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| 1 | Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma显示文摘AIM: To investigate the correlation between tissue ST6Gal I and serum msAFP in HCC patients, and to investigate their prognostic significance.METHODS: Preoperative sera,paired tumorous and non-tumorous tissues were collected from 19 consecutive patients who had undergone surgical resection of HCC.ST6Gal T activities in the tissues were measured by an in vitro microsomal enzyme activity assay. The percentages of tumor-specific msAFP in the sera were also estimated by an isoelectric focusing-immunoblotting assay.RESULTS: The tumor ST6Gal I activity was negatively correlated with serum msAFP percentage (r = -0.53,P = 0.019). Both decreased tumor ST6Gal I activity andincreased serum msAFP percentage were associatedwith poor tumor cell differentiation. Univariate analyses showed that both decreased tumor ST6Gal T activity (P = 0.028), increased serum msAFP percentage (P = 0.034) and poor tumor cell differentiation (P = 0.031)were associated with shorter overall survival. Multivariate analysis using the Cox regression model showed that the preoperative serum msAFP percentage (P = 0.022)and tumor cell differentiation status (P = 0.048) were independent prognostic indicators for patient overall survival.CONCLUSION: Our results indicate that the presence of msAFP in blood circulation is associated with a decreased activity of ST6Gal I activity in HCC. Both tissue ST6Gal I and serum msAFP are potential prognostic markers for patients with operable HCC. | Terence CW Poon Clarissa HS Chiu Paul BS Lai Tony SK Mok Benny Zee Anthony TC Chan Joseph JY Sung Philip J Johnson | 2005 | World Journal of Gastroenterology2005，11，42： | 4 |
| 2 | Global patterns of hepatocellular carcinoma management from diagnosis to death: the BRIDGE Study显示文摘 | Joong‐Won Park Minshan Chen Massimo Colombo Lewis R. Roberts Myron Schwartz Pei‐Jer Chen Masatoshi Kudo Philip Johnson Samuel Wagner Lucinda S. Orsini Morris Sherman | 2015 | Liver Int2015，，9： | 3 |
| 3 | SELDI-TOF/MS分析原发性肝癌TACE治疗前后血清蛋白质差异表达谱显示文摘目的分析原发性肝癌患者经导管肝动脉化疗栓塞(TACE)治疗后血清蛋白质4a.es~图谱的变化。方法应用SELDI—TOF/MS技术和IMAC30蛋白质芯片采集50例肝癌患者TACE治疗前后肝癌患者的血清蛋白质质谱,Biomarkerwizard软件分析差异表达蛋白质峰,应用支持向量机(supportvectormachine,SVM)建立TACE治疗前后分类模型,KOC评价各差异蛋白质峰和SVM分类模型的分类效率。结果在0~20000m/z质荷比范围内,共采集到199个蛋白质峰,BiomarkerWizard软件鉴定出13个差异表达蛋白质峰(P〈0.05),包括TACE治疗24h后7个高表达蛋白质峰和6个低表达蛋白质峰。2883、11535和11687等3个蛋白质峰区分TACE治疗前后HCC的敏感性和特异性分别为80%、76%、62%和80%、60%、62%,AUC为0.8;SVM分类模型区分TACE治疗前后HCC的敏感性和特异性均为100%。结论应用SELDI—TOF/MS技术可分析TACE治疗后血清差异表达蛋白质谱,SVM分类模型能有效区分TACE治疗前后HCC。 | 齐义军 马瑾 张天 王明 晁玮霞 朱晗 刘瑞敏 马远方 Philip Johnson | 2014 | 中国现代医学杂志2014，24，5： | 3 |
| 4 | Endoscopic Ultrasound and Computed Tomography Predictors of Pancreatic Cancer Resectability显示文摘 | Philip Q. Bao J. Chad Johnson Elizabeth H. Lindsey David A. Schwartz Ron C. Arildsen Ewa Grzeszczak Alexander A. Parikh Nipun B. Merchant | 2008 | Journal of Gastrointestinal Surgery2008，，1： | 2 |
| 5 | Multidisciplinary strategies to improve treatment outcomes in hepatocellular carcinoma: a European perspective显示文摘 | Massimo Colombo Jean-Luc Raoul Riccardo Lencioni Peter R. Galle Jessica Zucman-Rossi Rafael Ba?ares Daniel Seehofer Peter Neuhaus Philip Johnson | 2013 | European Journal of Gastroenterology & Hepatology2013，，6： | 2 |
