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| 1 | Helicobacter pylori upregulates prion protein expression in gastric mucosa: A possible link to prion disease显示文摘AIM: Pathological prion protein (PrPSC) is responsible for the development of transmissible spongiform encephalopathies (TSE). While PrPc enters the organism via the oral route, less data is available to know about its uptake and the role of gastrointestinal inflammation on the expression of prion precursor PrPc, which is constitutively expressed in the gastric mucosa.METHODS: We studied PrPc expression in the gastric mucosa of 10 Helicobacter pylori-positive patients before and after successful H pylori eradication compared to non-infected controls using RT-PCR and Western blotting.The effect of central mediators of gastric inflammation,i.e., gastrin, prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β) on PrPc expression was analyzed in gastric cell lines.RESULTS: PrPc expression was increased in H pyloriinfection compared with non-infected controls and decreased to normal after successful eradication. Gastrin,PGE2, and IL-1β dose-dependently upregulated PrPc in gastric cells, while TNF-α had no effect.CONCLUSION: H pylori infection leads to the upregulation of gastric PrPc expression. This can be linked to H pylori induced hypergastrinemia and increased mucosal PGE2 and IL-1β synthesis.H pylori creates a milieu for enhanced propagation of prions in the gastrointestinal tract. | Peter C Konturek Karolina Bazela Vitally Kukharskyy Michael Bauer Eckhart G Hahn Detlef Schuppan | 2005 | World Journal of Gastroenterology2005，11，48： | 9 |
| 2 | Perioperative chemotherapy for advanced gastric cancer - results from a tertiary-care hospital in Germany显示文摘BACKGROUND Neoadjuvant/perioperative chemotherapy is the recommended treatment for advanced stages of gastric cancer(>T2,N+)before tumour resection in many European guidelines.However,there is no consensus as to whether perioperative chemotherapy is as effective in distal as in proximal tumours,in addition to a relevant uncertainty concerning appropriate treatment modalities for elderly patients.AIM To investigate the role of perioperative chemotherapy in advanced gastric cancer in patients from a German tertiary clinic with respect to efficacy,localisation,and age.METHODS We performed a retrospective analysis of 158 patients from our clinic with adenocarcinoma of the stomach or the gastroesophageal junction who underwent resection between 2008 and 2016.The data were evaluated particularly in relation to patient age,tumour site,and perioperative therapy.RESULTS Administration of perioperative chemotherapy did not lead to a significant survival advantage in our study population.The 5-year survival rates were 40%for patients who received perioperative chemotherapy and 29%for the group without perioperative chemotherapy(P=0.125).Our patients were on average distinctly older than patients in most of the published randomised controlled trials.Patients elder than 75 years received perioperative chemotherapy far less frequently.Patients with a proximal tumour received perioperative chemotherapy much more often.CONCLUSION This analysis reconfirms our previous data concerning the effectiveness of perioperative chemotherapy for advanced gastric cancer.There is reasonable doubt that the quality of the existing randomized controlled trials is sufficient to generally justify perioperative chemotherapy in patients with advanced gastric cancer independent of tumour localization or age. | Katrin Bauer Giulia Manzini Doris Henne-Bruns Peter Buechler | 2020 | World Journal of Gastrointestinal Oncology2020，12，5： | 4 |
| 3 | Regional Ischemic ?Preconditioning? Protects Remote Virgin Myocardium From Subsequent Sustained Coronary Occlusion显示文摘 | Karin Przyklenk Barbara Bauer Michel Ovize Robert A. Kloner Peter Whittaker | 1993 | Circulation1993，，3： | 3 |
