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| 1 | Radix Achyranthis Bidentatae improves learning and memory capabilities in ovariectomized rats显示文摘Kidney-tonifying recipe can reduce the accumulation of advanced glycation end products, prevent neuronal degeneration and improve cognitive functions in ovariectomized rats. Radix Achyranthis Bidentatae alcohol extracts may dose-dependently inhibit non-enzymatic saccharification in vitro. This study aimed to examine the effect of Radix Achyranthis Bidentatae on advanced glycation end products and on learning and memory capabilities in ovariectomized rats. Ovariectomized rats were treated with Radix Achyranthis Bidentatae alcohol extracts (containing 1.5 g/kg crude drug) or 0.1% aminoguanidine for 12 weeks and behavioral testing was performed with the Y-electrical maze. This test revealed that Radix Achyranthis Bidentatae and aminoguanidine could improve the learning and memory capabilities of ovariectomized rats. Results of competitive enzyme-linked immunosorbent assay showed that treatment with Radix Achyranthis Bidentatae or aminoguanidine reduced the accumulation of advanced glycation end products in the frontal cortex of ovariectomized rats, while increasing content in the blood and urine. Biochemical tests showed that treatment with Radix Achyranthis Bidentatae or aminoguanidine decreased superoxide dismutase activity in the serum and frontal cortex, and increased serum levels of glutathione peroxidase in ovariectomized rats. In addition, there was no apparent effect on malondialdehyde levels. These experimental findings indicate that Radix Achyranthis Bidentatae inhibits production of advanced glycation end products and its accumulation in brain tissue, and improves learning and memory capabilities in ovariectomized rats. These effects may be associated with an anti-oxidative action of the extract. | Yuefen Wang Ya Xu Yanshu Pan Weihong Li Wei Zhang Yang Liu Jing Jia Pengtao Li | 2013 | Neural Regeneration Research2013，8，18： | 4 |
| 2 | Nontoxic virus nanofibers improve the detection sensitivity for the anti-p53 antibody, a biomarker in cancer patients显示文摘在浆液的 anti-p53 抗体的存在是为癌症的 biomarker。然而,它的高敏感察觉仍然是在癌症诊断的一个问题。处理这挑战,我们使用了 fd 噬菌体,对人安全的细菌特定的病毒 nanofiber 那能被以一种无差错的方式感染主人细菌大量生产,并且遗传上设计了它显示能够在它的方面墙上认出并且捕获 anti-p53 抗体的肽。我们作为一根俘获探针采用了结果的噬菌体 nanofibers 开发连接酶的 immunosorbent 试金(ELISA ) 的一个修改版本方法,称为的 phage-ELISA。我们为 anti-p53 抗体的察觉把它比作传统的 ELISA 方法, p53-ELISA,哪个使用 recombinant 捕获 anti-p53 的野类型的 p53 蛋白质抗体。我们使用了 phage-ELISA 与恶意的肿瘤的各种各样的类型在 316 个病人的一个试验性的组检测 anti-p53 抗体。我们发现 17.7% 的察觉率(56 个积极盒子) 被 phage-ELISA 完成,它为 p53-ELISA (65 个积极盒子) 比得上 20.6% 的察觉率。然而,当噬菌体和 p53 被联合为 phage/p53-ELISA 形成捕获抗体的探针时, 30.4% 的察觉率(96 个积极盒子) 被完成。我们的工作证明由于由噬菌体 nanofibers 和 p53 的 anti-p53 抗体的联合俘获, phage/p53-ELISA 与癌症的各种各样的类型在病人为 anti-p53 抗体完成了最高诊断的精确性和察觉效率。我们的工作建议那 nanofibers 和抗原的联合,哪个俘获抗体,能导致增加的察觉敏感,它为在生命科学,临床的药,和环境科学的应用是有用的。 | Pengtao Pan Yicun Wang Ye Zhu Xiang Gao Zhigang Ju Penghe Qiu Li Wang Chuanbin Mao | 2015 | Nano Research2015，8，11： | 3 |
| 3 | The Chinese herbal formula Tongluo Jiunao promotes expression of brain-derived neurotrophic factor/tropomyosin-related kinase B pathways in a rat model of ischemic brain injury显示文摘The neurotrophin-Trk receptor pathway is an intrinsic pathway to relieve damage to the central nervous system. The present study observed the effects of Tongluo Jiunao (TLJN), which comprises Panax Notoginseng and Gardenia Jasminoides, on expression of brain-derived neurotrophic factor (BDNF) and tropomyosin-related kinase B (TrkB) in a rat model of focal cerebral ischemic injury. Xue Sai Tong (XST), comprising Panax Notoginseng, served as the positive control. Mechanisms of neuroprotection were analyzed following TLJN injection. Following establishment of the middle cerebral artery occlusion models, TLJN and XST were intraperitoneally injected, and 2, 3, 5-triphenyltetrazolium chloride staining results revealed that TLJN injection reduced infarct volume, suggesting that TLJN exerted a neuroprotective effect. Enzyme-linked immunosorbent assay results showed that TLJN elevated BDNF and growth associated protein-43 expression in ischemic brain tissues, as well as serum BDNF levels. Reverse-transcription polymerase chain reaction and western blot results showed that TLJN injection did not affect TrkB expression in the ischemic brain tissues of rats. These results suggested that TLJN injection reduced damage to ischemic brain tissues and increased BDNF expression. In addition, TLJN injection resulted in better promoting effects on neurotrophic factor expression compared with XST. | Peiman Alesheikh Huiling Tang Pengtao Li Wei Zhang Yanshu Pan Arezou Mashoufi Liyun Zhao Runjun Wang Bo Di Yangyang Yan | 2011 | Neural Regeneration Research2011，6，12： | 1 |
