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| 1 | Early-Mid Ordovician brachiopod diversification in South China显示文摘Affected by paleogeographic position, paleoclimatic condition and depositional environments, the increase of the Early-Mid Ordovician brachiopod diversity of South China commenced at the beginning of the Ordovician (early Tremadoc), accelerated from the Tetra- graptus approximatus Biozone (base of Arenig), and reached its first acme in the Didymograptus eobifidus Biozone (mid early Arenig) when the number of brachiopod genera was over 7 times as great as that at the start of the Ordovician. This was the first radiation in the history of brachiopod macroevolution in South China, which occurred nearly 5 graptolitic biozones earlier than the global trend of the great Ordovician biodiversification (in the lower part of the Undulograptus austrodentatus Biozone). It is also characterized by (1) the origination or first occurrences of some major groups, such as the punctate dalmanelloids and the pseudopunctate stro- phomenoids including Plectambonitoidea (cardinal process simple or absent) and Stro- phomenoidea (cardinal process bilobed) in South China; (2) niche expansion, particularly in the first occupation of deeper water benthic regimes by the Euorthisina-Nocturnellia Association developed at Houping, Chengkou, northern Chongqing; and (3) the differentiation of brachiopod faunas under different environmental conditions. The gradual and increasing separation from Gondwana may have been one of the factors responsible for the radiation in South China. | ZHAN Renbin, RONG Jiayu, CHENG Jinhui & CHEN Pengfei Nanjing Institute of Geology and Palaeontology, Chinese Academy of Sciences State Key Laboratory of Palaeobiology and Stratigraphy, Nanjing 210008, China | 2005 | Science China Earth Sciences2005，48，5： | 14 |
| 2 | Difference between grid connections of large-scale wind power and conventional synchronous generation显示文摘In China, regions with abundant wind energy resources are generally located at the end of power grids. The power grid architecture in these regions is typically not sufficiently strong, and the energy structure is relatively simple. Thus, connecting large-capacity wind power units complicates the peak load regulation and stable operation of the power grids in these regions. Most wind turbines use power electronic converter technology, which affects the safety and stability of the power grid differently compared with conventional synchronous generators. Furthermore, fluctuations in wind power cause fluctuations in the output of wind farms, making it difficult to create and implement suitable power generation plans for wind farms. The generation technology and grid connection scheme for wind power and conventional thermal power generation differ considerably. Moreover, the active and reactive power control abilities of wind turbines are weaker than those of thermal power units, necessitating additional equipment to control wind turbines. Hence, to address the aforementioned issues with large-scale wind power generation, this study analyzes the differences between the grid connection and collection strategies for wind power bases and thermal power plants. Based on this analysis, the differences in the power control modes of wind power and thermal power are further investigated. Finally, the stability of different control modes is analyzed through simulation. The findings can be beneficial for the planning and development of large-scale wind power generation farms. | Jie Li Chao Liu Pengfei Zhang Yafeng Wang Jun Rong | 2020 | Global Energy Interconnection2020，3，5： | 7 |
| 3 | Inverse Kinematics Analysis of a 7-DOF Space Manipulator for Trajectory Design显示文摘To solve the inverse kinematics problem for redundant degrees of freedom(DOFs)manipulators has been and still continues to be quite challenging in the field of robotics.Aiming at trajectory planning for a 7-DOF space manipulator system,joint rotation trajectories are obtained from predetermined motion trajectories and poses of the end effector in Cartesian space based on the proposed generalized inverse kinematics method.A minimum norm method is employed to choose the best trajectory among available trajectories.Numerical simulations with the7-DOF manipulator show that the proposed method can achieve the planned trajectory and pose under the circumstances of minimum angular velocities.Moreover,trajectory results from the proposed kinematics model and inverse kinematics method has the advantages of simple modelling,low computation cost,easy to solve and plan trajectory conveniently.The smooth and continuous joint rotation functions obtained from the proposed method are suitable for practical engineering applications. | Pengfei Xin Jili Rong Yongtai Yang Dalin Xiang | 2017 | Journal of Beijing Institute of Technology2017，26，3： | 5 |