| 4 | Development of new electromagnetic suspension-based high-speed Maglev vehicles in China:Historical and recent progress in the field of dynamical simulation显示文摘High-speed Maglev is a cutting-edge technology brought back into the focus of research by plans of the Chinese government for the development of a new 600 km/h Maglev train.A Chinese‐German cooperation with industrial and academic partners has been established to pursue this ambitious goal and bring together experts from multiple disciplines.This contribution presents the joint work and achievements of CRRC Qingdao Sifang,thyssenkrupp Transrapid,CDFEB,and the ITM of the University of Stuttgart,regarding research and development in the field of high‐speed Maglev systems.Furthermore,an overview is given of the historical development of the Transrapid in Germany,the associated development of dynamical simulation models,and recent developments regarding high-speed Maglev trains in China. | Sansan Ding Peter Eberhard Georg Schneider Patrick Schmid Arnim Kargl Yong Cui Ullrich Martin Xin Liang Chao Huang Markus Bauer Florian Dignath Qinghua Zheng | 2023 | International Journal of Mechanical System Dynamics2023，3，2： | 3 |
| 5 | Impaired Myofibrillar Energetics and Oxidative Injury During Human Atrial Fibrillation显示文摘 | Michael J. Mihm Fushun Yu Cynthia A. Carnes Peter J. Reiser Patrick M. McCarthy David R. Van Wagoner John Anthony Bauer | 2001 | Circulation: Journal of the American Heart Association2001，，2： | 2 |
| 6 | Differential Expression of Human Beta Defensin 2 and 3 in Gastric Mucosa of H elicobacter pylori ‐Infected Individuals显示文摘 | Bianca Bauer Thomas Wex Doerthe Kuester Thomas Meyer Peter Malfertheiner | 2012 | Helicobacter2012，，1： | 2 |
| 7 | Highlights of the 2nd International Symposium on Tribbles and Diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer显示文摘The Tribbles(TRIB) family of pseudokinase proteins has been shown to play key roles in cell cycle, metabolic diseases, chronic inflammatory disease, and cancer development. A better understanding of the mechanisms of TRIB pseudokinases could provide new insights for disease development and help promote TRIB proteins as novel therapeutic targets for drug discovery. At the 2 nd International Symposium on Tribbles and Diseases held on May 7–9, 2018 in Beijing, China, a group of leading Tribbles scientists reported their findings and ongoing studies about the effects of the different TRIB proteins in the areas of immunity, metabolism, fundamental cell biology and cancer. Here, we summarize important and insightful overviews from 4 keynote lectures, 13 plenary lectures and 8 short talks that took place during this meeting. These findings may offer new insights for the understanding of the roles of TRIB pseudokinases in the development of various diseases. | Bing Cui Patrick A. Eyers Leonard L. Dobens Nguan Soon Tan Peter D. Mace Wolfgang A. Link Endre Kiss-Toth Karen Keeshan Takuro Nakamura Warren S. Pear Yodit Feseha Jessica Johnston Arkatiz Carracedo Marcel Scheideler Zabran llyas Robert C. Bauer Jorge D. Erusalimsky Dominika Grzesik Juan Salamanca-Viloria Xiaoxi Lv Yishi Jin Ke Li Guillermo Velasco Shuang Shang Jose M. Lizcano Xiaowei Zhang Jichao Zhou Jiaojiao Yu Fang Hua Feng Wang Shanshan Liu Jinmei Yu Zhuowei Hu | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 2 |
| 8 | Regional Ischemic ?Preconditioning? Protects Remote Virgin Myocardium From Subsequent Sustained Coronary Occlusion显示文摘 | Karin Przyklenk Barbara Bauer Michel Ovize Robert A. Kloner Peter Whittaker | 1993 | Circulation1993，，3： | 1 |
| 9 | Tubularized incised plate urethroplasty: expanded use in primary and repeat surgery for hypospadias 显示文摘 | Borer JG Bauer SB Peters CA | 2001 | J Urol2001，165，2： | 1 |