| 4 | Screening the effective components in treating dampness stagnancy due to spleen deficiency syndrome and elucidating the potential mechanism of Poria water extract显示文摘Poria is an important medicine for inducing diuresis to drain dampness from the middle energizer.However,the specific effective components and the potential mechanism of Poria remain largely unknown.To identify the effective components and the mechanism of Poria water extract(PWE)to treat dampness stagnancy due to spleen deficiency syndrome(DSSD),a rat model of DSSD was established through weight-loaded forced swimming,intragastric ice-water stimulation,humid living environment,and alternate-day fasting for 21 days.After 14 days of treatment with PWE,the results indicated that PWE increased fecal moisture percentage,urine output,D-xylose level and weight;amylase,albumin,and total protein levels;and the swimming time of rats with DSSD to different extents.Eleven highly related components were screened out using the spectrum-effect relationship and LC-MS.Mechanistic studies revealed that PWE significantly increased the expression of serum motilin(MTL),gastrin(GAS),ADCY5/6,p-PKAα/β/γcat,and phosphorylated cAMP-response element binding protein in the stomach,and AQP3 expression in the colon.Moreover,it decreased the levels of serum ADH,the expression of AQP3 and AQP4 in the stomach,AQP1 and AQP3 in the duodenum,and AQP4 in the colon.PWE induced diuresis to drain dampness in rats with DSSD.Eleven main effective components were identified in PWE.They exerted therapeutic effect by regulating the AC-cAMP-AQP signaling pathway in the stomach,MTL and GAS levels in the serum,AQP1 and AQP3 expression in the duodenum,and AQP3 and AQP4 expression in the colon. | LI Huijun ZHANG Dandan WANG Tianhe LUO Xinyao XIA Heyuan PAN Xiang HAN Sijie YOU Pengtao WEI Qiong LIU Dan ZOU Zhongmei YE Xiaochuan | 2023 | Chinese Journal of Natural Medicines2023，21，2： | 0 |
| 5 | Confining sulfur in sandwich structure of bamboo charcoal and aluminum fluoride(BC@S@AlF3) as a long cycle performance cathode for Li-S batteries显示文摘The ’shuttle effect’ of polysulfide causing rapid capacity fade and low coulo mbic efficiency of high ene rgy storage lithium-sulfur(Li-S) batteries.Herein,a sandwich structure of bamboo charcoal/sulfur coating by aluminum fluoride(BC@S@AlF3) composites is designed and fabricated for the first time.The as-designed cathode exhibited excellent electrochemical properties and stable capacity retention.The initial capacity reaches 1119 mA h/g and the capacity after 100 cycles is 869 mA h/g at 0.5 C,which is much stable than that of composite materials without bamboo charcoal or AlF3 coating.Moreover,the BC@S@AlF3 cathode presents excellent long-term capacity stability with a capacity decay of 0.073% per cycle during 500 charge/discharge cycles at 1 C,offering a potential for use in high energy Li-S batteries.The physical confinement,chemical ancho ring,and catalysis conversion for active sulfur are achieved simultaneously with the AlF3 coating and bamboo charcoal core with porous structure. | Zhenya Luo Xiao Wang Weixin Lei Pengtao Xia Yong Pan | 2020 | Journal of Materials Science & Technology2020，52，20： | 0 |
| 6 | Continuous-Variable Quantum Computation in Circuit QED显示文摘Quantum computation (QC) offers the promise of enhanced computational capabilities and drastic accelerations in solving complex tasks such as quantum chemistry^([1,2])and prime factorization.^([3])Various physical implementations for practical QC are being pursued across the academic and industrial research initiatives.Exemplary ones include trapped ions,^([4])nuclear spin,^([5]). | Xiaozhou Pan Pengtao Song Yvonne Y.Gao | 2023 | Chinese Physics Letters2023，40，11： | 0 |
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