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| 1 | Role of inflammation and infection in the pathogenesis of human acute liver failure: clinical implications for monitoring and therapy显示文摘Acute liver failure is a rare and devastating clinical condition. At present, emergency liver transplantation is the only life-saving therapy in advanced cases, yet the feasibility of transplantation is affected by the presence of systemic inflammation, infection and resultant multiorgan failure. The importance of immune dysregulation and acquisition of infection in the pathogenesis of acute liver failure and its associated complications is now recognised. In this review we discuss current thinking regarding the role of infection and inflammation in the pathogenesis of and outcome in human acute liver failure, the implications for the management of such patients and suggest directions for future research. | Mhairi C Donnelly Peter C Hayes Kenneth J Simpson | 2016 | World Journal of Gastroenterology2016，22，26： | 13 |
| 2 | Human thrombin for the treatment of gastric and ectopic varices显示文摘AIM:To evaluate the efficacy of human thrombin in the treatment of bleeding gastric and ectopic varices.METHODS:Retrospective observational study in a Tertiary Referral Centre.Between January 1999-October 2005,we identified 37 patients who were endoscopically treated with human thrombin injection therapy for bleeding gastric and ectopic varices.Patient details including age,gender and aetiology of liver disease/segmental portal hypertension were documented.The thrombin was obtained from the Scottish National Blood Transfusion Service and prepared to give a solution of 250 IU/mL which was injected via a standard injection needle.All patient case notes were reviewed and the total dose of thrombin given along with the number of endoscopy sessions was recorded.Initial haemostasis rates,rebleeding rates and mortality were catalogued along with the incidence of any immediate complications which could be attributable to the thrombin therapy.The duration of follow up was also listed.The study was conducted according to the United Kingdom research ethics guidelines.RESULTS:Thirty-seven patients were included.33 patients(89%) had thrombin(250 U/mL) for gastric varices,2(5.4%) for duodenal varices,1 for rectal varices and 1 for gastric and rectal varices.(1) Gastric varices,an average of 15.2 mL of thrombin was used per patient.Re-bleeding occurred in 4 patients(10.8%),managed in 2 by a transjugular intrahepatic portosystemic shunt(TIPSS)(one unsuccessfully who died) and in other 2 by a distal splenorenal shunt;(2) Duodenal varices(or type 2 isolated gastric varices),an average of 12.5 mL was used per patient over 2-3 endoscopy sessions.Re-bleeding occurred in one patient,which was treated by TIPSS;and(3) Rectal varices,an average of 18.3 mL was used per patient over 3 endoscopy sessions.No re-bleeding occurred in this group.CONCLUSION:Human thrombin is a safe,easy to use and effective therapeutic option to control haemorrhage from gastric and ectopic varices. | Norma C McAvoy John N Plevris Peter C Hayes | 2012 | World Journal of Gastroenterology2012，18，41： | 11 |
| 3 | Nature:通过控制血管生长来开发治疗癌症等多种疾病的新型疗法显示文摘最近,一项刊登在国际杂志Nature上的研究报告中,来自耶鲁大学的研究人员通过研究揭示了如何通过控制血管发育来帮助开发治疗心血管疾病以及癌症的新型疗法。 | Yu, Pengchun Wilhelm, Kerstin Dubrac, Alexandre Tung, Joe K. Alves, Tiago C. Fang, Jennifer S. Xie, Yi Zhu, Jie Chen, Zehua De Smet, Frederik Zhang, Jiasheng Jin, Suk-Won Sun, Lele Sun, Hongye Kibbey, Richard G. Hirschi, Karen K. Hay, Nissim Carmeliet, Peter Chittenden, Thomas W. Eichmann, Anne Potente, Michael Simons, Michael | 2017 | 现代生物医学进展2017，17，22： | 9 |
