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| 1 | Review of current diagnostic methods and advances in Helicobacter pylori diagnostics in the era of next generation sequencing显示文摘Helicobacter pylori(H.pylori)infection is highly prevalent in the human population and may lead to severe gastrointestinal pathology including gastric and duodenal ulcers,mucosa associated tissue lymphoma and gastric adenocarcinoma.In recent years,an alarming increase in antimicrobial resistance and subsequently failing empiric H.pylori eradication therapies have been noted worldwide,also in many European countries.Therefore,rapid and accurate determination of H.pylori’s antibiotic susceptibility prior to the administration of eradication regimens becomes ever more important.Traditionally,detection of H.pylori and its antimicrobial resistance is done by culture and phenotypic drug susceptibility testing that are cumbersome with a long turn-around-time.Recent advances in diagnostics provide new tools,like real-time polymerase chain reaction(PCR)and line probe assays,to diagnose H.pylori infection and antimicrobial resistance to certain antibiotics,directly from clinical specimens.Moreover,high-throughput whole genome sequencing technologies allow the rapid analysis of the pathogen’s genome,thereby allowing identification of resistance mutations and associated antibiotic resistance.In the first part of this review,we will give an overview on currently available diagnostic methods for detection of H.pylori and its drug resistance and their implementation in H.pylori management.The second part of the review focusses on the use of next generation sequencing technology in H.pylori research.To this end,we conducted a literature search for original research articles in English using the terms“Helicobacter”,“transcriptomic”,“transcriptome”,“next generation sequencing”and“whole genome sequencing”.This review is aimed to bridge the gap between current diagnostic practice(histology,rapid urease test,H.pylori culture,PCR and line probe assays)and new sequencing technologies and their potential implementation in diagnostic laboratory settings in order to complement the currently recommended H.pylori management guidelines and subsequently improve public health. | Daniel Pohl Peter M Keller Valentine Bordier Karoline Wagner | 2019 | World Journal of Gastroenterology2019，25，32： | 15 |
| 2 | Fecal markers of inflammation used as surrogate markers for treatment outcome in relapsing inflammatory bowel disease显示文摘AIM: To evaluate fecal calprotectin (FC) as a surrogate marker of treatment outcome of relapse of inflammatory bowel disease (IBD) and, to compare FC with fecal myeloperoxidase (MPO) and fecal eosinophil protein X (EPX). METHODS: Thirty eight patients with IBD, comprising of 27 with ulcerative colitis (UC) and 11 with Crohn’s disease (CD) were investigated before treatment (inclusion), and after 4 and 8 wk of treatment. Treatment outcomes were evaluated by clinical features of disease activity and endoscopy in UC patients, and disease activity in CD patients. In addition, fecal samples were analyzed for FC by enzyme-linked immunosorbent assay (ELISA), and for MPO and EPX with radioimmunoassay (RIA). RESULTS: At inclusion 37 of 38 (97%) patients had elevated FC levels (> 94.7 μg/g). At the end of the study, 31 of 38 (82%) patients fulfilled predefined criteria of a complete response [UC 21/27 (78%); CD 10/11 (91%)]. Overall, a normalised FC level at the end of the study predicted a complete response in 100% patients, whereas elevated FC level predicted incomplete response in 30%. Normalised MPO or EPX levels predicted a complete response in 100% and90% of the patients, respectively. However, elevated MPO or EPX levels predicted incomplete response in 23% and 22%, respectively. CONCLUSION: A normalised FC level has the potential to be used as a surrogate marker for successful treatment outcome in IBD patients. However, patients with persistent elevation of FC levels need further evaluation. FC and MPO provide superior discrimination than EPX in IBD treatment outcome. | Michael Wagner Christer GB Peterson Peter Ridefelt Per Sangfelt Marie Carlson | 2008 | World Journal of Gastroenterology2008，14，36： | 9 |
| 3 | Long-Term Follow-Up of Biopsy-Proven Viral Myocarditis显示文摘 | Stefan Grün Julia Schumm Simon Greulich Anja Wagner Steffen Schneider Oliver Bruder Eva-Maria Kispert Stephan Hill Peter Ong Karin Klingel Reinhardt Kandolf Udo Sechtem Heiko Mahrholdt | 2012 | Journal of the American College of Cardiology2012，，18： | 2 |
