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| 1 | Immunohistochemical expression of intrarenal renin angiotensin system components in response to tempol in rats fed a high salt diet显示文摘AIM To determine the effect of tempol in normal rats fed high salt on arterial pressure and the balance between antagonist components of the renal renin-angiotensin system.METHODS Sprague-Dawley rats were fed with 8% Na Cl highsalt(HS) or 0.4% Na Cl(normal-salt,NS) diet for 3 wk,with or without tempol(T)(1 mmol/L,administered in drinking water). Mean arterial pressure(MAP),glomerularfiltration rate(GFR),and urinary sodium excretion(UVNa) were measured. We evaluated angiotensin Ⅱ(Ang Ⅱ),angiotensin 1-7(Ang 1-7),angiotensin converting enzyme 2(ACE2),mas receptor(Mas R),angiotensin type 1 receptor(AT1R) and angiotensin type 2 receptor(AT2R) in renal tissues by immunohistochemistry.RESULTS The intake of high sodium produced a slight but significant increase in MAP and differentially regulated components of the renal renin-angiotensin system(RAS). This included an increase in Ang Ⅱ and AT1 R,and decrease in ACE-2 staining intensity using immunohistochemistry. Antioxidant supplementation with tempol increased natriuresis and GFR,prevented changes in blood pressure and reversed the imbalance of renal RAS components. This includes a decrease in Ang Ⅱ and AT1 R,as increase in AT2,ACE2,Ang(1-7) and Mas R staining intensity using immunohistochemistry. In addition,the natriuretic effects of tempol were observed in NS-T group,which showed an increased staining intensity of AT2,ACE2,Ang(1-7) and Mas R.CONCLUSION These findings suggest that a high salt diet leads to changes in the homeostasis and balance between opposing components of the renal RAS in hypertension to favour an increase in Ang Ⅱ. Chronic antioxidant supplementation can modulate the balance between the natriuretic and antinatriuretic components of the renal RAS. | Gabriel Cao Silvana Lorena Della Penna Nicolas Martín Kouyoumdzian Marcelo Roberto Choi Susana Gorzalczany Belisario Enrique Fernández Jorge Eduardo Toblli María Inés Roson | 2017 | World Journal of Nephrology2017，6，1： | 4 |
| 2 | Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil显示文摘Background:The predictive value of the serology to detection of IgM against the Mycobacterium leprae-derived phenolic glycolipid-I/PGL-I to identify leprosy patients who are at higher risk of developing reactions remains controversial.Whether baseline results of the ML Flow test can predict leprosy reactions was investigated among a cohort of patients enrolled in The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil(U-MDT/CT-BR).Methods:This was a descriptive study focusing on the main clinical manifestations of leprosy patients enrolled in the U-MDT/CT-BR from March 2007 to February 2012 at two Brazilian leprosy reference centers.For research purposes,753 leprosy patients were categorized according to a modified Ridley-Jopling(R&J)classification and according to the development of leprosy reactions(reversal reaction/RR and erythema nodosum leprosum/ENL),and whether they had a positive or negative bacillary index/BI.Results:More than half of the patients(55.5%)reported leprosy reaction:18.3%(138/753)had a RR and 5.4%(41/753)had ENL.Leprosy reactions were more frequent in the first year following diagnosis,as seen in 27%(205/753)of patients,while 19%(142/753)developed reactions during subsequent follow-up.Similar frequencies of leprosy reactions and other clinical manifestations were observed in paucibacillary(PB)and multibacillary(MB)leprosy patients treated with U-MDT and regular MDT(R-MDT)(P=0.43 and P=0.61,respectively).Compared with PB patients,leprosy reactions were significantly more frequent in MB patients with a high BI,and more patients developed RR than ENL.However,RR and neuritis were also reported in patients with a negative BI.At baseline,the highest rate of ML Flow positivity was observed in patients with a positive BI,especially those who developed ENL,followed by patients who had neuritis and RR.Among reaction-free patients,81.9%were ML Flow positive,however,the differences were not statistically significant compared to reactional patients(P=0.45).Conclusions:MB and PB patients treated with R-MDT and U-MDT showed similar frequencies of RR and