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1Re-Os isotopes and PGE geochemistry of black shales and intercalated Ni-Mo polymetallic sulfide bed from the Lower Cambrian Niutitang Formation, South China显示文摘The Lower Cambrian Niutitang Formation consists of a thick black shale sequence with a regionally distributed conformable Ni Mo polymetallic sulfide horizon and a chert bed at its basal strata on theYangtze Platform, South China. In this paper, we discuss all available data on Re Os isotopes and Platinum Group Element (PGE) distribution pattern of the Ni Mo polymetallic sulfide ore and its host rocks (black shales, cherts, and phosphorites) from Guizhou and Hunan provinces. Our results show that the black shales and the Ni Mo sulfide ore have a high initial 187 Os/ 188 Os ratio of 0.78~0.86, indicating that the Early Cambrian ocean across the Yangtze Platform had a highly radiogenic Os value. This ratio is slightly lower than but still similar to present day seawater, possibly as a result of high continental weathering at that time. The Ni Mo sulfide ore yields a Re Os isochron of 537±10 Ma (MSWD=11.9), possibly representing the depositional age of the Niutitang Formation. The chondrite normalized PGE pattern, Pt anomaly (Pt/Pt *), Pt/Pd, Ir/Pd, Au/Ir and Re/Mo ratios of the Ni Mo sulfide ore and its host rocks from South China indicate a varying source contribution of the PGE and other metals for different rocks. It is suggested that the cherts and Ni Mo sulfide ore may have a significant proportion of PGE and probably other metals deriving from submarine hydrothermal fluids with a mantle signature.JIANG Shaoyong*, YANG Jinghong, LING Hongfei, FENG Hongzhen, CHEN Yongquan and CHEN Jianhua(State Key Laboratory for Mineral Deposits Research, Department of Earth Sciences, Nanjing University, Nanjing 210093, China) 2003Progress in Natural Science:Materials International2003,13,10:78
2Pb-Pb isotope dating of black shales from the Lower Cambrian Niutitang Formation, Guizhou Province, South China显示文摘The Lower Cambrian black shales of the Niutitang Formation and their lateral equivalents occur widely on the Yangtze Platform, South China. In this study, we examine two sections of the Niutitang Formation in Guizhou Province. We employ a stepwise acid leaching technique to obtain Pb isotope compositions of the black shales. At the Zhongnan section, the black shales display large Pb isotope variations, with 206 Pb/ 204 Pb of 20.5396~33.5709, and 207 Pb/ 204 Pb of 15.8407~16.5782. In contrast, Pb isotope data show a relatively limited range in 206 Pb/ 204 Pb (18.2797~18.5972) and 207 Pb/ 204 Pb (15.6813~15.7159) at the Zhijin section. Data for all acid leached black shale samples from the two sections yield a Pb Pb isochron age of 531±24 Ma. This age may represent the sedimentary age of the black shales. The initial Pb isotope composition of the black shales falls near the upper crust evolution curve in a Zartman Pb Pb evolution diagram. Hence, it is likely that the Pb in the black shales may have been derived from an upper continental crustal source.CHEN Yongquan, JIANG Shaoyong*, LING Hongfei, FENG Hongzhen, YANG Jinghong and CHEN Jianhua (State Key Laboratory for Mineral Deposits Research, Department of Earth Sciences, Nanjing University, Nanjing 210093, China) 2003Progress in Natural Science:Materials International2003,13,10:19
3Geochemistry of pore waters from HQ-1PC of the Qiongdongnan Basin, northern South China Sea, and its implications for gas hydrate exploration显示文摘The Qiongdongnan Basin is one of the target areas for marine gas hydrate exploration in the northern margin of the South China Sea. In this study, major anion (e.g., SO42 , Cl, Br, I), cation (e.g., Ca, Mg, K, Na), and trace element (e.g., Sr, Ba) con- centrations of pore water samples collected from site HQ-1PC in the Qiongdongnan Basin were analyzed. These geochemical data suggest that the process of AOM (Anaerobic Oxidation of Methane) is dominant in sulfate-reduction zone in this site due to high upwelling iodine flux and strong microbial activities. The iodine-rich fluids, which may carry methane for the gas hydrate formation, pass through the gas hydrate stability zone, mix with brine released during gas hydrate formation, and cause the geochemical anomalies observed at site HQ-1PC. The pore water geochemical characteristics and anomalies in the Qiongdongnan Basin are quite similar to those found in other gas hydrate locations in the Shenhu area in the northern South China Sea, and a genetic link is suggested with the possibility of gas hydrate occurrence in the study area.YANG Tao JIANG ShaoYong GE Lu YANG JingHong WU NengYou ZHANG GuangXue LIU Jian CHEN DaoHua 2013Science China Earth Sciences2013,56,4:14