| 4 | Myocardial Scar Visualized by Cardiovascular Magnetic Resonance Imaging Predicts Major Adverse Events in Patients With Hypertrophic Cardiomyopathy显示文摘 | Oliver Bruder Anja Wagner Christoph J. Jensen Steffen Schneider Peter Ong Eva-Maria Kispert Kai Nassenstein Thomas Schlosser Georg V. Sabin Udo Sechtem Heiko Mahrholdt | 2010 | Journal of the American College of Cardiology2010，，11： | 2 |
| 5 | Groundwater ingress to tunnels – The exact analytical solution显示文摘 | Dimitrios Kolymbas Peter Wagner | 2006 | Tunnelling and Underground Space Technology incorporating Trenchless Technology Research2006，，： | 2 |
| 6 | CMR Imaging Predicts Death and Other Adverse Events in Suspected Cardiac Sarcoidosis显示文摘 | Simon Greulich Claudia Christina Deluigi Steffen Gloekler Andreas Wahl Christine Zürn Ulrich Kramer Detlev Nothnagel Helmut Bültel Julia Schumm Stefan Grün Peter Ong Anja Wagner Steffen Schneider Kai Nassenstein Meinrad Gawaz Udo Sechtem Oliver Bruder Hei | 2013 | JACC: Cardiovascular Imaging2013，，： | 2 |
| 7 | Microencapsulated cell-mediated treatment of inoperable pancreatic carcinoma显示文摘 | Matthias L?hr Anne Hoffmeyer Jens-Christian Kr?ger Mathias Freund Johannes Hain Albrecht Holle Peter Karle Wolfram T Kn?fel Stefan Liebe Petra Müller Horst Nizze Matthias Renner Robert M Saller Thomas Wagner Karlheinz Hauenstein Walter H Günzburg Brian Sa | 2001 | The Lancet2001，，9268： | 1 |
| 8 | Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 ( Abcb4 ) knockout mice显示文摘 | Peter Fickert Andrea Fuchsbichler Martin Wagner Gernot Zollner Arthur Kaser Herbert Tilg Robert Krause Frank Lammert Cord Langner Kurt Zatloukal Hanns-Ulrich Marschall Helmut Denk Michael Trauner | 2004 | Gastroenterology2004，，1： | 1 |
| 9 | Dose-dependent Regional Cerebral Blood Flow Changes during Remifentanil Infusion in Humans: A Positron Emission Tomography Study显示文摘 | Klaus J. Wagner Frode Willoch Eberhard F. Kochs Thomas Siessmeier Thomas R. T?lle Markus Schwaiger Peter Bartenstein | 2001 | Anesthesiology2001，，5： | 1 |
| 10 | Presentation, Patterns of Myocardial Damage, and Clinical Course of Viral Myocarditis显示文摘 | Heiko Mahrholdt Anja Wagner Claudia C. Deluigi Eva Kispert Stefan Hager Gabriel Meinhardt Holger Vogelsberg Peter Fritz Juergen Dippon C Thomas Bock Karin Klingel Reinhard Kandolf Udo Sechtem | 2006 | Circulation2006，，15： | 1 |
| 11 | Estimates of myocardium at risk and collateral flow in acute myocardial infarction using electrocardiographic indexes with comparison to radionuclide and angiographic measures显示文摘 | Timothy F. Christian Raymond J. Gibbons Ian P. Clements Peter B. Berger Ronald H. Selvester Galen S. Wagner | 1995 | Journal of the American College of Cardiology1995，，： | 1 |
| 12 | Calibration and validation of microscopic models of traffic flow 显示文摘 | Elmar Brockfeld Reinhart D Ktihne Peter Wagner | 2005 | Transportation Research Record2005，1934，1： | 1 |
| 13 | The Executive Turnover Risk Premium显示文摘 | Peters F S A F Wagner | 2014 | The Journal of Finance2014，，4： | 1 |
| 14 | Cognitive Impairment Following Traumatic Brain Injury 显示文摘 | David BAlviniegas Kerri Held Peter Wagner | 2002 | Current Treatment options in Neurology2002，4，： | 1 |
| 15 | Experimental investigations on hull-fin interferences of the LOTTE airship显示文摘 | Peter Funk Thorsten Lutz Siegfried Wagner | 2003 | Aerospace Science and Technology2003，7，： | 1 |
| 16 | Prognostic Value of Renal Vein and Inferior Vena Cava Involvement in Renal Cell Carcinoma显示文摘 | Bernd Wagner Jean-Jacques Patard Arnaud Méjean Karim Bensalah Grégory Verhoest Richard Zigeuner Vincenzo Ficarra Jacques Tostain Peter Mulders Denis Chautard Jean-Luc Descotes Alexandre de la Taille Laurent Salomon Tommaso Prayer-Galetti Luca Cindolo Anto | 2008 | European Urology2008，，2： | 1 |
| 17 | AHA/ACCF/HRS Recommendations for the Standardization and Interpretation of the Electrocardiogram显示文摘 | Galen S. Wagner Peter Macfarlane Hein Wellens Mark Josephson Anton Gorgels David M. Mirvis Olle Pahlm Borys Surawicz Paul Kligfield Rory Childers Leonard S. Gettes | 2009 | Journal of the American College of Cardiology2009，，11： | 1 |
| 18 | Directed Evolution of High-Affinity Antibody Mimics Using mRNA Display显示文摘 | Lihui Xu Patti Aha Ke Gu Robert G. Kuimelis Markus Kurz Terence Lam Ai Ching Lim Hongxiang Liu Peter A. Lohse Lin Sun Shawn Weng Richard W. Wagner Dasa Lipovsek | 2002 | Chemistry & Biology2002，，8： | 1 |
| 19 | Presentation, Patterns of Myocardial Damage, and Clinical Course of Viral Myocarditis显示文摘 | Heiko Mahrholdt Anja Wagner Claudia C. Deluigi Eva Kispert Stefan Hager Gabriel Meinhardt Holger Vogelsberg Peter Fritz Juergen Dippon C Thomas Bock Karin Klingel Reinhard Kandolf Udo Sechtem | 2006 | Circulation2006，，： | 1 |
| 20 | Lethal Waterhouse-Friderichsen syndrome in posttraumatic asplenia显示文摘 | Locker GJ Wagner A Peter A | 1995 | J Trauma1995，39，4： | 1 |
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