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| 1 | Galectin-3 and IL-33/ST2 axis roles and interplay in dietinduced steatohepatitis显示文摘Immune reactivity and chronic low-grade inflammation(metaflammation) play an important role in the pathogenesis of obesity-associated metabolic disorders, including type 2 diabetes and nonalcoholic fatty liver disease(NAFLD), a spectrum of diseases that include liver steatosis, nonalcoholic steatohepatitis(NASH), fibrosis, and cirrhosis. Increased adiposity and insulin resistance contribute to the progression from hepatic steatosis to NASH and fibrosis through the development of proinflammatory and profibrotic processes in the liver, including increased hepatic infiltration of innate and adaptive immune cells, altered balance of cytokines and chemokines, increased reactive oxygen species generation and hepatocellular death. Experimental models of dietary-induced NAFLD/NASH in mice on different genetic backgrounds or knockout mice with different immune reactivity are used for elucidating the pathogenesis of NASH and liver fibrosis. Galectin-3(Gal-3), a unique chimera-type β-galactoside-binding protein of the galectin family has a regulatory role in immunometabolism and fibrogenesis. Mice deficient in Gal-3 develop pronounced adiposity, hyperglycemia and hepatic steatosis, as well as attenuated liver inflammation and fibrosis when fed an obesogenic high-fat diet. Interleukin(IL)-33, a member of the IL-1 cytokine family, mediates its effects through the ST receptor, which is present on immune and nonimmune cells and participates in immunometabolic and fibrotic disorders. Recent evidence, including our own data, suggests a protective role for the IL-33/IL-33R(ST2) signaling pathway in obesity, adipose tissue inflammation and atherosclerosis, but a profibrotic role in NASH development. The link between Gal-3 and soluble ST2 in myocardial fibrosis and heart failure progression has been demonstrated and we have recently shown that Gal-3 and the IL-33/ST2 pathway interact and both have a profibrotic role in diet-induced NASH. This review discusses the current evidence on the roles of Gal-3 and the IL-33/ST2 pathway and their interplay in obesity-associated hepatic inflammation and fibrogenesis that may be of interest in the development of therapeutic interventions to prevent and/or reverse obesity-associated hepatic inflammation and fibrosis. | Nada Pejnovic Ilija Jeftic Nemanja Jovicic Nebojsa Arsenijevic Miodrag L Lukic | 2016 | World Journal of Gastroenterology2016，22，44： | 9 |
| 2 | Interleukin‐33/ST2 axis promotes breast cancer growth and metastases by facilitating intratumoral accumulation of immunosuppressive and innate lymphoid cells显示文摘 | Ivan P. Jovanovic Nada N. Pejnovic Gordana D. Radosavljevic Jelena M. Pantic Marija Z. Milovanovic Nebojsa N. Arsenijevic Miodrag L. Lukic | 2014 | Int. J. Cancer2014，，： | 2 |
| 3 | IL-33/ST2 axis in innate and acquired immunity to tumors显示文摘 | Ivan P. Jovanovic Nada N. Pejnovic Gordana D. Radosavljevic Nebojsa N. Arsenijevic Miodrag L. Lukic | 2012 | OncoImmunology2012，，： | 2 |
| 4 | The roles of Galectin-3 in autoimmunity and tumor progression显示文摘 | Gordana Radosavljevic Vladislav Volarevic Ivan Jovanovic Marija Milovanovic Nada Pejnovic Nebojsa Arsenijevic Daniel Hsu Miodrag Lukic | 2012 | Immunologic Research2012，，1： | 2 |