| 4 | Extracellular Polysaccharide from Rhizopus nigricans Inhibits Hepatocellular Carcinoma via miR-494-3p/TRIM36 Axis and Cyclin E Ubiquitination显示文摘Background and Aims:This study was designed to uncov-er the mechanism for extracellular polysaccharide(EPS1-1)-mediated effects on hepatocellular carcinoma(HCC)devel-opment.Methods:HCC cells were treated with EPS1-1,miR-494-3p mimic,sh-TRIM36,and pcDNA3.1-TRIM36.The levels of miR-494-3p and TRIM36 were measured in nor-mal hepatocytes,THLE-2,and HepG2 and HuH7HCC cell lines,along with the protein expression of cyclin D/E and p21.The proliferation,cell cycle,and apoptosis of HCC cells were assayed.The interactions between miR-494-3p and TRIM36,and between TRIM36 and cyclin E were assessed.Finally,the expression and localization of TRIM36 and cyclin E were monitored,and tumor apoptosis was detected,in tumor xenograft model.Results:EPS1-1 suppressed HCC cell proliferation and cyclin D/E expression and promoted apoptosis and p21 expression.miR-494-3p was upregulated and TRIM36 was downregulated in HCC cells.Transfection with miR-494-3p mimic or sh-TRIM36 facilitated HCC cell proliferation and the expression of cyclin D/E protein but they inhibited apoptosis and p21 expression in the pres-ence of EPS1-1.Overexpression of TRIM36 further con-solidated EPS1-1-mediated inhibition of HCC proliferation,cyclin D/E,and the promotion of apoptosis and p21 expres-sion.Those effects were reversed by miR-494-3p overex-pression.TRIM36 was a target gene of miR-494-3p,and TRIM36 induced cyclin E ubiquitination.EPS1-1 suppressed cyclin E expression,promoted TRIM36 expression and tu-mor apoptosis,all of which were abrogated by increasing the expression of miR-494-3p in vivo.Conclusions:EPS1-1 protected against HCC by limiting its proliferation and sur-vival through the miR-494-3p/TRIM36 axis and by inducing cyclin E ubiquitination. | Haixiong Yan XiaoQian Ma Ze Mi Zhenhu He Pengfei Rong | 2022 | Journal of Clinical and Translational Hepatology2022，10，4： | 2 |
| 5 | Salmonella-mediated blood-brain barrier penetration,tumor homing and tumor microenvironment regulation for enhanced chemo/bacterial glioma therapy显示文摘Chemotherapy is an important adjuvant treatment of glioma,while the efficacy is far from satisfactory,due not only to the biological barriers of blood-brain barrier(BBB)and blood-tumor barrier(BTB)but also to the intrinsic resistance of glioma cells via multiple survival mechanisms such as upregulation of P-glycoprotein(P-gp).To address these limitations,we report a bacteria-based drug delivery strategy for BBB/BTB transportation,glioma targeting,and chemo-sensitization.Bacteria selectively colonized into hypoxic tumor region and modulated tumor microenvironment,including macrophages repolarization and neutrophils infiltration.Specifically,tumor migration of neutrophils was employed as hitchhiking delivery of doxorubicin(DOX)-loaded bacterial outer membrane vesicles(OMVs/DOX).By virtue of the surface pathogen-associated molecular patterns derived from native bacteria,OMVs/DOX could be selectively recognized by neutrophils,thus facilitating glioma targeted delivery of drug with significantly enhanced tumor accumulation by 18-fold as compared to the classical passive targeting effect.Moreover,the P-gp expression on tumor cells was silenced by bacteria typeⅢsecretion effector to sensitize the efficacy of DOX,resulting in complete tumor eradication with 100%survival of all treated mice.In addition,the colonized bacteria were finally cleared by anti-bacterial activity of DOX to minimize the potential infection risk,and cardiotoxicity of DOX was also avoided,achieving excellent compatibility.This work provides an efficient trans-BBB/BTB drug delivery strategy via cell hitchhiking for enhanced glioma therapy. | Ze Mi Qing Yao Yan Qi Jinhai Zheng Jiahao Liu Zhenguo Liu Hongpei Tan Xiaoqian Ma Wenhu Zhou Pengfei Rong | 2023 | Acta Pharmaceutica Sinica B2023，13，2： | 1 |