| 6 | Cancer Transmission From Organ Donors—Unavoidable But Low Risk显示文摘 | Rajeev Desai Dave Collett Christopher J. Watson Philip Johnson Tim Evans James Neuberger | 2012 | Transplantation Journal2012，，12： | 2 |
| 7 | Endoscopic Ultrasound and Computed Tomography Predictors of Pancreatic Cancer Resectability显示文摘 | Philip Q. Bao J. Chad Johnson Elizabeth H. Lindsey David A. Schwartz Ron C. Arildsen Ewa Grzeszczak Alexander A. Parikh Nipun B. Merchant | 2008 | Journal of Gastrointestinal Surgery2008，，1： | 1 |
| 8 | Photon count- ing imaging: the digital APD 显示文摘 | Steben Johnson Philip Gatt Terry Nichols | 2006 | SPIE2006，，60： | 1 |
| 9 | Deposition and redistribution of fungicides applied by air and chemigation for control of late blight in commercial potato显示文摘 | BRAD GEARY PHILIP B HAMM DENNIS A JOHNSON | 2008 | Americal Journal of Patato to Research2008，81，5： | 1 |
| 10 | Dead-time effects on geiger-mode APD performance 显示文摘 | Philip Gatt Steven Johnson Terry Nichols | 2007 | SPIE2007，6550，65： | 1 |
| 11 | Blind Equalization Using the Constant Modulus Criterion: A Review 显示文摘 | C Richard Johnson JR Philip Schniter Thomas Genders | 1998 | Proceedings of the IEEE (S0018-9219)1998，86，10： | 1 |
| 12 | The relationship between asset growth and the cross-section of stock returns显示文摘 | Philip Gray Jessica Johnson | 2010 | Journal of Banking and Finance2010，，3： | 1 |
| 13 | Biology of Hepatocellular Carcinoma显示文摘 | Roberta W. C. Pang PhD Jae Won Joh MD Philip J. Johnson MD Morito Monden MD Timothy M. Pawlik MD MPH Ronnie T. P. Poon MS PhD | 2008 | Annals of Surgical Oncology2008，，4： | 1 |
| 14 | Early Antibiotic Treatment for Severe Acute Necrotizing Pancreatitis: A Randomized, Double-Blind, Placebo-Controlled Study显示文摘 | E Patchen Dellinger Jose M. Tellado Norberto E. Soto Stanley W. Ashley Philip S. Barie Thierry Dugernier Clement W. Imrie Colin D. Johnson Hanns-Peter Knaebel Pierre-Francois Laterre Enrique Maravi-Poma Jorge J. Olsina Kissler Miguel Sanchez-Garcia Stefan | 2007 | Annals of Surgery2007，，5： | 1 |
| 15 | Hyper-fihration studies(Ⅳ) salt rejection by dynamically formed hydrous oxide membrane显示文摘 | Marcinkowsky E Philips K A Johnson H O | 1966 | J Am Chem Soc1966，88，： | 1 |
| 16 | Enforcing Online Arbitration Agreements for Cross - Border Consumer Small Claims in China and the United States 显示文摘 | Philip Johnson | 2013 | Hastings International and Comparative Law Review2013，，： | 1 |
| 17 | Diamonds in det- onation soot 显示文摘 | Greiner NR Philips DS Johnson JD Volk F | 1988 | Nature 19881988，，： | 1 |
| 18 | GDNF overexpression fails to provoke muscle recovery from botulinum toxin poisoning: A preliminary study显示文摘 | Kenny F. Lin Hank H. Sun Matthew R. Macewan Susan E. Mackinnon Philip J. Johnson | 2012 | Microsurgery2012，，5： | 1 |
| 19 | Use of lamivudine to prevent hepatitis B virus reactivation during chemotherapy in breast cancer patients显示文摘 | Winnie Yeo Wing M. Ho Pun Hui Paul K. S. Chan Kwok C. Lam Jam J. Lee Philip J. Johnson | 2004 | Breast Cancer Research and Treatment2004，，3： | 1 |
| 20 | Diamonds in detonation soot 显示文摘 | G-reiner N R Philips D S Johnson J D | 1988 | Nature1988，333，2： | 1 |
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