| 4 | 富铅渣的性质及其还原机理显示文摘选用实验室制备的不同PbO含量的富铅渣,确定富铅渣的孔隙率和密度、软化温度、微观结构和相成分。在竖管炉中用石墨坩埚进行还原试验。研究结果表明,当温度低于900℃时,富铅渣与石墨之间没发生明显的反应。富铅渣与石墨之间的反应主要是通过液体形式进行。并对富铅渣相平衡进行热力学计算。 | 王吉坤 赵宝军 杨钢 Peter Hayes | 2004 | 有色金属(冶炼部分)2004，，6： | 8 |
| 5 | CaO/SiO_2比率对富铅渣还原反应的影响研究显示文摘制备不同CaO/SiO2比率的富铅渣,在实验室竖管炉中用石墨坩埚进行还原反应对比试验研究。结果表明,不同CaO/SiO2比率的富铅渣在不同温度条件下与碳反应,在800℃时,气体生成量随CaO与SiO2比率的增加而逐渐地增加,在1 200℃时,不同CaO/SiO2比率渣样的气体生成量趋于相同。 | 杨钢 赵宝军 王吉坤 Peter Hayes | 2008 | 有色金属(冶炼部分)2008，，4： | 4 |
| 6 | 富铅渣与铅烧结块在还原反应中的差异研究显示文摘选用实验室制备的不同PbO含量的富铅渣与工业化生产的铅烧结块在竖管炉中用石墨坩埚进行还原反应对比试验。结果表明,烧结块和富铅渣主要以液相形式与碳反应。它们之间由于结构上的差异对还原反应的影响要小于成分的影响。 | 杨钢 赵宝军 王吉坤 Peter Hayes | 2006 | 有色金属(冶炼部分)2006，，4： | 4 |
| 7 | Ki67 in breast cancer: prognostic and predictive potential显示文摘 | Rinat Yerushalmi Ryan Woods Peter M Ravdin Malcolm M Hayes Karen A Gelmon | 2010 | Lancet Oncology2010，，2： | 4 |
| 8 | 1H nuclear magnetic resonance spectroscopy-basedmetabonomic study in patients with cirrhosis and hepaticencephalopathy显示文摘AIM: To identify plasma metabolites used as biomarkers in order to distinguish cirrhotics from controls and encephalopathics.METHODS: A clinical study involving stable cirrhotic patients with and without overt hepatic encephalopathy was designed. A control group of healthy volunteers was used. Plasma from those patients was analysed using 1H- nuclear magnetic resonance spectroscopy. We used the Carr Purcell Meiboom Gill sequence to process the sample spectra at ambient probe temperature. We used a gated secondary irradiation field for water signal suppression. Samples were calibrated and referenced using the sodium trimethyl silyl propionate peak at 0.00 ppm. For each sample 128 transients(FID's) were acquired into 32 K complex data points over a spectral width of 6 KHz. 30 degree pulses were applied with an acquisition time of 4.0 s in order to achieve better resolution, followed by a recovery delay of 12 s, to allow for complete relaxation and recovery of the magnetisation. A metabolic profile was created for stable cirrhotic patients without signs of overt hepatic encephalopathy and encephalopathic patients as well as healthy controls. Stepwise discriminant analysis was then used and discriminant factors were created to differentiate between the three groups.RESULTS: Eighteen stabled cirrhotic patients, eighteen patients with overt hepatic encephalopathy and seventeen healthy volunteers were recruited. Patients with cirrhosis had significantly impaired ketone body metabolism, urea synthesis and gluconeogenesis. This was demonstrated by higher concentrations of acetoacetate(0.23 ± 0.02 vs 0.05 ± 0.00, P < 0.01), and b-hydroxybutarate(0.58 ± 0.14 vs 0.08 ± 0.00, P < 0.01), lower concentrations of glutamine(0.44 ± 0.08 vs 0.63 ± 0.03, P < 0.05), histidine(0.16 ± 0.01 vs 0.36 ± 0.04, P < 0.01) and arginine(0.08 ± 0.01 vs 0.14 ± 0.02, P < 0.03) and higher concentrations of glutamate(1.36 ± 0.25 vs 0.58 ± 0.04, P < 0.01), lactate(1.53 ± 0.11 vs 0.42 ± 0.05, P < 0.01), pyruvate(0.11 ± 0.02 vs 0.03 ± 0.00, P < 0.01) threonine(0.39 ± 0.02 vs 0.08 ± 0.01, P < 0.01) and aspartate(0.37 ± 0.03 vs 0.03 ± 0.01). A five metabolite signature by stepwise discriminant analysis could separate between controls and cirrhotic patients with an accuracy of 98%. In patients with encephalopathy we observed further derangement of ketone body metabolism, impaired