other clinical manifestations.Positive ML Flow tests were associated with MB leprosy and BI positivity.However,ML Flow test results at baseline showed limited sensitivity and specificity for predicting the development of leprosy reactions. | Emerith Mayra Hungria Regiane Morillas Oliveira Gerson Oliveira Penna Lúcio Cartaxo Aderaldo Maria Araci de Andrade Pontes Rossilene Cruz Heitor de SáGonçalves Maria Lúcia Fernandes Penna Ligia Regina Franco Sansigolo Kerr Mariane Martins de Araújo Stefani Samira Bührer-Sékula | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 3 | Human benign prostatic hyperplasia stromal cells as inducers and targets of chronic immuno - mediated inflammation 显示文摘 | Penna G Fibbl B Amuchastegni S etal | 2009 | J Immunol2009，182，1： | 1 |
| 4 | Spontaneous and prostatic steroid binding protein peptide-induced autoimmune prostatitis in the nonobese diabetic mouse显示文摘 | Penna G Amuchastegui S Cossetti C | | 0，，： | 1 |
| 5 | A vitamin D analog down-regulates proinftammatory chemokine production by pancreatic islets inhibiting T cell recruitment and type 1 diabetes development显示文摘 | Giarratana N Penna G Amuchastegui S | 2004 | J Immunol2004，173，4： | 1 |
| 6 | The paradigm of postconditioning to protect the heart 显示文摘 | PENNA C MANCARDI D RAIMONDO S | 2008 | J Cell Mol Med2008，12，2： | 1 |
| 7 | Molecular evolution of plant P5CS gene involved in proline biosynthesis 显示文摘 | RAI A N PENNA S | 2013 | Molecular Biology Reports2013，40，： | 1 |
| 8 | Expression of the inhibitory receptor ILT3 on dendritic cells is dispensable for induction of CD4 + Foxp3 + regulatory T cells by 1, 25- dihydroxyvitamin D3 显示文摘 | Penna G Roncari A Amuchastegui S | 2005 | Blood2005，106，10： | 1 |
| 9 | Postconditioning induces an anti-apoptotic effect and preserves mitochondrial integrity in isolated rat hearts显示文摘 | Penna C Perrelli MG Raimondo S | 2009 | Biochim Biophys Acta2009，1787，7： | 1 |
| 10 | Complete response of coloreetal liver metastases after chemotherapy: Does it mean cure? 显示文摘 | Benoist S Brouquet A Penna C | 2006 | J Clin Oncol2006，24，24： | 1 |
| 11 | MicroRNA -214 contributes to melanoma tumour progression through suppression of TFAP2C显示文摘 | Penna E Orso F Cimino D Tenag|ia E Lembo A Quaglino E Poliseno L Haimovic A Osella-Abate S De Pitta C Pinatel E Stadler M B Provero P Bemengo M G Osman I Taverna D | 2011 | EMBO Journal2011，30，10： | 1 |
| 12 | Electron beam melting of Ti-48A1-2Cr-2Nb alloy: Microstructure and me- chanical properties investigation显示文摘 | BIAMINO S PENNA A ACKELID U | 2011 | Intermetallics2011，19，6： | 1 |
| 13 | A hybrid algorithm for the Heterogeneous Fleet Vehicle Routing Problem显示文摘 | Subramanian A Penna P H V Uchoa E Ochi L S | 2012 | European Journal of Operational Researdti2012，221，2： | 1 |
| 14 | The vitamin D receptor agnnist elocalcitol inhibits IL - 8 - dependent benign prostatic hyper- plasia stromal cell proliferation and inflammatory response by tm'ge- ring the RhoA/Rho kinase and NF -kappaB pathways显示文摘 | Penna G Fibbi B Amuchastegui S | 2009 | Prostate2009，69，： | 1 |
| 15 | Multifaceted roles of aquaporins as molecular conduits in plant responses to abiotic stresses显示文摘 | Srivastava A K Penna S Nguyen D V | 2014 | Critical Reviews in Biotechnology2014，28，： | 1 |
| 16 | Treatment of experi- mental autoimmune prostatitis in nonobese diabetic mice by the vita- rain D receptor agonist elocalcltol显示文摘 | Penna G Amuchastegul S Cossetti C | 2006 | J Immunol2006，177，： | 1 |
| 17 | Influence of nutrient ratios on the vitro extracellular polysaccharide production by marine diatoms from the Adriatic Sea显示文摘 | Penna A Berluti S Penna N | 1999 | J Plankton Res1999，21，9： | 1 |
| 18 | A vitamin D analog down-regulates proinflammatory chemokine production by pancreatic islets inhibiting T cell recruitment and type 1 diabetes development显示文摘 | Giarratana N Penna G Amuchastegui S | | 0，，： | 1 |
| 19 | Hyperechogenic bowel in thesecond trimester fetus:a review显示文摘 | Penna S Bower S | | 0，，： | 1 |
| 20 | Development of a multiplex PCR for the detection of Haplosporidium nelsoni, Haplosporidium costale and Perkinsus marinus in the eastern oyster (Crassostrea virginica, Gmelin, 1971 ) 显示文摘 | PENNA M S KHAN M FRENCH R A | 2001 | Molecular and Cellular Probes2001，15，3： | 1 |
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