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| 1 | Integrated lipidomics and proteomics network analysis highlights lipid and immunity pathways associated with Alzheimer's disease显示文摘Background:There is an urgent need to understand the pathways and processes underlying Alzheimer's disease(AD)for early diagnosis and development of effective treatments.This study was aimed to investigate Alzheimer's dementia using an unsupervised lipid,protein and gene multi-omics integrative approach.Methods:A lipidomics dataset comprising 185 AD patients,40 mild cognitive impairment(MCI)individuals and 185 controls,and two proteomics datasets(295 AD,159 MCI and 197 controls)were used for weighted gene CO-expression network analyses(WGCNA).Correlations of modules created within each modality with clinical AD diagnosis,brain atrophy measures and disease progression,as well as their correlations with each other,were analyzed.Gene ontology enrichment analysis was employed to examine the biological processes and molecular and cellular functions of protein modules associated with AD phenotypes.Lipid species were annotated in the lipid modules associated with AD phenotypes.The associations between established AD risk loci and the lipid/protein modules that showed high correlation with AD phenotypes were also explored.Results:Five of the 20 identified lipid modules and five of the 17 identified protein modules were correlated with clinical AD diagnosis,brain atrophy measures and disease progression.The lipid modules comprising phospholipids,triglycerides,sphingolipids and cholesterol esters were correlated with AD risk loci involved in immune response and lipid metabolism.The five protein modules involved in positive regulation of cytokine production,neutrophil-mediated immunity,and humoral immune responses were correlated with AD risk loci involved in immune and complement systems and in lipid metabolism(the APOE ε4 genotype).Conclusions:Modules of tightly regulated lipids and proteins,drivers in lipid homeostasis and innate immunity,are strongly associated with AD phenotypes. | Jin Xu Giulia Bankov Min Kim Asger Wretlind Jodie Lord Rebecca Green Angela Hodges Abdul Hye Dag Aarsland Latha Velayudhan Richard J.B.Dobson Petroula Proitsi Cristina Legido-Quigley on behalf of the AddNeuroMed Consortium | 2020 | Translational Neurodegeneration2020，9，3： | 3 |
| 2 | What will the future hold for artificial organs in the service of assisted reproduction: prospects and considerations显示文摘Assisted reproduction provides a wide spectrum of treatments and strategies addressing infertility.However,distinct groups of infertile patients with unexplained infertility,congenital disorders,and other complex cases pose a challenge in in vitro fertilization(IVF)practices.This special cohort of patients is associated with futile attempts,IVF overuse,and dead ends in management.Cutting edge research on animal models introduced this concept,along with the development of artificial organs with the aim to mimic the respective physiological functions in reproduction.Extrapolation on clinical application leads to the future use of infertility management in humans.To date,the successful clinical application of artificial reproductive organs in humans is not feasible because further animal model studies are required prior to clinical trials.The application of these artificial organs could provide a solution to infertility cases with no other options.This manuscript presents an overview on the current status,future prospects,and considerations on the potential clinical application of artificial ovary,uterus,and gametes in humans.This paper presents how the IVF practice landscape may be shaped and challenged in the future,along with the subsequent concerns in assisted reproductive treatments. | Mara Simopoulou Konstantinos Sfakianoudis Petroula Tsioulou Anna Rapani Polina Giannelou Nikolaos Kiriakopoulos Agni Pantou Nikolaos Vlahos George Anifandis Stamatis Bolaris Konstantinos Pantos Michael Koutsilieri | 2019 | Frontiers of Medicine2019，13，6： | 2 |
| 3 | Smell identification function as a severity and progression marker in Alzheimer’s disease显示文摘 | Latha Velayudhan Megan Pritchard John F. Powell Petroula Proitsi Simon Lovestone | 2013 | International Psychogeriatrics2013，，7： | 1 |
| 4 | Entorhinal Cortex Thickness Predicts Cognitive Decline in Alzheimer's Disease显示文摘 | Latha Velayudhan Petroula Proitsi Eric Westman J-Sebastian Muehlboeck Patrizia Mecocci Bruno Vellas Magda Tsolaki Iwona K&lstrok oszewska Hilkka Soininen Christian Spenger Angela Hodges John Powell Simon Lovestone Andrew Simmons | 2012 | Journal of Alzheimer's Disease2012，，3： | 1 |
| 5 | Exploring Novel Tools for Assessing High School Students' Meaningfid Un- derstanding of Organic Reactions 显示文摘 | Vachliotis Theodoros Salta Katerina Vasiliou Petroula | 2011 | J Chem Educ2011，88，： | 1 |
| 6 | Evaluation of the prognostic value of HER-2 and VEGF in breast cancer patients participating in a randomized study with dose-dense sequential adjuvant chemotherapy 显示文摘 | Ioannis K Petroula AD Helen G | 2006 | Breast Cancer Research and Treatment2006，96，： | 1 |
| 7 | The effect of the euro on foreign direct investment 显示文摘 | Pavlos Petroulas | 2007 | European Economic Review2007，51，6： | 1 |
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