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| 1 | Plasticity of Sniffing Pattern and Neural Activity in the Olfactory Bulb of Behaving Mice During Odor Sampling,Anticipation,and Reward显示文摘The olfactory bulb(OB) is the first relay station in the olfactory system.In the OB,mitral/tufted cells(M/Ts),which are the main output neurons,play important roles in the processing and representation of odor information.Recent studies focusing on the function of M/Ts at the single-cell level in awake behaving mice have demonstrated that odor-evoked firing of single M/Ts displays transient/long-term plasticity during learning.Here,we tested whether the neural activity of M/Ts and sniffing patterns are dependent on anticipation and reward in awake behaving mice.We used an odor discrimination task combined with in vivo electrophysiological recordings in awake,head-fixed mice,and found that,while learning induced plasticity of spikes and beta oscillations during odor sampling,we also found plasticity of spikes,beta oscillation,sniffing pattern,and coherence between sniffing and theta oscillations during the periods of anticipation and/or reward.These results indicate that the activity of M/Ts plays important roles not only in odor representation but also in salience-related events such as anticipation and reward. | Penglai Liu Tiantian Cao Jinshan Xu Xingfeng Mao Dejuan Wang Anan Li | 2020 | Neuroscience Bulletin2020，36，6： | 2 |
| 2 | Advancedtreatment of coking wastewater by coagulation and zero-valent iron processes 显示文摘 | PengLai Hua-zhangZhao ChaoWang | 2007 | Journal of Hazardous Materials2007，147，： | 1 |
| 3 | High-performance γ-MnO_(2) Dual-Core,Pair-Hole Fiber for Ultrafast Photonics显示文摘Manganese dioxide(MnO2)is a widely used and well-studied 3-dimensional(3D)transition metal oxide,which has advantages in ultrafast optics due to large specific surface area,narrow bandgap,multiple pores,superior electron transfer capability,and a wide range of light absorption.However,few studies have considered its excellent performance in ultrafast photonics.y-MnO2 photonics devices were fabricated based on a special dual-core,pair-hole fiber(DCPHF)carrier and applied in ultrafast optics fields for the first time.The results show that the soliton molecule with tunable temporal separation(1.84 to 2.7 ps)and 600-MHz harmonic solitons are achieved in the experiment.The result proves that this kind of photonics device has goodapplications in ultrafast lasers,high-performance sensors,fiber optical communications,etc.,which can help expand the prospect of combining 3D materials with novel fiber for ultrafast optics device technology. | Xiaohui Li Xiangzhen Huang Yueheng Han Enci Chen Penglai Guo Wenmin Zhang Mingqi An Zhiwen Pan Qian Xu Xiaoxiao Guo Xiwei Huang Yishan Wang Wei Zhao | 2023 | Ultrafast Science2023，3，1： | 0 |
| 4 | Distinct Characteristics of Odor-evoked Calcium and Electrophysiological Signals in Mitral/Tufted Cells in the Mouse Olfactory Bulb显示文摘Fiber photometry is a recently-developed method that indirectly measures neural activity by monitoring Ca^(2+)signals in genetically-identified neuronal populations.Although fiber photometry is widely used in neuroscience research,the relationship between the recorded Ca^(2+)signals and direct electrophysiological measurements of neural activity remains elusive.Here,we simultaneously recorded odor-evoked Ca^(2+)and electrophysiological signals[single-unit spikes and local field potentials(LFPs)]from mitral/tufted cells in the olfactory bulb of awake,head-fixed mice.Odors evoked responses in all types of signal but the response characteristics(e.g.,type of response and time course)differed.The Ca^(2+)signal was correlated most closely with power in theβ-band of the LFP.The Ca^(2+)signal performed slightly better at odor classification than high-γoscillations,worse than single-unit spikes,and similarly toβoscillations.These results provide new information to help researchers select an appropriate method for monitoring neural activity under specific conditions. | Han Xu Chi Geng Xinzhong Hua Penglai Liu Jinshan Xu Anan Li | 2021 | Neuroscience Bulletin2021，37，7： | 0 |