production of glycerol and myoinositol, reversal of Fischer's ratio and impaired glutamine production as demonstrated by lower b-hydroxybutyrate(0.58 ± 0.14 vs 0.16 ± 0.02, P < 0.0002), higher acetoacetate(0.23 ± 0.02 vs 0.41 ± 0.16, P < 0.05), leucine(0.33 ± 0.02 vs 0.49 ± 0.05, P < 0.005) and isoleucine(0.12 ± 0.02 vs 0.27 ± 0.02, P < 0.0004) and lower glutamine(0.44 ± 0.08 vs 0.36 ± 0.04, P < 0.013), glycerol(0.53 ± 0.03 vs 0.19 ± 0.02, P < 0.000) and myoinositol(0.36 ± 0.04 vs 0.18 ± 0.02, P < 0.010) concentrations. A four metabolite signature by stepwise discriminant analysis could separate between encephalopathic and cirrhotic patients with an accuracy of 87%.CONCLUSION: Patients with cirrhosis and patients with hepatic encephalopathy exhibit distinct metabolic abnormalities and the use of metabonomics can select biomarkers for these diseases. | Konstantinos John Dabos John Andrew Parkinson Ian Howard Sadler John Nicholas Plevris Peter Clive Hayes | 2015 | World Journal of Hepatology2015，7，12： | 3 |
| 9 | The Role of the Operating Room Nurse Manager in the Successful Implementation of Preoperative Briefings and Postoperative Debriefings in the VHA Medical Team Training Program显示文摘 | Lori D. Robinson Douglas E. Paull Lisa M. Mazzia Lisa Falzetta James Hay Julia Neily Peter D. Mills Brian Carney James P. Bagian | 2010 | Journal of PeriAnesthesia Nursing2010，，： | 2 |
| 10 | Contemporary Approaches to Non-Contractual Obligations in Private International Law (Conflict of Laws) and the European Community’s “Rome II” Regulation显示文摘Introduction Traditional Private International Law(Conflict of Laws or,shorthand,“conflicts law,”in Anglo-American usage)was relatively straightforward in determining the law applicable to non-contractual obligations,particularly torts(delict):the“law of the place of the tort”was applicable。 | Peter Hay | 2008 | 中国国际私法与比较法年刊2008，11，1： | 2 |
| 11 | Primary graft dysfunction after liver transplantation: From pathogenesis to prevention显示文摘 | Khalid I Bzeizi Rajiv Jalan John N Plevris Peter C Hayes | 2003 | Liver Transpl2003，，2： | 2 |
| 12 | Human cord blood-derived cells can differentiate into hepatocytes in the mouse liver with no evidence of cellular fusion显示文摘 | Philip N Newsome Ingolfur Johannessen Shelagh Boyle Evangelos Dalakas Karen A Mcaulay Kay Samuel Frances Rae Lesley Forrester Marc L Turner Peter C Hayes David J Harrison Wendy A Bickmore John N Plevris | 2003 | Gastroenterology2003，，7： | 2 |
| 13 | Update of endoscopy in liver disease:More than just treating varices显示文摘The management of complications in liver disease is often complex and challenging.Endoscopy has undergone a period of rapid expansion with numerous novel and specialized endoscopic modalities that are of increasing value in the investigation and management of the patient with liver disease.In this review,relevant literature search and expert opinions have been used to provide a brief overview and update of the current endoscopic management of patients with liver disease and portal hypertension.The main areas covered are safety of endoscopy in patients with liver disease,the use of standard endoscopy for the treatment of varices and the role of new endoscopic modalities such as endoscopic ultrasound,esophageal capsule,argon plasma coagulation,spyglass and endomicroscopy in the investigation and treatment of liver-related gastrointestinal and biliary pathology.It is clear that the role of the endoscopy in liver disease is well beyond that of just treating varices.As the technology in endoscopy expands,so does the role of the endoscopist in liver disease. | Christoforos Krystallis Gail S Masterton Peter C Hayes John N Plevris | 2012 | World Journal of Gastroenterology2012，18，5： | 2 |
