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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Nonlinear process monitoring using kernel principal component analysis显示文摘 | Jong-Min Lee ChangKyoo Yoo Sang Wook Choi Peter A. Vanrolleghem In-Beum Lee | 2003 | Chemical Engineering Science2003，，1： | 3 |
| 3 | A multicenter, prospective, randomized comparison of a novel signal transmission capsule endoscope to an existing capsule endoscope显示文摘 | Eric H. Choi Klaus Mergener Carol Semrad Laurel Fisher David R. Cave Milan Dodig Carol Burke Jonathan A. Leighton David Kastenberg Peter Simpson James Sul Kanishka Bhattacharya Roger Charles Lauren Gerson Luke Weber Glenn Eisen Warren Reidel John J. Vargo | 2013 | Gastrointestinal Endoscopy2013，，2： | 2 |
| 4 | A Lethally Irradiated Allogeneic Granulocyte-Macrophage Colony Stimulating Factor-Secreting Tumor Vaccine for Pancreatic Adenocarcinoma: A Phase II Trial of Safety, Efficacy, and Immune Activation显示文摘 | Lutz Eric Charles J. Yeo Keith D. Lillemoe Barbara Biedrzycki Barry Kobrin Joseph Herman Elizabeth Sugar Steven Piantadosi John L. Cameron Sara Solt Beth Onners Irena Tartakovsky Miri Choi Rajni Sharma Peter B. Illei Hruban Ralph H. Ross A. Abrams Dung Le | 2011 | Annals of Surgery2011，，2： | 2 |
| 5 | Expression of Bcl-x L in ovarian carcinoma is associated with chemoresistance and recurrent disease显示文摘 | Jennifer Williams Peter C. Lucas Kent A. Griffith Milheon Choi Sarah Fogoros Yuan Yuan Hu J. Rebecca Liu | 2004 | Gynecologic Oncology2004，，2： | 2 |
| 6 | Experimental observations of the spatial anisotropy of the neutron emission in a medium energy plasma focus 显示文摘 | Aliaga-Rossel R Peter Choi | 1998 | IEEE Transactions on Plasma Science1998，26，4： | 2 |
| 7 | Zinc selectively blocks the action of N- methyl- D- aspartate on cortical neurons 显示文摘 | Peters S Koh J Choi DW | 1987 | Science1987，236，4810： | 1 |
| 8 | Challenges Facing Lithium Batteries and Electrical Double-Layer Capacitors显示文摘 | Nam-Soon Choi Jaephil Cho Peter G.Bruce | | 0，，： | 1 |
| 9 | Pharmacology of glutamate neurotoxicity in cortical cell culture :attenuation by NM-DA antagonists显示文摘 | Koh J Peters S | 1988 | J Neurosci1988，8，1： | 1 |
| 10 | Oxidation-Specific Epitopes Are Danger-Associated Molecular Patterns Recognized by Pattern Recognition Receptors of Innate Immunity显示文摘 | Yury I. Miller Soo-Ho Choi Philipp Wiesner Longhou Fang Richard Harkewicz Karsten Hartvigsen Agnès Boullier Ayelet Gonen Cody J. Diehl Xuchu Que Erica Montano Peter X. Shaw Sotirios Tsimikas Christoph J. Binder Joseph L. Witztum | 2011 | Circulation Research2011，，2： | 1 |
| 11 | Nonlinear process monitoring using kernel principal component analysis显示文摘 | Jong-Min Lee ChangKyoo Yoo Sang Wook Choi Peter A. Vanrolleghem In-Beum Lee | 2003 | Chemical Engineering Science2003，，1： | 1 |
| 12 | Immunolocalization of Gonadotropin-Releasing Hormone (GnRH)-I, GnRH-II, and Type I GnRH Receptor during Follicular Development in the Human Ovary显示文摘 | Jung-Hye Choi C Blake Gilks Nelly Auersperg Peter C. K. Leung | 2006 | The Journal of Clinical Endocrinology & Metabolism2006，，11： | 1 |
| 13 | Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial显示文摘Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of outcome.Tranexamic acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma growth.Methods and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical framework.Hypothesis In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with placebo.Sample size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of 0.05.An adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 patients.Intervention Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching placebo.Primary efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT scan.Discussion We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments. | Nawaf Yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis | 2022 | Stroke & Vascular Neurology2022，7，2： | 1 |
| 14 | Experimental Observa- tions of the Spatial Anisotropy of the Neutron Emission in a Medium Energy Plasma Focus 显示文摘 | Aliaga - Rossel R Peter Choi | 1998 | IEEE Transac- tions on Plasma Science1998，26，4： | 1 |
| 15 | Spectral and thermodynamic properties of Ag(I), Au(III), Cd(II), Co(II), Fe(III), Hg(II), Mn(II), Ni(II), Pb(II), U(IV), and Zn(II) binding by methanobactin from Methylosinus trichosporium OB3b显示文摘 | Dong W. Choi Young S. Do Corbin J. Zea Marcus T. McEllistrem Sung-W. Lee Jeremy D. Semrau Nicola L. Pohl Clint J. Kisting Lori L. Scardino Scott C. Hartsel Eric S. Boyd Gill G. Geesey Theran P. Riedel Peter H. Shafe Kim A. Kranski John R. Tritsch William | 2006 | Journal of Inorganic Biochemistry2006，，12： | 1 |
| 16 | A Comparative Study of Microstructures and Mechanical Properties Obtained by Bar and Plate Rolling显示文摘 | Sangwoo Choi Youngseog Lee Hodgson Peter D | 2002 | Journal of Materials Processing Technology2002，124，3： | 1 |
| 17 | Dynamic Contrast-Enhanced Magnetic Resonance Imaging in the Assessment of Early Response to Tumor Necrosis Factor Alpha in a Colon Carcinoma Model显示文摘 | Jin Shan Tang Garry Choy Marcelino Bernardo David Thomasson Steven K. Libutti Peter L. Choyke | 2006 | Investigative Radiology2006，，9： | 1 |
| 18 | Glidescope ? video-laryngoscopy versus direct laryngoscopy for endotracheal intubation: a systematic review and meta-analysis显示文摘 | Donald E. G. Griesdale David Liu James McKinney Peter T. Choi | 2012 | Canadian Journal of Anesthesia/Journal canadien d’anesthésie2012，，1： | 1 |
| 19 | The roles of multileaf collimators and micro - muhileaf collimator sin conformal and conventional nasopharyngeal carcinoma radiotherapy treatments 显示文摘 | Kin Yin Cheung Peter Ho Keung Choi Ricky Ming Chun Chau | 1999 | Med Phy1999，7，： | 1 |
| 20 | Pharmacology of glutamate neurotoxicity in cortical cell culture:attenuation by NMDA antagonists显示文摘 | Choi DW Koh J Peters S | 1988 | J Neurosci1988，8，： | 1 |
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