| 6 | Near-infrared-II deep tissue fluorescence microscopy and application显示文摘Fluorescence imaging has become an essential tool in biomedical research.However,non-invasive deep-tissue threedimensional optical in vivo imaging with the high spatiotemporal resolution is challenging due to the interaction between photons and tissues.Beam shaping has been used to tailor microscopy techniques to enhance microscope performance.The nearinfrared window(NIR)between 700 and 1,700 nm,generally emphasized as the NIR-II(1,000–1,700 nm)window,has been developed into a promising bio-optical solution chosen as the lower interaction effect in this spectrum,showing potential in basic biological research and clinical application.In this review,we summarize the existing methods to increase penetration depth and extensively describe biological microscopy techniques,NIR-II spectral windows,and fluorophores.Strategies to improve bioimaging performance and NIR-II imaging applications are introduced.Based on the current research achievements,we elucidate the main challenges and provide some recommendations and prospects for deep tissue penetration fluorescence for future biomedical applications. | Pengfei Liu Rong Zhao Hongwei Li Tianyu Zhu Yuan Li Hao Wang Xiao-Dong Zhang | 2023 | Nano Research2023，16，1： | 1 |
| 7 | The First High-quality Reference Genome of Sika Deer Provides Insights into High-tannin Adaptation显示文摘Sika deer are known to prefer oak leaves,which are rich in tannins and toxic to most mammals;however,the genetic mechanisms underlying their unique ability to adapt to living in the jungle are still unclear.In identifying the mechanism responsible for the tolerance of a highly toxic diet,we have made a major advancement by explaining the genome of sika deer.We generated the first high-quality,chromosome-level genome assembly of sika deer and measured the correlation between tannin intake and RNA expression in 15 tissues through 180 experiments.Comparative genome analyses showed that the UGT and CYP gene families are functionally involved in the adaptation of sika deer to high-tannin food,especially the expansion of the UGT family 2 subfamily B of UGT genes.The first chromosome-level assembly and genetic characterization of the tolerance to a highly toxic diet suggest that the sika deer genome may serve as an essential resource for understanding evolutionary events and tannin adaptation.Our study provides a paradigm of comparative expressive genomics that can be applied to the study of unique biological features in non-model animals. | Xiumei Xing Cheng Ai Tianjiao Wang Yang Li Huitao Liu Pengfei Hu Guiwu Wang Huamiao Liu Hongliang Wang Ranran Zhang Junjun Zheng Xiaobo Wang Lei Wang Yuxiao Chang Qian Qian Jinghua Yu Lixin Tang Shigang Wu Xiujuan Shao Alun Li Peng Cui Wei Zhan Sheng Zhao Zhichao Wu Xiqun Shao Yimeng Dong Min Rong Yihong Tan Xuezhe Cui Shuzhuo Chang Xingchao Song Tongao Yang Limin Sun Yan Ju Pei Zhao Huanhuan Fan Ying Liu Xinhui Wang Wanyun Yang Min Yang Tao Wei Shanshan Song Jiaping Xu Zhigang Yue Qiqi Liang Chunyi Li Jue Ruan Fuhe Yang | 2023 | Genomics, Proteomics & Bioinformatics2023，21，1： | 1 |
| 8 | Self-curling electroconductive nerve dressing for enhancing peripheral nerve regeneration in diabetic rats显示文摘Conductive scaffolds have been shown to exert a therapeutic effect on patients suffering from peripheral nerve injuries(PNIs).However,conventional conductive conduits are made of rigid structures and have limited applications for impaired diabetic patients due to their mechanical mismatch with neural tissues and poor plasticity.We propose the development of biocompatible electroconductive hydrogels(ECHs)that are identical to a surgical dressing in this study.Based on excellent adhesive and self-healing properties,the thin film-like dressing can be easily attached to the injured nerve fibers,automatically warps a tubular structure without requiring any invasive techniques.The ECH offers an intimate and stable electrical bridge coupling with the electrogenic nerve tissues.The in vitro experiments indicated that the ECH promoted the migration and adhesion of the Schwann cells.Furthermore,the ECH facilitated axonal regeneration and remyelination in vitro and in vivo through the MEK/ERK pathway,thus preventing muscle denervation atrophy while retaining functional recovery.The results of this study are likely to facilitate the development of non-invasive treatment techniques for PNIs in diabetic patients utilizing electroconductive hydrogels. | Can Liu Lei Fan Zhenming Tian Huiquan Wen Lei Zhou Pengfei Guan Yian Luo Chuncheung Chan Guoxin Tan Chengyun Ning Limin Rong Bin Liu | 2021 | Bioactive Materials2021，6，11： | 1 |