4An experimental study exploring the influencing factors for ultrasonic-assisted extraction of flavonoid compounds from leaves of Amorpha fruticosa L.显示文摘In this paper,the ultrasonic-assisted extraction process of flavonoid compounds from leaves of Amorpha fruticosa is optimized.In single factor experiments,solid/liquid ratios,ultrasonic power,ethanol concentrations and extraction cycles were experimental factors.Box–Behnken central composite design and RSM analyzed the effects of the four factors on the yield of total flavonoids.The optimal extraction parameters were solid/liquid ratio 1:50 g/mL,ultrasonic power 316 W,ethanol concentration 50%,4 extraction cycles.In the optimized condition,the estimated value of the regression model was 66.6456 mg/g while the measured value was 66.4329 mg/g.Jingyao Tian Siddique Muhammad Ai Chen Peng Chen Jinghong Wang Chengwu Yang Hui Yuan Zhensheng Wang 2019Journal of Forestry Research2019,30,5:14
5Pressure balance and imbalance in the optic nerve chamber: The Beijing Intracranial and Intraocular Pressure (iCOP) Study显示文摘To determine the interdependence of intracranial pressure(ICP) and intraocular pressure(IOP) and how it affects optic nerve pressures, eight normal dogs were examined using pressure-sensing probes implanted into the left ventricle, lumbar cistern, optic nerve subarachnoid space in the left eye, and anterior chamber in the left eye. This allowed ICP, lumbar cistern pressure(LCP), optic nerve subarachnoid space pressure(ONSP) and IOP to be simultaneously recorded. After establishing baseline pressure levels, pressure changes that resulted from lowering ICP(via shunting cerebrospinal fluid(CSF) from the ventricle) were recorded. At baseline, all examined pressures were different(ICP>LCP>ONSP), but correlated(P<0.001). As ICP was lowered during CSF shunting, IOP also dropped in a parallel time course so that the trans-lamina cribrosa gradient(TLPG) remained stable(ICP-IOP dependent zone). However, once ICP fell below a critical breakpoint, ICP and IOP became uncoupled and TLPG changed as ICP declined(ICP-IOP independent zone). The optic nerve pressure gradient(ONPG) and trans-optic nerve pressure gradient(TOPG) increased linearly as ICP decreased through both the ICP-IOP dependent and independent zones. We conclude that ICP and IOP are coupled in a specific pressure range, but when ICP drops below a critical point, IOP and ICP become uncoupled and TLPG increases. When ICP drops, a rise in the ONPG and TOPG creates more pressure and reduces CSF flow around the optic nerve. This change may play a role in the development and progression of various ophthalmic and neurological diseases, including glaucoma.Ruowu Hou Zheng Zhang Diya Yang Huaizhou Wang Weiwei Chen Zhen Li Jinghong Sang Sumeng Liu Yiwen Cao Xiaobin Xie Ruojing Ren Yazhuo Zhang Bernhard A. Sabel Ningli Wang 2016Science China(Life Sciences)2016,59,5:11
6Effects of regulating intestinal microbiota on anxiety symptoms: A systematic review显示文摘Background Anxiety symptoms are common in mental diseases and a variety of physical disorders, especially in disorders related to stress. More and more basic studies have indicated that gut microbiota can regulate brain function through the gut-brain axis, and dysbiosis of intestinal microbiota was related to anxiety. However, there is no specific evidence to support treatment of anxiety by regulating intestinal microbiota. Aims To find evidence sup porting improvement of anxiety symptoms by regulation of intestinal microbiota. Methods This systematic review of randomised controlled trials was searched based on the following databases: