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| 1 | The clinical impact of bacterial biofilms显示文摘Bacteria survive in nature by forming biofilms on surfaces and probably most, if not all, bacteria (and fungi) are capable of forming biofilms. A biofilm is a structured consortium of bacteria embedded in a self-produced polymer matrix consisting of polysaccharide, protein and extracellular DNA. Bacterial biofilms are resistant to antibiotics, disinfectant chemicals and to phagocytosis and other components of the innate and adaptive inflammatory defense system of the body. It is known, for example, that persistence of staphylococcal infections related to foreign bodies is due to biofilm formation. Likewise, chronic Pseudomonas aeruginosa lung infections in cystic fibrosis patients are caused by biofilm growing mucoid strains. Gradients of nutrients and oxygen exist from the top to the bottom of biofilms and the bacterial cells located in nutrient poor areas have decreased metabolic activity and increased doubling times. These more or less dormant cells are therefore responsible for some of the tolerance to antibiotics. Biofilm growth is associated with an increased level of mutations. Bacteria in biofilms communicate by means of molecules, which activates certain genes responsible for production of virulence factors and, to some extent, biofilm structure. This phenomenon is called quorum sensing and depends upon the concentration of the quorum sensing molecules in a certain niche, which depends on the number of the bacteria. Biofilms can be prevented by antibiotic prophylaxis or early aggressive antibiotic therapy and they can be treated by chronic suppressive antibiotic therapy. Promising strategies may include the use of compounds which can dissolve the biofilm matrix and quorum sensing inhibitors, which increases biofilm susceptibility to antibiotics and phagocytosis. | Niels Hoiby Oana Ciofu Helle Krogh Johansen Zhi-jun Song Claus Moser Peter Ostrup Jenser Soren Molin Michael Givskov Tim Tolker-Nieisen Thomas Bjamsholt | 2011 | International Journal of Oral Science2011，3，2： | 48 |
| 2 | Ecarin clotting time but not APTT correlates with PEG-hirudin plasma activity 显示文摘 | MOSER M RUEF J PETER K | 2001 | J Thromb Thrombolysis2001，12，2： | 1 |
| 3 | Drug-resistant pulmonary tuberculosis in the Baja California-San Diego County border population显示文摘 | Peter CR Schultz E Moser K | 1998 | West J Med1998，169，4： | 1 |
| 4 | Influence of air supply parameters on indoor air diffusion:Building and Environment显示文摘 | Chen Qingyan Suter Peter Moser Alfred | 1991 | ASHRAE Trans1991，97，4： | 1 |
| 5 | Abciximab, Eptifibatide, and Tirofiban Exhibit Dose-dependent Potencies to Dissolve Platelet Aggregates显示文摘 | Martin Moser Ulf Bertram Karlheinz Peter Christoph Bode Johannes Ruef | 2003 | Journal of Cardiovascular Pharmacology2003，，4： | 1 |
| 6 | RAGE Drives the Development of Glomerulosclerosis and Implicates Podocyte Activation in the Pathogenesis of Diabetic Nephropathy显示文摘 | Thoralf M. Wendt Nozomu Tanji Jiancheng Guo Thomas R. Kislinger Wu Qu Yan Lu Loredana G. Bucciarelli Ling Ling Rong Bernhard Moser Glen S. Markowitz Gunther Stein Angelika Bierhaus Birgit Liliensiek Bernd Arnold Peter P. Nawroth David M. Stern Vivette D. | 2003 | The American Journal of Pathology2003，，4： | 1 |
| 7 | Loss of membranous expression of the intracellular domain of Ep CAM is a frequent event and predicts poor survival in patients with pancreatic cancer显示文摘 | Dominic Fong Patrizia Moser Armin Kasal Andreas Seeber Guenther Gastl Agnieszka Martowicz Martin Wurm Christine Mian Peter Obrist Guido Mazzoleni Gilbert Spizzo | 2014 | Histopathology2014，，5： | 1 |
| 8 | Influence of air supply parameters on indoor air diffusion显示文摘 | Chen Qingyan Peter Suter Alfred Moser | 1991 | Building and Environ- ment1991，26，4： | 1 |
| 9 | Abciximab, eptifi- batide, and tirofiban exhibit dose-dependent potencies to dissolve platelet aggregates显示文摘 | MOSER M BERTRAM U PETER K et ol | 2003 | J Cardiovasc Pharmacol2003，41，4： | 1 |
| 10 | αβ T-cell receptors from multiple sclerosis brain lesions show MAIT cell–related features显示文摘 | Kathrin Held Latika Bhonsle-Deeng Katherina Siewert Wakiro Sato Eduardo Beltrán Stephan Schmidt Geraldine Rühl Judy K.M. Ng Peter Engerer Markus Moser Wolfgang E.F. Klinkert Holger Babbe Thomas Misgeld Hartmut Wekerle David-Axel Laplaud Reinhard Hohlfeld | 2015 | Neurology: Neuroimmunology & Neuroinflammation2015，，4： | 1 |
