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| 1 | CONSORT 2010说明与详述:报告平行对照随机临床试验指南的更新显示文摘大量证据显示随机对照临床试验(randomised controlled trial,RCT)的报告质量不理想。报告不透明,则读者既不能评判试验结果是否真实可靠,也不能从中提取可用于系统综述的信息。最近的方法学分析表明,报告不充分和设计不合理与对治疗效果产生评价偏倚有关。这种系统误差对RCT损害严重,而RCT正是以其能减少或避免偏倚而被视为评价干预措施的金标准。为了提高RCT的报告质量,一个由专家和编辑组成的工作组制定了临床试验报告的统一标准(Consolidated Standards of Reporting Trials,CONSORT)声明。CONSORT声明于1996年首次发表,并于2001年更新。声明由对照检查清单和流程图组成,供作者在报告RCT时使用。许多核心医学期刊和主要国际性编辑组织都已认可CONSORT声明。该声明促进了对RCT的严格评价和解释。2001年,在对CONSORT进行修订时,人们就已经清楚地认识到,解释和说明制定CONSORT声明的原理,有助于研究人员等撰写或评价临床试验报告。一篇CONSORT说明与详述文章于2001年同2001版CONSORT声明一起发表。2007年1月的专家会议之后,对CONSORT声明作了进一步修订并已发表,即'CONSORT2010声明'。这次更新对原版对照检查清单作了文字上的修改,使其更为明晰,并收入了与一些新近才认识到的主题相关的建议,如选择性报告结局产生的偏倚。说明与详述文件旨在加强人们对CONSORT声明的理解、应用和传播,这次也作了大量修订,对每一项新增或更新的清单条目的含义和增改理由进行了解释,提供了优秀的报告实例,还尽可能地提供了相关的经验性研究的参考文献。文中收入了若干流程图实例。'CONSORT2010声明'、其说明与详述文件,以及相关网站(www.consort-statement.org),对于改进随机临床试验报告必将有所裨益。 | David Moher Sally Hopewell Kenneth F Schulz Victor Montori Peter C Gφtzsche P J Devereaux Diana Elbourne Matthias Egger Douglas G Altman 周庆辉 卞兆祥 刘建平 | 2010 | 中西医结合学报2010，8，8： | 318 |
| 2 | Capecitabine and irinotecan with and without bevacizumab for advanced colorectal cancer patients显示文摘AIM:To investigate the efficacy and safety of capecitabine plus irinotecan±bevacizumab in advanced or metastatic colorectal cancer patients. METHODS:Forty six patients with previously untreated,locally-advanced or metastatic colorectal cancer(mCRC) were recruited between 2001-2006 in a prospective open-label phaseⅡtrial,in German community-based outpatient clinics.Patients received a standard capecitabine plus irinotecan(CAPIRI) or CAPIRI plus bevacizumab(CAPIRI-BEV) regimen every 3 wk. Dose reductions were mandatory from the first cycle in cases of>grade 2 toxicity.The treatment choice of bevacizumab was at the discretion of the physician.Theprimary endpoints were response and toxicity and secondary endpoints included progression-free survival and overall survival. RESULTS:In the CAPIRI group vs the CAPRI-Bev group there were more female than male patients(47% vs 24%) ,and more patients had colon as the primary tumor site(58.8%vs 48.2%) with fewer patients having sigmoid colon as primary tumor site(5.9%vs 20.7%) .Grade 3/4 toxicity was higher with CAPIRI than CAPIRI-Bev:82%vs 58.6%.Partial response rates were 29.4%and 34.5%,and tumor control rates were 70.6%and 75.9%,respectively.No complete responses were observed.The median progression-free survival was 11.4 mo and 12.8 mo for CAPIRI and CAPIRI-Bev,respectively.The median overall survival for CAPIRI was 15 mo(458 d) and for CAPIRI-Bev 24 mo(733 d) .These differences were not statistically different.In the CAPIRI-Bev,group,two patients underwent a full secondary tumor resection after treatment,whereas in the CAPIRI group no cases underwent this procedure. CONCLUSION:Both regimens were well tolerated and offered effective tumor growth control in this outpatient setting.Severe gastrointestinal toxicities and thromboembolic events were rare and if observed were never fatal. | Markus Moehler Martin F Sprinzl Murad Abdelfattah Carl C Schimanski Bernd Adami Werner Godderz Klaus Majer Dimitri Flieger Andreas Teufel Juergen Siebler Thomas Hoehler Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，4： | 10 |
| 3 | High-density SNP-based genetic maps for the parents of an outcrossed and a selfed tetraploid garden rose cross, inferred from admixed progeny using the 68k rose SNP array显示文摘Dense genetic maps create a base for QTL analysis of important traits and future implementation of marker-assisted breeding.In tetraploid rose,the existing linkage maps include<300 markers to cover 28 linkage groups(4 homologous sets of 7 chromosomes).Here we used the 68k WagRhSNP Axiom single-nucleotide polymorphism(SNP)array for rose,in combination with SNP dosage calling at the tetraploid level,to genotype offspring from the garden rose cultivar‘Red New Dawn’.The offspring proved to be not from a single bi-parental cross.In rose breeding,crosses with unintended parents occur regularly.We developed a strategy to separate progeny into putative populations,even while one of the parents was unknown,using principle component analysis on pairwise genetic distances based on sets of selected SNP markers that