PubMed, EMBASE, the Cochrane Library, OVID, Web of Knowledge, China National Knowledge Infrastructure (CNKI), Wanfang Data, VIP databases and SinoMed. The retrieval time dated back to 25 July 2018. Then we screened research literatures based on established inclusion and exclusion criteria. Quality evaluation for each included study was done using the Cochrane risk of bias and the Jadad scale. Results A total of 3334 articles were retrieved and 21 studies were included which contained 1503 subjects. In the 21 studies, 15 chose probiotics as interventions to regulate intestinal microbiota and six chose non-probiotic ways such as adjusting daily diets. Probiotic supplements in seven studies contained only one kind of probiotic, two studies used a product that contained two kinds of probiotics and the supplements used in the other five studies included at least three kinds of probiotics. In the studies that used treatment as usual plus interventions regulating intestinal flora (IRIF) as interventions (five studies), only non-probiotic ways were effective (two studies), which means 40% of studies were effective;in the studies that used IRIF alone (16 studies, 11 studies used probiotic ways and 5 studies used non-probiotic ways), 56% of studies could improve anxiety symptoms, and 80% of studies that conducted the non-probiotic interventions were effective, while 45% of studies that used probiotic supplementations had positive effects on anxiety symptoms. Overall, 11 studies showed a positive effect on anxiety symptoms by regulating intestinal microbiota, which indicated 52% of the 21 studies were effective, and there were five studies that used probiotic supplements as interventions and six used non-probiotic interventions. In addition, it should be noted that six of seven studies showed that regulation of intestinal microbiota could treat anxiety symptoms, the rate of efficacy was 86%.Conclusions We find that more than half of the studies included showed it was positive to treat anxiety symptoms by regulation of intestinal microbiota. There are two kinds of interventions (probiotic and non-probiotic interventions) to regulate intestinal microbiota, and it should be highlighted that the non-probiotic interventions were more effective than the probiotic interventions. More studies are needed to clarify this conclusion since we still cannot run meta-analysis so far.Beibei Yang Jinbao Wei Peijun Ju Jinghong Chen 2019General Psychiatry2019,32,2:9
7Effects of Xiangsha Liujunzi decoction drug serum on gastric antrum smooth muscle cells from rats with functional dyspepsia by regulating gastrointestinal hormones显示文摘Objective:To observe the effect and mechanism of Xiangsha Liujunzi decoction(XSLJZD)drug serum on gastric antrum smooth muscle cells(SMCs)in rats with functional dyspepsia(FD).Methods:Gastric antrum SMCs from rats with FD were isolated,cultured,and then divided into six groups as follows:control,model,domperidone,low-dose XSLJZD(LXSLJZD),medium-dose XSLJZD(MXSLJZD),and high-dose XSLJZD(HXSLJZD).Each group was administered the corresponding drug serum for intervention.Drug serum intervention conditions and proliferative activity of SMCs were tested by cholecystokinin octapeptide.Ghrelin,gastrin,somatostatin,and substance P(SP)levels were measured by ELISA.Somatostatin and SP mRNA expression was measured by real-time PCR.Results:A concentration of 10%drug serum for 24 h was decided to be the best intervention condition for later study.The mean optical density value in the model group was lower than that in the control group(P紏.001).Optical density values in the domperidone and HXSLJZD groups were higher than those in the model group(P?.025,P?.032,respectively).Gastrin,SP,and ghrelin levels in the model group were lower(P?.007,P?.037,P?.005,respectively),but somatostatin levels were higher,compared with those in the control group(P?.031).Gastrin,SP,and ghrelin levels in the domperidone,MXSLJZD,and HXSLJZD groups were higher than those in the model group(all P<.05).Somatostatin levels in the four drug-treated groups were lower than those in the model group(P?.002,P?.007,P?.001,P?.009,respectively).SP mRNA levels in the model group were lower than those in the control,domperidone,MXSLJZD,and HXSLJZD groups(P?.037 P?.016,P?.025,P?.002,respectively).Somatostatin mRNA levels in the model group were higher than those in the control and MXSLJZD groups(P紏.042,P紏.035).Conclusions:XSLJZD and domperidone drug serum effectively promote proliferative activity of gastric antrum SMCs in an FD model.The mechanism of this activity may be regulated by gastrointestinal hormones.Ning Dai Jinghong Hu Yan Liu Dongyu Ge Ruijuan Dong Fengzhi Wu Jiaojiao Yu Mindan Chen Deborah CMa Feng Li 2020Journal of Traditional Chinese Medical Sciences2020,7,1:6
8Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases显示文摘Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel therapeutics.In this study,we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents—findings that evaluated histopathological changes;immune cell signature and inflammatory factor expression in the lungs,spleen and lymph nodes.Here we show that the major pulmonary alterations included diffuse alveolar damage,interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates,macrophage infiltration and abundant production of inflammatory factors(IL-6,IP-10,TNFo?and IL-I f).The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation,including lymphopenia and macrophage accumulation.These findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients.Qian Liu Yu Shi Jun Cai Yaqi Duan Rongshuai Wang Hongyan Zhang Qiurong Ruan Jiansha Li Lei Zhao Yifang Ping Rong Chen Liang Ren Xiaochun Fei Heng Zhang Rui Tang Xi Wang Tao Luo Xindong Liu Xuequan Huang Zhenhua Liu Qilin Ao Yong Ren Jing Xiong Zhicheng He Haibo Wu Wenjuan Fu Pengnan Zhao Xinwei Chen Guoqiang Qu Yunyun Wang Xi Wang Jia Liu Dongfang Xiang Sanpeng Xu Xiaowei Zhou Qingrui Li Jinghong Ma Heng Li Jie Zhang Sizhe Huang Xiaohong Yao Yiwu Zhou Chaofu Wang Dingyu Zhang Guoping Wang Liang Liu Xiu-Wu Bian 2020National Science Review2020,7,12:6
9Controllable synthesis of well-ordered TiO_2 nanotubes in a mixed organic electrolyte for high-efficiency photocatalysis显示文摘Well-ordered TiO 2 nanotube arrays (TNAs) were fabricated by electrochemical anodization in a mixed organic electrolyte consisting of ethylene glycol and glycerol. The morphology, structure, crystalline phase, and photocatalytic properties of TNAs were characterized by using TEM, SEM, XRD and photodegradation of methylene blue. It was found that the morphology and structure of TNAs could be significantly influenced by the anodization time and applied voltage. The obtained tube length was found to be proportional to anodization time, and the calculated growth rate of nanotubes was 0.6 m/h. The microstructure analysis demonstrated that the diameter and thickness of the nanotubes increased with the increase of anodization voltage. The growth mechanism of TNAs was also proposed according to the observed relationship between current density and time during anodization. As expected, the obtained TNAs showed a higher photocatalytic activity than the commercial TiO 2 P25 nanoparticles.WANG Chao CHEN Da PING GuangXing LIU Shu HUANG XiaNi HUANG YueXiang SHU KangYing LI JingHong 2012Science China Chemistry2012,55,11:3
10One-step synthesis of dimethyl ether from syngas on ordered mesoporous copper incorporated alumina显示文摘Ordered mesoporous copper incorporated Al_2O_3(Cu/Al_2O_3) with high Cu dispersion were prepared by a facile solution combustion synthesis method using aluminum nitrate and copper nitrate as oxidants and urea as fuel. It is a facile and green route to synthesize catalysts for dimethyl ether directly from syngas. Cu/Al_2O_3 catalysts were characterized by XRD, N_2 adsorption–desorption, SEM-EDS, and H_2-TPR.The results indicate that the catalysts obtain an ordered mesoporous structure and copper is homogenously dispersed. The mesoporous Cu/Al_2O_3 catalysts were utilized as bifunctional catalysts in syngas to dimethyl ether reaction(STD). The copper content affects the catalytic performance in STD reaction. The CO conversion and DME selectivity of Cu/Al_2O_3 with 15% copper molar ratio achieve 52.9% and 66.1%,respectively. Moreover, the mesoporous Cu/Al_2O_3 catalysts show excellent stability in STD reaction.Yan Wang Yuexian Chen Feng Yu Dahai Pan Binbin Fan Jinghong Ma Ruifeng Li 2016Journal of Energy Chemistry2016,25,5:3