| 11 | 1-Trichloromethyl-1,2,3,4-tetrahydro-β-carboline (TaClo) and related derivatives: chemistry and biochemical effects on catecholamine biosynthesis显示文摘 | Gerhard Bringmann Doris Feineis Ralf God Karl Peters Eva-Maria Peters Joachim Scholz Franz Riederer Andreas Moser | 2002 | Bioorganic & Medicinal Chemistry2002，，7： | 1 |
| 12 | Forget about theory-practice is all? Student teachers' learning in practicum 显示文摘 | Tina Hascher Yves Cocard Peter Moser | 2004 | Teachers and Teaching: theory and practice2004，10，6： | 1 |
| 13 | McGill Brisbane Symptom Score for patients with resectable pancreatic head adenocarcinoma显示文摘AIM:To evaluate the ability of the McGill Brisbane Symptom Score(MBSS)to predict survival in resectable pancreatic head adenocarcinoma(PHA)patients.METHODS:All PHA patients(n=83)undergoing pancreaticoduodenectomy at the McGill University Health Center,Quebec between 1/2001-1/2010 were evaluated.Data related to patient and cancer characteristics,MBSS variables,and treatment were collected;univariable and multivariable survival analyses were performed.We obtained complete follow-up until February 2011 in all patients through the database of the provincial health insurance plan of Quebec.The unique health insurance numbers of these patients were used to retrieve information from this database which captures all billable clinical encounters,and ensures 100%actual survival data.RESULTS:Median survival was 23 mo overall:45 mo for patients with low MBSS,17 mo for high MBSS(P=0.005).At twelve months survival was 83.3%(95%CI:66.6-92.1)vs 58.1%(95%CI:42.1-71.2)in those with low vs high MBSS,and24 mo survival was 63.8%(95%CI:45.9-77.1)and 34.0%(95%CI:20.2-48.2)respectively.In the multivariate Cox model(stratified by chemotherapy),after addition of clinically meaningful covariates,MBSS was the variable with the strongest association with survival(HR=2.63;P=0.001).Adjuvant chemotherapy interacted with MBSS category such that only high MBSS patients accrued a benefit.In univariate analysis we found a lower mortality in high MBSS but not low MBSS patients receiving adjuvant chemotherapy.This interaction variable,on Cox model,resulted in an adjusted mortality HR for the high MBSS(compared to low MBSS)of 4.14(95%CI:1.48-11.64)without chemotherapy and 2.11(95%CI:1.06-4.17)with chemotherapy.CONCLUSION:The MBSS is a simple prognostic tool for resectable PHA.Preoperative categorization of patients according to the MBSS allows effective stratification of patients to guide therapy. | Mohammed H Jamal Suhail A R Doi A James Moser Sinziana Dumitra Jad abou Khalil Eve Simoneau Prosanto Chaudhury Adedayo A Onitilo Peter Metrakos Jeffrey S Barkun | 2014 | World Journal of Gastroenterology2014，20，34： | 1 |
| 14 | Influence of air supply parameters on indoor air diffusion 显示文摘 | Chen Qingyan Peter Suter Alfred Moser | 1991 | Building and Environment1991，26，4： | 1 |
| 15 | Scheduling of design projects with uncertain number of iterations显示文摘 | LUH Peter B LIU Feng MOSER Bryan | 1999 | European Journal of Operational Research1999，113，3： | 1 |
| 16 | Environmental effects on the identified natural frequencies of the Dowling Hall Footbridge显示文摘 | Peter Moser Babak Moaveni | 2011 | Mechanical Systems and Signal Processing2011，，7： | 1 |
| 17 | High prevalence of urinary schistosomiasis in a desert population: results from an exploratory study around the Ounianga lakes in Chad显示文摘Background Researching a water-borne disease in the middle of the Sahara desert might not seem the most relevant concern.However,nomadic Sahelian pastoralists health concerns regarding their livestock and anecdotal reports about trematode infections of Fasciola spp.and Schistosoma spp.in desert-raised animals justified an exploratory study focusing on the lakes of Ounianga in Northern Chad.The aim was to test whether trematode parasites such as Schistosoma spp.occur in human populations living around the Sahara desert lakes of Ounianga Kebir and Ounianga Serir in northern Chad.Methods The study was carried out in January 2019 and comprised of three components.First,a cross sectional survey based on a random sample drawn from the population to detect infections with S.haematobium and S.mansoni;second,focus group discussions exploring disease priorities,access to health and health seeking behaviour;and third,surveying water contact sites for intermediate host snails.Samples of trematode parasites and snails were confirmed on species level by molecular genetic methods.For parasitological and malacological surveys descriptive statistics were performed.Qualitative data analysis included the