| 5 | Clinical significance of IL-18,IL-15,IL-12 and TNF-alpha measurement in rheumatoid arthritis显示文摘 | Petrovic-Rackov L Pejnovic N | 2006 | Clin Rheumatol2006，25，4： | 1 |
| 6 | Longitudinal study of 16 patients with Takayasu's arteritis:clinical features and therapeutic management显示文摘 | Petrovic-Rackov L Pejnovic N Jevtic M | 2009 | Clin Rheumatol2009，28，2： | 1 |
| 7 | Aberrant levels of cytokines with in the healing wound after burn injury显示文摘 | PEJNOVIC N LILIC D ZUNIC G | 1995 | Arch Surg1995，130，： | 1 |
| 8 | NKT cell subsets in infection and inflammation 显示文摘 | Chan WL Pejnovic N Liew TV | 2003 | Immunol Lett2003，85，2： | 1 |
| 9 | Disease modifying and imnmnomodulatory effects of high dose 1 alpha (OH) D3 in rheumatoid arthritis patients 显示文摘 | Andjelkovic Z Vojinovic J Pejnovic N | 1999 | Clin Exp Rheumatol1999，17，4： | 1 |
| 10 | Disease modifying and immunomodulatory effects of high dose 1 alpha (OH) D3 in rheumatoid arthritis patients显示文摘 | Andjelkovic Z Vojinovie J Pejnovic N | 1999 | Clin Exper Rheumatol1999，17，4： | 1 |
| 11 | Longitudinal study of 16 patients with Takayasu' s arteritis:clinical features and therapeutic mangement显示文摘 | Petrovic-Rackov L Pejnovic N Jevtic M | 2009 | Clin Rheumatol2009，28，2： | 1 |
| 12 | Clinical significance of IL-18,IL-15,IL-12 and TNF-alpha measurement in rheumatoid arthritis显示文摘 | Petrovic-Rackov L Pejnovic N | 2006 | Clin Rheumatol2006，25，4： | 1 |
| 13 | Interleukin-33/ST2 axis promotes breast cancer growth and metastases by facilitating intratumoral accumulation of immunosnppressive and innate lymphoid cells 显示文摘 | Jovanovic IP Pejnovic NN Radosavlievic GD | 2014 | Int J Cancer2014，134，7： | 1 |
| 14 | Interleukin-33/ST2 axis promotes breast cancer growth and metastases by facilitating intratumoral accumulation of immunosuppressive and innate lymphoid cells 显示文摘 | Jovanovic IP Pejnovic NN Radosavljevic GD | 2014 | Int J Cancer2014，134，7： | 1 |
| 15 | Increased atherosclerotic lesions and Thl7 in interleukin-18 deficient apolipoprotein E-knockout mice fed high-fat diet显示文摘 | Pejnovic N Vratinos A Lee SH | 2009 | Mol Immunol2009，47，1： | 1 |
| 16 | Increased ather- osclerotic lesions and Thl7 in interleukin-18 deficient apolipoprotein E-knockout mice fed high-fat diet 显示文摘 | Pejnovic N Vratimos A Lee SH | 2009 | Molecular Immunology2009，47，1： | 1 |
| 17 | The roles of Galectin-3 in autoimmunity and tumor progression显示文摘 | Gordana Radosavljevic Vladislav Volarevic Ivan Jovanovic Marija Milovanovic Nada Pejnovic Nebojsa Arsenijevic Daniel Hsu Miodrag Lukic | 2012 | Immunologic Research2012，，1： | 1 |
| 18 | Clinical significance of IL-18,IL-15,IL-12,and TNF-alpha measurement in rheumatoid arthritis显示文摘 | Petrovic-Rackov L Pejnovic N | 2006 | ClinRheumatol2006，25，4： | 1 |
| 19 | Human IL-18 receptor and ST2L are stable and selective markers for the respective type 1 and type 2 circulating lymphocytes 显示文摘 | Chan WL Pejnovic N Lee CA | 2001 | J lmmunol2001，167，3： | 1 |
| 20 | Increased atherosclerotic lesions and Th17 in inter leukin-18 deficient apolipoprotein E-knockout mice fed high-fat diet显示文摘 | Pejnovic N Vratimos A Lee SH | | 0，，01： | 1 |
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