11γδT17 Cells Promote the Accumulation and Expansion of Myeloid-Derived Suppressor Cells in Human Colorectal Cancer显示文摘Pin Wu Dang Wu Chao Ni Jun Ye Wuzhen Chen Guoming Hu Zhen Wang Changrong Wang Zhigang Zhang Wenjie Xia Zhigang Chen Ke Wang Tao Zhang Jinghong Xu Yuehua Han Ting Zhang Xianguo Wu Jianwei Wang Weihua Gong Shu Zheng Fuming Qiu Jun Yan Jian Huang 2014Immunity2014,,5:2
12CUMS and dexamethasone induce depression- like phenotypes in mice by differentially altering gut microbiota and triggering macroglia activation显示文摘Background Although the link between gut microbiota and depression has been suggested,changes of gut microbiota vary largely among individuals with depression.Aims Explore the heterogeneity of microbiota-gut-brain axis and new pathogenic characteristics in murine models of depression.Methods Adolescent female mice were randomly divided into control(CON)group(n=10),chronic unexpected mild stress(CUMS)group(n=15)and dexamethasone(DEX)group(n=15).Mice in the DEX group were gavaged twice a day with 0.2 mg/kg of DEX for 5 weeks,whereas CON mice were given the same amount of solvent.Mice in the CUMS group were exposed to stressors.After behavioural evaluations,all mice were sacrificed for harvesting tissues and blood samples.Enzyme-linked immunosorbent assay(ELISA)was conducted for measuring levels of corticosterone(CORT)and interleukin-1β(IL-1β)in sera,whereas levels of protein expression in colon and hippocampal tissues were examined by western blot.Faecal microbial communities were analysed by sequencing 16S rDNAs.Results Mice in CUMS and DEX groups exhibited severe depression-like behaviours.Compared with CON mice,CUMS-exposed mice showed a significant increase in bothαandβdiversity.Prevotellaceae and Desulfovibrio were enriched,whereas Bacilli were decreased in the faeces of mice in the CUMS group.DEX-treated mice had a decrease in the abundance of Clostridium XVIII.Levels of occludin in colon tissue of DEX-treated mice were reduced.Relative to mice in the CON and CUMS groups,DEX-treated mice contained higher serum levels of CORT and IL-1β.Compared with CON mice,mice in the DEX and CUMS groups had higher levels of IL-1βin sera and lower levels of glial fibrillary acidic protein(GFAP),Nestin,Synapsin-1 and P2Y12 receptor in the hippocampus.Conclusions Changes of gut microbiota diversity,intestinal integrity and neuroinflammation in the brain contribute to CUMS-induced depression,whereas pathobionts and excessive immunosuppression with damaged neuronal synapses is a basis of the DEX-induced depression.Jing Wu Jinhang Li Chhetri Gaurav Usman Muhammad Yantian Chen Xueyi Li Jinghong Chen Zejian Wang 2021General Psychiatry2021,34,6:2
13Metallic and ferromagnetic MoS2 nanobelts with vertically aligned edges显示文摘Edge effects are predicted to significantly impact the properties of low dimensional materials with layered structures. The synthesis of low dimensional materials with copious edges is desired for exploring the effects of edges on the band structure and properties of these materials. Here we developed an approach for synthesizing MoS2 nanobelts terminated with vertically aligned edges by sulfurizing hydrothermally synthesized MoO3 nanobelts in the gas phase through a kinetically driven process; we then investigated the electrical and magnetic properties of these metastable materials. These edge-terminated MoS2 nanobelts were found to be metallic and ferromagnetic, and thus dramatically different from the semiconducting and nonmagnetic two-dimensional (2D) and three-dimensional (3D) 2H-MoS2 materials. The transitions in electrical and magnetic properties elucidate the fact that edges can tune the properties of low dimensional materials. The unique structure and properties of this one-dimensional (1D) MoS2 material will enable its applications in electronics, spintronics, and catalysis.Guanchen Xu Xinsheng Wang Yupeng Sun Xiao Chen Jingying Zheng Lifei Sun Liying Jiao Jinghong Li 2015Nano Research2015,8,9:2