| 10 | Impact of nosocomial infections on clinical outcome and resource consumption in critically ill patients显示文摘 | Heinz Burgmann J. Michael Hiesmayr Anne Savey Peter Bauer Barbara Metnitz Philipp G. H. Metnitz | 2010 | Intensive Care Medicine2010，，： | 1 |
| 11 | Linking Transgene Expression of Engineered Mesenchymal Stem Cells and Angiopoietin-1–induced Differentiation to Target Cancer Angiogenesis显示文摘 | Claudius Conrad Yves Hüsemann Hanno Niess Irene von Luettichau Ralf Huss Christian Bauer Karl-Walter Jauch Christoph A. Klein Christiane Bruns Peter J. Nelson | 2011 | Annals of Surgery2011，，3： | 1 |
| 12 | How Do Stomata Sense Reductions in Atmospheric Relative Humidity?显示文摘Dear Editor, It has been known since the work of Francis Darwin that,in response to a reduction in atmospheric relative humidity (rh),stomatal aperture decreases.Screening for Arabidopsis mutants compromised in stomatal responses to reduced rh resulted in the identification of two genes,OST1 and ABA2,that are involved in stomatal response to low rh conditions.Interestingly both encode proteins previously known to be involved in ABA signaling (Xie et al.,2006,and references therein).These findings strongly suggested that,at least in part,the stomatal response to low rh is mediated by ABA and the intracellular ABA signaling pathway.Our most recent data show that low rh-induced stomatal closure can proceed by guard cell autonomous ABA synthesis (Bauer et al.,2013),suggesting that there is significant overlap between the guard cell low air humidity-induced signaling pathway and the guard cell ABA signaling pathway.Such convergence has been noted before (Xie et al.,2006,and references therein) and the example of Open STomata 1 (OST1/SRK2E)that encodes a serine-threonine protein kinase and the SLow Anion Channel SLAC1 may represent a common mechanism for most other closure-inducing signals,too. | Hubert Bauer Peter Ache Florian Wohlfart Khaled A.S. Al-Rasheid Sophia Sonnewald Uwe Sonnewald Susanne Kneitz Alistair M. Hetherington Rainer Hedrich | 2013 | Molecular Plant2013，6，5： | 1 |
| 13 | 2001 Use of 14C and 13C natural abundances for evaluating riverine,estuarine,and coastal DOC and POC sources and cycling:a review and synthesis显示文摘 | Peter A Raymond James E Bauer | 2001 | Organic Geochemisty2001，32，： | 1 |
| 14 | Traditional Chinese medicine research in the post-genomic era: Good practice, priorities, challenges and opportunities显示文摘 | Halil Uzuner Rudolf Bauer Tai-Ping Fan De-an Guo Alberto Dias Hani El-Nezami Thomas Efferth Elizabeth M. Williamson Michael Heinrich Nicola Robinson Peter J. Hylands Bruce M. Hendry Yung-Chi Cheng Qihe Xu | 2012 | Journal of Ethnopharmacology2012，，3： | 1 |
| 15 | Effect of cardiac resynchronization therapy on the incidence of electrical storm显示文摘 | Peter Nordbeck Bernhard Seidl Beatrix Fey Wolfgang R. Bauer Oliver Ritter | 2009 | International Journal of Cardiology2009，，3： | 1 |
| 16 | Chronic Cerebral Ischemia: Where “Evidence-Based Medicine” Fails Patients显示文摘 | Andrew M. Bauer Mark D. Bain Peter A. Rasmussen | 2015 | World Neurosurgery2015，，： | 1 |
| 17 | Studies on Effects of Microbial Transglutaminase on Gluten Proteins of Wheat显示文摘 | Nicole Bauer Peter Koehler Herbert Wieser | 2003 | Cereal Chemistry2003，80，6： | 1 |
| 18 | Fondaparin-ux, a syntheti c pent asaccharide: the first in a new class of antithrombotic agents--the selective factor Xa inhibitors显示文摘 | BAUER KA HAWKINS DW PETERS PC | 2002 | Cardiovasc Drug Rev2002，20，1： | 1 |
| 19 | [20] Analysis of altered gene expression by differential display显示文摘 | Peng Liang David Bauer Lidia Averboukh Peter Warthoe Markus Rohrwild Heiko Muller Michael Strauss Arthur B. Pardee | 1995 | Methods in Enzymology1995，，： | 1 |
| 20 | Estimation of the evapotranspiration rate from diurnal groundwater level fluctuations in the Okavango Delta, Botswana 显示文摘 | Peter Bauer George Thabeng Fritz Stauffer | 2004 | Journal of Hydrology2004，288，34： | 1 |
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