| 9 | Genistein protection against acetaminophen-induced liver injury via its potential impact on the activation of UDP-glucuronosyltransferase and antioxidant enzymes显示文摘 | FAN Yuanjing RONG Yu LI Pengfei | | 0，，： | 1 |
| 10 | Observation of non-Markovianity at room temperature by prolonging entanglement in solids显示文摘Open quantum systems are always exposed to an external environment,which result in interacting and exchanging information between quantum systems and their surroundings.The dynamics of real open quantum systems are often expected to deviate from the idealized Markovian process of losing information to their surrounding environment and to exhibit non-Markovian | Shijie Peng Xiangkun Xu Kebiao Xu Pu Huang Pengfei Wang Xi Kong Xing Rong Fazhan Shi Changkui Duan Jiangfeng Du | 2018 | Science Bulletin2018，63，6： | 1 |
| 11 | MEMS ultrasonic transducers for safe,low-power and portable eye-blinking monitoring显示文摘Eye blinking is closely related to human physiology and psychology.It is an effective method of communication among people and can be used in human-machine interactions.Existing blink monitoring methods include videooculography,electro-oculograms and infrared oculography.However,these methods suffer from uncomfortable use,safety risks,limited reliability in strong light or dark environments,and infringed informational security.In this paper,we propose an ultrasound-based portable approach for eye-blinking activity monitoring.Low-power pulse-echo ultrasound featuring biosafety is transmitted and received by microelectromechanical system(MEMS)ultrasonic transducers seamlessly integrated on glasses.The size,weight and power consumption of the transducers are 2.5 mm by 2.5 mm,23.3 mg and 71μW,respectively,which provides better portability than conventional methods using wearable devices.Eye-blinking activities were characterized by open and closed eye states and validated by experiments on dfferent volunteers.Finally,real-time eye-blinking monitoring was successfully demonstrated with a response time less than 1 ms.The proposed solution paves the way for ultrasound-based wearable eye-blinking monitoring and offers miniaturization,light weight,low power consumption,high informational security and biosafety. | Sheng Sun Jianyuan Wang Menglun Zhang Yuan Ning Dong Ma Yi Yuan Pengfei Niu Zhicong Rong Zhuochen Wang Wei Pang | 2022 | Microsystems & Nanoengineering2022，8，3： | 0 |
| 12 | Representation of the Madden–Julian Oscillation in CAMS-CSM显示文摘The Madden–Julian Oscillation(MJO)has a significant impact on global weather and climate and can be used as a predictability resource in extended-term forecasting.We evaluate the ability of the Chinese Academy of Meteorological Sciences Climate System Model(CAMS-CSM)to represent the MJO by using the diagnostic method proposed by the US Climate Variability and Predictability Program(CLIVAR)MJO Working Group(MJOWG).In general,the model simulates some major characteristics of MJO well,such as the seasonality characteristics and geographical dependence,the intensity of intraseasonal variability(ISV),dominant periodicity,propagation characteristics,coherence between outgoing longwave radiation(OLR)and wind,and life cycle of MJO signals.However,there are a few biases in the model when compared with observational/reanalyzed data.These include an overestimate of precipitation in the convergence zone of the North and South Pacific,a slightly weaker eastward propagation,and a shift in the dominant periodicity toward lower frequencies with slower speeds of eastward propagation.The model gives a poor simulation of the northward propagation of MJO in summer and shows less coherence between the MJO convection