghui Yi Tifei Yuan Jinghong Chen | 2023 | Neuroscience Bulletin2023，39，1： | 0 |
| 7 | Alteration of faecal microbiota balance related to long-term deep meditation显示文摘Background Advancements in research have confirmed that gut microbiota can influence health through the microbiota–gut–brain axis.Meditation,as an inner mental exercise,can positively impact the regulation of an individual’s physical and mental health.However,few studies have comprehensively investigated faecal microbiota following long-term(several years)deep meditation.Therefore,we propose that long-term meditation may regulate gut microbiota homeostasis and,in turn,affect physical and mental health.Aims To investigate the effects of long-term deep meditation on the gut microbiome structure.Methods To examine the intestinal flora,16S rRNA gene sequencing was performed on faecal samples of 56 Tibetan Buddhist monks and neighbouring residents.Based on the sequencing data,linear discriminant analysis effect size(LEfSe)was employed to identify differential intestinal microbial communities between the two groups.Phylogenetic Investigation of Communities by Reconstruction of Unobserved States(PICRUSt)analysis was used to predict the function of faecal microbiota.In addition,we evaluated biochemical indices in the plasma.Results Theα-diversity indices of the meditation and control groups differed significantly.At the genus level,Prevotella and Bacteroides were significantly enriched in the meditation group.According to the LEfSe analysis,two beneficial bacterial genera(Megamonas and Faecalibacterium)were significantly enriched in the meditation group.Functional predictive analysis further showed that several pathways—including glycan biosynthesis,metabolism and lipopolysaccharide biosynthesis—were significantly enriched in the meditation group.Moreover,plasma levels of clinical risk factors were significantly decreased in the meditation group,including total cholesterol and apolipoprotein B.Conclusions Long-term traditional Tibetan Buddhist meditation may positively impact physical and mental health.We confirmed that the gut microbiota composition differed between the monks and control subjects.The microbiota enriched in monks was associated with a reduced risk of anxiety,depression and cardiovascular disease and could enhance immune function.Overall,these results suggest that meditation plays a positive role in psychosomatic conditions and well-being. | Ying Sun Peijun Ju Ting Xue Usman Ali Donghong Cui Jinghong Chen | 2023 | General Psychiatry2023，36，1： | 0 |
| 8 | Intermediary roles of prospective memory and retrospective memory in the comorbidity of depression and pain显示文摘Background Patients who suffer comorbidity of major depressive disorder(MDD)and chronic pain(CP)maintain a complex interplay between maladaptive prospective memory(PM)and retrospective memory(RM)with physical pain,and their complications are still unknown.Aims We aimed to focus on the full cognitive performance and memory complaints in patients with MDD and CP,patients with depression without CP,and control subjects,considering the possible influence of depressed affect and chronic pain severity.Methods According to the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders and the criteria given by the International Association of Pain,a total of 124 participants were included in this cross-sectional cohort study.Among them,82 depressed inpatients and outpatients from Anhui Mental Health centre were divided into two groups:a comorbidity group(patients with MDD and CP)(n=40)and a depression group(patients with depression without CP)(n=42).Meanwhile,42 healthy controls were screened from the hospital’s physical examination centre from January 2019 to January 2022.The Hamilton Depression Rating Scale-24(HAMD-24)and Beck Depression Inventory-II(BDI-II)were used to evaluate the severity of depression.The Pain Intensity Numerical Rating Scale(PI-NRS),Short-Form McGill Pain Questionnaire-2 Chinese version(SF-MPQ-2-CN),Montreal Cognitive Assessment-Basic Section(MoCA-BC),and Prospective and Retrospective Memory Questionnaire(PRMQ)were used to assess pain-related features and the global cognitive functioning of study participants.Results The impairments in PM and RM differed remarkably among the three groups(F=7.221,p<0.001;F=7.408,p<0.001)and were severe in the comorbidity group.Spearman correlation analysis revealed the PM and RM were positively correlated with continuous pain and neuropathic pain(r=0.431,p<0.001;r=0.253,p=0.022 and r=0.415,p<0.001;r=0.247,p=0.025),respectively.Regression analysis indicated a significant positive relationship between affective descriptors and total BDI-II score(β=0.594,t=6.600,p<0.001).Examining the mediator pathways revealed the indirect role of PM and RM in patients with comorbid MDD and CP.Conclusions Patients with comorbid MDD and CP presented more PM and RM impairments than patients with MDD without CP.PM and RM are possibly mediating factors that affect the aetiology of comorbid MDD and CP. | Hua Gao Qingrong Xia Xulai Zhang Yuanyuan Chen Junwei Yan Jianliang Gao Loufeng Zhang Jie Zhang Keming Wang Chao Li Peijun Ju Cuizhen Zhu | 2023 | General Psychiatry2023，36，1： | 0 |
| 9 | Analgesic alkaloids from Urticae Fissae Herba显示文摘Objective:To investigate the analgesic substances in the aerial part of Urtica fissa(Urticae Fissae Herba),commonly used for rheumatoid and rheumatism arthritis.Methods:The analgesic constituents were isolated with the active guidance of hot plate and acetic acid writhing models,and identified by comprehensive spectroscopic analysis.Results:Thirteen alkaloids(1–13),two lignans(14,15),and three amides(16–18)were isolated from the active fractions.Among them,compound 1 was a new alkaloid,and compound 6 was a new natural product.The activity evaluation in vivo indicated that various pyrrole alkaloids(1,3,6,and 12)possessed significant analgesic activities,they could significantly inhibit the mice pain response induced by acetic acid and hot plate at the dosage of 2 mg/kg BW.Conclusion:The study revealed that the pyrrole alkaloids played important roles in the analgesic activities of Urticae Fissae Herba. | Xiaoru Feng Peijun Ju Yan Chen Xiaobo Li Mengyue Wang | 2022 | Chinese Herbal Medicines2022，14，1： | 0 |
| 10 | GLOBAL EXPONENTIAL STABILITY FOR AN IMPULSIVE DELAYED INTEGRO-DIFFERENTIAL EQUATION显示文摘In this paper, the stability of an impulsive integro-differential equation with finite and infinite delays is investigated. By applying the Lyapunov-Razumikin method, sufficient condition for global exponential stability of such equation is obtained. | Peijun Ju Tao Chen | 2013 | Annals of Differential Equations2013，29，2： | 0 |
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