| 14 | Energy security and sustainability in Northeast Asia显示文摘 | David von Hippel Tatsujiro Suzuki James H. Williams Timothy Savage Peter Hayes | 2009 | Energy Policy2009，，11： | 1 |
| 15 | A New Approach to Molten Steel Refining Using Fine Gas Bubbles显示文摘 | Laihua WANG Hae-Geon LEE Peter HAYES | 1996 | ISIJ Int1996，36，1： | 1 |
| 16 | Pregnancy is not a risk factor for gallstone disease: Results of a randomly selected population sample显示文摘AIM: To investigate the prevalence, risk factors, and selection of the study population for cholecystolithiasis in an urban population in Germany, in relation to our own findings and to the results in the international literature.METHODS: A total of 2 147 persons (1 111 females,age 42.8±12.7 years; 1 036 males, age 42.3±13.1 years)participating in an investigation on the prevalence of Echinococcus multilocularis were studied for risk factors and prevalence of gallbladder stone disease.Risk factors were assessed by means of a standardized interview and calculation of body mass index (BMI). A diagnostic ultrasound examination of the gallbladder was performed. Data were analyzed by multiple logistic regression, using the SAS statistical software package.RESULTS: Gallbladder stones were detected in 171study participants (8.0%, n = 2 147). Risk factors for the development of gallbladder stone disease included age, sex, BMI, and positive family history. In a separate analysis of female study participants, pregnancy (yes/no)and number of pregnancies did not exert any influence.CONCLUSION: Findings of the present study confirm that age, female sex, BMI, and positive family history are risk factors for the development of gallbladder stone disease. Pregnancy and the number of pregnancies,however, could not be shown to be risk factors. There seem to be no differences in the respective prevalence for gallbladder stone disease in urban and rural populations. | Thomas Walcher Mark Martin Haenle Martina Kron Birgit Hay Richard Andrew Mason Alexa Friederike Alice von Schmiesing Armin Imhof Wolfgang Koenig Peter Kern Bernhard Otto Boehm Wolfgang Kratzer | 2005 | World Journal of Gastroenterology2005，11，43： | 1 |
| 17 | The ATHEROMA (Atorvastatin Therapy: Effects on Reduction of Macrophage Activity) Study显示文摘 | Tjun Y. Tang Simon P.S. Howarth Sam R. Miller Martin J. Graves Andrew J. Patterson Jean-Marie U-King-Im Zhi Y. Li Stewart R. Walsh Andrew P. Brown Peter J. Kirkpatrick Elizabeth A. Warburton Paul D. Hayes Kevin Varty Jonathan R. Boyle Michael E. Gaunt And | 2009 | Journal of the American College of Cardiology2009，，22： | 1 |
| 18 | The Outsourcing of Health, Sport and Physi-cal Education Work : A State of Play 显示文摘 | Benjamin James Williams Peter James Hay and DouneMacdonald | 2011 | Physical Educa-tion and Sport Pedagogy2011，16，4： | 1 |
| 19 | Physical model of studies on slag foaming 显示文摘 | Ghag Surinder S Hayes Peter C Lee Hae-Geon | 1998 | ISIJ International1998，38，11： | 1 |
| 20 | Pathogenesis of intracranial hypertension in acute liver failure: inflammation, ammonia and cerebral blood flow显示文摘 | Rajiv Jalan Steven W.M. Olde Damink Peter C. Hayes Nicolaas E.P. Deutz Alistair Lee | 2004 | Journal of Hepatology2004，，4： | 1 |
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