and wind.The role of moistening in the planetary boundary layer(PBL)in the eastward/northward propagation of MJO was also explored.An accurate representation of the vertical titling structure of moisture anomalies in CAMS-CSM leads to moistening of the PBL ahead of convection,which accounts for the eastward/northward propagation of MJO.Poor simulation of the vertical structure of the wind and moisture anomalies in the western Pacific leads to a poor simulation of the northward propagation of MJO in this area.Budget analysis of the PBL integral moisture anomalies shows that the model gives a good simulation of the moisture charging process ahead of MJO convection and that the zonal advection of moisture convergence term has a primary role in the detour of MJO over the Maritime Continent. | Pengfei REN Li GAO Hong-Li REN Xinyao RONG Jian LI | 2019 | Journal of Meteorological Research2019，33，4： | 0 |
| 13 | Enhanced thermoelectric performance of 3D-printed Bi2Te3-based materials via adding Te/Se显示文摘Bi_(2)Te_(3)-based materials were prepared by direct ink writing(DIW)3D printing and their microstructure and thermoelectric properties were investigated with an emphasis on the effect of the content of DMF and Te/Se addition.As the mass ratio of DMF in the composition increased from 6.5%to 8.0%(in mass),the electrical conductivity deteriorated because of the corresponding increased porosity and organic remains in the samples.However,the volatilization of DMF would reduce the fluidity of the slurry.Thus,thermoelectric slurry with 7.0%DMF is the most suitable mass ratio for 3D printing.Additionally,adding Te in the p-type Bi0.4Sb1.6Te3 and adding Se in the n-type Bi2Te2.6Se0.4 have significantly improved their electrical conductivity due to the increased carrier concentration and mobility.Combining with the moderate Seebeck coefficient(~200 mV/K),high power factors with~802 mW·m^(-1)·K^(-2)and 1266 mW·m^(-1)·K^(-2)were obtained for the n-type Bi_(2)Te_(2.6)Se_(0.4)þ10%Se and p-type Bi_(0.4)Sb_(1.6)Te_(3)þ7%Te,respectively,which result in the final relatively high zT values of 0.68 at 573 K and 0.56 at 330 K for ntype and p-type 3D-printed samples. | Xuedi Zhang Jin Chen Han Zhang Pengfei Zhu Rong Wang Fu Li Bo Li | 2023 | Journal of Materiomics2023，9，2： | 0 |
| 14 | Modeling and Simulation Analysis of Solar Thermal Electric Plants Based on Petri Net显示文摘At present,solar thermal power generation is in the demonstration stage,and the large-scale production is affected by many factors.In view of the characteristics of different operating modes of photothermal power generation,it is analyzed that the turbine needs to be started and stopped frequently due to different operating modes,which will lead to the instability of the output energy and the reduction of power generation efficiency.In this paper,the dynamic equation of energy conversion process is established by using the law of conservation of energy and conservation of mass.Combined with the logic switching criterion of the system,the system model was established by using the extended differential Petri net,and the validity and accuracy of the model were verified.Through the Petri net model of the system,the system’s working mode switching and power generation situation are analyzed due to the difference of direct normal irradiation intensity(DNI).Finally,the accuracy of the model is proved by comparing it with experimental data of the photovoltaic and thermal demonstration projects that have been connected to the grid. | Rong Huang Xiaojuan Lu Zeping Liang Pengfei Gao Tian Liang | 2022 | Energy Engineering2022，119，4： | 0 |
| 15 | Nitric oxide-releasing polyurethane/S-nitrosated keratin mats for accelerating wound healing显示文摘Nitric oxide(NO)plays an important role in wound healing,due to its ability to contract wound surfaces,dilate blood vessels,participate in inflammation as well as promote collagen synthesis,angiogenesis and fibroblast proliferation.Herein,keratin was first nitrosated to afford S-nitrosated keratin(KSNO).As a NO donor,KSNO was then co-electrospun with polyurethane(PU).These as-spun PU/KSNO biocomposite mats could release NO sustainably for 72 h,matching the renewal time of the wound dressing.Moreover,these mats exhibited excellent cytocompatibility with good cell adhesion and cell migration.Further,the biocomposite mats exhibited antibacterial properties without inducing severe inflammatory responses.The wound repair in vivo demonstrated that these mats accelerated wound healing by promoting tissue formation,collagen deposition,cell migration,re-epithelialization and angiogenesis.Overall,PU/KSNO mats may be promising candidates for wound dressing. | Jie Dou Rong Yang Xingxing Jin Pengfei Li Xiao Han Lijuan Wang Bo Chi Jian Shen Jiang Yuan | 2022 | Regenerative Biomaterials2022，9，1： | 0 |
