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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Remote sensing and geographic information systems in the spatial temporal dynamics modeling of infectious diseases显示文摘Similar to species immigration or exotic species invasion,infectious disease transmis-sion is strengthened due to the globalization of human activities. Using schistosomiasis as an exam-ple,we propose a conceptual model simulating the spatio-temporal dynamics of infectious diseases. We base the model on the knowledge of the interrelationship among the source,media,and the hosts of the disease. With the endemics data of schistosomiasis in Xichang,China,we demonstrate that the conceptual model is feasible; we introduce how remote sensing and geographic information systems techniques can be used in support of spatio-temporal modeling; we compare the different effects caused to the entire population when selecting different groups of people for schistosomiasis control. Our work illustrates the importance of such a modeling tool in supporting spatial decisions. Our mod-eling method can be directly applied to such infectious diseases as the plague,lyme disease,and hemorrhagic fever with renal syndrome. The application of remote sensing and geographic informa-tion systems can shed light on the modeling of other infectious disease and invasive species studies. | GONG Peng 1,XU Bing 2 & LIANG Song 1、3 1. State Key Laboratory of Remote Sensing Science,Jointly Sponsored by the Institute of Remote Sensing Applications,Chi-nese Academy of Sciences and Beijing Normal University,Box 9718,Beijing 100101,China 2. Department of Geography,University of Utah,Salt Lake City,UT 84112,USA 3. School of Public Health,University of California,Berkeley,CA 94720,USA | 2006 | Science China(Life Sciences)2006，49，6： | 5 |
| 3 | Characterization of proteolipid protein-peptide-specific CD_4^+ T cell of experimental allergic encephalomyelitis in Biozzi AB/H mice | Yong Peng and Chih pin Liu Department of Neurology, The Third Affiliated Hospital, Hunan Medical University , Changsha 410013, China (Peng Y) Division of Immunology, Beckman Research Institute, City of Hope National M edical Center, Duarte, CA 9 | 2002 | Chinese Medical Journal2002，，4： | 3 |
| 4 | Outcome of oculomotor nerve palsy from posterioa communicating atery aneurysm:comparison of clipping and coiling显示文摘 | Peng RC Sepideh AH Felipe CA | 2006 | Neurosurgy2006，58，： | 1 |
| 5 | 1-3-n-Butylphthalide amelio- rates beta- amyloid-indueed neuronal toxicity in cultured neuronal cells显示文摘 | Peng Y Xing C Lemere CA | 2008 | Neurosei Lett2008，434，2： | 1 |
| 6 | Magnetic resonance imaging of vascular oxygenation changes during hyperoxia and carbogen challenges in the human retinae显示文摘 | Zhang Y Peng Q Kiel JW Rosende CA Duong TQ | 2011 | Invest Ophthalmol Vis Sci2011，52，1： | 1 |
| 7 | l-3-n-Butylphthalide ameliorates beta-amyloid-induced neuronal toxicity in cultured neuronal cells显示文摘 | Peng Y Xing C Lemere CA | 2008 | Neurosci Lett2008，434，2： | 1 |
| 8 | Marked prolongation of cardiac allograft survival by dendritic cells genetically engineered with NF-kappa B oligodeoxyribonucleotide decoys and adenoviral vectors encoding CTLA4-Ig显示文摘 | Bonham CA Peng L Liang X | | 0，，6： | 1 |
| 9 | Focal segmental glomerulosclerosis is associated with a PDSS2 haplotype and, independently, with a decreased content of coenzyme Q10 显示文摘 | Gasser DL Winkler CA Peng M | 2013 | Am J Physiol Renal Physiol2013，305，： | 1 |
| 10 | Enhancement of antibody detection in cancer using panel of recombinant tumor-associated antigens显示文摘 | Zhang JY Casiano CA Peng XX | 2003 | Cancer Epidemiol Biomark- ers Prey2003，12，2： | 1 |
| 11 | 1-3-n-Butylphthalide ameliorates beta-amyloid-induced neuronal toxicity in cultured neuronal cells显示文摘 | PENG Y XING C LEMERE CA | 2008 | Neurosci lett2008，434，2： | 1 |
| 12 | Outcome of oculomo tor nerve palsy from posterioa communicating atery aneu rysm:comparison of clipping and coiling显示文摘 | Peng RC Sepideh AH Fekipe CA | 2006 | Neurosurgy2006，58，： | 1 |
| 13 | Differential anti atherosclerotic effects in the innominate artery and aortic sinus by the liver X receptor agonist T0901317 显示文摘 | Peng D Hiipakka RA Reardon CA | 2009 | Atherosclerosis2009，203，1： | 1 |
| 14 | Enhancement of antibody detection in cancer using panel of recombinant tumor-associated antigens显示文摘 | Zhang JY Casiano CA Peng XX | 2003 | Cancer Epidemiol Biomarkers Prev2003，12，2： | 1 |
| 15 | Enhancement of antibody detection in cancer using panel of recombinant tumor-associated antigens显示文摘 | Zhang JY Casiano CA Peng XX | 2003 | Cancer Epidemiology Biomarkers Prey2003，12，2： | 1 |
| 16 | Enhancement of antibody detection in cancer using a panel of recombinant tumor-associated antigens显示文摘 | Zhang JY Casiano CA Peng XX | 2003 | Cancer Epidemiol Biomarkers Prev2003，12，2： | 1 |
| 17 | Enhance ment of antibody detecttion in cancer using Panel of recombinant tumor asssociated antigens显示文摘 | Zhang JY Casiano CA Peng XX | 2003 | Cancer Epidemiol Bionarkers Prev2003，12，2： | 1 |
| 18 | Enhancement of antibody de- tection in cancer using panel of recombinant tumor-associated anti- gens显示文摘 | Zhang JY Casiano CA Peng XX | 2003 | Cancer Epidemiol Biomarkers Prey2003，12，2： | 1 |
| 19 | Enhancement of antibody detection in cancer using panel of recombinant tumor-associated antigens 显示文摘 | Zhang JY Casiano CA Peng | 2003 | Cancer Epidemiol Biomarkers Prev2003，12，2： | 1 |
| 20 | Nonviral transfection of suspension cells in ultrasound standing wave fields显示文摘 | Lee YH Peng CA | 2007 | Ultrasound Med Biol2007，33，5： | 1 |
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