|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 2 | An empirical study on the influence of environmental labels on consumers 显示文摘 | Clare D' Souza Mehdi Taghian Peter Lamb | 2006 | Corporate Communications: An International Journal2006，11，2： | 1 |
| 3 | US Renal Data System 2011 Annual Data Report显示文摘 | Allan J. Collins Robert N. Foley Blanche Chavers David Gilbertson Charles Herzog Kirsten Johansen Bertram Kasiske Nancy Kutner Jiannong Liu Wendy St. Peter Haifeng Guo Sally Gustafson Brooke Heubner Kenneth Lamb Shuling Li Suying Li Yi Peng Yang Qiu Trici | 2011 | American Journal of Kidney Diseases2011，，1： | 1 |
| 4 | Green products and corporate strategy: an empirical investigation显示文摘 | Clare D’Souza Mehdi Taghian Peter Lamb Roman Peretiatkos | 2006 | Society and Business Review2006，，： | 1 |
| 5 | The Role of Lymphadenectomy in Esophageal Cancer显示文摘 | Glyn G. Jamieson Peter J. Lamb Sarah K. Thompson | 2009 | Annals of Surgery2009，，2： | 1 |
| 6 | US Renal Data System 2011 Annual Data Report显示文摘 | Allan J. Collins Robert N. Foley Blanche Chavers David Gilbertson Charles Herzog Kirsten Johansen Bertram Kasiske Nancy Kutner Jiannong Liu Wendy St. Peter Haifeng Guo Sally Gustafson Brooke Heubner Kenneth Lamb Shuling Li Suying Li Yi Peng Yang Qiu Trici | 2011 | American Journal of Kidney Diseases2011，，1： | 1 |
| 7 | Taking a Calculated Risk显示文摘 | William Bailey Benoit Couet Fiona Lamb Graeme Simpson Peter Rose | 2000 | Oilfield Review Autumn2000，2035，： | 1 |
| 8 | Improving pathways to adoption: Putting the right P’s in precision agriculture显示文摘 | David W. Lamb Paul Frazier Peter Adams | 2007 | Computers and Electronics in Agriculture2007，，1： | 1 |
| 9 | Spatially explicit competition in a mixed planting of Araucaria cunninghamii and Flindersia brayleyana显示文摘 | Jerome K. Vanclay David Lamb Peter D. Erskine David M. Cameron | 2013 | Annals of Forest Science2013，，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员