14Long-term follow-up of optic neuropathy in chronic low cerebrospinal fluid pressure monkeys: the Beijing Intracranial and Intraocular Pressure(iCOP) Study显示文摘Dear Editor,Clinical and anatomic investigations strongly suggest that a low orbital cerebrospinal fluid pressure (CSFP), parallel to an elevated intraocular pressure (IOP), may have a role in the pathogenesis of optic neuropathy (Ren et al., 2011, Wang et al., 2012). Optic neuropathy including glaucoma demonstrated structural alterations in the optic nerve head (ONH)and retinal nerve fiber layer (RNFL), as well as functional abnormalities such as visual field (VF) that eventually cause severe visual impairment and blindness.Jing Li Diya Yang Jacky MKKwong Jidi Fu Ruowu Hou Jost BJonas Huaizhou Wang Zheng Zhang Weiwei Chen Zhen Li Jinghong Sang Xiaobin Xie Ruojin Ren Robert NWeinreb Ningli Wang 2020Science China(Life Sciences)2020,63,11:2
15Viral vectors as a novel tool for clinical and neuropsychiatric research applications显示文摘Background A viral vector is a genetically modified vector produced by genetic engineering. As pathogenic genes in the virus are completely or largely eliminated, it is safe to be widely used in multidisciplinary research fields for expressing genes, such as neuroscience, metabolism, oncology and so on. Neuroscience and psychiatry are the most closely related disciplines in either basic research or clinical research, but the application of viral vectors in neuropsychiatry has not received much attention or not been widely accepted.Aim This article will focus on the application of viral vectors in basic and clinical neuropsychiatric research.Methods By using viral vectors, scientists can perform neurological labelling, gene expression regulation and physiological manipulation for investigating phenomenon from molecular mechanisms to behaviours. At the same time, to treat mental or neurological disorders, viral vectors can be designed for gene therapy, which alter gene expression levels or repair mutated genes in the brains of patients.Perspective Viral vectors play an important role in basic research and clinical applications. To further understand brain function and prevent mental and neurological diseases, we hypothesize that viral vectors could be used along with various advanced technologies, such as sequencing and high-throughput expression analysis in the neuroscience research field.Yao Wang Zhiwei Hu Peijun Ju Shan Yin Fujie Wang Oudong Pan Jinghong Chen 2018General Psychiatry2018,31,5:2
16Graphene oxide: preparation, functionalization, and electrochemical applications显示文摘Da Chen Hongbin Feng Jinghong Li 2012Chemical Reviews2012,112,11:1
17Reduced-order modeling of weakly nonlinear MEMS devices with Taylor-series expansion and Arnoldi approach 显示文摘Jinghong Chen Sung-Mo Kang 2004Journal of Micmelectromechanical Systems (S1057-7157)2004,13,3:1
18Decoding psychosis:from national genome project to national brain project显示文摘The mind has puzzled humans for centuries,and its disorders,such as psychoses,have caused tremendous difficulties.However,relatively recent biotechnological breakthroughs,such as DNA technology and neuroimaging,have empowered scientists to explore the more fundamental aspects of psychosis.From searching for psychosis-causing genes to imaging the depths of the brain,scientists worldwide seek novel methods to understand the mind and the causes of its disorders.This article will briefly review the history of understanding and managing psychosis and the main findings of modern genetic research and then attempt to stimulate thought for decoding the biological mechanisms of psychosis in the present era of brain science.Liya Sun Manfei Xu Yongyong Shi Yifeng Xu Jinghong Chen Lin He 2022General Psychiatry2022,35,4:1
19Interracial design and functionization on metal electrodes through self-assembled monolayers显示文摘Da Chen Jinghong Li 2006Surface Science Reports2006,61,:1
20Distributional characteristics of planktonic Amphipoda(Hyperiidea) in the South Huanghai Sea and East China Sea显示文摘Distributional characteristics of planktonic Amphipoda(Hyperiidea) in the South Huanghai Sea and East China SeaLinJinghongand...Lin Jinghong and Chen Ruixiang 1995Acta Oceanologica Sinica1995,14,4:1
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