| 16 | The Paradigm of Power Bounded High-Performance Computing显示文摘Modern computer systems are increasingly bounded by the available or permissible power at multiple layers from individual components to data centers.To cope with this reality,it is necessary to understand how power bounds im-pact performance,especially for systems built from high-end nodes,each consisting of multiple power hungry components.Because placing an inappropriate power bound on a node or a component can lead to severe performance loss,coordinat-ing power allocation among nodes and components is mandatory to achieve desired performance given a total power bud-get.In this article,we describe the paradigm of power bounded high-performance computing,which considers coordinated power bound assignment to be a key factor in computer system performance analysis and optimization.We apply this paradigm to the problem of power coordination across multiple layers for both CPU and GPU computing.Using several case studies,we demonstrate how the principles of balanced power coordination can be applied and adapted to the inter-play of workloads,hardware technology,and the available total power for performance improvement. | Rong Ge Xizhou Feng Pengfei Zou Tyler Allen | 2023 | Journal of Computer Science & Technology2023，38，1： | 0 |
| 17 | Study design of deep learning based automatic detection of cerebrovascular diseases on medical imaging: a position paper from Chinese Association of Radiologists显示文摘In recent years,with the development of artificial intelligence,especially deep learning technology,researches on automatic detection of cerebrovascular diseases on medical images have made tremendous progress and these models are gradually entering into clinical practice.However,because of the complexity and flexibility of the deep learning algorithms,these researches have great variability on model building,validation process,performance description and results interpretation.The lack of a reliable,consistent,standardized design protocol has,to a certain extent,affected the progress of clinical translation and technology development of computer aided detection systems.After reviewing a large number of literatures and extensive discussion with domestic experts,this position paper put forward recommendations of standardized design on the key steps of deep learning-based automatic image detection models for cerebrovascular diseases.With further research and application expansion,this position paper would continue to be updated and gradually extended to evaluate the generalizability and clinical application efficacy of such tools. | Longjiang Zhang Zhao Shi Min Chen Yingmin Chen Jingliang Cheng Li Fan Nan Hong Wenxiao Jia Guihua Jiang Shenghong Ju Xiaogang Li Xiuli Li Changhong Liang Weihua Liao Shiyuan Liu Zaiming Lu Lin Ma Ke Ren Pengfei Rong Bin Song Gang Sun Rongpin Wang Zhibo Wen Haibo Xu Kai Xu Fuhua Yan Yizhou Yu Yunfei Zha Fandong Zhang Minwen Zheng Zhen Zhou Wenzhen Zhu Guangming Lu Zhengyu Jin on behalf of Chinese Association of Radiologists | 2022 | Intelligent Medicine2022，2，4： | 0 |
| 18 | Impacts of cone-structured interface and aperiodicity on nanoscalethermal transport in Si/Gesuperlattices显示文摘Si/Ge 超点阵正在答应热电的材料把热精力变换成电力。nanoscale 在 Si/Ge 超点阵的热运输经由分子的动力学(MD ) 被调查在这短通讯的模拟。在 Si/Ge 超点阵的跨飞机的热传导性减小上的 Si 和 Ge 接口的影响被设计在 Si 和 Ge 层之间的组织锥的接口和不定期学习。Si/Ge 超点阵的左和右边之间的温度差别为 nonequilibrium MD 模拟被建立。温度的空间分发被记录检验是否不变被到达了。作为一个关键因素确定热运输,热流动通过 Si/Ge 超点阵流动的时间的进化被计算。与平接口相比,组织锥的接口贡献显著抵抗到热运输,而有不相等的厚度的 Si 和 Ge 层的非周期的安排在有效热电导率的减小上有边缘的影响。分叉的锥结构的接口显示出所有模仿的盒子的最优秀的性能,它与平、会聚的组织锥的接口和非周期的安排把平均热传导性的 33% 减小带到另外的 Si/Ge 超点阵。分叉的组织锥的接口的设计流答应提高 Si/Ge 的热电的效率上的光基于材料。 | Pengfei JI Yiming RONG Yuwen ZHANG Yong TANG | 2018 | Frontiers in Energy2018，12，1： | 0 |
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