| 5 | Tunable Negative Poisson’s Ratio in Van der Waals Superlattice显示文摘Negative Poisson’s ratio(NPR)materials are functional and mechanical metamaterials that shrink(expand)longitudinally after being compressed(stretched)laterally.By using first-principles calculations,we found that Poisson’s ratio can be tuned from near zero to negative by different stacking modes in van der Waals(vdW)graphene/hexagonal boron nitride(G/h-BN)superlattice.We attribute the NPR effect to the interaction of pz orbitals between the interfacial layers.Furthermore,a parameter calculated by analyzing the electronic band structure,namely,distance-dependent hopping integral,is used to describe the intensity of this interaction.We believe that this mechanism is not only applicable to G/h-BN superlattice but can also explain and predict the NPR effect in other vdW layered superlattices.Therefore,the NPR phenomenon,which was relatively rare in 3D and 2D materials,can be realized in the vdW superlattices by different stacking orders.The combinations of tunable NPRs with the excellent electrical/optical properties of 2D vdW superlattices will pave a novel avenue to a wide range of multifunctional applications. | Xiaowen Li Xiaobin Qiang Zhenhao Gong Yubo Zhang Penglai Gong Lang Chen | 2021 | Research2021，，1： | 0 |
| 6 | A novel odor stimulation system in freely moving,behaving animals显示文摘Precise and reliable presentation of odorants to animals is crucial for olfactory studies.Although odor stimulation systems in anesthetized or awake,head-fixed animals are well established,temporally precise odor presentation in awake,freely moving animals remains a challenge.Here,we describe a new odor stimulation system which presents odors directly to the nostrils of freely moving mice.The system comprises 3 modules:an odor-delivery module,an odor-generation module,and a control module.The new system is precise and temporally reliable,and odor stimulation can be triggered by specific sniffing phases or other events.Moreover,the system can be combined with neural recordings,such as electrophysiology,and olfactory behavioral tests to investigate how neurons in the brain represent odor information during individual olfactory behaviors.This innovative odor stimulation system may replace traditional stimulation systems:It will enable precise odor presentation in a wide range of olfactory studies in freely moving animals. | Xinsong GUO Shan LI Xuejie YU Tingting WU Penglai LIU Yufeng SHAO Anan LI | 2023 | Integrative Zoology2023，18，4： | 0 |
| 7 | RSPSSL:A novel high-fidelity Raman spectral preprocessing scheme to enhance biomedical applications and chemical resolution visualization显示文摘Raman spectroscopy has tremendous potential for material analysis with its molecular fingerprinting capability in many branches of science and technology.It is also an emerging omics technique for metabolic profiling to shape precision medicine.However,precisely attributing vibration peaks coupled with specific environmental,instrumental,and specimen noise is problematic.Intelligent Raman spectral preprocessing to remove statistical bias noise and sample-related errors should provide a powerful tool for valuable information extraction.Here,we propose a novel Raman spectral preprocessing scheme based on self-supervised learning(RSPSSL)with high capacity and spectral fidelity.It can preprocess arbitrary Raman spectra without further training at a speed of~1900 spectra per second without human interference.The experimental data preprocessing trial demonstrated its excellent capacity and signal fidelity with an 88%reduction in root mean square error and a 60%reduction in infinite norm({L}_{{\infty}})compared to established techniques.With this advantage,it remarkably enhanced various biomedical applications with a 400%accuracy elevation(ΔAUC)in cancer diagnosis,an average 38%(few-shot)and 242%accuracy improvement in paraquat concentration prediction,and unsealed the chemical resolution of biomedical hyperspectral images,especially in the spectral fingerprint region.It precisely preprocessed various Raman spectra from different spectroscopy devices,laboratories,and diverse applications.This scheme will enable biomedical mechanism screening with the label-free volumetric molecular imaging tool on organism and disease metabolomics profiling with a scenario of high throughput,cross-device,various analyte complexity,and diverse applications. | Jiaqi Hu Gina Jinna Chen Chenlong Xue Pei Liang Yanqun Xiang Chuanlun Zhang Xiaokeng Chi Guoying Liu Yanfang Ye Dongyu Cui De Zhang Xiaojun yu Hong Dang Wen Zhang Junfan Chen Quan Tang Penglai Guo Ho-Pui Ho Yuchao Li Longqing Cong Perry Ping Shum | 2024 | Light(Science & Applications)2024，13，2： | 0 |
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