full review of all transcripts,followed by a descriptive and explorative thematic analysis.Results Among 258 participants,the overall S.haematobium prevalence using urine filtration was 39.2%[95%confidence interval(CI):33.5–45.1%],with 51.5%of the infected suffering from heavy infection.The intermediate host snail of S.haematobium(Bulinus truncatus)occurred at water contact sites near both study villages,revealing the potential for local transmission.Although a positive S.mansoni point-of-care circulating cathodic antigen(POC-CCA)test result was obtained from 8.6%(95%CI 5.7–12.8%)of the samples,no intermediate host snails of S.mansoni were found,and the relevance of S.mansoni remains uncertain.Qualitative findings underline the importance of morbidity caused by urinary schistosomiasis,and the lack of access to diagnostics and treatment as a major health concern.Conclusions This research revealed a high prevalence of urinary schistosomiasis in the population living around the lakes of Ounianga in the Sahara,a United Nations Educational,Scientific and Cultural Organization(UNESCO)world heritage site in Chad.Despite the high public health importance of the associated morbidity expressed by the population,there is no access to diagnostics and treatment.Further work is needed to develop and test a context-adapted intervention. | Wendelin Moser Annour Adoum Batil Rebekka Ott Moussa Abderamane Ruth Clements Rahel Wampfler Sven Poppert Peter Steinmann Fiona Allan Helena Greter | 2022 | Infectious Diseases of Poverty2022，11，1： | 0 |
| 18 | Safety and efficacy of purified clinoptilolite-tuff treatment in patients with irritable bowel syndrome with diarrhea:Randomized controlled trial显示文摘BACKGROUND Irritable bowel syndrome(IBS)is a highly prevalent gastrointestinal disorder with poor response to treatment.IBS with predominant diarrhea(IBS-D)is accompanied by abdominal pain as well as high stool frequency and urgency.Purified clinoptilolite-tuff(PCT),which is approved by the Food and Drug Administration for use as a dietary supplement with the brand name G-PUR®,has previously shown therapeutic potential in other indications based on its physical adsorption capacity.AIM To assess whether symptoms of IBS-D can be ameliorated by oral treatment with PCT.METHODS In this randomized,placebo-controlled,double-blind pilot study,30 patients with IBS-D diagnosis based on Rome IV criteria were enrolled.Following a 4-wk run-in phase,14 patients were randomized to receive a 12-wk treatment with G-PUR®(2 g three times daily),and 16 patients received placebo.The relief from IBS-D symptoms as measured by the proportion of responders according to the Subject’s Global Assessment(SGA)of Relief was assessed as the primary outcome.For the secondary outcomes,validated IBS-D associated symptom questionnaires,exploratory biomarkers and microbiome data were collected.RESULTS The proportions of SGA of Relief responders after 12 wk were comparable in both groups,namely 21%in the G-PUR®group and 25%in the placebo group.After 4 wk of treatment,36%of patients in the G-PUR®group vs 0%in the placebo group reported complete or considerable relief.An improvement in daily abdominal pain was noted in 94%vs 83%(P=0.0353),and the median number of days with diarrhea per week decreased by 2.4 d vs 0.3 d in the G-PUR®and placebo groups,respectively.Positive trends were observed for 50%of responders in the Bristol Stool Form Scale.Positive trends were also noted for combined abdominal pain and stool consistency response and the Perceived Stress Questionnaire score.Only 64%in the G-PUR®group compared to 86%in the placebo group required rescue medication intake during the study.Stool microbiome studies showed a minor increase in diversity in the G-PUR®group but not in the placebo group.No PCT-related serious adverse events were reported.CONCLUSION In this randomized,double-blind,placebo-controlled study,the PCT product,G-PUR®,demonstrated safety and clinical benefit towards some symptoms of IBS-D,representing a promising novel treatment option for these patients. | Karolina Anderle Michael Wolzt Gabriele Moser Bettina Keip Johannes Peter Claudia Meisslitzer Ghazaleh Gouya Michael Freissmuth Cornelius Tschegg | 2022 | World Journal of Gastroenterology2022，28，46： | 0 |
| 19 | 苯茨越野车用3.5升轿车增压柴油机显示文摘越野车用梅蔡得斯—苯茨(简称苯茨)3.5升轿车增压柴油机是预燃室式柴油机系列中装有“DieseL’89”燃烧系统的一种变型。用优化方法确定的最佳燃烧参数,实现了柴油机低排放大扫矩的高性能,该机装在新一代越野车系列中。 | Manfred Fortnagel Peter Moser 王树英 | 1994 | 内燃机与动力装置1994，0，2： | 0 |
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