were homozygous,and therefore uninformative for one parent.One of the inferred populations was consistent with self-fertilization of‘Red New Dawn’.Subsequently,linkage maps were generated for a bi-parental and a self-pollinated population with‘Red New Dawn’as the common maternal parent.The densest map,for the selfed parent,had 1929 SNP markers on 25 linkage groups,covering 1765.5 cM at an average marker distance of 0.9 cM.Synteny with the strawberry(Fragaria vesca)genome was extensive.Rose ICM1 corresponded to F.vesca pseudochromosome 7(Fv7),ICM4 to Fv4,ICM5 to Fv3,ICM6 to Fv2 and ICM7 to Fv5.Rose ICM2 corresponded to parts of F.vesca pseudochromosomes 1 and 6,whereas ICM3 is syntenic to the remainder of Fv6. | Mirjana Vukosavljev Paul Arens Roeland E Voorrips Wendy P C van't Westende G D Esselink Peter M Bourke Peter Cox W Eric van de Weg Richard G F Visser Chris Maliepaard Marinus J M Smulders | 2016 | Horticulture Research2016，3，1： | 6 |
| 4 | Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: a phase II study显示文摘 | Olivier Rixe Ronald M Bukowski M Dror Michaelson George Wilding Gary R Hudes Oliver Bolte Robert J Motzer Paul Bycott Katherine F Liau James Freddo Peter C Trask Sinil Kim Brian I Rini | 2007 | Lancet Oncology2007，，： | 2 |
| 5 | Alterations in levels of CD28^ -/CD8^ + suppressor cell precursor and CD45RO^+/CD4^+ memory T- lymphocytes in the periph- eral blood of multiple sclerosis patients 显示文摘 | Brian C Peter D Herman F | 1995 | Clin Diagn Lab Immunol1995，2，2： | 1 |
| 6 | Shock tube pyrolysis of pyridine显示文摘 | John C Mackie Meredith B ColketⅢ Peter F Nelson | 1990 | J Phys Chem1990，94，10： | 1 |
| 7 | Shock tube pyrolysis of pyrrole and kinetics modelling显示文摘 | John C Mackie Meredith B ColketⅢ Peter F Nelson | 1991 | Int J Chem Kinet1991，23，8： | 1 |
| 8 | Base - catalyzed reaction of nitriles with al- cohols: A convenient route to imidates and amidine salts 显示文摘 | Schaefer F C Peters G A | 1961 | J Org Chem1961，26，： | 1 |
| 9 | Field verification of ADCP surface gravity wave elevation spectra显示文摘 | HOITINK A J F PETERS H C SCHROEVERS M | 2007 | J Atmos Oceanic Technol2007，24，5： | 1 |
| 10 | Hydrogenolysis of cellulose to valuable chemicals over actived carbon supported monoandbimetallic nickel/tungsten catalysts显示文摘 | KATERINA F OLIVER M MARTIN L PETER C | | Green Chem0，16，： | 1 |
| 11 | Molded rigid polymer monoliths as separation media for capmary electrochromatography显示文摘 | PETERS E C PETRO M SBEC F | 1998 | Anal Chem1998，70，11： | 1 |
| 12 | Increased density and male-male interactions reduce male longevity in the medfly,Ceratitis capitata显示文摘 | GASKIN T PETER F TRACEY C | 2002 | Animal Behaviour2002，63，： | 1 |
| 13 | An endochronic plasticity theory with shear-volumetric coupling 显示文摘 | Valanis K C Peters J F | 1991 | International Journal for Numerical and Analytical Methods in Geomechanics1991，15，： | 1 |
| 14 | Illness severity,viral shedding,and antibody responses in infants hospitalized with bronchiolitis caused by respiratory syncytial virus显示文摘 | WRIGHT P F GRUBER W C PETERS M | 2002 | Infect Dis2002，185，8： | 1 |
| 15 | The recent depositional trend of polycyclic aromatic hydrocarbons and elemental carbon to the Agassiz Ice Cap, Ellesmere Island, Canada显示文摘 | Peters A J Gregor D J Teixeira C F | 1995 | The Science of the Total Environment1995，，： | 1 |
| 16 | Hepatic encephalopathy in thioacetamide - induced acute liver failure in rat : characterization of improve model and study of aminoacidergic neurotransmission显示文摘 | Zimmermann C Peter F Christian P | 1989 | Hepatology1989，9，4： | 1 |
| 17 | Mean-Risk analysis with risk associated with below-target Returns 显示文摘 | Peter C F | 1977 | The American Economic Review1977，67，2： | 1 |
| 18 | An analysis of endodontic treatment with three nickel-titanium rotary root canal preparation techniques显示文摘 | Peters O A Barbakow F Peters C I | | 0，，12： | 1 |
| 19 | A Simple Method for Calibra- ting Force Plates and Force Treadmills Using an Instrumented Pole 显示文摘 | Steven H C Peter G A Daniel P F | 2009 | Gait and Posture2009，29，： | 1 |
| 20 | Investigation of soybean oil as a diesel fuel extender:endurance tests显示文摘 | Adams C Peters J F Rand M C | 1983 | Journal America Oil Chemistry Soc1983，60，： | 1 |
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